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Gene: Sh3rf2 (SH3 domain containing ring finger 2) Rattus norvegicus

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Symbol:

Sh3rf2

Name:

SH3 domain containing ring finger 2

RGD ID:

1308415

Description:

Predicted to enable protein phosphatase 1 binding activity and ubiquitin protein ligase activity. Involved in negative regulation of JNK cascade; negative regulation of apoptotic process; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Orthologous to human SH3RF2 (SH3 domain containing ring finger 2); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

E3 ubiquitin-protein ligase SH3RF2; LOC307472; MGC114566; Posh2; Ppp1r39; protein phosphatase 1 regulatory subunit 39; protein phosphatase 1, regulatory subunit 39; putative E3 ubiquitin-protein ligase SH3RF2; RING finger protein 158; RING-type E3 ubiquitin transferase SH3RF2; SH3 domain-containing RING finger protein 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	34,296,753 - 34,397,880 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	34,296,733 - 34,397,876 (+)	Ensembl				GRCr8
mRatBN7.2	18	34,045,715 - 34,148,342 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	34,046,879 - 34,146,856 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	18	34,151,092 - 34,251,070 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	34,869,409 - 34,969,391 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	34,246,335 - 34,346,293 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	36,371,041 - 36,471,020 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	36,371,041 - 36,471,015 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	18	36,038,469 - 36,138,307 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	18	35,242,898 - 35,344,485 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	18	33,643,909 - 33,743,873 (+)	NCBI		Celera
RGSC_v3.1	18	35,278,198 - 35,379,745 (+)	NCBI
Cytogenetic Map	18	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',5,5'-tetrachlorobiphenyl (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (EXP,ISO)

beta-lapachone (ISO)

bisphenol A (EXP)

cadmium dichloride (ISO)

carbon nanotube (ISO)

chloroprene (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

cytarabine (ISO)

doxorubicin (ISO)

genistein (ISO)

gentamycin (EXP)

glyphosate (ISO)

graphite (EXP)

hydroquinone (ISO)

lead diacetate (ISO)

lipopolysaccharide (ISO)

manganese(II) chloride (EXP)

methoxychlor (EXP)

mono(2-ethylhexyl) phthalate (ISO)

N-methyl-4-phenylpyridinium (EXP)

okadaic acid (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

PCB138 (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

pirinixic acid (ISO)

progesterone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

temozolomide (ISO)

testosterone (ISO)

thiram (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of apoptotic process (IBA,IEA,IMP,ISO,ISS)

negative regulation of JNK cascade (IMP)

negative regulation of protein ubiquitination (IEA,ISO)

positive regulation of cell migration (IEA,ISO,ISS)

positive regulation of JNK cascade (IBA,IEA,ISO,ISS)

positive regulation of proteasomal ubiquitin-dependent protein catabolic process (IEA,IMP,ISO)

protein autoubiquitination (IEA,ISO,ISS)

protein ubiquitination (IEA)

regulation of JNK cascade (IEA)

Cellular Component

nucleoplasm (IBA,IEA,ISO)

nucleus (IEA,ISO,ISS)

Molecular Function

metal ion binding (IEA)

phosphatase binding (IEA,ISO,ISS)

protein binding (IPI,ISO)

protein phosphatase 1 binding (IBA,IEA,ISO,ISS)

protein phosphatase inhibitor activity (IEA)

transferase activity (IEA)

ubiquitin protein ligase activity (IBA,IEA,ISO,ISS)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Sh3rf2/POSHER protein promotes cell survival by ring-mediated proteasomal degradation of the c-Jun N-terminal kinase scaffold POSH (Plenty of SH3s) protein.	Wilhelm M, etal., J Biol Chem. 2012 Jan 13;287(3):2247-56. doi: 10.1074/jbc.M111.269431. Epub 2011 Nov 28.

