Appl1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1) - Rat Genome Database

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Gene: Appl1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1) Rattus norvegicus
Analyze
Symbol: Appl1
Name: adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
RGD ID: 1309388
Description: Predicted to enable several functions, including beta-tubulin binding activity; phospholipid binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; positive regulation of biosynthetic process; and regulation of endocytosis. Is active in postsynapse and presynapse. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 14. Orthologous to human APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1); PARTICIPATES IN colorectal cancer pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1; DCC-interacting protein 13-alpha; LOC290537; RGD1309388; similar to DIP13 alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8162,125,234 - 2,173,457 (-)NCBIGRCr8
mRatBN7.2162,118,503 - 2,166,741 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl162,121,255 - 2,166,692 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx162,125,142 - 2,173,305 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0163,270,829 - 3,318,993 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0162,131,417 - 2,179,844 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0162,560,103 - 2,602,035 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl162,563,520 - 2,602,103 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0162,534,851 - 2,581,754 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4162,180,613 - 2,227,905 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1162,179,191 - 2,228,173 (-)NCBI
Celera162,089,133 - 2,134,528 (-)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2-butoxyethanol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
aflatoxin B1  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
bafilomycin A1  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
chloroquine  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
diethylstilbestrol  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
geraniol  (ISO)
haloperidol  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
metformin  (EXP)
methyl methanesulfonate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodimethylamine  (EXP)
paracetamol  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
resiquimod  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
torcetrapib  (ISO)
trametinib  (ISO)
triphenyl phosphate  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. An APPL1/Akt signaling complex regulates dendritic spine and synapse formation in hippocampal neurons. Majumdar D, etal., Mol Cell Neurosci. 2011 Mar;46(3):633-44. doi: 10.1016/j.mcn.2011.01.003. Epub 2011 Jan 12.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. The interaction of Akt with APPL1 is required for insulin-stimulated Glut4 translocation. Saito T, etal., J Biol Chem. 2007 Nov 2;282(44):32280-7. Epub 2007 Sep 11.
Additional References at PubMed
PMID:15016378   PMID:17502098   PMID:17581628   PMID:18034774   PMID:18570454   PMID:19056867   PMID:19416712   PMID:19433865   PMID:19661063   PMID:21291857   PMID:21543456   PMID:21552570  
PMID:21645192   PMID:21849472   PMID:23478100   PMID:23497197   PMID:24255018   PMID:24879834   PMID:25099270   PMID:25108566   PMID:25328665   PMID:25416956   PMID:25568335   PMID:26073777  
PMID:26445298   PMID:26583432   PMID:27219021   PMID:27257087   PMID:29406784   PMID:31515488   PMID:34304702   PMID:34919285   PMID:37795615  


Genomics

Comparative Map Data
Appl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8162,125,234 - 2,173,457 (-)NCBIGRCr8
mRatBN7.2162,118,503 - 2,166,741 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl162,121,255 - 2,166,692 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx162,125,142 - 2,173,305 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0163,270,829 - 3,318,993 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0162,131,417 - 2,179,844 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0162,560,103 - 2,602,035 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl162,563,520 - 2,602,103 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0162,534,851 - 2,581,754 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4162,180,613 - 2,227,905 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1162,179,191 - 2,228,173 (-)NCBI
Celera162,089,133 - 2,134,528 (-)NCBICelera
Cytogenetic Map16p16NCBI
APPL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38357,227,729 - 57,273,471 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl357,227,726 - 57,278,105 (+)EnsemblGRCh38hg38GRCh38
GRCh37357,261,757 - 57,307,499 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36357,236,805 - 57,282,539 (+)NCBINCBI36Build 36hg18NCBI36
Celera357,227,340 - 57,273,073 (+)NCBICelera
Cytogenetic Map3p14.3NCBI
HuRef357,310,967 - 57,356,664 (+)NCBIHuRef
CHM1_1357,211,913 - 57,257,646 (+)NCBICHM1_1
T2T-CHM13v2.0357,267,997 - 57,313,740 (+)NCBIT2T-CHM13v2.0
Appl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391426,640,943 - 26,692,567 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1426,640,945 - 26,693,189 (-)EnsemblGRCm39 Ensembl
GRCm381426,918,986 - 26,970,611 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1426,918,988 - 26,971,232 (-)EnsemblGRCm38mm10GRCm38
MGSCv371427,732,174 - 27,783,737 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361425,745,872 - 25,797,435 (-)NCBIMGSCv36mm8
Celera1423,158,676 - 23,210,368 (-)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1416.09NCBI
Appl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554306,986,759 - 7,018,938 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554306,986,977 - 7,018,938 (+)NCBIChiLan1.0ChiLan1.0
APPL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2257,196,344 - 57,241,732 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1357,201,137 - 57,246,504 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0357,161,299 - 57,206,672 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1358,370,424 - 58,415,258 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl358,370,430 - 58,415,258 (+)Ensemblpanpan1.1panPan2
APPL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12033,123,577 - 33,166,831 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2033,130,723 - 33,166,792 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2033,051,161 - 33,094,218 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02033,395,990 - 33,439,031 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2033,402,695 - 33,439,040 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12032,845,010 - 32,887,864 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02033,203,498 - 33,246,471 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02033,374,797 - 33,418,067 (-)NCBIUU_Cfam_GSD_1.0
Appl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118174,441,878 - 174,476,919 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364737,579,780 - 7,611,923 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364737,580,495 - 7,647,471 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APPL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1339,089,077 - 39,129,781 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11339,089,157 - 39,124,969 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
APPL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12218,546,694 - 18,591,239 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2218,546,751 - 18,589,552 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041148,278,109 - 148,324,433 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Appl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462482233,880 - 74,308 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462482231,175 - 74,252 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Appl1
151 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:83
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000018413
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)163802452995463Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
12903952Cm117Cardiac mass QTL 1170.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)168323802995225Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
12903954Bw186Body weight QTL 1860.011body mass (VT:0001259)body weight (CMO:0000012)168323802995225Rat
12903955Kidm69Kidney mass QTL 690.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)168323804227609Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
12903278Am16Aortic mass QTL 160.019aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)168323802995225Rat
12903279Cm115Cardiac mass QTL 1150.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)168323802995225Rat
2325838Bp347Blood pressure QTL 3470.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1613080679Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
12903281Cm116Cardiac mass QTL 1160.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)168323802995225Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2301404Bp321Blood pressure QTL 3210.05arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)168323802995225Rat

