Amn1 (antagonist of mitotic exit network 1 homolog)

Gene: Amn1 (antagonist of mitotic exit network 1 homolog) Rattus norvegicus

Analyze

Symbol:

Amn1

Name:

antagonist of mitotic exit network 1 homolog

RGD ID:

1308119

Description:

Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in microvillus membrane. Orthologous to human AMN1 (antagonist of mitotic exit network 1 homolog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 5-aza-2'-deoxycytidine; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

antagonist of mitotic exit network 1 homolog (S. cerevisiae); LOC302032; MGC105998; protein AMN1 homolog; RGD1308119; similar to F-box protein FBL2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	183,886,469 - 183,913,411 (-)	NCBI		GRCr8
mRatBN7.2	4	182,155,140 - 182,182,085 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	182,155,142 - 182,182,016 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	188,435,598 - 188,462,671 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	184,220,128 - 184,247,201 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	182,840,625 - 182,867,698 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	183,670,589 - 183,697,531 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	183,670,596 - 183,697,531 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	247,795,748 - 247,822,690 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	186,585,328 - 186,612,239 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	186,830,452 - 186,857,333 (-)	NCBI
Celera	4	170,621,084 - 170,648,033 (-)	NCBI		Celera
Cytogenetic Map	4	q44	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2-hydroxypropanoic acid (ISO)

3,3',4,4'-tetrachlorobiphenyl (ISO)

5-aza-2'-deoxycytidine (EXP)

6-propyl-2-thiouracil (EXP)

amitrole (EXP)

amphetamine (EXP)

antirheumatic drug (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

cisplatin (ISO)

cocaine (EXP)

cyclosporin A (ISO)

dibutyl phthalate (EXP)

fenvalerate (EXP)

fipronil (EXP)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

gallic acid (ISO)

genistein (ISO)

gentamycin (EXP)

inulin (ISO)

lead(0) (ISO)

leflunomide (ISO)

methimazole (EXP)

methyl methanesulfonate (ISO)

oxaliplatin (EXP)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phenytoin (EXP)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

sodium arsenate (ISO)

sotorasib (ISO)

sunitinib (ISO)

temozolomide (ISO)

thioacetamide (EXP)

topotecan (EXP)

trametinib (ISO)

trichloroethene (ISO)

trichostatin A (ISO)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (IBA)

Cellular Component

cytoplasm (IEA)

microvillus membrane (IEA,ISO)

SCF ubiquitin ligase complex (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12060780	PMID:12477932

Genomics

Comparative Map Data

Amn1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	183,886,469 - 183,913,411 (-)	NCBI		GRCr8
mRatBN7.2	4	182,155,140 - 182,182,085 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	182,155,142 - 182,182,016 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	188,435,598 - 188,462,671 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	184,220,128 - 184,247,201 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	182,840,625 - 182,867,698 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	183,670,589 - 183,697,531 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	183,670,596 - 183,697,531 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	247,795,748 - 247,822,690 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	186,585,328 - 186,612,239 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	186,830,452 - 186,857,333 (-)	NCBI
Celera	4	170,621,084 - 170,648,033 (-)	NCBI		Celera
Cytogenetic Map	4	q44	NCBI

AMN1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	31,671,137 - 31,729,174 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	31,671,142 - 31,729,121 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	31,824,071 - 31,882,108 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	31,715,338 - 31,773,251 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	11,646,334 - 11,704,593 (-)	NCBI		Celera
Cytogenetic Map	12	p11.21	NCBI
HuRef	12	31,576,765 - 31,634,732 (-)	NCBI		HuRef
CHM1_1	12	31,790,043 - 31,848,054 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	31,547,967 - 31,606,023 (-)	NCBI		T2T-CHM13v2.0

Amn1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	149,059,075 - 149,090,210 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	149,058,645 - 149,090,210 (-)	Ensembl		GRCm39 Ensembl
GRCm38	6	149,157,261 - 149,188,712 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	149,157,147 - 149,188,712 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	149,106,099 - 149,137,234 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	149,114,747 - 149,145,882 (-)	NCBI		MGSCv36	mm8
Celera	6	152,197,656 - 152,228,808 (-)	NCBI		Celera
Cytogenetic Map	6	G3	NCBI
cM Map	6	78.81	NCBI