Additional References at PubMed

PMID:12477932	PMID:15489334	PMID:17762203	PMID:19389623	PMID:19945436	PMID:24130170

Genomics

Comparative Map Data

Sh3rf2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	34,296,753 - 34,397,880 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	18	34,296,733 - 34,397,876 (+)	Ensembl				GRCr8
mRatBN7.2	18	34,045,715 - 34,148,342 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	34,046,879 - 34,146,856 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	18	34,151,092 - 34,251,070 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	34,869,409 - 34,969,391 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	34,246,335 - 34,346,293 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	36,371,041 - 36,471,020 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	36,371,041 - 36,471,015 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	18	36,038,469 - 36,138,307 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	18	35,242,898 - 35,344,485 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	18	33,643,909 - 33,743,873 (+)	NCBI		Celera
RGSC_v3.1	18	35,278,198 - 35,379,745 (+)	NCBI
Cytogenetic Map	18	p11	NCBI

SH3RF2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	145,936,578 - 146,081,773 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	145,936,425 - 146,085,976 (+)	Ensembl			hg38	GRCh38
GRCh37	5	145,316,141 - 145,442,855 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	145,296,335 - 145,423,048 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	5	145,296,334 - 145,423,047	NCBI
Celera	5	141,396,292 - 141,522,973 (+)	NCBI		Celera
Cytogenetic Map	5	q32	NCBI
HuRef	5	140,462,976 - 140,589,659 (+)	NCBI		HuRef
CHM1_1	5	144,748,936 - 144,875,627 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	5	146,470,962 - 146,616,058 (+)	NCBI		T2T-CHM13v2.0

Sh3rf2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	42,185,531 - 42,291,760 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	42,186,732 - 42,292,025 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	18	42,052,502 - 42,158,695 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	42,053,667 - 42,158,960 (+)	Ensembl			mm10	GRCm38
MGSCv37	18	42,213,364 - 42,318,349 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	18	42,179,683 - 42,284,424 (+)	NCBI		MGSCv36	mm8
Celera	18	43,415,332 - 43,520,074 (+)	NCBI		Celera
Cytogenetic Map	18	B3	NCBI
cM Map	18	22.21	NCBI

Sh3rf2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	8,042,380 - 8,147,564 (-)	Ensembl
ChiLan1.0	NW_004955415	8,024,984 - 8,148,970 (-)	NCBI	ChiLan1.0	ChiLan1.0

SH3RF2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	141,189,983 - 141,335,567 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	139,329,533 - 139,471,859 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	141,386,060 - 141,530,993 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	147,401,188 - 147,545,703 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	147,401,188 - 147,545,703 (+)	Ensembl			panPan2	panpan1.1

