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Gene: Psmc6 (proteasome 26S subunit, ATPase 6) Rattus norvegicus

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Symbol:

Psmc6

Name:

proteasome 26S subunit, ATPase 6

RGD ID:

1308825

Description:

Predicted to enable identical protein binding activity. Involved in positive regulation of inclusion body assembly. Located in inclusion body. Part of cytosolic proteasome complex. Orthologous to human PSMC6 (proteasome 26S subunit, ATPase 6); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; aripiprazole.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

26S protease regulatory subunit 10B; 26S proteasome regulatory subunit 10B; LOC289990; proteasome (prosome, macropain) 26S subunit, ATPase, 6; proteasome (prosome, macropain) 26S subunit, ATPase, 6-like

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PSMC6 (proteasome 26S subunit, ATPase 6)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Psmc6 (proteasome (prosome, macropain) 26S subunit, ATPase, 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Psmc6 (proteasome 26S subunit, ATPase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PSMC6 (proteasome 26S subunit, ATPase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LOC100687259 (26S proteasome regulatory subunit 10B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Psmc6 (proteasome 26S subunit, ATPase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PSMC6 (proteasome 26S subunit, ATPase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PSMC6 (proteasome 26S subunit, ATPase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Psmc6 (proteasome 26S subunit, ATPase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Psmc6 (proteasome 26S subunit, ATPase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PSMC6 (proteasome 26S subunit, ATPase 6)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Psmc6 (proteasome (prosome, macropain) 26S subunit, ATPase, 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	psmc6 (proteasome 26S subunit, ATPase 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rpt-4	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	RPT4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Rpt4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Rpt4R	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	psmc6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	psmc6	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	21,022,314 - 21,043,785 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	15	21,022,314 - 21,043,785 (+)	Ensembl				GRCr8
mRatBN7.2	15	18,542,585 - 18,564,057 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	18,542,563 - 18,564,055 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	15	21,337,420 - 21,358,885 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	22,294,373 - 22,315,842 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	20,550,951 - 20,572,416 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	19,667,453 - 19,688,916 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	19,667,453 - 19,688,914 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	15	23,631,640 - 23,653,072 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	15	21,217,367 - 21,239,320 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	15	18,970,916 - 18,992,439 (+)	NCBI		Celera
RGSC_v3.1	15	21,217,379 - 21,238,663 (+)	NCBI
Cytogenetic Map	15	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(R,R,R)-alpha-tocopherol (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

1H-pyrazole (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-di-tert-butyl-4-methylphenol (ISO)

2-palmitoylglycerol (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3H-1,2-dithiole-3-thione (ISO)

4,4'-sulfonyldiphenol (ISO)

acetylsalicylic acid (ISO)

acrolein (ISO)

alpha-pinene (ISO)

aripiprazole (EXP)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzo[a]pyrene (EXP)

beta-naphthoflavone (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

butylated hydroxyanisole (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

Calphostin C (ISO)

clofibrate (ISO)

clothianidin (ISO)

cobalt dichloride (EXP,ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (ISO)

dicrotophos (ISO)

doxorubicin (ISO)

elesclomol (ISO)

ethanol (ISO)

fenofibrate (ISO)

finasteride (EXP)

fipronil (EXP)

flutamide (EXP)

folic acid (ISO)

glafenine (EXP)

hydralazine (ISO)

hydrogen peroxide (ISO)

isoprenaline (EXP)

ivermectin (ISO)

kojic acid (ISO)

lead diacetate (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

miconazole (ISO)

mifepristone (ISO)

monocrotaline (EXP)

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal (ISO)

nefazodone (EXP)

nobiletin (ISO)

ozone (ISO)

paracetamol (EXP)

Pentoxifylline (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenytoin (EXP)

phlorizin (ISO)

phorbol 13-acetate 12-myristate (ISO)

pirinixic acid (ISO)

reactive oxygen species (ISO)

resveratrol (EXP,ISO)

rotenone (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

Soman (EXP)

sulindac (EXP)

temozolomide (ISO)

tetrachloroethene (ISO)

tetrachloromethane (ISO)

thiram (ISO)

trichloroethene (ISO)

triphenyl phosphate (ISO)

tungsten (ISO)

valdecoxib (EXP)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of inclusion body assembly (IMP)

proteasomal protein catabolic process (NAS)

regulation of AMPA receptor activity (IDA)