Amn1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955505	3,840,570 - 3,897,720 (-)	NCBI	ChiLan1.0	ChiLan1.0

AMN1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	65,041,996 - 65,101,596 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	65,037,608 - 65,097,988 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	54,514,238 - 54,572,338 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	57,100,801 - 57,159,736 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	57,102,071 - 57,159,736 (+)	Ensembl	panpan1.1		panPan2

AMN1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	17,044,301 - 17,100,444 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	27	17,044,309 - 17,361,570 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	29,316,938 - 29,373,223 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	17,225,395 - 17,281,723 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	27	17,225,426 - 17,282,310 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	27	17,035,706 - 17,092,138 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	17,068,360 - 17,124,591 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	29,470,206 - 29,526,651 (-)	NCBI		UU_Cfam_GSD_1.0

Amn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	77,656,871 - 77,694,315 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936607	4,489,472 - 4,527,690 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936607	4,490,229 - 4,527,682 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AMN1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	42,518,655 - 42,567,687 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	42,518,566 - 42,567,946 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

AMN1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	31,149,544 - 31,208,554 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	31,147,521 - 31,207,507 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666069	3,770,577 - 3,829,352 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Amn1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624778	4,534,556 - 4,614,284 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624778	4,534,378 - 4,603,028 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Amn1
91 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	339
Count of miRNA genes:	198
Interacting mature miRNAs:	222
Transcripts:	ENSRNOT00000055441
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
6478718	Anxrr34	Anxiety related response QTL 34		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	144639524	182687754	Rat
6478748	Anxrr42	Anxiety related response QTL 42		0.28008	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	144639524	182687754	Rat
6478754	Anxrr43	Anxiety related response QTL 43		0.14035	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	144639524	182687754	Rat
6478693	Anxrr32	Anxiety related response QTL 32		0.00092	locomotor behavior trait (VT:0001392)	measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)	4	144639524	182687754	Rat
6478700	Anxrr33	Anxiety related response QTL 33		0.00896	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	144639524	182687754	Rat
10401796	Kidm48	Kidney mass QTL 48			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	4	145568712	182687754	Rat
10053718	Scort25	Serum corticosterone level QTL 25	2.15	0.0097	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	155561574	182687754	Rat
1300109	Rf13	Renal function QTL 13	3.91		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	4	157710145	182687754	Rat

Markers in Region

D4Got243

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	182,180,061 - 182,180,161 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	183,695,508 - 183,695,607	NCBI	Rnor6.0
Rnor_5.0	4	247,820,667 - 247,820,766	UniSTS	Rnor5.0
RGSC_v3.4	4	186,610,216 - 186,610,315	UniSTS	RGSC3.4
Celera	4	170,646,010 - 170,646,109	UniSTS
Cytogenetic Map	4	q44	UniSTS

RH143772

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	182,174,795 - 182,174,920 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	183,690,243 - 183,690,367	NCBI	Rnor6.0
Rnor_5.0	4	247,815,402 - 247,815,526	UniSTS	Rnor5.0
RGSC_v3.4	4	186,604,982 - 186,605,106	UniSTS	RGSC3.4
Celera	4	170,640,745 - 170,640,869	UniSTS
RH 3.4 Map	4	1133.65	UniSTS
Cytogenetic Map	4	q44	UniSTS

RH134737

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	182,155,178 - 182,155,367 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	183,670,628 - 183,670,816	NCBI	Rnor6.0
Rnor_5.0	4	247,795,787 - 247,795,975	UniSTS	Rnor5.0
RGSC_v3.4	4	186,585,365 - 186,585,553	UniSTS	RGSC3.4
Celera	4	170,621,121 - 170,621,309	UniSTS
RH 3.4 Map	4	1126.13	UniSTS
Cytogenetic Map	4	q44	UniSTS

BM385590

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	182,173,798 - 182,174,004 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	183,689,246 - 183,689,451	NCBI	Rnor6.0
Rnor_5.0	4	247,814,405 - 247,814,610	UniSTS	Rnor5.0
RGSC_v3.4	4	186,603,985 - 186,604,190	UniSTS	RGSC3.4
Celera	4	170,639,748 - 170,639,953	UniSTS
RH 3.4 Map	4	1132.85	UniSTS
Cytogenetic Map	4	q44	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	28	36	22	18	22			74	26	41	11
Low	1	15	21	19	1	19	8	11		9			8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001008333	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006237700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC086357	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BG672304	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473964	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000055441 ⟹ ENSRNOP00000052308

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	182,155,142 - 182,178,596 (-)	Ensembl
Rnor_6.0 Ensembl	4	183,670,596 - 183,697,531 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000117439 ⟹ ENSRNOP00000089244

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	182,155,142 - 182,182,016 (-)	Ensembl

RefSeq Acc Id:

NM_001008333 ⟹ NP_001008334

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	183,886,469 - 183,913,411 (-)	NCBI
mRatBN7.2	4	182,155,142 - 182,182,085 (-)	NCBI
Rnor_6.0	4	183,670,591 - 183,697,531 (-)	NCBI
Rnor_5.0	4	247,795,748 - 247,822,690 (-)	NCBI
RGSC_v3.4	4	186,585,328 - 186,612,239 (-)	RGD
Celera	4	170,621,084 - 170,648,033 (-)	RGD

Sequence:

show sequence

TGTTTATGGAGGGCCGTAACTGCGGTCCAAGCTTAAGAGGGCTTCCGCGATGCCTTCGTCGCGA
GTAGTCAGTCAACTTCTGGAACTATGTCTTCGGTGCCTAATAATCAATATTTCCAGATATATAT
CAGATATTAAATATCTGCCTCCCAACATTAAAGATAGACTGATTAAAATAATGAGCATGCGGGG
TCGGATAACAGATTCCAATATAAATGAGGTGTTACATCCTGAAGTCCAAAGACTAGATCTGAGG
AGCTGTAATATCTCAGATGTGGCTCTCCAGCACCTGTGTAAGTGCAGAAAACTGAAGGCACTAA
ATCTAAAATCCTGCAGAGAACATAGAAATAGCATAACTTCAGAAGGAATAAAAGCTGTGGCTTC
ATCCTGTTCAGACCTTCATGAAATTTCTTTGAAAGGATGTTGCAGTGTCACTGATGAAGGGGTC
CTTGCTCTTGCACTCAATTGTCAGCTGCTGAAGATCATTGATTTGGGTGGCTGCTTAAGTATTA
CTGATGAGTCCTTACATGCATTAGGGAAAAACTGCCCATTTTTGCAGTGTGTTGACTTTTCAAC
TACTCAGGTCTCTGACAATGGTGTGGTTGCACTTGTTAGTGGACCGTGTGCCAAACAATTAGAG
GAGATTAACATGGGCTACTGTATAAATCTAACTGATAAGGCTGTTGAAGCTGCCCTGACTGCCT
GTCCTCAAATATGTATACTTCTTTTCCATGGCTGCCCCCTGATAACAGATCATTCACGAGAAGT
CTTGGAGCAACTAATAGGATCAAGAAAACTAAAGCAAGTGACTTGGTCTGTTTACTGATCTTTA
CTAAGGCTGATCCCAGGACCTTGCCCAGGATGTACGCTATACATACTTGTTTTTTTACTTAATT
TAACACCAATTTATTGTTTTATTGTCCTAGTTAAGCTGTGACTTTCAGAGAATCTCCTCAATCT
TAATGTAAATGTTTGTGCTTTAAAGTTAACAGACTCAACATTTTAACACTTCTATTATCCCATA
TTTGTTTGAGCCATTTTTTTAAATGGTGATTCTGACATGAACTGTACTTGATGGAGAGGGGGCT
GAGTTTCTTTCTTTAATAACAAGTTTCAAATTACGTATTGTAGGCTTAGATTTTTCAAAACCTA
CTTTAATAAGGGTTCTTAAATATTTCAGCCTCCCTTCTAGCCCATGAGAGGAAGTGGAAAAGAA
AGGTTAATAAAAAGCTGTTTTGAAATAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006237700 ⟹ XP_006237762

