Raet1l (retinoic acid early transcript 1L) - Rat Genome Database

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Gene: Raet1l (retinoic acid early transcript 1L) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Raet1l (Ensembl: AABR07000147.1)
Name: retinoic acid early transcript 1L
RGD ID: 1308785
Description: Predicted to enable natural killer cell lectin-like receptor binding activity. Involved in positive regulation of natural killer cell mediated cytotoxicity. Predicted to be located in plasma membrane and side of membrane. Predicted to be active in external side of plasma membrane and extracellular space. Orthologous to several human genes including RAET1E (retinoic acid early transcript 1E); INTERACTS WITH 17beta-estradiol 3-benzoate; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC292461
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813,799,823 - 3,804,799 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl13,799,833 - 3,804,799 (-)EnsemblGRCr8
mRatBN7.211,979,433 - 1,984,410 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl11,979,443 - 1,984,410 (-)EnsemblmRatBN7.2
Rnor_6.07114,233,896 - 114,234,243 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_5.07114,169,705 - 114,170,052 (+)NCBIRnor_5.0Rnor_5.0rn5
Cytogenetic Map1p13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
5. Identification of the rat NKG2D ligands, RAE1L and RRLT, and their role in allograft rejection. Zhuo M, etal., Eur J Immunol. 2010 Jun;40(6):1748-57. doi: 10.1002/eji.200939779.
Additional References at PubMed
PMID:10894171   PMID:18292522   PMID:20166740  


Genomics

Variants

.
Variants in Raet1l
34 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1126564886Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)1143965634Rat
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1126564886Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)1134184556Rat
1300170Rf6Renal function QTL 63.14renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)1128483164Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
hemolymphoid system
mesenchyme
mesoderm
renal system
reproductive system
1 2 5 2 2 8

Sequence


RefSeq Acc Id: NM_001013063   ⟹   NP_001013081
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813,799,823 - 3,804,799 (-)NCBI
mRatBN7.211,979,433 - 1,984,410 (-)NCBI
Rnor_6.07114,233,896 - 114,234,243 (+)NCBI
Rnor_5.07114,169,705 - 114,170,052 (+)NCBI
RGSC_v3.412,150,617 - 2,155,593 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001013081 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79076 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000082608
  ENSRNOP00000082608.1
RefSeq Acc Id: NP_001013081   ⟸   NM_001013063
- Peptide Label: precursor
- UniProtKB: A0A8I5ZTU3 (UniProtKB/TrEMBL),   Q6AYE9 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
Retinoic acid early-inducible protein

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LUU5-F1-model_v2 AlphaFold F1LUU5 1-300 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308785 AgrOrtholog
BioCyc Gene G2FUF-62460 BioCyc
Ensembl Genes ENSRNOG00000023659 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000104454 ENTREZGENE
  ENSRNOT00000104454.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.500.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7122284 IMAGE-MGC_LOAD
InterPro MHC_class-I_related UniProtKB/TrEMBL
  MHC_I-like_Ag-recog_sf UniProtKB/TrEMBL
  MHC_I/II-like_Ag-recog UniProtKB/TrEMBL
  RAE-1 UniProtKB/TrEMBL
KEGG Report rno:292461 UniProtKB/TrEMBL
MGC_CLONE MGC:94032 IMAGE-MGC_LOAD
NCBI Gene 292461 ENTREZGENE
PANTHER MHC CLASS I-RELATED UniProtKB/TrEMBL
  RETINOIC ACID EARLY TRANSCRIPT 1E UniProtKB/TrEMBL
Pfam MHC_I_2 UniProtKB/TrEMBL
PhenoGen Raet1l PhenoGen
RatGTEx ENSRNOG00000023659 RatGTEx
Superfamily-SCOP MHC_I/II-like_Ag-recog UniProtKB/TrEMBL
UniProt A0A8I5ZTU3 ENTREZGENE, UniProtKB/TrEMBL
  Q6AYE9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Raet1l  retinoic acid early transcript 1L  Raet1l_predicted  retinoic acid early transcript 1L (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Raet1l_predicted  retinoic acid early transcript 1L (predicted)      Symbol and Name status set to approved 70820 APPROVED