Glrx2 (glutaredoxin 2) - Rat Genome Database

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Gene: Glrx2 (glutaredoxin 2) Rattus norvegicus
Analyze
Symbol: Glrx2
Name: glutaredoxin 2
RGD ID: 1307950
Description: Predicted to enable protein-disulfide reductase activity. Involved in cellular response to superoxide. Located in dendrite; mitochondrial matrix; and neuronal cell body. Orthologous to human GLRX2 (glutaredoxin 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glutaredoxin 2 (thioltransferase); glutaredoxin-2, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81358,032,199 - 58,055,061 (+)NCBIGRCr8
mRatBN7.21355,481,875 - 55,504,737 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1355,482,694 - 55,492,831 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1358,049,631 - 58,073,274 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01359,317,533 - 59,340,392 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01356,602,199 - 56,625,867 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01360,529,057 - 60,552,115 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1360,529,932 - 60,537,916 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01365,517,621 - 65,540,676 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41357,567,017 - 57,589,873 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11357,581,096 - 57,603,951 (+)NCBI
Celera1355,569,577 - 55,592,422 (+)NCBICelera
Cytogenetic Map13q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
clotrimazole  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
Diallyl sulfide  (EXP)
dibenzo[a,l]pyrene  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
elemental selenium  (EXP)
finasteride  (EXP)
flutamide  (EXP)
genistein  (ISO)
hexane  (EXP)
isotretinoin  (ISO)
mercury dibromide  (ISO)
Mesaconitine  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylene blue  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paraquat  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
toluene  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system. Aon-Bertolino ML, etal., Biochim Biophys Acta. 2011 Jan;1810(1):93-110. Epub 2010 Jul 8.
2. Aging-dependent changes in rat heart mitochondrial glutaredoxins-Implications for redox regulation. Gao XH, etal., Redox Biol. 2013 Nov 12;1(1):586-98. doi: 10.1016/j.redox.2013.10.010. eCollection 2013.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. What is the functional significance of the unique location of glutaredoxin 1 (GRx1) in the intermembrane space of mitochondria? Pai HV, etal., Antioxid Redox Signal. 2007 Nov;9(11):2027-33.
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:11297543   PMID:11397793   PMID:15057822   PMID:15489334   PMID:18614015   PMID:20929858   PMID:23872354   PMID:25735211  


Genomics

Comparative Map Data
Glrx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81358,032,199 - 58,055,061 (+)NCBIGRCr8
mRatBN7.21355,481,875 - 55,504,737 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1355,482,694 - 55,492,831 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1358,049,631 - 58,073,274 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01359,317,533 - 59,340,392 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01356,602,199 - 56,625,867 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01360,529,057 - 60,552,115 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1360,529,932 - 60,537,916 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01365,517,621 - 65,540,676 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41357,567,017 - 57,589,873 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11357,581,096 - 57,603,951 (+)NCBI
Celera1355,569,577 - 55,592,422 (+)NCBICelera
Cytogenetic Map13q21NCBI
GLRX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381193,096,465 - 193,106,114 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1193,090,866 - 193,106,114 (-)EnsemblGRCh38hg38GRCh38
GRCh371193,065,595 - 193,075,244 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361191,332,223 - 191,341,867 (-)NCBINCBI36Build 36hg18NCBI36
Build 341189,797,256 - 189,806,213NCBI
Celera1166,175,205 - 166,184,851 (-)NCBICelera
Cytogenetic Map1q31.2NCBI
HuRef1164,301,400 - 164,311,051 (-)NCBIHuRef
CHM1_11194,487,507 - 194,497,156 (-)NCBICHM1_1