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	183,886,469 - 183,913,310 (-)	NCBI
mRatBN7.2	4	182,155,140 - 182,182,016 (-)	NCBI
Rnor_6.0	4	183,670,589 - 183,697,438 (-)	NCBI
Rnor_5.0	4	247,795,748 - 247,822,690 (-)	NCBI

Sequence:

show sequence

CCTCCCCTGGCCAGCCCTCCTTCGTGTCCGCCCCAGCCCCCAGTCCTTTCCCTCACCTACTCAT
GTCCGGCTGGATCCTAGTCCTTGGCCCGGCCTTGCGCCTGGTCGCTGAGGACCGTGGTGCAGCG
TGGGGCTGGTGGCTCCACCCGATGGATGGGCTCGGGTGTGCGCTGAGTATCTAGGCAGAACAAA
AGAAACCTGGATCCGGGCTGGACAAACAAACCTCCGCTAATACCGGCGCGACTTGATAGCTTTG
GAACCATGAACAGTAACTTATCTCTCCTGATACAGGAGAGCTTTCTAAAATTCGGGTAACAGCA
GGGCATGGAGTTCACGCCTGTAGTCCCAGCCATCTGAAAACTGAAACAGGAAGATTGCCACAAA
TTCGAGGCTAACGGTGTAATGTTGTAAGACAAACACACCCAAGCCAATAAATAGAATCTTGAAA
ATTCGTGTATCAGTACCTATCTCAGGGATTCTTTGTGAGAATCAGCTTACTATATGTAAAACCT
GAGCATGACAGCAAACACCGTTTGAGATGATCAAAAGTTCAAGGCCCTCTTCAGCTATATAATG
TCTTCGGTGCCTAATAATCAATATTTCCAGATATATATCAGATATTAAATATCTGCCTCCCAAC
ATTAAAGATAGACTGATTAAAATAATGAGCATGCGGGGTCGGATAACAGATTCCAATATAAATG
AGGTGTTACATCCTGAAGTCCAAAGACTAGATCTGAGGAGCTGTAATATCTCAGATGTGGCTCT
CCAGCACCTGTGTAAGTGCAGAAAACTGAAGGCACTAAATCTAAAATCCTGCAGAGAACATAGA
AATAGCATAACTTCAGAAGGAATAAAAGCTGTGGCTTCATCCTGTTCAGACCTTCATGAAATTT
CTTTGAAAGGATGTTGCAGTGTCACTGATGAAGGGGTCCTTGCTCTTGCACTCAATTGTCAGCT
GCTGAAGATCATTGATTTGGGTGGCTGCTTAAGTATTACTGATGAGTCCTTACATGCATTAGGG
AAAAACTGCCCATTTTTGCAGTGTGTTGACTTTTCAACTACTCAGGTCTCTGACAATGGTGTGG
TTGCACTTGTTAGTGGACCGTGTGCCAAACAATTAGAGGAGATTAACATGGGCTACTGTATAAA
TCTAACTGATAAGGCTGTTGAAGCTGCCCTGACTGCCTGTCCTCAAATATGTATACTTCTTTTC
CATGGCTGCCCCCTGATAACAGATCATTCACGAGAAGTCTTGGAGCAACTAATAGGATCAAGAA
AACTAAAGCAAGTGACTTGGTCTGTTTACTGATCTTTACTAAGGCTGATCCCAGGACCTTGCCC
AGGATGTACGCTATACATACTTGTTTTTTTACTTAATTTAACACCAATTTATTGTTTTATTGTC
CTAGTTAAGCTGTGACTTTCAGAGAATCTCCTCAATCTTAATGTAAATGTTTGTGCTTTAAAGT
TAACAGACTCAACATTTTAACACTTCTATTATCCCATATTTGTTTGAGCCATTTTTTTAAATGG
TGATTCTGACATGAACTGTACTTGATGGAGAGGGGGCTGAGTTTCTTTCTTTAATAACAAGTTT
CAAATTACGTATTGTAGGCTTAGATTTTTCAAAACCTACTTTAATAAGGGTTCTTAAATATTTC
AGCCTCCCTTCTAGCCCATGAGAGGAAGTGGAAAAGAAAGGTTAATAAAAAGCTGTTTTGAAAT
AGT