SH3RF2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	40,380,313 - 40,514,211 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	40,380,218 - 40,510,853 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	37,425,282 - 37,559,026 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	40,843,992 - 40,977,969 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	40,843,847 - 40,977,015 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	37,910,939 - 38,044,681 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	38,727,553 - 38,861,209 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	39,552,296 - 39,686,259 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Sh3rf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	147,025,186 - 147,157,157 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936504	8,599,157 - 8,731,118 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936504	8,602,116 - 8,731,099 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SH3RF2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	147,290,579 - 147,413,143 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	147,290,322 - 147,413,151 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	153,801,407 - 153,932,618 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SH3RF2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	48,512,549 - 48,655,652 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	48,512,548 - 48,658,365 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666034	29,132,374 - 29,278,260 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sh3rf2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624774	5,327,570 - 5,555,645 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624774	5,319,329 - 5,554,823 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Sh3rf2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	15	3,227,129 - 3,332,798 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Sh3rf2
418 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	46
Count of miRNA genes:	43
Interacting mature miRNAs:	46
Transcripts:	ENSRNOT00000025408
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	25071126	83910656	Rat
1358358	Sradr6	Stress Responsive Adrenal Weight QTL 6	2.49		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	18	22015562	61600538	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	23494057	85487725	Rat
1331742	Bp228	Blood pressure QTL 228	3.88752		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
12904668	Bw188	Body weight QTL 188		0.03	body mass (VT:0001259)	body weight (CMO:0000012)	18	26822186	71822186	Rat
12904669	Cm125	Cardiac mass QTL 125		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	26822186	71822186	Rat
12904670	Cm126	Cardiac mass QTL 126		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	26822186	71822186	Rat
1331727	Bp237	Blood pressure QTL 237	3.053		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	63968306	Rat
12904677	Kidm72	Kidney mass QTL 72		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	26822186	71822186	Rat
12904673	Cm127	Cardiac mass QTL 127		0.005	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	26822186	71822186	Rat
12904675	Am19	Aortic mass QTL 19		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	26822186	71822186	Rat
1331774	Bp226	Blood pressure QTL 226	4.41065		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
9589816	Gluco68	Glucose level QTL 68	7.25	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	31990891	76990891	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	12066482	85493247	Rat
2303120	Mamtr8	Mammary tumor resistance QTL 8		0.001	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	18	31610505	85493247	Rat
12880368	Bw187	Body weight QTL 187		0.045	body mass (VT:0001259)	body weight (CMO:0000012)	18	33379158	78379158	Rat
2300180	Bmd67	Bone mineral density QTL 67	4.8	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	18	1	34566578	Rat
2299160	Iddm35	Insulin dependent diabetes mellitus QTL 35	2.79		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	18	4482648	49482648	Rat
9590318	Scort22	Serum corticosterone level QTL 22	7.64	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	18	31990891	76990891	Rat
1331753	Bp231	Blood pressure QTL 231	3.643		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	1	54490981	Rat
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	12066482	85493247	Rat
11565454	Kidm59	Kidney mass QTL 59		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	7065728	52065728	Rat
1331754	Bp230	Blood pressure QTL 230	4.61609		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	15642280	86134022	Rat
2293661	Bss50	Bone structure and strength QTL 50	4.64	0.0003	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	18	1	34566578	Rat
61375	Bp41	Blood pressure QTL 41	2.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	18	4307354	49307354	Rat
12904069	Cm123	Cardiac mass QTL 123		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	33379158	78379158	Rat
2301409	Cm70	Cardiac mass QTL 70		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	18	7065728	52065728	Rat
1331798	Bp224	Blood pressure QTL 224	3.53873		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	31610505	77371277	Rat
12904070	Cm124	Cardiac mass QTL 124		0.01	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	33379158	78379158	Rat
12904071	Am18	Aortic mass QTL 18		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	33379158	78379158	Rat
2301413	Bp318	Blood pressure QTL 318		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	26822186	71822186	Rat
61383	Bp47	Blood pressure QTL 47	17.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	31522783	76522783	Rat
12904067	Cm122	Cardiac mass QTL 122		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	33379158	78379158	Rat
12904716	Am21	Aortic mass QTL 21		0.005	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	7065728	52065728	Rat
2301417	Bp319	Blood pressure QTL 319		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	33379158	78379158	Rat
12904073	Kidm71	Kidney mass QTL 71		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	33379158	78379158	Rat
12904714	Cm131	Cardiac mass QTL 131		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	7065728	52065728	Rat
12904715	Cm132	Cardiac mass QTL 132		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	7065728	52065728	Rat
1331776	Bp225	Blood pressure QTL 225	2.829		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	31610505	77371277	Rat
6903345	Bp349	Blood pressure QTL 349	3.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	3917226	48917226	Rat
2313082	Bss85	Bone structure and strength QTL 85	0.8	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	18	15226101	42690662	Rat
1641923	Colcr8	Colorectal carcinoma resistance QTL 8	3.1	0.0014	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	31990891	76990891	Rat
2312568	Glom21	Glomerulus QTL 21	2	0.005	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	5460455	42690191	Rat
6903349	Bp351	Blood pressure QTL 351	3.5		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	3917226	48917226	Rat
631509	Sald2	Serum aldosterone level QTL 2	2.9		blood aldosterone amount (VT:0005346)	serum aldosterone level (CMO:0000487)	18	26415821	71415821	Rat
6903351	Bp352	Blood pressure QTL 352	3.3		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	3917226	48917226	Rat
631274	Sprol1	Serum protein level QTL 1	5.3		blood total protein amount (VT:0005567)	serum total protein level (CMO:0000661)	18	31644508	79484311	Rat
2325839	Bp348	Blood pressure QTL 348		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	1	44930869	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19553532	85493247	Rat
2293708	Bss46	Bone structure and strength QTL 46	8.8	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	18	12066482	57066482	Rat
8694378	Bw157	Body weight QTL 157	3.59	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	31990891	76990891	Rat
61429	Cia17	Collagen induced arthritis QTL 17	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	18	31610505	72538878	Rat

Markers in Region

D18Mit114

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	34,046,048 - 34,046,185 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	36,370,211 - 36,370,347	NCBI	Rnor6.0
Rnor_5.0	18	36,037,639 - 36,037,775	UniSTS	Rnor5.0
RGSC_v3.4	18	35,242,068 - 35,242,204	UniSTS	RGSC3.4
Celera	18	33,643,079 - 33,643,215	UniSTS
Cytogenetic Map	18	p11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	66	130	74	73	42	51	42	6	297	150	11	104	81	92	31	3	3

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001034187	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096853	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC100155	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000025408 ⟹ ENSRNOP00000025409

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	34,296,733 - 34,397,876 (+)	Ensembl
mRatBN7.2 Ensembl	18	34,046,879 - 34,146,856 (+)	Ensembl
Rnor_6.0 Ensembl	18	36,371,041 - 36,471,015 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105237 ⟹ ENSRNOP00000093747

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	18	34,296,733 - 34,397,876 (+)	Ensembl
mRatBN7.2 Ensembl	18	34,046,879 - 34,146,856 (+)	Ensembl

RefSeq Acc Id:

NM_001034187 ⟹ NP_001029359

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	34,297,922 - 34,397,880 (+)	NCBI
mRatBN7.2	18	34,046,879 - 34,146,861 (+)	NCBI
Rnor_6.0	18	36,371,041 - 36,471,020 (+)	NCBI
Rnor_5.0	18	36,038,469 - 36,138,307 (+)	NCBI
RGSC_v3.4	18	35,242,898 - 35,344,485 (+)	RGD
Celera	18	33,643,909 - 33,743,873 (+)	RGD

Sequence:

show sequence

TTTTTTTTTTTTTTTTTTTTCCTCCTTCTTTCAAACAGGCAGGGAGTTCTGATGCTCCCAAAAG
ACTGGCTCTACCCCTTCGGTTCGGCTGCCCCTACAATGTGGATCCTGCTTCTCCAGGTTGGGAC
TGGAGTTTTAAAATAAAATGGATGATTTGACGTTACTTGATCTCCTGGAGTGCCCCGTGTGCTT
TGAAAAGCTCGATGTTACAGCCAAAGTTCTCCCCTGCCAGCACACCTTCTGCAAACCATGTCTA
CAGCGGATTTTCAAGGCCCACAAGGAGCTGAGGTGCCCGGAATGCAGGACCCTGGTGTTCTGCA
GCATCGAGGCTCTGCCAGCCAACCTGTTGCTGGTGCGTCTGCTGGATGGAGTGCGCTCCGGGCA
CAACTCGTGGAGAGGAGGCTCCTTTCGAAGGCCTCGAATACTAACCTTGCAGGACAACAGGAAA
GCCAAGAGCAGCCCCAGAAGTCTGCAGGCCAGCCCTTTCCGGCTGGGGCCCACTGTCAGGATCC
ACATGGATGGGGTGCCTCGAGCCAAGGCCTTGTGCAACTACAGAGGGAAGAATCCTGGCGACCT
GAAGTTTAATAAAGGAGATGTCATCCTCCTTCAGAGACAGCTTGATGAGAACTGGTACCAGGGG
GAGATCAATGGGGTCAGTGGGTTCTTCCCAGCCAGCTCTGTGGAAGTCATCAAGCAGCTGCCCC
AGCCACCCCCTCTCTGCAGAGCCCTCTACAACTTTGACCTTCGAGATAAGGATAAGAGTGAGAA
CCAGGATTGCCTGACCTTCCTCAAGGATGATGTCATCACAGTGATCAGCCGAGTAGACGAGAAC
TGGGCAGAAGGAAAACTCGGAGATAAAGTAGGCATCTTCCCCATCTTGTTTGTAGAGCCAAACC
TCTCTGCAAGACACCTCCTAGAGAAGAGCAAAGGGCATCAGTTATCACGCACAAAACATCTGTC
CCTGATGTCCTCACCATCTAGAGGCAAAGCAACCAACACATCCACTCTCCGCAAGAGCCCAGGG
TCCAGGAGGAAAGGATCCGGGCAGTTCGCCATGACTACAGCTTTGAATACACTCAACCGCATGG
TCCATTCTCCTGAAGGTCACCAGATGGTGGAAATCAGCACCCCAGTGCTCATCAGCTCTACCAG
TCCCTCTATGCTCACCCAGCATGGGGACAGGGCCGATTTCCCTGCCAGCTCTGCAGGACAGGTC
AGCACTTCTCACCCTGCTCCTGCCTCCCCAGGACATTCCACAGCCATGGTCAGTGTGCCCAGCT
CCCAGCAACACCTCTCAACGAACATGTTTGTAGCCCTGCACACTTACTCAGCCCAGGGACCTGA
AGAGCTGGACCTGAAGAAGGGAGAAGGTATCAGGGTTCTGGGCAAGAATCAGGATGGCTGGCTG
AGGGGCGTCTCCTTAGTCACTGGACGAACTGGCATCTTTCCAAGCGACTATGTCATCCCCGTTT
TCAGCTCAACAGCTAGAAAGACATCTAGTTTTCCTGATTCCCGGCACCCCACTGTCTGCACCAC
ATGGGCGTTATCCACCTCCTCTGTGTCCTCCCAGGGTAGCTTTTCAGAAGGCGATCCCCGGCAA
AGTGGACCCTTCAGATCTGTCTTTGTGCCCACTGCCGTTAACCCTCCAAGGAGCACATCTGGCC
CTGGGACTTCTGGACAAGGGTCTCTTAGGAAAGTGCGGAGCAGCATGAGAAAGAATGGATCCCT
GCAGAGACCAGTTCAATCAGGGATCCCCACTTTCATGGTGGGCTCCCTCAGGTGCAGTCCTGCC
ATGGTGATCCGGCCTCAGAAGTTCCAGTTTTATCAGCCACAGGGGATGACCCCTTCCCCAACAC
CCATAATGGTGGAGATAGGGTCTAAATCTATTTCCACTGGGGAGCCTGCCCTGACCTGCATCAA
CAGAGGTGGCAAGACCAGGACCCACTCCGCAGGCAATTCCATCATCATGGAAGGCAAAGAAACA
CCCATCAAGAGTGAGCCTCCACCCAAGCCGCCTGCGTCTGCACCACCCTCCATCCTCGTGAAAC
CAGAAAATTCAAAAAATGGTATTGAAAAGCAAGTCAAAACCGTGAGATTTCAGAATTACAGCCC
TCCGCCCACCAAACACTCTGCCTCCGGTCCCACCTCTGGAAAGCATGAACAGCCAGCCACCTTG
AAGGGGTCCCAACCTGAAGCAGTCTCCTCAGAAGGAGAGATGACCATTCTATTTGCCCACCGAA
GTGGCTGCCACTCCGGGCAACAGACAGACCTTCGGAGAAAGTCAGCCTTTAGCAAGACCACACC
CCCAGTGTCCACTGCTTCAGTCTCACAGACCTTATTTCCCAGCAAATGATTCTTCAAGTGGCTT
TTCTTAGTCACAAAAGGGGTAAATTGCATATAAATACAGTCTGCCTCCACCACAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
A