T2T-CHM13v2.01192,443,673 - 192,453,323 (-)NCBIT2T-CHM13v2.0
Glrx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391143,614,787 - 143,625,416 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1143,592,076 - 143,625,414 (+)EnsemblGRCm39 Ensembl
GRCm381143,739,224 - 143,749,678 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1143,716,338 - 143,749,676 (+)EnsemblGRCm38mm10GRCm38
MGSCv371145,586,479 - 145,596,808 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361145,501,567 - 145,511,896 (+)NCBIMGSCv36mm8
Celera1146,314,372 - 146,324,701 (+)NCBICelera
Cytogenetic Map1FNCBI
cM Map162.53NCBI
Glrx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540630,497,562 - 30,509,340 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540630,497,562 - 30,506,463 (-)NCBIChiLan1.0ChiLan1.0
GLRX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2156,686,397 - 56,696,287 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1156,350,292 - 56,360,174 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01168,555,858 - 168,565,949 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11172,848,858 - 172,859,970 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1172,849,013 - 172,859,062 (-)Ensemblpanpan1.1panPan2
GLRX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1385,963,800 - 5,971,673 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl385,964,039 - 5,971,676 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha386,060,945 - 6,068,683 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0385,980,501 - 5,988,282 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1385,979,964 - 5,987,654 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0386,345,372 - 6,353,229 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0386,574,000 - 6,582,001 (+)NCBIUU_Cfam_GSD_1.0
Glrx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934480,810,029 - 80,819,376 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366381,325,076 - 1,333,994 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLRX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.110679,305 - 689,890 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GLRX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12536,318,894 - 36,328,567 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2536,319,637 - 36,328,417 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605537,267,701 - 37,276,856 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Glrx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624814482,545 - 509,507 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624814481,981 - 505,052 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Glrx2
126 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1160
Count of miRNA genes:271
Interacting mature miRNAs:331
Transcripts:ENSRNOT00000004558, ENSRNOT00000060062
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134372077062022792Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat

Markers in Region
D13Rat150  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21355,481,090 - 55,481,217 (+)MAPPERmRatBN7.2
Rnor_6.01360,528,276 - 60,528,402NCBIRnor6.0
Rnor_5.01365,516,837 - 65,516,963UniSTSRnor5.0
RGSC_v3.41357,566,232 - 57,566,359RGDRGSC3.4
RGSC_v3.41357,566,233 - 57,566,359UniSTSRGSC3.4
RGSC_v3.11357,580,312 - 57,580,439RGD
Celera1355,568,793 - 55,568,919UniSTS
SHRSP x BN Map1320.8298RGD
SHRSP x BN Map1320.8298UniSTS
Cytogenetic Map13q13UniSTS
RH131213  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21355,496,129 - 55,496,286 (+)MAPPERmRatBN7.2
Rnor_6.01360,543,508 - 60,543,664NCBIRnor6.0
Rnor_5.01365,532,069 - 65,532,225UniSTSRnor5.0
RGSC_v3.41357,581,272 - 57,581,428UniSTSRGSC3.4
Celera1355,583,818 - 55,583,974UniSTS
Cytogenetic Map13q13UniSTS
AI645710  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21355,490,587 - 55,490,670 (+)MAPPERmRatBN7.2
Rnor_6.01360,537,773 - 60,537,855NCBIRnor6.0
Rnor_5.01365,526,334 - 65,526,416UniSTSRnor5.0
RGSC_v3.41357,575,730 - 57,575,812UniSTSRGSC3.4
Celera1355,578,276 - 55,578,358UniSTS
Cytogenetic Map13q13UniSTS
RH128827  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21355,494,674 - 55,494,863 (+)MAPPERmRatBN7.2
Rnor_6.01360,542,053 - 60,542,241NCBIRnor6.0
Rnor_5.01365,530,614 - 65,530,802UniSTSRnor5.0
RGSC_v3.41357,579,817 - 57,580,005UniSTSRGSC3.4