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Protein Sequences


Protein RefSeqs	NP_001008334	(Get FASTA)	NCBI Sequence Viewer
	XP_006237762	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH86357	(Get FASTA)	NCBI Sequence Viewer
	EDM01365	(Get FASTA)	NCBI Sequence Viewer
	EDM01366	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000052308
	ENSRNOP00000052308.3
	ENSRNOP00000089244
	ENSRNOP00000089244.1
GenBank Protein	Q5U201	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001008334 ⟸ NM_001008333

- UniProtKB:

Q5U201 (UniProtKB/Swiss-Prot), A6IN73 (UniProtKB/TrEMBL), A0A8L2QRD5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPSSRVVSQLLELCLRCLIINISRYISDIKYLPPNIKDRLIKIMSMRGRITDSNINEVLHPEVQ
RLDLRSCNISDVALQHLCKCRKLKALNLKSCREHRNSITSEGIKAVASSCSDLHEISLKGCCSV
TDEGVLALALNCQLLKIIDLGGCLSITDESLHALGKNCPFLQCVDFSTTQVSDNGVVALVSGPC
AKQLEEINMGYCINLTDKAVEAALTACPQICILLFHGCPLITDHSREVLEQLIGSRKLKQVTWS
VY

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RefSeq Acc Id:	XP_006237762 ⟸ XM_006237700
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6ABJ0 (UniProtKB/TrEMBL), A0A8L2QRD5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSMRGRITDSNINEVLHPEVQRLDLRSCNISDVALQHLCKCRKLKALNLKSCREHRNSITSEGI KAVASSCSDLHEISLKGCCSVTDEGVLALALNCQLLKIIDLGGCLSITDESLHALGKNCPFLQC VDFSTTQVSDNGVVALVSGPCAKQLEEINMGYCINLTDKAVEAALTACPQICILLFHGCPLITD HSREVLEQLIGSRKLKQVTWSVY hide sequence

RefSeq Acc Id:

ENSRNOP00000052308 ⟸ ENSRNOT00000055441

RefSeq Acc Id:

ENSRNOP00000089244 ⟸ ENSRNOT00000117439

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5U201-F1-model_v2	AlphaFold	Q5U201	1-258	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693516

Promoter ID:

EPDNEW_R4041

Type:

initiation region

Name:

Amn1_1

Description:

antagonist of mitotic exit network 1 homolog

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	183,697,526 - 183,697,586	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308119	AgrOrtholog
BioCyc Gene	G2FUF-42360	BioCyc
Ensembl Genes	ENSRNOG00000036917	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000055441	ENTREZGENE
	ENSRNOT00000055441.3	UniProtKB/TrEMBL
	ENSRNOT00000117439.1	UniProtKB/TrEMBL
Gene3D-CATH	3.80.10.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7303722	IMAGE-MGC_LOAD
InterPro	Leu-rich_rpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Leu-rich_rpt_Cys-con_subtyp	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LRR_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:302032	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:105998	IMAGE-MGC_LOAD
NCBI Gene	302032	ENTREZGENE
PANTHER	MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN AMN1 HOMOLOG	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	LRR_6	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Amn1	PhenoGen
RatGTEx	ENSRNOG00000036917	RatGTEx
SMART	LRR_CC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	RNI-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6ABJ0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2QRD5	ENTREZGENE, UniProtKB/TrEMBL
	A6IN73	ENTREZGENE, UniProtKB/TrEMBL
	AMN1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-07-09	Amn1	antagonist of mitotic exit network 1 homolog	Amn1	antagonist of mitotic exit network 1 homolog (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-23	Amn1	antagonist of mitotic exit network 1 homolog (S. cerevisiae)	RGD1308119	similar to F-box protein FBL2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1308119	similar to F-box protein FBL2	RGD1308119_predicted	similar to F-box protein FBL2 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1308119_predicted	similar to F-box protein FBL2 (predicted)	LOC302032_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC302032_predicted	similar to F-box protein FBL2 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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