Lrrc8d (leucine rich repeat containing 8 VRAC subunit D) - Rat Genome Database

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Gene: Lrrc8d (leucine rich repeat containing 8 VRAC subunit D) Rattus norvegicus
Analyze
Symbol: Lrrc8d
Name: leucine rich repeat containing 8 VRAC subunit D
RGD ID: 1309601
Description: Contributes to volume-sensitive anion channel activity. Involved in aspartate transmembrane transport; cellular response to osmotic stress; and taurine transmembrane transport. Part of monoatomic ion channel complex. Orthologous to human LRRC8D (leucine rich repeat containing 8 VRAC subunit D); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: leucine rich repeat containing 5; leucine rich repeat containing 8 family, member D; leucine rich repeat containing 8D; leucine-rich repeat-containing 5; leucine-rich repeat-containing protein 5; leucine-rich repeat-containing protein 8D; LOC305131; Lrrc5; MGC93739; volume-regulated anion channel subunit LRRC8D
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8144,335,114 - 4,411,549 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl144,332,130 - 4,445,639 (-)EnsemblGRCr8
mRatBN7.2144,029,971 - 4,134,922 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl144,029,473 - 4,135,877 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx144,031,137 - 4,046,274 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0145,331,273 - 5,346,414 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0144,034,927 - 4,050,056 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0145,085,606 - 5,194,808 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl145,086,054 - 5,101,177 (-)Ensemblrn6Rnor6.0
Rnor_5.0145,077,476 - 5,157,358 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4145,104,878 - 5,120,038 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera144,193,278 - 4,208,420 (-)NCBICelera
RGSC_v3.1145,104,878 - 5,120,038 (-)NCBI
Cytogenetic Map14p22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dichlorobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,6-dinitrotoluene  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
avobenzone  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cobalt dichloride  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
fipronil  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
glafenine  (EXP)
GSK-J4  (ISO)
hypochlorous acid  (ISO)
iron dichloride  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
prothioconazole  (ISO)
quercetin  (ISO)
resorcinol  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO,ISS)
endoplasmic reticulum membrane  (IEA)
membrane  (IEA,ISO,ISS)
monoatomic ion channel complex  (IBA,IMP,ISO,ISS)
plasma membrane  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Molecular composition and heterogeneity of the LRRC8-containing swelling-activated osmolyte channels in primary rat astrocytes. Schober AL, etal., J Physiol. 2017 Nov 15;595(22):6939-6951. doi: 10.1113/JP275053. Epub 2017 Sep 12.
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:19946888   PMID:24790029   PMID:26824658   PMID:28193731  


Genomics

Comparative Map Data
Lrrc8d
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8144,335,114 - 4,411,549 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl144,332,130 - 4,445,639 (-)EnsemblGRCr8
mRatBN7.2144,029,971 - 4,134,922 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl144,029,473 - 4,135,877 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx144,031,137 - 4,046,274 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0145,331,273 - 5,346,414 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0144,034,927 - 4,050,056 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0145,085,606 - 5,194,808 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl145,086,054 - 5,101,177 (-)Ensemblrn6Rnor6.0
Rnor_5.0145,077,476 - 5,157,358 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4145,104,878 - 5,120,038 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera144,193,278 - 4,208,420 (-)NCBICelera
RGSC_v3.1145,104,878 - 5,120,038 (-)NCBI
Cytogenetic Map14p22NCBI
LRRC8D
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38189,821,032 - 89,936,611 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl189,820,978 - 89,936,611 (+)Ensemblhg38GRCh38
GRCh37190,286,591 - 90,402,170 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36190,060,101 - 90,174,148 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34189,999,533 - 90,113,580NCBI
Celera188,532,275 - 88,647,680 (+)NCBICelera
Cytogenetic Map1p22.2NCBI
HuRef188,403,943 - 88,519,276 (+)NCBIHuRef
CHM1_1190,401,923 - 90,517,356 (+)NCBICHM1_1
T2T-CHM13v2.0189,664,217 - 89,779,829 (+)NCBIT2T-CHM13v2.0
Lrrc8d
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395105,847,829 - 105,963,081 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5105,847,835 - 105,980,302 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385105,699,963 - 105,815,215 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5105,699,969 - 105,832,436 (+)Ensemblmm10GRCm38
MGSCv375106,128,988 - 106,244,234 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365105,934,781 - 106,055,512 (+)NCBIMGSCv36mm8
Celera5102,815,568 - 102,929,479 (+)NCBICelera
Cytogenetic Map5E5NCBI
cM Map550.68NCBI
Lrrc8d
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554234,237,651 - 4,240,227 (-)Ensembl
ChiLan1.0NW_0049554234,237,263 - 4,360,352 (-)NCBIChiLan1.0ChiLan1.0
LRRC8D
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21137,088,794 - 137,203,964 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11136,244,564 - 136,359,775 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0192,481,871 - 92,606,922 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1191,232,146 - 91,346,539 (+)NCBIPanPan1.1PanPan1.1panPan2
LRRC8D
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1658,692,352 - 58,805,004 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl658,692,792 - 58,695,368 (-)NCBIcanFam3CanFam3.1
Dog10K_Boxer_Tasha661,401,528 - 61,514,644 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0659,086,742 - 59,089,777 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl659,086,746 - 59,111,772 (-)NCBIROS_Cfam_1.0 Ensembl
ROS_Cfam_1.0 Ensembl659,086,746 - 59,111,772 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1658,777,879 - 58,890,397 (-)NCBIUMICH_Zoey_3.1
UU_Cfam_GSD_1.0659,211,040 - 59,323,995 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lrrc8d
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505899,984,575 - 100,097,562 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365378,850,411 - 8,963,448 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365378,850,411 - 8,963,601 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRC8D
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4126,766,211 - 126,874,275 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.14126,751,720 - 126,883,344 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24138,807,385 - 138,915,877 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRRC8D
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12043,542,451 - 43,659,465 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2043,542,806 - 43,545,382 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603374,274,555 - 74,391,546 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrrc8d
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247427,822,880 - 7,946,087 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247427,822,880 - 7,947,731 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Lrrc8d
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11115,423,877 - 15,533,506 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lrrc8d
334 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:41
Interacting mature miRNAs:45
Transcripts:ENSRNOT00000002888
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14395787821572472Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14395787818558812Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
724541Niddm53Non-insulin dependent diabetes mellitus QTL 530.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1439578789393298Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14111334906Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14117877928Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat

Markers in Region
D14Rat54  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2144,041,872 - 4,042,062 (+)MAPPERmRatBN7.2
Rnor_6.0145,097,667 - 5,097,856NCBIRnor6.0
Rnor_5.0145,089,537 - 5,089,726UniSTSRnor5.0
RGSC_v3.4145,116,492 - 5,116,681UniSTSRGSC3.4
RGSC_v3.4145,116,491 - 5,116,681RGDRGSC3.4
Celera144,204,900 - 4,205,089UniSTS
RGSC_v3.1145,116,492 - 5,116,681RGD
RH 3.4 Map1479.2RGD
RH 3.4 Map1479.2UniSTS
RH 2.0 Map14105.5RGD
SHRSP x BN Map142.29RGD
FHH x ACI Map141.33RGD
Cytogenetic Map14p22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000002888   ⟹   ENSRNOP00000002888
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl144,332,217 - 4,428,766 (-)Ensembl
mRatBN7.2 Ensembl144,030,260 - 4,045,384 (-)Ensembl
Rnor_6.0 Ensembl145,086,054 - 5,101,177 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094660   ⟹   ENSRNOP00000096115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl144,334,276 - 4,440,668 (-)Ensembl
mRatBN7.2 Ensembl144,029,721 - 4,135,877 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105738   ⟹   ENSRNOP00000091428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl144,334,725 - 4,411,554 (-)Ensembl
mRatBN7.2 Ensembl144,029,854 - 4,106,975 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106093   ⟹   ENSRNOP00000081098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl144,332,217 - 4,415,024 (-)Ensembl
mRatBN7.2 Ensembl144,029,854 - 4,118,076 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109682   ⟹   ENSRNOP00000090251
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl144,334,676 - 4,386,024 (-)Ensembl
mRatBN7.2 Ensembl144,029,812 - 4,129,314 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112887   ⟹   ENSRNOP00000087579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl144,332,130 - 4,368,556 (-)Ensembl
mRatBN7.2 Ensembl144,029,812 - 4,135,626 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117756   ⟹   ENSRNOP00000092059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl144,332,130 - 4,440,107 (-)Ensembl
mRatBN7.2 Ensembl144,029,473 - 4,134,929 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118999   ⟹   ENSRNOP00000096292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl144,332,130 - 4,386,983 (-)Ensembl
mRatBN7.2 Ensembl144,029,473 - 4,134,803 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119904   ⟹   ENSRNOP00000078114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl144,334,265 - 4,440,668 (-)Ensembl
mRatBN7.2 Ensembl144,029,473 - 4,134,957 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000138025   ⟹   ENSRNOP00000105257
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl144,332,217 - 4,445,639 (-)Ensembl
RefSeq Acc Id: NM_001008338   ⟹   NP_001008339
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8144,335,114 - 4,350,236 (-)NCBI
mRatBN7.2144,030,259 - 4,045,384 (-)NCBI
Rnor_6.0145,086,053 - 5,101,177 (-)NCBI
Rnor_5.0145,077,476 - 5,157,358 (-)NCBI
RGSC_v3.4145,104,878 - 5,120,038 (-)RGD
Celera144,193,278 - 4,208,420 (-)RGD
Sequence:
RefSeq Acc Id: XM_039091810   ⟹   XP_038947738
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8144,335,114 - 4,411,549 (-)NCBI
mRatBN7.2144,029,971 - 4,134,922 (-)NCBI
RefSeq Acc Id: NP_001008339   ⟸   NM_001008338
- UniProtKB: A0A0H2UHA3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002888   ⟸   ENSRNOT00000002888
RefSeq Acc Id: XP_038947738   ⟸   XM_039091810
- Peptide Label: isoform X1
- UniProtKB: Q5U308 (UniProtKB/Swiss-Prot),   A6K5Q0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000090251   ⟸   ENSRNOT00000109682
Ensembl Acc Id: ENSRNOP00000092059   ⟸   ENSRNOT00000117756
Ensembl Acc Id: ENSRNOP00000078114   ⟸   ENSRNOT00000119904
Ensembl Acc Id: ENSRNOP00000081098   ⟸   ENSRNOT00000106093
Ensembl Acc Id: ENSRNOP00000096115   ⟸   ENSRNOT00000094660
Ensembl Acc Id: ENSRNOP00000087579   ⟸   ENSRNOT00000112887
Ensembl Acc Id: ENSRNOP00000091428   ⟸   ENSRNOT00000105738
Ensembl Acc Id: ENSRNOP00000096292   ⟸   ENSRNOT00000118999
Ensembl Acc Id: ENSRNOP00000105257   ⟸   ENSRNOT00000138025
Protein Domains
LRRC8 pannexin-like TM region