hide sequence

RefSeq Acc Id:

XM_039096853 ⟹ XP_038952781

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	34,296,753 - 34,397,880 (+)	NCBI
mRatBN7.2	18	34,045,715 - 34,148,342 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001029359	(Get FASTA)	NCBI Sequence Viewer
	XP_038952781	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI00156	(Get FASTA)	NCBI Sequence Viewer
	EDL76476	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000025409
	ENSRNOP00000025409.4
GenBank Protein	Q498M5	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001029359 ⟸ NM_001034187

- UniProtKB:

Q498M5 (UniProtKB/Swiss-Prot), A6J3J4 (UniProtKB/TrEMBL), A0A8I6AJG7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDDLTLLDLLECPVCFEKLDVTAKVLPCQHTFCKPCLQRIFKAHKELRCPECRTLVFCSIEALP
ANLLLVRLLDGVRSGHNSWRGGSFRRPRILTLQDNRKAKSSPRSLQASPFRLGPTVRIHMDGVP
RAKALCNYRGKNPGDLKFNKGDVILLQRQLDENWYQGEINGVSGFFPASSVEVIKQLPQPPPLC
RALYNFDLRDKDKSENQDCLTFLKDDVITVISRVDENWAEGKLGDKVGIFPILFVEPNLSARHL
LEKSKGHQLSRTKHLSLMSSPSRGKATNTSTLRKSPGSRRKGSGQFAMTTALNTLNRMVHSPEG
HQMVEISTPVLISSTSPSMLTQHGDRADFPASSAGQVSTSHPAPASPGHSTAMVSVPSSQQHLS
TNMFVALHTYSAQGPEELDLKKGEGIRVLGKNQDGWLRGVSLVTGRTGIFPSDYVIPVFSSTAR
KTSSFPDSRHPTVCTTWALSTSSVSSQGSFSEGDPRQSGPFRSVFVPTAVNPPRSTSGPGTSGQ
GSLRKVRSSMRKNGSLQRPVQSGIPTFMVGSLRCSPAMVIRPQKFQFYQPQGMTPSPTPIMVEI
GSKSISTGEPALTCINRGGKTRTHSAGNSIIMEGKETPIKSEPPPKPPASAPPSILVKPENSKN
GIEKQVKTVRFQNYSPPPTKHSASGPTSGKHEQPATLKGSQPEAVSSEGEMTILFAHRSGCHSG
QQTDLRRKSAFSKTTPPVSTASVSQTLFPSK