Cellular Component

cytoplasm (IEA)

cytosolic proteasome complex (IDA)

inclusion body (IDA)

nucleus (IEA,ISO)

proteasome accessory complex (IEA,ISO)

proteasome complex (IEA,ISO)

synaptic vesicle (IDA,NAS)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IEA)

identical protein binding (IEA,ISO)

nucleotide binding (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

ubiquitin/proteasome degradation pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Misfolding of proteins with a polyglutamine expansion is facilitated by proteasomal chaperones.	Rousseau E, etal., J Biol Chem. 2009 Jan 16;284(3):1917-29. doi: 10.1074/jbc.M806256200. Epub 2008 Nov 5.
7.	An abundance of free regulatory (19S) proteasome particles regulates neuronal synapses.	Sun C, etal., Science. 2023 May 26;380(6647):eadf2018. doi: 10.1126/science.adf2018. Epub 2023 May 26.

Additional References at PubMed

PMID:8889548	PMID:9464850	PMID:10419517	PMID:12477932	PMID:16857966	PMID:17323924	PMID:17911097	PMID:19056867	PMID:19946888	PMID:21630459	PMID:22871113	PMID:23376485
PMID:25416956	PMID:35352799

Genomics

Comparative Map Data

Psmc6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	21,022,314 - 21,043,785 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	15	21,022,314 - 21,043,785 (+)	Ensembl				GRCr8
mRatBN7.2	15	18,542,585 - 18,564,057 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	18,542,563 - 18,564,055 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	15	21,337,420 - 21,358,885 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	22,294,373 - 22,315,842 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	20,550,951 - 20,572,416 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	19,667,453 - 19,688,916 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	19,667,453 - 19,688,914 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	15	23,631,640 - 23,653,072 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	15	21,217,367 - 21,239,320 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	15	18,970,916 - 18,992,439 (+)	NCBI		Celera
RGSC_v3.1	15	21,217,379 - 21,238,663 (+)	NCBI
Cytogenetic Map	15	p14	NCBI

PSMC6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	52,707,200 - 52,728,590 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	52,707,156 - 52,728,590 (+)	Ensembl			hg38	GRCh38
GRCh37	14	53,173,918 - 53,195,308 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	52,243,668 - 52,264,466 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	14	52,243,667 - 52,264,465	NCBI
Celera	14	33,041,500 - 33,062,289 (+)	NCBI		Celera
Cytogenetic Map	14	q22.1	NCBI
HuRef	14	33,334,988 - 33,355,703 (+)	NCBI		HuRef
CHM1_1	14	53,112,814 - 53,133,601 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	46,915,014 - 46,936,383 (+)	NCBI		T2T-CHM13v2.0

Psmc6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	45,567,285 - 45,587,150 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	45,567,245 - 45,587,162 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	14	45,329,823 - 45,349,074 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	45,329,788 - 45,349,705 (+)	Ensembl			mm10	GRCm38
MGSCv37	14	45,949,499 - 45,968,746 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	14	44,251,701 - 44,270,948 (+)	NCBI		MGSCv36	mm8
Celera	14	41,509,669 - 41,529,121 (+)	NCBI		Celera
Cytogenetic Map	14	C1	NCBI
cM Map	14	22.89	NCBI

Psmc6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	10,452,615 - 10,475,100 (-)	Ensembl
ChiLan1.0	NW_004955409	10,454,210 - 10,474,872 (-)	NCBI	ChiLan1.0	ChiLan1.0

PSMC6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	53,838,194 - 53,859,022 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	53,054,704 - 53,075,532 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	33,303,689 - 33,324,502 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	51,587,467 - 51,608,044 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	51,587,467 - 51,608,044 (+)	Ensembl			panPan2	panpan1.1

LOC100687259
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	35,814,756 - 35,816,311 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	6,196,263 - 6,197,815 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha

Psmc6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	76,348,572 - 76,369,833 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936697	2,121,677 - 2,144,066 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936697	2,122,727 - 2,143,988 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PSMC6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	182,328,521 - 182,354,958 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	182,329,070 - 182,354,959 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	202,599,698 - 202,625,501 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PSMC6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	29,784,825 - 29,807,701 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	29,784,826 - 29,807,490 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666053	18,060,172 - 18,082,302 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Psmc6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624731	16,386,194 - 16,414,485 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624731	16,386,194 - 16,414,554 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Psmc6
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	12	77,687,856 - 77,708,972 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Psmc6
192 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	153
Count of miRNA genes:	109
Interacting mature miRNAs:	126
Transcripts:	ENSRNOT00000009649
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1641913	Colcr2	Colorectal carcinoma resistance QTL 2	6.57	0.0197	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	15	2315759	47315759	Rat
61424	Scl1	Serum cholesterol level QTL 1	7.7	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	15	19155762	87086765	Rat
10401805	Kidm51	Kidney mass QTL 51			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	15	2785923	47785923	Rat
5684946	Bss98	Bone structure and strength QTL 98	3.9	0.0026	tibia strength trait (VT:1000284)	tibia ultimate force (CMO:0001734)	15	1	39411584	Rat
1354657	Despr13	Despair related QTL 13		0.0022	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	15	1	32342855	Rat
2317750	Glom26	Glomerulus QTL 26	4.3		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	15	14926594	71614418	Rat
1641887	Alcrsp14	Alcohol response QTL 14			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	15	1	44836456	Rat
738017	Hcas7	Hepatocarcinoma susceptibility QTL 7	2.91		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	15	2315759	53331089	Rat
5685002	Bss103	Bone structure and strength QTL 103	2.8		tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	15	16911521	32439851	Rat

Markers in Region

RH139811

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	18,563,710 - 18,563,914 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	19,688,570 - 19,688,773	NCBI	Rnor6.0
Rnor_5.0	15	23,652,726 - 23,652,929	UniSTS	Rnor5.0
RGSC_v3.4	15	21,238,974 - 21,239,177	UniSTS	RGSC3.4
Celera	15	18,992,093 - 18,992,296	UniSTS
RH 3.4 Map	15	156.3	UniSTS
Cytogenetic Map	15	p14	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001100509	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039093096	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC107950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BP502794	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB327094	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474040	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DY570284	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214043	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ227742	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000009649 ⟹ ENSRNOP00000009649

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	15	21,022,314 - 21,043,785 (+)	Ensembl
mRatBN7.2 Ensembl	15	18,542,585 - 18,564,055 (+)	Ensembl
Rnor_6.0 Ensembl	15	19,667,453 - 19,688,914 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099537 ⟹ ENSRNOP00000091801

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	18,542,563 - 18,555,669 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105410 ⟹ ENSRNOP00000082787

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	18,542,632 - 18,563,263 (+)	Ensembl

RefSeq Acc Id:

NM_001100509 ⟹ NP_001093979

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	21,022,314 - 21,043,785 (+)	NCBI
mRatBN7.2	15	18,542,585 - 18,564,057 (+)	NCBI
Rnor_6.0	15	19,667,453 - 19,688,916 (+)	NCBI
Rnor_5.0	15	23,631,640 - 23,653,072 (+)	NCBI
RGSC_v3.4	15	21,217,367 - 21,239,320 (+)	RGD
Celera	15	18,970,916 - 18,992,439 (+)	NCBI

Sequence:

