Wwc1 (WW and C2 domain containing 1) - Rat Genome Database

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Gene: Wwc1 (WW and C2 domain containing 1) Rattus norvegicus
Analyze
Symbol: Wwc1
Name: WW and C2 domain containing 1
RGD ID: 1308329
Description: Predicted to enable kinase binding activity; signaling adaptor activity; and transcription coactivator activity. Involved in cell migration. Part of protein-containing complex. Is active in postsynaptic density, intracellular component. Orthologous to human WWC1 (WW and C2 domain containing 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC303039; protein KIBRA; RGD1308329; similar to KIAA0869 protein; WW, C2 and coiled-coil domain containing 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Kidm50
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81020,804,173 - 20,958,437 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1020,799,237 - 20,958,437 (-)EnsemblGRCr8
mRatBN7.21020,300,735 - 20,454,393 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1020,300,833 - 20,454,497 (-)EnsemblmRatBN7.2
Rnor_6.01020,662,996 - 20,818,500 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1020,663,541 - 20,818,128 (-)Ensemblrn6Rnor6.0
Rnor_5.01020,535,256 - 20,689,364 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41020,750,770 - 20,910,298 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1019,920,851 - 20,074,311 (-)NCBICelera
RGSC_v3.11020,751,819 - 20,911,409 (-)NCBI
Cytogenetic Map10q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
diethylstilbestrol  (EXP,ISO)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
hexestrol  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
mestranol  (ISO)
methapyrilene  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel sulfate  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (EXP)
Rutecarpine  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Temporal-spatial expression and novel biochemical properties of the memory-related protein KIBRA. Johannsen S, etal., Neuroscience. 2008 Sep 9;155(4):1165-73. doi: 10.1016/j.neuroscience.2008.06.054. Epub 2008 Jul 3.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation. Rosse C, etal., PLoS Biol. 2009 Nov;7(11):e1000235. Epub 2009 Nov 3.
Additional References at PubMed
PMID:16684779   PMID:18190796   PMID:18596123   PMID:20159598   PMID:24117625   PMID:24141945   PMID:24682284   PMID:38906255  


Genomics

Comparative Map Data
Wwc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81020,804,173 - 20,958,437 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1020,799,237 - 20,958,437 (-)EnsemblGRCr8
mRatBN7.21020,300,735 - 20,454,393 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1020,300,833 - 20,454,497 (-)EnsemblmRatBN7.2
Rnor_6.01020,662,996 - 20,818,500 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1020,663,541 - 20,818,128 (-)Ensemblrn6Rnor6.0
Rnor_5.01020,535,256 - 20,689,364 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41020,750,770 - 20,910,298 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1019,920,851 - 20,074,311 (-)NCBICelera
RGSC_v3.11020,751,819 - 20,911,409 (-)NCBI
Cytogenetic Map10q12NCBI
WWC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385168,291,645 - 168,472,303 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5168,291,563 - 168,472,303 (+)Ensemblhg38GRCh38
GRCh375167,718,650 - 167,899,308 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365167,651,670 - 167,829,342 (+)NCBIBuild 36Build 36hg18NCBI36
Celera5163,754,431 - 163,934,646 (+)NCBICelera
Cytogenetic Map5q34NCBI
HuRef5162,818,257 - 162,998,068 (+)NCBIHuRef
CHM1_15167,152,124 - 167,332,374 (+)NCBICHM1_1
T2T-CHM13v2.05168,826,515 - 169,007,094 (+)NCBIT2T-CHM13v2.0
Wwc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,729,226 - 35,871,354 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1135,729,227 - 35,871,354 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381135,838,399 - 35,980,527 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1135,838,400 - 35,980,527 (-)Ensemblmm10GRCm38
MGSCv371135,652,680 - 35,793,591 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361135,682,601 - 35,823,512 (-)NCBIMGSCv36mm8
Celera1139,622,284 - 39,698,629 (-)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1121.96NCBI
Wwc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540821,362,644 - 21,529,157 (+)Ensembl
ChiLan1.0NW_00495540821,362,644 - 21,529,164 (+)NCBIChiLan1.0ChiLan1.0
WWC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24163,452,373 - 163,632,466 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15161,591,925 - 161,772,011 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05163,654,833 - 163,835,006 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15170,420,221 - 170,602,373 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5170,418,414 - 170,602,373 (+)EnsemblpanPan2panpan1.1
WWC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1443,279,788 - 43,431,503 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl443,280,447 - 43,431,144 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha443,232,465 - 43,387,800 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0443,697,915 - 43,852,863 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl443,701,311 - 43,853,163 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1443,467,250 - 43,622,670 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0443,661,922 - 43,817,102 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0444,168,112 - 44,323,632 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Wwc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721397,318,811 - 97,464,704 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936622935,130 - 1,080,308 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936622934,436 - 1,080,318 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WWC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1655,418,397 - 55,595,189 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11655,418,391 - 55,595,202 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
WWC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12370,515,573 - 70,684,973 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2370,515,173 - 70,684,971 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660347,997,955 - 8,171,322 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wwc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473321,542,389 - 21,712,457 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473321,541,654 - 21,712,604 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Wwc1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1919,020,411 - 19,170,430 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Wwc1
865 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:38
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000011061
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat

Markers in Region
D10Rat216  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81020,805,102 - 20,805,471 (+)Marker Load Pipeline
mRatBN7.21020,301,043 - 20,301,412 (+)MAPPERmRatBN7.2
Rnor_6.01020,663,926 - 20,664,294NCBIRnor6.0
Rnor_5.01020,536,186 - 20,536,554UniSTSRnor5.0
RGSC_v3.41020,751,336 - 20,751,704UniSTSRGSC3.4
RGSC_v3.41020,751,195 - 20,751,726RGDRGSC3.4
Celera1019,921,393 - 19,921,761UniSTS
Celera1019,919,648 - 19,919,975UniSTS
RGSC_v3.11020,752,244 - 20,752,775RGD
RH 2.0 Map10226.3RGD
SHRSP x BN Map1023.85RGD
Cytogenetic Map10q12UniSTS
D10Got36  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21020,455,980 - 20,456,083 (+)MAPPERmRatBN7.2
Rnor_6.01020,820,086 - 20,820,188NCBIRnor6.0
Rnor_5.01020,691,249 - 20,691,351UniSTSRnor5.0
RGSC_v3.41020,912,274 - 20,912,376UniSTSRGSC3.4
RGSC_v3.41020,912,273 - 20,912,376RGDRGSC3.4
Celera1020,075,897 - 20,076,006UniSTS
RGSC_v3.11020,913,323 - 20,913,425RGD
RH 3.4 Map10215.82UniSTS
RH 3.4 Map10215.82RGD
RH 2.0 Map10227.6RGD
Cytogenetic Map10q12UniSTS
D10Mco52  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81020,836,173 - 20,836,437 (+)Marker Load Pipeline
mRatBN7.21020,332,116 - 20,332,380 (+)MAPPERmRatBN7.2
Rnor_6.01020,695,341 - 20,695,604NCBIRnor6.0
Rnor_5.01020,567,376 - 20,567,639UniSTSRnor5.0
RGSC_v3.41020,782,382 - 20,782,645UniSTSRGSC3.4
RGSC_v3.41020,782,381 - 20,782,645RGDRGSC3.4
Celera1019,952,392 - 19,952,657UniSTS
RGSC_v3.11020,783,430 - 20,783,694RGD
Cytogenetic Map10q12UniSTS
RH139729  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21020,300,136 - 20,300,325 (+)MAPPERmRatBN7.2
Rnor_6.01020,663,019 - 20,663,207NCBIRnor6.0
Rnor_5.01020,535,279 - 20,535,467UniSTSRnor5.0
RGSC_v3.41020,750,429 - 20,750,617UniSTSRGSC3.4