hide sequence

Ensembl Acc Id:

ENSRNOP00000025409 ⟸ ENSRNOT00000025408

RefSeq Acc Id:	XP_038952781 ⟸ XM_039096853
- Peptide Label:	isoform X1
- UniProtKB:	Q498M5 (UniProtKB/Swiss-Prot), A6J3J4 (UniProtKB/TrEMBL), A0A8I6AJG7 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000093747 ⟸ ENSRNOT00000105237

Protein Domains

RING-type SH3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q498M5-F1-model_v2	AlphaFold	Q498M5	1-735	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700747

Promoter ID:

EPDNEW_R11271

Type:

single initiation site

Name:

Sh3rf2_1

Description:

SH3 domain containing ring finger 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	18	36,371,051 - 36,371,111	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308415	AgrOrtholog
BioCyc Gene	G2FUF-7708	BioCyc
Ensembl Genes	ENSRNOG00000018780	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000025408	ENTREZGENE
	ENSRNOT00000025408.7	UniProtKB/Swiss-Prot
Gene3D-CATH	3.30.40.10	UniProtKB/Swiss-Prot
	SH3 Domains	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7461488	IMAGE-MGC_LOAD
InterPro	Endophilin_SH3RF	UniProtKB/Swiss-Prot
	SH3-like_dom_sf	UniProtKB/Swiss-Prot
	SH3_domain	UniProtKB/Swiss-Prot
	SH3RF2_RING-HC_Zfn	UniProtKB/Swiss-Prot
	SH3RF2_SH3_1	UniProtKB/Swiss-Prot
	SH3RF2_SH3_2	UniProtKB/Swiss-Prot
	SH3RF2_SH3_3	UniProtKB/Swiss-Prot
	Znf_RING	UniProtKB/Swiss-Prot
	Znf_RING/FYVE/PHD	UniProtKB/Swiss-Prot
	Znf_RING_CS	UniProtKB/Swiss-Prot
KEGG Report	rno:307472	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:114566	IMAGE-MGC_LOAD
NCBI Gene	307472	ENTREZGENE
PANTHER	PTHR14167:SF60	UniProtKB/Swiss-Prot
	SH3 DOMAIN-CONTAINING	UniProtKB/Swiss-Prot
Pfam	SH3_1	UniProtKB/Swiss-Prot
	SH3_2	UniProtKB/Swiss-Prot
	zf-RING_2	UniProtKB/Swiss-Prot
PhenoGen	Sh3rf2	PhenoGen
PRINTS	P67PHOX	UniProtKB/Swiss-Prot
	SH3DOMAIN	UniProtKB/Swiss-Prot
PROSITE	SH3	UniProtKB/Swiss-Prot
	ZF_RING_1	UniProtKB/Swiss-Prot
	ZF_RING_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000018780	RatGTEx
SMART	RING	UniProtKB/Swiss-Prot
	SH3	UniProtKB/Swiss-Prot
Superfamily-SCOP	RING/U-box	UniProtKB/Swiss-Prot
	SSF50044	UniProtKB/Swiss-Prot
UniProt	A0A8I6AJG7	ENTREZGENE, UniProtKB/TrEMBL
	A6J3J4	ENTREZGENE, UniProtKB/TrEMBL
	Q498M5	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-12-06	Sh3rf2	SH3 domain containing ring finger 2	Ppp1r39	protein phosphatase 1, regulatory subunit 39	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-10-21	Ppp1r39	protein phosphatase 1, regulatory subunit 39	Sh3rf2	SH3 domain containing ring finger 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Sh3rf2	SH3 domain containing ring finger 2	Sh3rf2_predicted	SH3 domain containing ring finger 2 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Sh3rf2_predicted	SH3 domain containing ring finger 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - MGI