Ppp1r3c (protein phosphatase 1, regulatory subunit 3C) - Rat Genome Database

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Gene: Ppp1r3c (protein phosphatase 1, regulatory subunit 3C) Rattus norvegicus
Analyze
Symbol: Ppp1r3c
Name: protein phosphatase 1, regulatory subunit 3C
RGD ID: 1309132
Description: Enables [phosphorylase] phosphatase activity and enzyme binding activity. Contributes to phosphoprotein phosphatase activity. Involved in regulation of glycogen biosynthetic process and regulation of glycogen catabolic process. Located in glycogen granule. Orthologous to human PPP1R3C (protein phosphatase 1 regulatory subunit 3C); PARTICIPATES IN glycogen biosynthetic pathway; glycogen degradation pathway; insulin signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC100910671; LOC309513; PP1 subunit R5; protein phosphatase 1 regulatory subunit 3C; protein phosphatase 1 regulatory subunit 3C-like; protein phosphatase 1 regulatory subunit 5; protein phosphatase 1, regulatory (inhibitor) subunit 3C; protein targeting to glycogen; PTG; R5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81243,873,524 - 243,878,527 (-)NCBIGRCr8
mRatBN7.21234,460,958 - 234,465,961 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,460,652 - 234,465,961 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1242,855,971 - 242,860,979 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01249,778,292 - 249,783,285 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01242,616,484 - 242,621,477 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01255,371,830 - 255,376,833 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1255,371,810 - 255,376,833 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01262,628,937 - 262,633,940 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41240,991,884 - 240,996,887 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11241,175,278 - 241,180,280 (-)NCBI
Celera1231,556,257 - 231,561,260 (-)NCBICelera
Cytogenetic Map1q53NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-amphetamine  (ISO)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
amphetamine  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atazanavir sulfate  (ISO)
atrazine  (ISO)
avobenzone  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibric acid  (EXP)
clothianidin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
diethyl maleate  (EXP)
dioxygen  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (ISO)
glutathione  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GW 4064  (ISO)
hydrogen peroxide  (ISO)
imiquimod  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
menadione  (ISO)
metformin  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
miconazole  (ISO)
N(4)-hydroxycytidine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nimesulide  (EXP)
obeticholic acid  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
PCB138  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tartrazine  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (EXP)
triptonide  (ISO)
triticonazole  (EXP)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vinclozolin  (EXP)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The level of the glycogen targetting regulatory subunit R5 of protein phosphatase 1 is decreased in the livers of insulin-dependent diabetic rats and starved rats. Browne GJ, etal., Biochem J. 2001 Dec 1;360(Pt 2):449-59.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. A novel glycogen-targeting subunit of protein phosphatase 1 that is regulated by insulin and shows differential tissue distribution in humans and rodents. Munro S, etal., FEBS J. 2005 Mar;272(6):1478-89.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9045612   PMID:10683377   PMID:12477932   PMID:15632090   PMID:18852261   PMID:21471512   PMID:21552327  