Celera1355,582,363 - 55,582,551UniSTS
Cytogenetic Map13q13UniSTS
RH133629  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21355,496,596 - 55,496,781 (+)MAPPERmRatBN7.2
Rnor_6.01360,543,975 - 60,544,159NCBIRnor6.0
Rnor_5.01365,532,536 - 65,532,720UniSTSRnor5.0
RGSC_v3.41357,581,739 - 57,581,923UniSTSRGSC3.4
Celera1355,584,285 - 55,584,469UniSTS
Cytogenetic Map13q13UniSTS
RH134315  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21355,492,552 - 55,492,755 (+)MAPPERmRatBN7.2
Rnor_6.01360,539,738 - 60,539,940NCBIRnor6.0
Rnor_5.01365,528,299 - 65,528,501UniSTSRnor5.0
RGSC_v3.41357,577,695 - 57,577,897UniSTSRGSC3.4
Celera1355,580,241 - 55,580,443UniSTS
Cytogenetic Map13q13UniSTS
RH143907  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21355,500,894 - 55,501,105 (+)MAPPERmRatBN7.2
Rnor_6.01360,548,273 - 60,548,483NCBIRnor6.0
Rnor_5.01365,536,834 - 65,537,044UniSTSRnor5.0
RGSC_v3.41357,586,037 - 57,586,247UniSTSRGSC3.4
Celera1355,588,586 - 55,588,796UniSTS
Cytogenetic Map13q21UniSTS
Cytogenetic Map13q13UniSTS
BE117735  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21355,494,903 - 55,495,065 (+)MAPPERmRatBN7.2
Rnor_6.01360,542,282 - 60,542,443NCBIRnor6.0
Rnor_5.01365,530,843 - 65,531,004UniSTSRnor5.0
RGSC_v3.41357,580,046 - 57,580,207UniSTSRGSC3.4
Celera1355,582,592 - 55,582,753UniSTS
Cytogenetic Map13q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001394170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001394171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001394172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_172084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001840761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001840762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001840763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001840764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001840765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001840766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001840767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010056897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010056898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_358962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_595464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC079292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000060062   ⟹   ENSRNOP00000056811
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1355,482,694 - 55,492,831 (+)Ensembl
Rnor_6.0 Ensembl1360,529,932 - 60,537,916 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106322   ⟹   ENSRNOP00000096477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1355,482,728 - 55,492,822 (+)Ensembl
RefSeq Acc Id: NM_001394170   ⟹   NP_001381099
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,033,007 - 58,043,157 (+)NCBI
mRatBN7.21355,482,683 - 55,492,833 (+)NCBI
RefSeq Acc Id: NM_001394171   ⟹   NP_001381100
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,033,878 - 58,043,157 (+)NCBI
mRatBN7.21355,483,554 - 55,492,833 (+)NCBI
RefSeq Acc Id: NM_001394172   ⟹   NP_001381101
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,032,770 - 58,043,157 (+)NCBI
mRatBN7.21355,482,446 - 55,492,833 (+)NCBI
RefSeq Acc Id: NR_172084
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,032,199 - 58,055,055 (+)NCBI
mRatBN7.21355,481,875 - 55,504,731 (+)NCBI
RefSeq Acc Id: XM_006249955   ⟹   XP_006250017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,032,459 - 58,043,154 (+)NCBI
mRatBN7.21355,482,539 - 55,492,833 (+)NCBI
Rnor_6.01360,529,734 - 60,540,015 (+)NCBI
Rnor_5.01365,517,621 - 65,540,676 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769526   ⟹   XP_008767748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,032,459 - 58,041,181 (+)NCBI
mRatBN7.21355,482,542 - 55,492,833 (+)NCBI
Rnor_6.01360,529,740 - 60,538,042 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039090229   ⟹   XP_038946157
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,032,459 - 58,041,181 (+)NCBI
mRatBN7.21355,482,079 - 55,492,833 (+)NCBI
RefSeq Acc Id: XM_039090231   ⟹   XP_038946159
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,032,459 - 58,041,181 (+)NCBI
mRatBN7.21355,482,542 - 55,492,833 (+)NCBI
RefSeq Acc Id: XM_063271953   ⟹   XP_063128023
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,032,201 - 58,041,181 (+)NCBI
RefSeq Acc Id: XM_063271954   ⟹   XP_063128024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,033,873 - 58,043,154 (+)NCBI
RefSeq Acc Id: XR_001840761
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,032,459 - 58,055,061 (+)NCBI
mRatBN7.21355,482,539 - 55,504,737 (+)NCBI
Rnor_6.01360,529,734 - 60,552,115 (+)NCBI
Sequence:
RefSeq Acc Id: XR_010056897
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,032,459 - 58,054,264 (+)NCBI
RefSeq Acc Id: XR_010056898
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81358,033,873 - 58,055,061 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_006250017   ⟸   XM_006249955
- Peptide Label: isoform X1
- UniProtKB: Q6AXW1 (UniProtKB/Swiss-Prot),   A6ICN9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767748   ⟸   XM_008769526
- Peptide Label: isoform X2
- UniProtKB: A6ICP1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000056811   ⟸   ENSRNOT00000060062
RefSeq Acc Id: XP_038946157   ⟸   XM_039090229
- Peptide Label: isoform X2
- UniProtKB: A6ICP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946159   ⟸   XM_039090231
- Peptide Label: isoform X2
- UniProtKB: A6ICP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000096477   ⟸   ENSRNOT00000106322
RefSeq Acc Id: NP_001381101   ⟸   NM_001394172
- Peptide Label: 2
- UniProtKB: A6ICP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001381099   ⟸   NM_001394170
- Peptide Label: 1
- UniProtKB: Q6AXW1 (UniProtKB/Swiss-Prot),   A6ICN9 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001381100   ⟸   NM_001394171
- Peptide Label: 2
- UniProtKB: A6ICP1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128023   ⟸   XM_063271953
- Peptide Label: isoform X1
- UniProtKB: Q6AXW1 (UniProtKB/Swiss-Prot),   A6ICN9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128024   ⟸   XM_063271954
- Peptide Label: isoform X2
- UniProtKB: A6ICP1 (UniProtKB/TrEMBL)
Protein Domains
Glutaredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AXW1-F1-model_v2 AlphaFold Q6AXW1 1-157 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698872
Promoter ID:EPDNEW_R9397
Type:initiation region
Name:Glrx2_1
Description:glutaredoxin 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01360,529,888 - 60,529,948EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307950 AgrOrtholog
BioCyc Gene G2FUF-18027 BioCyc
Ensembl Genes ENSRNOG00000003385 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055000771 UniProtKB/Swiss-Prot
  ENSRNOG00060005408 UniProtKB/Swiss-Prot
  ENSRNOG00065005766 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000060062.5 UniProtKB/Swiss-Prot
  ENSRNOT00000106322 ENTREZGENE
  ENSRNOT00000106322.1 UniProtKB/Swiss-Prot
  ENSRNOT00055001324 UniProtKB/Swiss-Prot
  ENSRNOT00060009014 UniProtKB/Swiss-Prot
  ENSRNOT00065008628 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7134405 IMAGE-MGC_LOAD
InterPro Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaredoxin_euk/vir UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaredoxin_subgr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114022 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:94426 IMAGE-MGC_LOAD
NCBI Gene 114022 ENTREZGENE
PANTHER GLUTAREDOXIN-2, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46679 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Glrx2 PhenoGen
PRINTS GLUTAREDOXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GLUTAREDOXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003385 RatGTEx
  ENSRNOG00055000771 RatGTEx
  ENSRNOG00060005408 RatGTEx
  ENSRNOG00065005766 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6ICN9 ENTREZGENE, UniProtKB/TrEMBL
  A6ICP0_RAT UniProtKB/TrEMBL
  A6ICP1 ENTREZGENE, UniProtKB/TrEMBL
  A6ICP2_RAT UniProtKB/TrEMBL
  GLRX2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-16 Glrx2  glutaredoxin 2  Glrx2  glutaredoxin 2 (thioltransferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Glrx2  glutaredoxin 2 (thioltransferase)  Glrx2_predicted  glutaredoxin 2 (thioltransferase) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Glrx2_predicted  glutaredoxin 2 (thioltransferase) (predicted)      Symbol and Name status set to approved 70820 APPROVED