Numbl (NUMB-like, endocytic adaptor protein) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Numbl (NUMB-like, endocytic adaptor protein) Rattus norvegicus
Analyze
Symbol: Numbl
Name: NUMB-like, endocytic adaptor protein
RGD ID: 1307579
Description: Involved in positive regulation of dendrite morphogenesis and regulation of postsynapse assembly. Is active in glutamatergic synapse. Orthologous to human NUMBL (NUMB like endocytic adaptor protein); PARTICIPATES IN Notch signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC292732; numb homolog (Drosophila)-like; numb homolog-like; numb-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8191,677,437 - 91,701,415 (+)NCBIGRCr8
mRatBN7.2182,549,814 - 82,573,788 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,550,054 - 82,573,776 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx187,952,653 - 87,976,474 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0196,439,576 - 96,463,388 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0189,708,524 - 89,732,343 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0184,067,841 - 84,091,659 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl184,067,938 - 84,091,671 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0185,278,493 - 85,302,558 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4182,333,804 - 82,356,657 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1182,411,551 - 82,435,519 (+)NCBI
Celera176,962,645 - 76,985,442 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO)
glutamatergic synapse  (IDA,IMP)

Molecular Function
protein binding  (IPI,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation. Ma Q, etal., Cell Signal. 2008 Jun;20(6):1044-51. Epub 2008 Jan 31.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Role of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2. Nishimura T, etal., Mol Biol Cell. 2006 Mar;17(3):1273-85. Epub 2006 Jan 4.
6. Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. Pece S, etal., J Cell Biol 2004 Oct 25;167(2):215-21. Epub 2004 Oct 18.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:9169836   PMID:12410312   PMID:12477932   PMID:14687546   PMID:15598981   PMID:16105844   PMID:17174898   PMID:17589506   PMID:20079715   PMID:21150807   PMID:22437994   PMID:29476059  


Genomics

Comparative Map Data
Numbl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8191,677,437 - 91,701,415 (+)NCBIGRCr8
mRatBN7.2182,549,814 - 82,573,788 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl182,550,054 - 82,573,776 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx187,952,653 - 87,976,474 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0196,439,576 - 96,463,388 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0189,708,524 - 89,732,343 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0184,067,841 - 84,091,659 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl184,067,938 - 84,091,671 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0185,278,493 - 85,302,558 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4182,333,804 - 82,356,657 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1182,411,551 - 82,435,519 (+)NCBI
Celera176,962,645 - 76,985,442 (+)NCBICelera
Cytogenetic Map1q21NCBI
NUMBL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381940,665,905 - 40,690,651 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1940,665,905 - 40,690,972 (-)EnsemblGRCh38hg38GRCh38
GRCh371941,171,810 - 41,196,556 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361945,863,650 - 45,888,396 (-)NCBINCBI36Build 36hg18NCBI36
Build 341945,864,436 - 45,888,374NCBI
Celera1937,972,233 - 37,996,968 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1937,605,109 - 37,629,863 (-)NCBIHuRef
CHM1_11941,171,471 - 41,196,210 (-)NCBICHM1_1
T2T-CHM13v2.01943,486,573 - 43,511,317 (-)NCBIT2T-CHM13v2.0
Numbl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39726,957,884 - 26,981,570 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl726,957,858 - 26,981,569 (+)EnsemblGRCm39 Ensembl
GRCm38727,258,438 - 27,282,150 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl727,258,433 - 27,282,144 (+)EnsemblGRCm38mm10GRCm38
MGSCv37728,043,780 - 28,067,169 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36726,967,521 - 26,990,910 (+)NCBIMGSCv36mm8
Celera721,835,674 - 21,859,077 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map715.86NCBI
Numbl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955578636,282 - 661,566 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955578636,298 - 661,566 (+)NCBIChiLan1.0ChiLan1.0
NUMBL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22046,925,149 - 46,950,151 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11948,795,345 - 48,820,069 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01937,710,882 - 37,734,873 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11946,217,935 - 46,238,106 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1946,217,935 - 46,238,103 (-)Ensemblpanpan1.1panPan2
NUMBL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11113,076,678 - 113,103,114 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1113,057,141 - 113,102,074 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,479,240 - 112,505,295 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01113,675,540 - 113,701,533 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1113,655,984 - 113,701,252 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11113,235,023 - 113,261,128 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01112,866,854 - 112,892,744 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01113,861,016 - 113,887,287 (+)NCBIUU_Cfam_GSD_1.0
Numbl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934914,534,669 - 14,560,586 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366612,963,510 - 2,984,740 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366612,962,741 - 2,984,763 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUMBL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl648,889,801 - 48,918,173 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1648,890,056 - 48,918,195 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2644,720,850 - 44,748,293 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NUMBL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1635,119,062 - 35,141,712 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607313,253,734 - 13,279,161 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Numbl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624925596,448 - 622,641 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624925595,679 - 623,479 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Numbl
143 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:289
Count of miRNA genes:174
Interacting mature miRNAs:200
Transcripts:ENSRNOT00000057213
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat

Markers in Region
RH129503  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2182,548,931 - 82,549,133 (+)MAPPERmRatBN7.2
Rnor_6.0184,066,816 - 84,067,017NCBIRnor6.0
Rnor_5.0185,277,759 - 85,277,960UniSTSRnor5.0
RGSC_v3.4182,332,572 - 82,332,773UniSTSRGSC3.4
Celera176,961,413 - 76,961,614UniSTS
RH 3.4 Map1827.1UniSTS
Cytogenetic Map1q21UniSTS
BF406395  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2182,558,323 - 82,558,513 (+)MAPPERmRatBN7.2
Rnor_6.0184,076,207 - 84,076,396NCBIRnor6.0
Rnor_5.0185,287,150 - 85,287,339UniSTSRnor5.0
RGSC_v3.4182,341,963 - 82,342,152UniSTSRGSC3.4
Celera176,970,799 - 76,970,988UniSTS
RH 3.4 Map1840.7UniSTS
Cytogenetic Map1q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 73 12 36
Low 3 41 39 25 17 25 8 11 1 23 5 11 8
Below cutoff 18 16 2 16

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000057213   ⟹   ENSRNOP00000054039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl182,550,054 - 82,573,776 (+)Ensembl
Rnor_6.0 Ensembl184,067,938 - 84,091,659 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090478   ⟹   ENSRNOP00000074945
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl182,552,176 - 82,573,776 (+)Ensembl
Rnor_6.0 Ensembl184,070,983 - 84,091,671 (+)Ensembl
RefSeq Acc Id: NM_001033888   ⟹   NP_001029060
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8191,677,644 - 91,701,415 (+)NCBI
mRatBN7.2182,550,004 - 82,573,776 (+)NCBI
Rnor_6.0184,068,048 - 84,090,902 (+)NCBI
Rnor_5.0185,278,493 - 85,302,558 (+)NCBI
RGSC_v3.4182,333,804 - 82,356,657 (+)RGD
Celera176,962,645 - 76,985,442 (+)RGD
Sequence:
RefSeq Acc Id: NM_001398697   ⟹   NP_001385626
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8191,677,644 - 91,701,415 (+)NCBI
mRatBN7.2182,550,004 - 82,573,776 (+)NCBI
RefSeq Acc Id: XM_006228565   ⟹   XP_006228627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8191,677,901 - 91,701,415 (+)NCBI
mRatBN7.2182,550,246 - 82,573,788 (+)NCBI
Rnor_6.0184,068,102 - 84,091,659 (+)NCBI
Rnor_5.0185,278,493 - 85,302,558 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006228566   ⟹   XP_006228628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8191,677,900 - 91,701,415 (+)NCBI
mRatBN7.2182,550,245 - 82,573,788 (+)NCBI
Rnor_6.0184,068,102 - 84,091,659 (+)NCBI
Rnor_5.0185,278,493 - 85,302,558 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039104071   ⟹   XP_038959999
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8191,677,437 - 91,701,415 (+)NCBI
mRatBN7.2182,549,814 - 82,573,788 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001029060   ⟸   NM_001033888
- Peptide Label: isoform 2
- UniProtKB: Q3MUI2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228627   ⟸   XM_006228565
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K9C5 (UniProtKB/TrEMBL),   Q3MUI2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228628   ⟸   XM_006228566
- Peptide Label: isoform X2
- UniProtKB: Q3MUI2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000054039   ⟸   ENSRNOT00000057213
RefSeq Acc Id: ENSRNOP00000074945   ⟸   ENSRNOT00000090478
RefSeq Acc Id: XP_038959999   ⟸   XM_039104071
- Peptide Label: isoform X3
- UniProtKB: Q3MUI2 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001385626   ⟸   NM_001398697
- Peptide Label: isoform 1
- UniProtKB: A1L1I3 (UniProtKB/Swiss-Prot)
Protein Domains
PID

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A1L1I3-F1-model_v2 AlphaFold A1L1I3 1-614 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689847
Promoter ID:EPDNEW_R372
Type:initiation region
Name:Numbl_1
Description:NUMB-like, endocytic adaptor protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0184,067,888 - 84,067,948EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307579 AgrOrtholog
BioCyc Gene G2FUF-60318 BioCyc
Ensembl Genes ENSRNOG00000020867 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057213 ENTREZGENE
  ENSRNOT00000057213.4 UniProtKB/Swiss-Prot
  ENSRNOT00000090478.2 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7189989 IMAGE-MGC_LOAD
InterPro Numb/numb-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Numb_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTB/PI_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:292732 UniProtKB/TrEMBL
MGC_CLONE MGC:156511 IMAGE-MGC_LOAD
NCBI Gene 292732 ENTREZGENE
PANTHER NUMB-LIKE PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR47368 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam NumbF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Numbl PhenoGen
PIRSF Numb/numb-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PID UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020867 RatGTEx
SMART PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K9C5 ENTREZGENE, UniProtKB/TrEMBL
  A1L1I3 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3MUI2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Numbl  NUMB-like, endocytic adaptor protein  Numbl  numb homolog (Drosophila)-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-17 Numbl  numb homolog (Drosophila)-like  Numbl  numb-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Numbl  numb-like  Numbl_predicted  numb-like (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Numbl_predicted  numb-like (predicted)      Symbol and Name status set to approved 70820 APPROVED