show sequence

CGCCCGGGCTGCTATGGCCCTTCCCGGCATCCCCTATGAGCGACGGCTTCTCATCATGGCGGAC
CCTAGAGATAAGGCGCTTCAGGACTACCGCAAGAAGCTGCTAGAACACAAGGAGATTGACGGCC
GTCTTAAGGAGCTAAGGGAACAATTAAAAGAACTTACCAAGCAGTATGAAAAGTCTGAAAATGA
TCTGAAGGCACTACAAAGTGTTGGACAGATTGTAGGCGAAGTGCTTAAACAGTTAACAGAAGAA
AAGTTCATTGTTAAAGCAACAAACGGACCAAGATACGTCGTAGGCTGTCGTCGGCAGCTTGATA
AAAGTAAGCTGAAGCCAGGAACCAGAGTTGCTTTGGATATGACCACCCTAACCATCATGAGGTA
TCTGCCGAGAGAGGTGGATCCATTGGTTTATAACATGTCTCATGAGGATCCTGGAAATGTATCT
TATTCTGAGATTGGAGGCCTGTCAGAACAGATTCGGGAATTAAGAGAGGTAATAGAATTACCTC
TTACAAATCCAGAATTATTCCAGCGTGTAGGAATAATACCTCCAAAAGGCTGTTTGCTCTATGG
ACCACCAGGCACTGGGAAAACACTCTTGGCACGAGCTGTCGCCAGCCAGCTGGACTGCAACTTC
CTAAAGGTTGTGTCAAGCTCTATTGTAGACAAGTACATTGGGGAAAGCGCTCGTTTGATTAGAG
AAATGTTTAATTATGCCAGGGACCACCAGCCATGCATCATTTTTATGGATGAAATAGATGCTAT
TGGTGGTCGTCGGTTTTCTGAGGGAACATCAGCTGACAGAGAGATTCAGAGAACTTTAATGGAG
TTACTAAATCAAATGGATGGATTTGACACTCTTCATAGAGTTAAAATGATCATGGCTACAAACA
GACCAGATACACTGGATCCTGCTTTGCTGCGCCCAGGAAGATTAGATAGAAAAATACATATTGA
TTTACCAAATGAACAAGCAAGATTAGATATATTGAAAATCCACGCTGGTCCTATTACAAAGCAT
GGTGAAATAGATTATGAAGCCATTGTAAAGCTTTCAGATGGCTTTAATGGAGCAGACCTGAGAA
ATGTTTGTACTGAAGCAGGTATGTTTGCAATTCGTGCTGATCATGATTTTGTAGTTCAGGAAGA
CTTCATGAAAGCAGTCAGAAAAGTGGCTGACTCCAAGAAGCTAGAGTCCAAACTGGACTATAAA
CCTGTGTAATTTTCTATAAGGTTTTTGGTGGCTGCATGACAGACATTGGCTTAATGTAAAAATA
AAGTTAAGGAAAATAATGTATGTATTGGCAATGATCTCATTAAAAGTGAATAAACATGTATAAG
CAACATAATAAGCAATGTAACAGTAATTCCTTTAAAACTGGTACAGAAGAAAGTTGTATGTTTG
TTAATGTTGCATTTACTGCAGCAGAACTTACAAAAGACATGCTGAAGCTTTTCGTATTTGCTTT
GTGAGCATTTTGTACAACATTCAAAATGGTTGAGATAGTAGAGGAGAGCATTTCTTATGACTTA
TTTCATATCTTGTTTTCCTCGTCCTAAAAAAAAAAGCAATAAAGTCTGTTTTAGCTGTCCTGTA
TATATTCCTGTCTTTTCTAAGAGCATTTATTCTAGACCTTTTGGATCAGTAAGTACATGATTTG
AGAGCCTGGGAAACTGAAAATTAAAATAGGACTTTGAATTTTATTTTAAAACAATATTCAGGGG
CTGGGGTAGTAGCTCAGTGGTAGAGCGCTTGCCTAGGAAGCGCAAGGCCCTGGGTTCGGTCCCC
AGCTCCGAAAAAAAGAACCAAAAAAAAAAAAACAATATTCAAAGAGTCTACAAAATTGTCTTCT
TGTATATATCATACAGTGTGGGTATGGAATGCATACATGCATTTGTGTCTTCCAAGAAATCTCT
GTACCTGCTGCAGTTAGGCTATAACTTAAAGATTATGACTGGGAGTAATGCTCATAGTTAATTT
GGTTTATGTCAAAAAGTAATTGCCTTTTGAGGTCTGGATCCAGGAAAGGTCCGTGTGGACATAT
AATTTTACATATCCATGATTTCTAGAGATGTATTATTTATTTCCTAGGCTCACCAACAGATGCT
ATAACCATCTTCCGGTAGATACCAGGCTGAGAGTGTCTATTCTATGGAATGTGAATGTCAGAAA
TGTTCAAAATAAAAGTTCTGTTATCTATACACAATTCTAATTTCATGTGGCAATCAAAAGTTGT
ATAAGGAAATTGTCAATGTCTAAAACTTGATTATTTATAGTTAAAGCTTTGTTTAAATAAAGAT
ACCAAACTTCAATTTCATAAGTACCAAAGGACTAACCATAAATATAAATGATCTGGCTAGGTAT
GTAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039093096 ⟹ XP_038949024

