Flnc (filamin C) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Flnc (filamin C) Rattus norvegicus
Analyze
Symbol: Flnc
Name: filamin C
RGD ID: 1308807
Description: Enables ankyrin binding activity. Predicted to be involved in sarcomere organization. Located in sarcolemma and sarcoplasm. Human ortholog(s) of this gene implicated in distal myopathy 4; hypertrophic cardiomyopathy 26; and myofibrillar myopathy 5. Orthologous to human FLNC (filamin C); PARTICIPATES IN integrin mediated signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ABP-L; filamin C, gamma; filamin C, gamma (actin binding protein 280); filamin-2; filamin-C; FLN-C; gamma-filamin; LOC362332
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8458,999,445 - 59,027,240 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl458,999,547 - 59,027,240 (+)EnsemblGRCr8
mRatBN7.2458,034,088 - 58,061,882 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl458,034,189 - 58,061,844 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx463,017,203 - 63,044,933 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0458,933,350 - 58,961,083 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0457,335,244 - 57,362,974 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0456,710,934 - 56,738,779 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl456,711,049 - 56,738,791 (+)Ensemblrn6Rnor6.0
Rnor_5.0456,478,171 - 56,505,940 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4456,313,707 - 56,341,400 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera453,142,130 - 53,169,823 (+)NCBICelera
RGSC_v3.1456,572,156 - 56,598,993 (+)NCBI
Cytogenetic Map4q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dimethoxyphenol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
7,12-dimethyltetraphene  (ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
choline  (ISO)
ciglitazone  (EXP)
cisplatin  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP,ISO)
cyclophosphamide  (ISO)
cytarabine  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (EXP)
diarsenic trioxide  (ISO)
Didecyldimethylammonium  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (ISO)
dimethylselenide  (ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (EXP)
ethylparaben  (ISO)
etoposide  (ISO)
fenamidone  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
furfural  (ISO)
hydrogen peroxide  (ISO)
hydroxyl  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
mercury dibromide  (ISO)
methamphetamine  (ISO)
methylarsonic acid  (ISO)
methylseleninic acid  (ISO)
Monobutylphthalate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel sulfate  (ISO)
Nutlin-3  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
raloxifene  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitrosoglutathione  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sotorasib  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trametinib  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
costamere  (TAS)
cytoplasm  (IEA,ISO)
cytoskeleton  (IEA)
cytosol  (IEA,ISO)
membrane  (IEA)
sarcolemma  (IDA,IEA,ISO)
sarcoplasm  (IDA)
Z disc  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Integrin inactivators: balancing cellular functions in vitro and in vivo. Bouvard D, etal., Nat Rev Mol Cell Biol. 2013 Jul;14(7):430-42. doi: 10.1038/nrm3599. Epub 2013 May 30.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Novel interactions of ankyrins-G at the costameres: the muscle-specific Obscurin/Titin-Binding-related Domain (OTBD) binds plectin and filamin C. Maiweilidan Y, etal., Exp Cell Res. 2011 Apr 1;317(6):724-36. doi: 10.1016/j.yexcr.2011.01.002. Epub 2011 Jan 9.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12393796   PMID:15642266   PMID:15886195   PMID:16914736   PMID:17987659   PMID:21423176   PMID:22082260   PMID:23106098   PMID:25351925   PMID:35352799  


Genomics

Comparative Map Data
Flnc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8458,999,445 - 59,027,240 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl458,999,547 - 59,027,240 (+)EnsemblGRCr8
mRatBN7.2458,034,088 - 58,061,882 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl458,034,189 - 58,061,844 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx463,017,203 - 63,044,933 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0458,933,350 - 58,961,083 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0457,335,244 - 57,362,974 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0456,710,934 - 56,738,779 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl456,711,049 - 56,738,791 (+)Ensemblrn6Rnor6.0
Rnor_5.0456,478,171 - 56,505,940 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4456,313,707 - 56,341,400 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera453,142,130 - 53,169,823 (+)NCBICelera
RGSC_v3.1456,572,156 - 56,598,993 (+)NCBI
Cytogenetic Map4q22NCBI
FLNC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387128,830,406 - 128,859,272 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7128,830,312 - 128,859,275 (+)Ensemblhg38GRCh38
GRCh377128,470,460 - 128,499,326 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367128,257,719 - 128,286,572 (+)NCBIBuild 36Build 36hg18NCBI36
Build 347128,064,593 - 128,093,276NCBI
Celera7123,266,997 - 123,295,842 (+)NCBICelera
Cytogenetic Map7q32.1NCBI
HuRef7122,832,064 - 122,860,967 (+)NCBIHuRef
CHM1_17128,403,744 - 128,432,589 (+)NCBICHM1_1
T2T-CHM13v2.07130,143,333 - 130,172,198 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27127,854,228 - 127,883,073 (+)NCBI
Flnc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39629,433,150 - 29,461,888 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl629,433,255 - 29,461,882 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38629,433,153 - 29,461,889 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl629,433,256 - 29,461,883 (+)Ensemblmm10GRCm38
MGSCv37629,383,153 - 29,411,888 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36629,383,163 - 29,411,899 (+)NCBIMGSCv36mm8
Celera629,440,371 - 29,469,772 (+)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.36NCBI
Flnc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554799,633,598 - 9,661,777 (+)Ensembl
ChiLan1.0NW_0049554799,633,817 - 9,661,725 (+)NCBIChiLan1.0ChiLan1.0
FLNC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26165,634,918 - 165,663,848 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1717,645,161 - 17,674,094 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07120,782,584 - 120,811,504 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17133,307,041 - 133,335,896 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7133,307,041 - 133,335,896 (+)EnsemblpanPan2panpan1.1
FLNC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1147,792,708 - 7,819,723 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl147,793,449 - 7,819,940 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha147,479,565 - 7,506,435 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0147,558,590 - 7,585,437 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl147,558,591 - 7,585,635 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1147,763,614 - 7,790,446 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0147,505,626 - 7,532,496 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0147,651,043 - 7,677,902 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Flnc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511854,632,610 - 54,660,604 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647915,756,370 - 15,784,359 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647915,756,370 - 15,784,365 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLNC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1819,759,740 - 19,787,618 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11819,759,734 - 19,787,616 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21820,855,080 - 20,882,950 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FLNC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12197,431,666 - 97,460,178 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2197,431,648 - 97,461,135 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660425,941,273 - 5,970,541 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Flnc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247837,334,312 - 7,361,134 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247837,334,421 - 7,360,795 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Flnc
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16110,105,242 - 110,132,893 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Flnc
170 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:176
Count of miRNA genes:127
Interacting mature miRNAs:149
Transcripts:ENSRNOT00000027237
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41564430960644309Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)43511329080113290Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)44049044275726188Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45807987582597589Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45808014680212111Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41890069763900697Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)44047145375939996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42228845363245191Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)41890069763900697Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41891315163913151Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42786220462997402Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42192515166925151Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 154 91 90 59 77 59 6 336 177 11 133 76 92 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000027237   ⟹   ENSRNOP00000027237
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl458,999,547 - 59,027,240 (+)Ensembl
mRatBN7.2 Ensembl458,034,189 - 58,061,844 (+)Ensembl
Rnor_6.0 Ensembl456,711,049 - 56,738,791 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088149   ⟹   ENSRNOP00000070379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl458,999,547 - 59,027,240 (+)Ensembl
mRatBN7.2 Ensembl458,034,189 - 58,061,844 (+)Ensembl
Rnor_6.0 Ensembl456,711,275 - 56,738,100 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098293   ⟹   ENSRNOP00000079220
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl458,999,547 - 59,027,240 (+)Ensembl
mRatBN7.2 Ensembl458,038,691 - 58,061,844 (+)Ensembl
RefSeq Acc Id: NM_001191862   ⟹   NP_001178791
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8458,999,547 - 59,027,240 (+)NCBI
mRatBN7.2458,034,189 - 58,061,882 (+)NCBI
Rnor_6.0456,711,086 - 56,738,779 (+)NCBI
Rnor_5.0456,478,171 - 56,505,940 (+)NCBI
Celera453,142,130 - 53,169,823 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236214   ⟹   XP_006236276
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8458,999,447 - 59,027,236 (+)NCBI
mRatBN7.2458,034,090 - 58,061,878 (+)NCBI
Rnor_6.0456,710,934 - 56,738,775 (+)NCBI
Rnor_5.0456,478,171 - 56,505,940 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107774   ⟹   XP_038963702
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8458,999,445 - 59,027,236 (+)NCBI
mRatBN7.2458,034,088 - 58,061,878 (+)NCBI
RefSeq Acc Id: XM_039107775   ⟹   XP_038963703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8458,999,446 - 59,027,236 (+)NCBI
mRatBN7.2458,034,089 - 58,061,878 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001178791 (Get FASTA)   NCBI Sequence Viewer  
  XP_006236276 (Get FASTA)   NCBI Sequence Viewer  
  XP_038963702 (Get FASTA)   NCBI Sequence Viewer  
  XP_038963703 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D3ZHA0 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000027237
  ENSRNOP00000027237.7
  ENSRNOP00000079220
RefSeq Acc Id: NP_001178791   ⟸   NM_001191862
- UniProtKB: D3ZHA0 (UniProtKB/Swiss-Prot),   A0A8L2R384 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236276   ⟸   XM_006236214
- Peptide Label: isoform X3
- UniProtKB: A0A0H2UHR7 (UniProtKB/TrEMBL),   A0A8L2R384 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027237   ⟸   ENSRNOT00000027237
Ensembl Acc Id: ENSRNOP00000070379   ⟸   ENSRNOT00000088149
RefSeq Acc Id: XP_038963702   ⟸   XM_039107774
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R384 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963703   ⟸   XM_039107775
- Peptide Label: isoform X2
- UniProtKB: A0A8L2R384 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079220   ⟸   ENSRNOT00000098293
Protein Domains
Calponin-homology (CH)

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692931
Promoter ID:EPDNEW_R3449
Type:single initiation site
Name:Flnc_1
Description:filamin C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0456,711,073 - 56,711,133EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308807 AgrOrtholog
BioCyc Gene G2FUF-45394 BioCyc
Ensembl Genes ENSRNOG00000007281 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027237 ENTREZGENE
  ENSRNOT00000027237.8 UniProtKB/Swiss-Prot
  ENSRNOT00000098293 ENTREZGENE
Gene3D-CATH 1.10.418.10 UniProtKB/Swiss-Prot
  2.60.40.10 UniProtKB/Swiss-Prot
InterPro Actinin_actin-bd_CS UniProtKB/Swiss-Prot
  CH-domain UniProtKB/Swiss-Prot
  CH_dom_sf UniProtKB/Swiss-Prot
  Filamin UniProtKB/Swiss-Prot
  Filamin/ABP280_repeat-like UniProtKB/Swiss-Prot
  Filamin/ABP280_rpt UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_E-set UniProtKB/Swiss-Prot
KEGG Report rno:362332 UniProtKB/Swiss-Prot
NCBI Gene 362332 ENTREZGENE
PANTHER FILAMIN-A UniProtKB/Swiss-Prot
  PTHR38537 UniProtKB/Swiss-Prot
Pfam Filamin UniProtKB/Swiss-Prot
  PF00307 UniProtKB/Swiss-Prot
PhenoGen Flnc PhenoGen
PROSITE ACTININ_1 UniProtKB/Swiss-Prot
  ACTININ_2 UniProtKB/Swiss-Prot
  FILAMIN_REPEAT UniProtKB/Swiss-Prot
  PS50021 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007281 RatGTEx
SMART IG_FLMN UniProtKB/Swiss-Prot
  SM00033 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47576 UniProtKB/Swiss-Prot
  SSF81296 UniProtKB/Swiss-Prot
UniProt A0A0H2UHR7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R384 ENTREZGENE, UniProtKB/TrEMBL
  D3ZHA0 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Flnc  filamin C  Flnc  filamin C, gamma  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-10-22 Flnc  filamin C, gamma  Flnc  filamin C, gamma (actin binding protein 280)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Flnc  filamin C, gamma (actin binding protein 280)   Flnc_predicted  filamin C, gamma (actin binding protein 280) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Flnc_predicted  filamin C, gamma (actin binding protein 280) (predicted)      Symbol and Name status set to approved 70820 APPROVED