Genomics

Comparative Map Data
Ppp1r3c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81243,873,524 - 243,878,527 (-)NCBIGRCr8
mRatBN7.21234,460,958 - 234,465,961 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,460,652 - 234,465,961 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1242,855,971 - 242,860,979 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01249,778,292 - 249,783,285 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01242,616,484 - 242,621,477 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01255,371,830 - 255,376,833 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1255,371,810 - 255,376,833 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01262,628,937 - 262,633,940 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41240,991,884 - 240,996,887 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11241,175,278 - 241,180,280 (-)NCBI
Celera1231,556,257 - 231,561,260 (-)NCBICelera
Cytogenetic Map1q53NCBI
PPP1R3C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381091,628,442 - 91,633,071 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1091,628,442 - 91,633,071 (-)EnsemblGRCh38hg38GRCh38
GRCh371093,388,199 - 93,392,828 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361093,378,179 - 93,382,838 (-)NCBINCBI36Build 36hg18NCBI36
Build 341093,378,180 - 93,382,838NCBI
Celera1087,131,841 - 87,136,500 (-)NCBICelera
Cytogenetic Map10q23.32NCBI
HuRef1087,016,754 - 87,021,415 (-)NCBIHuRef
CHM1_11093,669,964 - 93,674,625 (-)NCBICHM1_1
T2T-CHM13v2.01092,511,668 - 92,516,296 (-)NCBIT2T-CHM13v2.0
Ppp1r3c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391936,709,131 - 36,714,004 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1936,709,131 - 36,714,053 (-)EnsemblGRCm39 Ensembl
GRCm381936,731,731 - 36,736,604 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1936,731,731 - 36,736,653 (-)EnsemblGRCm38mm10GRCm38
MGSCv371936,806,221 - 36,811,094 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361936,796,877 - 36,801,797 (-)NCBIMGSCv36mm8
Celera1937,506,440 - 37,511,313 (-)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1931.89NCBI
Ppp1r3c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554251,606,069 - 1,611,586 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554251,606,069 - 1,611,001 (+)NCBIChiLan1.0ChiLan1.0
PPP1R3C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28103,668,222 - 103,673,064 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110103,673,537 - 103,678,379 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01088,377,396 - 88,382,205 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11091,900,112 - 91,904,764 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1091,900,112 - 91,904,764 (-)Ensemblpanpan1.1panPan2
PPP1R3C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1286,167,532 - 6,172,057 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl286,168,917 - 6,172,004 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha286,341,554 - 6,346,099 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0286,423,121 - 6,427,666 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl286,423,123 - 6,427,604 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1286,146,246 - 6,150,797 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0286,178,972 - 6,183,517 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0286,342,849 - 6,347,399 (-)NCBIUU_Cfam_GSD_1.0
Ppp1r3c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721341,297,720 - 41,302,426 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366012,930,208 - 2,935,092 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366012,930,250 - 2,935,024 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R3C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14103,273,405 - 103,278,762 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114103,273,401 - 103,278,757 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214112,652,689 - 112,657,293 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R3C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1984,918,592 - 84,923,281 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl984,918,591 - 84,923,334 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604845,645,616 - 45,650,669 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r3c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247372,893,256 - 2,901,452 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247372,896,677 - 2,901,393 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppp1r3c
48 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:518
Count of miRNA genes:249
Interacting mature miRNAs:304
Transcripts:ENSRNOT00000024941, ENSRNOT00000073381
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1214537555238757011Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1123556856242907031Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1228581588259647894Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228985440245907899Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1210702053240947965Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1213533809243914901Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1224054293243747962Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1224054293243747962Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1223262787260522016Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1232156370259647894Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1233948574260522016Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233190394258625266Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat

Markers in Region
RH129209  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21234,460,983 - 234,461,163 (+)MAPPERmRatBN7.2
Rnor_6.01255,371,856 - 255,372,035NCBIRnor6.0
Rnor_5.01262,669,381 - 262,669,560UniSTSRnor5.0
Rnor_5.01262,628,963 - 262,629,142UniSTSRnor5.0
RGSC_v3.41240,991,910 - 240,992,089UniSTSRGSC3.4
Celera1231,556,283 - 231,556,462UniSTS
RH 3.4 Map11582.5UniSTS
Cytogenetic Map1q53UniSTS
RH138361  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21234,462,295 - 234,462,468 (+)MAPPERmRatBN7.2
Rnor_6.01255,373,168 - 255,373,340NCBIRnor6.0
Rnor_5.01262,670,693 - 262,670,865UniSTSRnor5.0
Rnor_5.01262,630,275 - 262,630,447UniSTSRnor5.0
RGSC_v3.41240,993,222 - 240,993,394UniSTSRGSC3.4
Celera1231,557,595 - 231,557,767UniSTS
RH 3.4 Map11582.1UniSTS
Cytogenetic Map1q53UniSTS
RH127645  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21234,461,029 - 234,461,216 (+)MAPPERmRatBN7.2
Rnor_6.01255,371,902 - 255,372,088NCBIRnor6.0
Rnor_5.01262,669,427 - 262,669,613UniSTSRnor5.0
Rnor_5.01262,629,009 - 262,629,195UniSTSRnor5.0
RGSC_v3.41240,991,956 - 240,992,142UniSTSRGSC3.4
Celera1231,556,329 - 231,556,515UniSTS
RH 3.4 Map11582.5UniSTS
Cytogenetic Map1q53UniSTS
RH140525  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21234,461,029 - 234,461,170 (+)MAPPERmRatBN7.2
Rnor_6.01255,371,902 - 255,372,042NCBIRnor6.0
Rnor_5.01262,669,427 - 262,669,567UniSTSRnor5.0
Rnor_5.01262,629,009 - 262,629,149UniSTSRnor5.0
RGSC_v3.41240,991,956 - 240,992,096UniSTSRGSC3.4
Celera1231,556,329 - 231,556,469UniSTS
RH 3.4 Map11583.0UniSTS
Cytogenetic Map1q53UniSTS
AA800273  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21234,461,197 - 234,461,402 (+)MAPPERmRatBN7.2
Rnor_6.01255,372,070 - 255,372,274NCBIRnor6.0
Rnor_5.01262,669,595 - 262,669,799UniSTSRnor5.0
Rnor_5.01262,629,177 - 262,629,381UniSTSRnor5.0
RGSC_v3.41240,992,124 - 240,992,328UniSTSRGSC3.4
Celera1231,556,497 - 231,556,701UniSTS
RH 3.4 Map11582.7UniSTS
Cytogenetic Map1q53UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000024941   ⟹   ENSRNOP00000024941
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,460,962 - 234,465,961 (-)Ensembl
Rnor_6.0 Ensembl1255,371,810 - 255,376,833 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107925   ⟹   ENSRNOP00000082332
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,460,652 - 234,465,837 (-)Ensembl
RefSeq Acc Id: NM_001012072   ⟹   NP_001012072
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81243,873,524 - 243,878,527 (-)NCBI
mRatBN7.21234,460,958 - 234,465,961 (-)NCBI
Rnor_6.01255,371,830 - 255,376,833 (-)NCBI
Rnor_5.01262,628,937 - 262,633,940 (-)NCBI
RGSC_v3.41240,991,884 - 240,996,887 (-)RGD
Celera1231,556,257 - 231,561,260 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001012072 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH85894 (Get FASTA)   NCBI Sequence Viewer  
  EDM13188 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024941.4
  ENSRNOP00000082332.1
GenBank Protein Q5U2R5 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001012072   ⟸   NM_001012072
- UniProtKB: Q5U2R5 (UniProtKB/Swiss-Prot),   A6I157 (UniProtKB/TrEMBL),   G3V8E0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024941   ⟸   ENSRNOT00000024941
Ensembl Acc Id: ENSRNOP00000082332   ⟸   ENSRNOT00000107925
Protein Domains
CBM21

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U2R5-F1-model_v2 AlphaFold Q5U2R5 1-317 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690873
Promoter ID:EPDNEW_R1398
Type:single initiation site
Name:Ppp1r3c_1
Description:protein phosphatase 1, regulatory subunit 3C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01255,376,841 - 255,376,901EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309132 AgrOrtholog
BioCyc Gene G2FUF-55824 BioCyc
Ensembl Genes ENSRNOG00000018494 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024941.7 UniProtKB/TrEMBL
  ENSRNOT00000107925.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.2440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7192942 IMAGE-MGC_LOAD
InterPro CBM21_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CBM21_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pase-1_reg-su_3B/C/D_met UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP1_3C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP1_regulatory_subunit_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:309513 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94701 IMAGE-MGC_LOAD
NCBI Gene 309513 ENTREZGENE
PANTHER PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12307:SF15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CBM_21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppp1r3c PhenoGen
PIRSF PP1_GT_animal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP1_PTG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CBM21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018494 RatGTEx
UniProt A0A8I6G7A0_RAT UniProtKB/TrEMBL
  A6I157 ENTREZGENE, UniProtKB/TrEMBL
  G3V8E0 ENTREZGENE, UniProtKB/TrEMBL
  PPR3C_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-13 Ppp1r3c  protein phosphatase 1, regulatory subunit 3C  LOC100910671  protein phosphatase 1 regulatory subunit 3C-like  Data merged from RGD:6497444 737654 PROVISIONAL
2012-07-05 LOC100910671  protein phosphatase 1 regulatory subunit 3C-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2011-10-18 Ppp1r3c  protein phosphatase 1, regulatory subunit 3C  Ppp1r3c  protein phosphatase 1, regulatory (inhibitor) subunit 3C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Ppp1r3c  protein phosphatase 1, regulatory (inhibitor) subunit 3C  Ppp1r3c_predicted  protein phosphatase 1, regulatory (inhibitor) subunit 3C (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Ppp1r3c_predicted  protein phosphatase 1, regulatory (inhibitor) subunit 3C (predicted)      Symbol and Name status set to approved 70820 APPROVED