Markers in Region
RH129512  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2162,118,669 - 2,118,856 (+)MAPPERmRatBN7.2
Rnor_6.0162,560,270 - 2,560,456NCBIRnor6.0
Rnor_5.0162,535,018 - 2,535,204UniSTSRnor5.0
RGSC_v3.4162,179,359 - 2,179,545UniSTSRGSC3.4
Celera162,086,549 - 2,086,735UniSTS
RH 3.4 Map1616.3UniSTS
Cytogenetic Map16p16UniSTS
RH139821  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2162,121,529 - 2,121,738 (+)MAPPERmRatBN7.2
Rnor_6.0162,563,130 - 2,563,338NCBIRnor6.0
Rnor_5.0162,537,878 - 2,538,086UniSTSRnor5.0
RGSC_v3.4162,182,219 - 2,182,427UniSTSRGSC3.4
Celera162,089,409 - 2,089,617UniSTS
RH 3.4 Map161.6UniSTS
Cytogenetic Map16p16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000018413   ⟹   ENSRNOP00000018413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl162,121,255 - 2,166,692 (-)Ensembl
Rnor_6.0 Ensembl162,563,520 - 2,602,103 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094750   ⟹   ENSRNOP00000084269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl162,121,255 - 2,155,942 (-)Ensembl
RefSeq Acc Id: NM_001399084   ⟹   NP_001386013
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8162,125,234 - 2,173,396 (-)NCBI
mRatBN7.2162,118,503 - 2,166,667 (-)NCBI
RefSeq Acc Id: XM_039095136   ⟹   XP_038951064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8162,125,234 - 2,173,457 (-)NCBI
mRatBN7.2162,118,503 - 2,166,741 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001386013 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951064 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018413.7
  ENSRNOP00000084269.1
Ensembl Acc Id: ENSRNOP00000018413   ⟸   ENSRNOT00000018413
RefSeq Acc Id: XP_038951064   ⟸   XM_039095136
- Peptide Label: isoform X1
- UniProtKB: A6KMK1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000084269   ⟸   ENSRNOT00000094750
RefSeq Acc Id: NP_001386013   ⟸   NM_001399084
- UniProtKB: D3ZWA8 (UniProtKB/TrEMBL)
Protein Domains
PH   PID

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZWA8-F1-model_v2 AlphaFold D3ZWA8 1-671 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309388 AgrOrtholog
BioCyc Gene G2FUF-12247 BioCyc
Ensembl Genes ENSRNOG00000013574 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018413.7 UniProtKB/TrEMBL
  ENSRNOT00000094750.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.60 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro AH/BAR-dom UniProtKB/TrEMBL
  APPL1_BAR UniProtKB/TrEMBL
  BAR_dom UniProtKB/TrEMBL
  DP13A/B UniProtKB/TrEMBL
  PH_DP13A/B UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  PTB_APPL UniProtKB/TrEMBL
  PTyr_interaction_dom UniProtKB/TrEMBL
NCBI Gene 290537 ENTREZGENE
PANTHER ADAPTOR PROTEIN, PHOSPHOTYROSINE INTERACTION, PH DOMAIN AND LEUCINE ZIPPER-CONTAINING 2 UniProtKB/TrEMBL
  DCC-INTERACTING PROTEIN 13-ALPHA UniProtKB/TrEMBL
Pfam BAR_3 UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  PID UniProtKB/TrEMBL
PhenoGen Appl1 PhenoGen
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  PID UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013574 RatGTEx
SMART PTB UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF103657 UniProtKB/TrEMBL
UniProt A0A8I5ZXF9_RAT UniProtKB/TrEMBL
  A6KMK1 ENTREZGENE, UniProtKB/TrEMBL
  D3ZWA8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Appl1  adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1  Appl1  adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1309388  similar to DIP13 alpha   RGD1309388_predicted  similar to DIP13 alpha (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1309388_predicted  similar to DIP13 alpha (predicted)  LOC290537_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC290537_predicted  similar to DIP13 alpha (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL