Slc39a8 (solute carrier family 39 member 8) - Rat Genome Database

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Gene: Slc39a8 (solute carrier family 39 member 8) Rattus norvegicus
Analyze
Symbol: Slc39a8
Name: solute carrier family 39 member 8
RGD ID: 1308236
Description: Enables zinc:bicarbonate symporter activity. Involved in monoatomic cation transmembrane transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIn. Orthologous to human SLC39A8 (solute carrier family 39 member 8); PARTICIPATES IN iron uptake pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC108350117; LOC295455; metal cation symporter ZIP8; MGC108852; solute carrier family 39 (metal ion transporter), member 8; solute carrier family 39 (zinc transporter), member 8; uncharacterized LOC108350117; zinc transporter ZIP8; ZIP-8; zrt- and Irt-like protein 8
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82226,845,686 - 226,992,668 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2226,929,644 - 226,992,667 (+)EnsemblGRCr8
mRatBN7.22224,171,787 - 224,319,326 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2224,256,654 - 224,319,129 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2231,982,580 - 232,044,754 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02229,882,319 - 229,944,486 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02224,746,913 - 224,809,087 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02241,028,851 - 241,092,584 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2241,029,693 - 241,092,582 (+)Ensemblrn6Rnor6.0
Rnor_5.02259,584,747 - 259,648,098 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42233,340,397 - 233,403,461 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2216,458,405 - 216,522,357 (+)NCBICelera
RGSC_v3.12233,327,136 - 233,390,197 (+)NCBI
Cytogenetic Map2q43NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
Azoxymethane  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzoates  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt atom  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diethylstilbestrol  (ISO)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
flutamide  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
hydrogencarbonate  (ISO)
indometacin  (EXP)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
isotretinoin  (ISO)
L-ethionine  (EXP)
lead diacetate  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
N-methylformamide  (ISO)
N-nitrosodimethylamine  (EXP)
naled  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
omeprazole  (EXP)
panobinostat  (ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
potassium cyanide  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercitrin  (ISO)
resveratrol  (ISO)
rimonabant  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium hydrogencarbonate  (EXP)
Soman  (EXP)
sunitinib  (ISO)
tartrazine  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical plasma membrane  (IEA,ISO,ISS)
basolateral plasma membrane  (IEA,ISO,ISS)
lysosomal membrane  (IEA,ISO,ISS)
membrane  (IEA)
organelle membrane  (IEA,ISO,ISS)
plasma membrane  (IBA,IDA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease. Bogdan AR, etal., Trends Biochem Sci. 2016 Mar;41(3):274-86. doi: 10.1016/j.tibs.2015.11.012. Epub 2015 Dec 23.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Lane DJ, etal., Biochim Biophys Acta. 2015 May;1853(5):1130-44. doi: 10.1016/j.bbamcr.2015.01.021. Epub 2015 Feb 4.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading. Wang CY, etal., J Biol Chem. 2012 Oct 5;287(41):34032-43. doi: 10.1074/jbc.M112.367284. Epub 2012 Aug 16.
Additional References at PubMed
PMID:12477932   PMID:12504855   PMID:15722412   PMID:16638970   PMID:17108009   PMID:18037372   PMID:18390834   PMID:19401385   PMID:21509381   PMID:23598904   PMID:24529376   PMID:25007852  
PMID:27166256   PMID:27466201   PMID:28338971   PMID:28481222   PMID:29337306   PMID:29453449   PMID:30015240   PMID:31699897   PMID:33677133  


Genomics

Comparative Map Data
Slc39a8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82226,845,686 - 226,992,668 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2226,929,644 - 226,992,667 (+)EnsemblGRCr8
mRatBN7.22224,171,787 - 224,319,326 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2224,256,654 - 224,319,129 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2231,982,580 - 232,044,754 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02229,882,319 - 229,944,486 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02224,746,913 - 224,809,087 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02241,028,851 - 241,092,584 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2241,029,693 - 241,092,582 (+)Ensemblrn6Rnor6.0
Rnor_5.02259,584,747 - 259,648,098 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42233,340,397 - 233,403,461 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2216,458,405 - 216,522,357 (+)NCBICelera
RGSC_v3.12233,327,136 - 233,390,197 (+)NCBI
Cytogenetic Map2q43NCBI
SLC39A8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384102,251,041 - 102,345,482 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4102,251,080 - 102,431,258 (-)Ensemblhg38GRCh38
GRCh374103,172,198 - 103,266,639 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364103,401,844 - 103,485,371 (-)NCBIBuild 36Build 36hg18NCBI36
Build 344103,539,998 - 103,623,526NCBI
Celera4100,470,678 - 100,565,146 (-)NCBICelera
Cytogenetic Map4q24NCBI
HuRef498,909,550 - 99,003,934 (-)NCBIHuRef
CHM1_14103,148,714 - 103,243,025 (-)NCBICHM1_1
T2T-CHM13v2.04105,565,252 - 105,659,701 (-)NCBIT2T-CHM13v2.0
Slc39a8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393135,522,644 - 135,594,333 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3135,531,040 - 135,594,333 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm383135,816,882 - 135,888,572 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3135,825,279 - 135,888,572 (+)Ensemblmm10GRCm38
MGSCv373135,488,455 - 135,551,536 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363135,763,475 - 135,825,778 (+)NCBIMGSCv36mm8
Celera3142,245,991 - 142,312,950 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map363.04NCBI
Slc39a8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554966,040,029 - 6,109,907 (+)Ensembl
ChiLan1.0NW_0049554966,016,727 - 6,106,965 (+)NCBIChiLan1.0ChiLan1.0
SLC39A8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23100,339,570 - 100,430,481 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14100,626,388 - 100,716,146 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0494,675,458 - 94,770,380 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14105,339,488 - 105,433,813 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4105,339,488 - 105,433,568 (-)EnsemblpanPan2panpan1.1
SLC39A8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13223,727,920 - 23,801,459 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3223,729,476 - 23,800,941 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3218,223,143 - 18,296,028 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03223,949,019 - 24,021,586 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3223,949,029 - 24,022,702 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13223,928,002 - 24,000,562 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03223,708,061 - 23,781,012 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03216,083,043 - 16,156,566 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc39a8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530117,620,065 - 17,693,363 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936520962,756 - 1,037,274 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936520961,376 - 1,036,801 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC39A8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8118,605,402 - 118,678,107 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18118,604,852 - 118,678,115 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28127,753,647 - 127,825,292 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC39A8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1750,355,756 - 50,451,253 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl750,367,436 - 50,451,510 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603728,867,139 - 28,956,324 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc39a8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248305,514,780 - 5,574,894 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248305,514,595 - 5,573,250 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc39a8
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1323,217,584 - 23,278,645 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc39a8
2216 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:157
Count of miRNA genes:109
Interacting mature miRNAs:135
Transcripts:ENSRNOT00000033413
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2212145502231732847Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2202029709236904960Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2210956252251712708Rat
8693697Alc36Alcohol consumption QTL 3620.592drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2219814164239320906Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2214404877251712708Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2204795005249795005Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2214404877251712708Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2218051934251712708Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
1302789Stl26Serum triglyceride level QTL 263.10.0035blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)2206613059226891081Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2214404877251712708Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2214404877251712708Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2205135267250135267Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2192287802229609668Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2221088977243501206Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2203664411248664411Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2214404877251712708Rat
8693622Alc26Alcohol consumption QTL 262.40.667drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2223810546243965570Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
1359019Hrtrt19Heart rate QTL 192.9heart pumping trait (VT:2000009)heart rate (CMO:0000002)2221270493228950743Rat

Markers in Region
AI501854  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22224,318,762 - 224,318,968 (+)MAPPERmRatBN7.2
Rnor_6.02241,092,021 - 241,092,226NCBIRnor6.0
Rnor_5.02259,647,535 - 259,647,740UniSTSRnor5.0
RGSC_v3.42233,403,091 - 233,403,296UniSTSRGSC3.4
Celera2216,521,987 - 216,522,192UniSTS
RH 3.4 Map21564.2UniSTS
Cytogenetic Map2q43UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000033413   ⟹   ENSRNOP00000030977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2226,929,644 - 226,992,667 (+)Ensembl
mRatBN7.2 Ensembl2224,256,654 - 224,319,129 (+)Ensembl
Rnor_6.0 Ensembl2241,029,693 - 241,092,582 (+)Ensembl
RefSeq Acc Id: NM_001011952   ⟹   NP_001011952
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82226,930,191 - 226,992,663 (+)NCBI
mRatBN7.22224,256,654 - 224,319,133 (+)NCBI
Rnor_6.02241,029,669 - 241,092,391 (+)NCBI
Rnor_5.02259,584,747 - 259,648,098 (+)NCBI
RGSC_v3.42233,340,397 - 233,403,461 (+)RGD
Celera2216,458,405 - 216,522,357 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233356   ⟹   XP_006233418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82226,929,599 - 226,992,668 (+)NCBI
mRatBN7.22224,256,108 - 224,319,326 (+)NCBI
Rnor_6.02241,029,188 - 241,092,584 (+)NCBI
Rnor_5.02259,584,747 - 259,648,098 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233357   ⟹   XP_006233419
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82226,929,772 - 226,992,668 (+)NCBI
mRatBN7.22224,256,273 - 224,319,326 (+)NCBI
Rnor_6.02241,029,254 - 241,092,584 (+)NCBI
Rnor_5.02259,584,747 - 259,648,098 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017590787   ⟹   XP_017446276
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82226,929,371 - 226,992,668 (+)NCBI
mRatBN7.22224,255,837 - 224,319,326 (+)NCBI
Rnor_6.02241,028,851 - 241,092,584 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039102102   ⟹   XP_038958030
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82226,845,686 - 226,992,668 (+)NCBI
mRatBN7.22224,171,787 - 224,319,326 (+)NCBI
RefSeq Acc Id: XM_039102104   ⟹   XP_038958032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82226,929,595 - 226,992,668 (+)NCBI
mRatBN7.22224,256,064 - 224,319,326 (+)NCBI
RefSeq Acc Id: XR_010063595
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82226,966,379 - 226,988,723 (+)NCBI
RefSeq Acc Id: NP_001011952   ⟸   NM_001011952
- Peptide Label: precursor
- UniProtKB: Q5FVQ0 (UniProtKB/Swiss-Prot),   A6HVY9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233418   ⟸   XM_006233356
- Peptide Label: isoform X1
- UniProtKB: Q5FVQ0 (UniProtKB/Swiss-Prot),   A6HVY9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233419   ⟸   XM_006233357
- Peptide Label: isoform X1
- UniProtKB: Q5FVQ0 (UniProtKB/Swiss-Prot),   A6HVY9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446276   ⟸   XM_017590787
- Peptide Label: isoform X1
- UniProtKB: Q5FVQ0 (UniProtKB/Swiss-Prot),   A6HVY9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000030977   ⟸   ENSRNOT00000033413
RefSeq Acc Id: XP_038958030   ⟸   XM_039102102
- Peptide Label: isoform X1
- UniProtKB: Q5FVQ0 (UniProtKB/Swiss-Prot),   A6HVY9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038958032   ⟸   XM_039102104
- Peptide Label: isoform X1
- UniProtKB: Q5FVQ0 (UniProtKB/Swiss-Prot),   A6HVY9 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5FVQ0-F1-model_v2 AlphaFold Q5FVQ0 1-462 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691772
Promoter ID:EPDNEW_R2297
Type:initiation region
Name:Slc39a8_2
Description:solute carrier family 39 member 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2298  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02241,029,614 - 241,029,674EPDNEW
RGD ID:13691773
Promoter ID:EPDNEW_R2298
Type:initiation region
Name:Slc39a8_1
Description:solute carrier family 39 member 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2297  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02241,029,883 - 241,029,943EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308236 AgrOrtholog
BioCyc Gene G2FUF-51125 BioCyc
Ensembl Genes ENSRNOG00000012508 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000033413 ENTREZGENE
  ENSRNOT00000033413.6 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7368889 IMAGE-MGC_LOAD
InterPro ZIP UniProtKB/Swiss-Prot
  ZIP_Transporter UniProtKB/Swiss-Prot
KEGG Report rno:295455 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108852 IMAGE-MGC_LOAD
NCBI Gene 295455 ENTREZGENE
PANTHER METAL CATION SYMPORTER ZIP8 UniProtKB/Swiss-Prot
  SOLUTE CARRIER FAMILY 39 UniProtKB/Swiss-Prot
Pfam Zip UniProtKB/Swiss-Prot
PhenoGen Slc39a8 PhenoGen
RatGTEx ENSRNOG00000012508 RatGTEx
UniProt A6HVY9 ENTREZGENE, UniProtKB/TrEMBL
  Q5FVQ0 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Slc39a8  solute carrier family 39 member 8  LOC108350117  uncharacterized LOC108350117  Data merged from RGD:11409806 737654 PROVISIONAL
2016-08-02 LOC108350117  uncharacterized LOC108350117      Symbol and Name status set to provisional 70820 PROVISIONAL
2016-02-24 Slc39a8  solute carrier family 39 member 8  Slc39a8  solute carrier family 39 (zinc transporter), member 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-16 Slc39a8  solute carrier family 39 (zinc transporter), member 8  Slc39a8  solute carrier family 39 (metal ion transporter), member 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Slc39a8  solute carrier family 39 (metal ion transporter), member 8  Slc39a8_predicted  solute carrier family 39 (metal ion transporter), member 8 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Slc39a8_predicted  solute carrier family 39 (metal ion transporter), member 8 (predicted)      Symbol and Name status set to approved 70820 APPROVED