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U308-F1-model_v2 AlphaFold Q5U308 1-858 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309601 AgrOrtholog
BioCyc Gene G2FUF-16554 BioCyc
Ensembl Genes ENSRNOG00000002121 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000094660.1 UniProtKB/Swiss-Prot
  ENSRNOT00000105738 ENTREZGENE
  ENSRNOT00000105738.1 UniProtKB/Swiss-Prot
  ENSRNOT00000106093.1 UniProtKB/Swiss-Prot
  ENSRNOT00000109682.1 UniProtKB/Swiss-Prot
  ENSRNOT00000112887.1 UniProtKB/Swiss-Prot
  ENSRNOT00000117756.1 UniProtKB/Swiss-Prot
  ENSRNOT00000118999.1 UniProtKB/Swiss-Prot
  ENSRNOT00000119904.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7107805 IMAGE-MGC_LOAD
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  LRR_domain-containing UniProtKB/Swiss-Prot
  LRRC8_Pannexin-like UniProtKB/Swiss-Prot
KEGG Report rno:305131 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93739 IMAGE-MGC_LOAD
NCBI Gene 305131 ENTREZGENE
PANTHER LEUCINE-RICH REPEAT-CONTAINING PROTEIN UniProtKB/Swiss-Prot
  PTHR48051 UniProtKB/Swiss-Prot
Pfam LRR_8 UniProtKB/Swiss-Prot
  Pannexin_like UniProtKB/Swiss-Prot
PhenoGen Lrrc8d PhenoGen
PROSITE LRR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002121 RatGTEx
SMART LRR_SD22 UniProtKB/Swiss-Prot
  LRR_TYP UniProtKB/Swiss-Prot
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot
UniProt A0A0H2UHA3 ENTREZGENE, UniProtKB/TrEMBL
  A6K5Q0 ENTREZGENE, UniProtKB/TrEMBL
  LRC8D_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-16 Lrrc8d  leucine rich repeat containing 8 VRAC subunit D  Lrrc8d  leucine rich repeat containing 8 family, member D  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-18 Lrrc8d  leucine rich repeat containing 8 family, member D  Lrrc8d  leucine rich repeat containing 8D  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Lrrc8d  leucine rich repeat containing 8D  Lrrc8d  leucine rich repeat containing 8 family, member D  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Lrrc8d  leucine rich repeat containing 8 family, member D  Lrrc5  leucine-rich repeat-containing 5  Symbol and Name updated 1299863 APPROVED
2005-12-06 Lrrc5  leucine-rich repeat-containing 5  Lrrc5_predicted  leucine-rich repeat-containing 5 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Lrrc5_predicted  leucine-rich repeat-containing 5 (predicted)      Symbol and Name status set to approved 70820 APPROVED