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	21,022,355 - 21,043,004 (+)	NCBI
mRatBN7.2	15	18,542,664 - 18,563,275 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001093979	(Get FASTA)	NCBI Sequence Viewer
	XP_038949024	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI07951	(Get FASTA)	NCBI Sequence Viewer
	EDL88301	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000009649
	ENSRNOP00000009649.4

RefSeq Acc Id:

NP_001093979 ⟸ NM_001100509

- UniProtKB:

G3V6W6 (UniProtKB/TrEMBL), Q32PW9 (UniProtKB/TrEMBL), A6KDZ6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MALPGIPYERRLLIMADPRDKALQDYRKKLLEHKEIDGRLKELREQLKELTKQYEKSENDLKAL
QSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVALDMTTLTIMRYLPRE
VDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGT
GKTLLARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRR
FSEGTSADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNE
QARLDILKIHAGPITKHGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQEDFMKA
VRKVADSKKLESKLDYKPV

hide sequence

Ensembl Acc Id:

ENSRNOP00000009649 ⟸ ENSRNOT00000009649

RefSeq Acc Id:	XP_038949024 ⟸ XM_039093096
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000082787 ⟸ ENSRNOT00000105410

Ensembl Acc Id:

ENSRNOP00000091801 ⟸ ENSRNOT00000099537

Protein Domains

AAA+ ATPase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V6W6-F1-model_v2	AlphaFold	G3V6W6	1-403	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699596

Promoter ID:

EPDNEW_R10119

Type:

multiple initiation site

Name:

Psmc6_1

Description:

proteasome 26S subunit, ATPase 6

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	15	19,667,488 - 19,667,548	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308825	AgrOrtholog
BioCyc Gene	G2FUF-14221	BioCyc
Ensembl Genes	ENSRNOG00000007203	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000009649	ENTREZGENE
	ENSRNOT00000009649.7	UniProtKB/TrEMBL
Gene3D-CATH	1.10.8.60	UniProtKB/TrEMBL
	2.40.50.140	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7446304	IMAGE-MGC_LOAD
InterPro	26S_Proteasome_ATPase	UniProtKB/TrEMBL
	AAA_lid_3	UniProtKB/TrEMBL
	ATPase_AAA+_core	UniProtKB/TrEMBL
	ATPase_AAA_core	UniProtKB/TrEMBL
	ATPase_AAA_CS	UniProtKB/TrEMBL
	NA-bd_OB-fold	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	Prot_ATP_ID_OB	UniProtKB/TrEMBL
KEGG Report	rno:289990	UniProtKB/TrEMBL
MGC_CLONE	MGC:125205	IMAGE-MGC_LOAD
NCBI Gene	289990	ENTREZGENE
PANTHER	26S PROTEASOME REGULATORY SUBUNIT	UniProtKB/TrEMBL
Pfam	AAA	UniProtKB/TrEMBL
	AAA_lid_3	UniProtKB/TrEMBL
	Prot_ATP_ID_OB	UniProtKB/TrEMBL
PhenoGen	Psmc6	PhenoGen
PROSITE	AAA	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000007203	RatGTEx
SMART	AAA	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	A6KDZ6	ENTREZGENE, UniProtKB/TrEMBL
	G3V6W6	ENTREZGENE, UniProtKB/TrEMBL
	Q32PW9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-08-19	Psmc6	proteasome 26S subunit, ATPase 6	Psmc6	proteasome (prosome, macropain) 26S subunit, ATPase, 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Psmc6	proteasome (prosome, macropain) 26S subunit, ATPase, 6			Symbol and Name updated	1299863	APPROVED
2006-03-07	Psmc6	proteasome (prosome, macropain) 26S subunit, ATPase, 6	Psmc6_predicted	proteasome (prosome, macropain) 26S subunit, ATPase, 6 (predicted)	Symbol and Name status set to approved	1299863	APPROVED
2005-01-12	Psmc6_predicted	proteasome (prosome, macropain) 26S subunit, ATPase, 6 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)