Celera1019,918,855 - 19,919,043UniSTS
RH 3.4 Map10240.61UniSTS
Cytogenetic Map10q12UniSTS
RH141360  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81020,804,536 - 20,804,760 (+)Marker Load Pipeline
mRatBN7.21020,300,477 - 20,300,701 (+)MAPPERmRatBN7.2
Rnor_6.01020,663,360 - 20,663,583NCBIRnor6.0
Rnor_5.01020,535,620 - 20,535,843UniSTSRnor5.0
RGSC_v3.41020,750,770 - 20,750,993UniSTSRGSC3.4
Celera1019,920,827 - 19,921,050UniSTS
Celera1019,919,194 - 19,919,412UniSTS
Cytogenetic Map10q12UniSTS
BI282183  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21020,300,289 - 20,300,457 (+)MAPPERmRatBN7.2
Rnor_6.01020,663,172 - 20,663,339NCBIRnor6.0
Rnor_5.01020,535,432 - 20,535,599UniSTSRnor5.0
RGSC_v3.41020,750,582 - 20,750,749UniSTSRGSC3.4
Celera1019,920,639 - 19,920,806UniSTS
Celera1019,919,008 - 19,919,175UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 68 59 6 332 168 10 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000011061   ⟹   ENSRNOP00000011061
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1020,799,237 - 20,958,437 (-)Ensembl
mRatBN7.2 Ensembl1020,300,833 - 20,454,497 (-)Ensembl
Rnor_6.0 Ensembl1020,663,541 - 20,818,128 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000143840   ⟹   ENSRNOP00000110014
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1020,804,173 - 20,895,549 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000147901   ⟹   ENSRNOP00000106766
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1020,804,173 - 20,894,547 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000166412   ⟹   ENSRNOP00000101995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1020,804,173 - 20,958,437 (-)Ensembl
RefSeq Acc Id: NM_001427362   ⟹   NP_001414291
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81020,804,173 - 20,958,437 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414291 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CDM21937 (Get FASTA)   NCBI Sequence Viewer  
  CDM22295 (Get FASTA)   NCBI Sequence Viewer  
  EDM04097 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000011061.7
  ENSRNOP00000101995
  ENSRNOP00000101995.1
  ENSRNOP00000106766.1
  ENSRNOP00000110014.1
Ensembl Acc Id: ENSRNOP00000011061   ⟸   ENSRNOT00000011061
RefSeq Acc Id: NP_001414291   ⟸   NM_001427362
- UniProtKB: A6HDJ2 (UniProtKB/TrEMBL),   F1M6U0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000106766   ⟸   ENSRNOT00000147901
Ensembl Acc Id: ENSRNOP00000110014   ⟸   ENSRNOT00000143840
Ensembl Acc Id: ENSRNOP00000101995   ⟸   ENSRNOT00000166412
Protein Domains
C2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M6U0-F1-model_v2 AlphaFold F1M6U0 1-1108 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308329 AgrOrtholog
BioCyc Gene G2FUF-25536 BioCyc
Ensembl Genes ENSRNOG00000008065 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011061.9 UniProtKB/TrEMBL
  ENSRNOT00000143840.1 UniProtKB/TrEMBL
  ENSRNOT00000147901.1 UniProtKB/TrEMBL
  ENSRNOT00000166412 ENTREZGENE
  ENSRNOT00000166412.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.70.10 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  C2_WWC UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
  WWC/KIBRA_Hippo_Reg UniProtKB/TrEMBL
NCBI Gene 303039 ENTREZGENE
PANTHER BOMB/KIRA PROTEINS UniProtKB/TrEMBL
  PROTEIN KIBRA UniProtKB/TrEMBL
Pfam PF00168 UniProtKB/TrEMBL
  PF00397 UniProtKB/TrEMBL
  WWC1 UniProtKB/TrEMBL
PhenoGen Wwc1 PhenoGen
PROSITE PS50004 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008065 RatGTEx
SMART SM00456 UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
UniProt A0ABK0L144_RAT UniProtKB/TrEMBL
  A0ABK0LLY0_RAT UniProtKB/TrEMBL
  A0ABK0LUS0_RAT UniProtKB/TrEMBL
  A6HDJ2 ENTREZGENE, UniProtKB/TrEMBL
  F1M6U0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Wwc1  WW and C2 domain containing 1  Wwc1  WW, C2 and coiled-coil domain containing 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-26 Wwc1  WW, C2 and coiled-coil domain containing 1  RGD1308329_predicted  similar to KIAA0869 protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1308329_predicted  similar to KIAA0869 protein (predicted)  LOC303039_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC303039_predicted  similar to KIAA0869 protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL