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Gene: Slc27a4 (solute carrier family 27 member 4) Rattus norvegicus

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Symbol:

Slc27a4

Name:

solute carrier family 27 member 4

RGD ID:

1307383

Description:

Predicted to enable fatty acid-CoA ligase activity and long-chain fatty acid transmembrane transporter activity. Involved in response to nutrient. Predicted to be located in brush border membrane; endoplasmic reticulum; and microvillus. Predicted to be active in endoplasmic reticulum membrane and plasma membrane. Biomarker of steatotic liver disease. Orthologous to human SLC27A4 (solute carrier family 27 member 4); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 4-amino-2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Fatp4; fatty acid transport protein 4; LOC311839; long-chain fatty acid transport protein 4; solute carrier family 27 (fatty acid transporter), member 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	33,472,903 - 33,485,824 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	33,472,903 - 33,485,824 (+)	Ensembl				GRCr8
mRatBN7.2	3	13,075,022 - 13,087,943 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	13,075,022 - 13,087,943 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	16,149,797 - 16,162,720 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	24,734,758 - 24,747,681 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	22,985,916 - 22,998,946 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	8,363,937 - 8,376,858 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	8,363,937 - 8,376,858 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	13,707,126 - 13,720,047 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	8,791,504 - 8,802,884 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	7,852,688 - 7,865,609 (+)	NCBI		Celera
RGSC_v3.1	3	8,790,457 - 8,803,184 (+)	NCBI
Cytogenetic Map	3	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal recessive congenital ichthyosis (ISO)

genetic disease (ISO)

Ichthyosis Prematurity Syndrome (ISO)

Insulin Resistance (ISO)

obesity (ISO)

restrictive dermopathy (ISS)

steatotic liver disease (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4-amino-2,6-dinitrotoluene (EXP)

8-Br-cAMP (ISO)

aflatoxin B1 (EXP)

Alisol B (ISO)

all-trans-retinoic acid (ISO)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

Butylbenzyl phthalate (EXP)

C60 fullerene (EXP)

cadmium atom (EXP)

cadmium dichloride (EXP)

chromium(6+) (ISO)

cisplatin (ISO)

clofibrate (ISO)

cobalt dichloride (ISO)

dextran sulfate (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

diethyl phthalate (EXP)

diisobutyl phthalate (EXP)

diisononyl phthalate (EXP)

dioxygen (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

ethanol (ISO)

fenofibrate (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

gentamycin (EXP)

hydroquinone O-beta-D-glucopyranoside (ISO)

inulin (ISO)

ivermectin (ISO)

lead diacetate (ISO)

linalool (ISO)

Monobutylphthalate (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-Nitrosopyrrolidine (ISO)

nickel atom (ISO)

nicotinic acid (ISO)

okadaic acid (ISO)

oleic acid (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

PCB138 (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

SB 431542 (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

sulforaphane (ISO)

sulindac (EXP)

tetrachloromethane (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

Torularhodin (ISO)

trichloroethene (EXP)

tungsten (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

fatty acid metabolic process (IEA,ISO)

fatty acid transport (IEA,ISO)

glucose import in response to insulin stimulus (IEA,ISO)

lipid metabolic process (IEA)

lipid transport (IEA)

lipid transport across blood-brain barrier (IEA,ISO)

long-chain fatty acid import into cell (IBA,IEA,ISO)

long-chain fatty acid metabolic process (IBA,IEA,ISO)

long-chain fatty acid transport (IEA,ISO)

medium-chain fatty acid transport (IBA,ISO)

negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity (ISO)

negative regulation of insulin receptor signaling pathway (IEA,ISO)

positive regulation of apoptotic process (IEA,ISO)

response to nutrient (IEP)

skin development (ISO)

very long-chain fatty acid catabolic process (ISO)

very long-chain fatty acid metabolic process (ISO)

Cellular Component

brush border membrane (IEA,ISO)

endomembrane system (IEA)

endoplasmic reticulum (IEA,ISO)

endoplasmic reticulum membrane (IBA,IEA,ISO)

membrane (IEA)

microvillus (IEA,ISO)

plasma membrane (IBA,IEA,ISO)

Molecular Function

arachidonate-CoA ligase activity (IEA)

ligase activity (IEA)

long-chain fatty acid transmembrane transporter activity (IBA,IEA,ISO)

long-chain fatty acid-CoA ligase activity (IEA,ISO)

nucleotide binding (IEA)

oleoyl-CoA ligase activity (IBA,IEA,ISO)

palmitoyl-CoA ligase activity (IEA,ISO)

protein binding (ISO)

very long-chain fatty acid-CoA ligase activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	[The expression and the significance of L-FABP and FATP4 in the development of nonalcoholic fatty liver disease in rats]	Feng AJ and Chen DF, Zhonghua Gan Zang Bing Za Zhi. 2005 Oct;13(10):776-9.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance.	Gertow K, etal., Diabetologia. 2004 Jun;47(6):1118-25. Epub 2004 May 28.
4.	Morphological changes of the rat intestinal lining in relation to body stores depletion during fasting and after refeeding.	Habold C, etal., Pflugers Arch. 2007 Nov;455(2):323-32. Epub 2007 Jul 19.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
7.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Comprehensive gene review and curation	RGD comprehensive gene curation

Additional References at PubMed

PMID:10518211	PMID:11404000	PMID:12477932	PMID:12821645	PMID:14512415	PMID:15496455	PMID:15653672	PMID:16354193	PMID:17062637	PMID:17401141	PMID:17522045	PMID:18258213
PMID:18843142	PMID:19380575	PMID:19946888	PMID:21395585	PMID:22022213	PMID:23407971	PMID:36360622

Genomics

Comparative Map Data

Slc27a4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	33,472,903 - 33,485,824 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	33,472,903 - 33,485,824 (+)	Ensembl				GRCr8
mRatBN7.2	3	13,075,022 - 13,087,943 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	13,075,022 - 13,087,943 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	16,149,797 - 16,162,720 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	24,734,758 - 24,747,681 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	22,985,916 - 22,998,946 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	8,363,937 - 8,376,858 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	8,363,937 - 8,376,858 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	13,707,126 - 13,720,047 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	8,791,504 - 8,802,884 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	7,852,688 - 7,865,609 (+)	NCBI		Celera
RGSC_v3.1	3	8,790,457 - 8,803,184 (+)	NCBI
Cytogenetic Map	3	p12	NCBI

SLC27A4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	128,340,527 - 128,361,470 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	128,340,506 - 128,363,283 (+)	Ensembl			hg38	GRCh38
GRCh37	9	131,102,806 - 131,123,749 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	130,142,661 - 130,163,323 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	9	128,182,393 - 128,203,055	NCBI
Celera	9	101,753,743 - 101,774,653 (+)	NCBI		Celera
Cytogenetic Map	9	q34.11	NCBI
HuRef	9	100,715,663 - 100,736,574 (+)	NCBI		HuRef
CHM1_1	9	131,253,875 - 131,274,787 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	140,547,613 - 140,568,573 (+)	NCBI		T2T-CHM13v2.0

Slc27a4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	29,692,646 - 29,707,534 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	29,692,646 - 29,707,534 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	29,802,634 - 29,817,522 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	29,802,634 - 29,817,522 (+)	Ensembl			mm10	GRCm38
MGSCv37	2	29,658,200 - 29,673,042 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	29,624,689 - 29,639,531 (+)	NCBI		MGSCv36	mm8
Celera	2	29,509,747 - 29,524,590 (+)	NCBI		Celera
Cytogenetic Map	2	B	NCBI
cM Map	2	20.64	NCBI

Slc27a4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955570	853,849 - 866,383 (+)	Ensembl
ChiLan1.0	NW_004955570	853,856 - 866,383 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC27A4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	10,990,848 - 11,008,669 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	10,984,462 - 11,011,018 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	99,463,338 - 99,483,802 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	128,133,365 - 128,151,077 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	128,133,365 - 128,151,077 (+)	Ensembl			panPan2	panpan1.1

SLC27A4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	55,164,106 - 55,177,567 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	55,164,817 - 55,177,511 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	54,357,436 - 54,372,577 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	56,084,580 - 56,099,730 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	56,086,220 - 56,099,724 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	54,844,157 - 54,859,298 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	55,158,426 - 55,173,562 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	55,250,305 - 55,265,445 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Slc27a4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	196,108,549 - 196,137,225 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936487	15,876,606 - 15,891,160 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0 Ensembl	NW_004936487	15,876,606 - 15,906,003 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936487	15,877,075 - 15,905,752 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC27A4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	268,773,806 - 268,788,731 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	268,773,792 - 268,788,208 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	302,768,102 - 302,778,920 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC27A4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	9,769,242 - 9,788,214 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666079	6,439,879 - 6,467,278 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc27a4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	6,529,027 - 6,542,149 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624760	6,529,028 - 6,542,067 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Slc27a4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	5	6,918,882 - 6,931,706 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Slc27a4
102 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	128
Count of miRNA genes:	90
Interacting mature miRNAs:	111
Transcripts:	ENSRNOT00000019500
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1558647	Cm46	Cardiac mass QTL 46	5.4	0.0000055	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	22677150	50766390	Rat
1358357	Srcrtb1	Stress Responsive Cort Basal QTL 1	6.36	0.002	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	29056275	47904329	Rat
6893355	Bw101	Body weight QTL 101	0.4	0.38	body mass (VT:0001259)	body weight (CMO:0000012)	3	5766390	50766390	Rat
10450811	Scl73	Serum cholesterol level QTL 73	4.7	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	2904329	47904329	Rat
2292615	Ept17	Estrogen-induced pituitary tumorigenesis QTL 17	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6556347	51556347	Rat
10450808	Scl72	Serum cholesterol level QTL 72	4.4	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	2904329	47904329	Rat
10450806	Scl71	Serum cholesterol level QTL 71	5.8	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	2904329	47904329	Rat
1558654	Bw56	Body weight QTL 56	4.5	0.0000171	body mass (VT:0001259)	body weight (CMO:0000012)	3	5766390	50766390	Rat
10401810	Kidm53	Kidney mass QTL 53			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	28625339	67641995	Rat
1298526	Arunc3	Aerobic running capacity QTL 3	2.2		exercise endurance trait (VT:0002332)	longest distance run on treadmill (CMO:0001406)	3	6125437	51125437	Rat
8693641	Alc30	Alcohol consumption QTL 30	2	0.739	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	3	30832384	44921701	Rat
631545	Bp85	Blood pressure QTL 85	3.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	36721849	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	1	141509147	Rat
631679	Cm10	Cardiac mass QTL 10	7.34	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	6556347	51556347	Rat
1558657	Cm43	Cardiac mass QTL 43	6.6	3e-08	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	22677150	50766390	Rat
631568	Bp92	Blood pressure QTL 92	2.2	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	15272348	60272348	Rat
6893363	Bw105	Body weight QTL 105	2.6	0.0036	body mass (VT:0001259)	body weight (CMO:0000012)	3	5766390	50766390	Rat
70203	Gcr2	Gastric cancer resistance QTL 2	2.6		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	3	29056275	47904329	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	5675975	141509147	Rat
1358185	Ept6	Estrogen-induced pituitary tumorigenesis QTL 6	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6556347	51556347	Rat

Markers in Region

RH132571

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	13,087,636 - 13,087,848 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	8,376,552 - 8,376,763	NCBI	Rnor6.0
Rnor_5.0	3	13,719,741 - 13,719,952	UniSTS	Rnor5.0
RGSC_v3.4	3	8,802,578 - 8,802,789	UniSTS	RGSC3.4
Celera	3	7,865,303 - 7,865,514	UniSTS
RH 3.4 Map	3	21.9	UniSTS
Cytogenetic Map	3	p12	UniSTS

BF417583

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	13,078,843 - 13,079,024 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	8,367,759 - 8,367,939	NCBI	Rnor6.0
Rnor_5.0	3	13,710,948 - 13,711,128	UniSTS	Rnor5.0
RGSC_v3.4	3	8,793,785 - 8,793,965	UniSTS	RGSC3.4
Celera	3	7,856,510 - 7,856,690	UniSTS
RH 3.4 Map	3	21.9	UniSTS
Cytogenetic Map	3	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	160	91	90	59	92	59	6	356	192	11	139	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001100706	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC114363	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC091430	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000019500 ⟹ ENSRNOP00000019500

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	33,472,903 - 33,485,824 (+)	Ensembl
mRatBN7.2 Ensembl	3	13,075,022 - 13,087,943 (+)	Ensembl
Rnor_6.0 Ensembl	3	8,363,937 - 8,376,858 (+)	Ensembl

RefSeq Acc Id:

NM_001100706 ⟹ NP_001094176

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	33,472,903 - 33,485,824 (+)	NCBI
mRatBN7.2	3	13,075,022 - 13,087,943 (+)	NCBI
Rnor_6.0	3	8,363,937 - 8,376,858 (+)	NCBI
Rnor_5.0	3	13,707,126 - 13,720,047 (+)	NCBI
Celera	3	7,852,688 - 7,865,609 (+)	NCBI

Sequence:

show sequence

AGTGGCGCGCGCAGGGCTGAAGGGGCTGGGCGGTGTCGGGCGCGCTGAGGCTGGGTTGCGCTGT
GGAACACGGGCTCAGAAGCTCGCCCTCTGCGGGGACGGCAGGGAAGGCGGTGCTGCCGGCCGGC
ACAGCCGGTGCGGGTGCGGGAGGCGGGTGGGGGTGGAGCGCGACAGAGGTACAGACCCTACAAG
GGCGAGGAGTGGGCCAGACGCGCCGAACTCGGCTGTGTGCGCCCCGGGGCGGCCGATGCCCCCA
GCGCATCGCACTCCGCTGCCGCAACCGGGCCGCATCCTGACGGGGCTCCGCGCCGCGCAGCCGC
AGCCAGGCCACAATGCTGCTTGGAGCATCTCTGGTGGGGGCGCTGCTGTTCTCCAAGCTGGTGC
TGAAGCTACCCTGGACCCAGGTGGGATTCTCCTTGTTGCTCCTGTACTTGGGGTCTGGTGGCTG
GCGTTTCATCCGGGTCTTCATCAAGACGGTCAGGAGAGATGTCTTCGGCGGCATGGTGCTCCTG
AAGGTGAAGACCAAGGTCCGACGGTACCTTCAGGAGCGGAAGACAGTGCCCTTGCTGTTTGCCT
CAGTGGTTCGGCGCCACCCCGACAAGACAGCCCTGATTTTCGAGGGCACGAATACTCACTGGAC
CTTCCGCCAGCTGGATGACTACTCCAGCAGTGTGGCCAACTTCCTGCAGGCCCGGGGCCTGGTC
TCAGGCAATGTAGTTGCTCTCTTTATGGAAAACCGTAACGAGTTTGTGGGTCTGTGGCTAGGCA
TGGCCAAGCTGGGCGTGGAGGCGGCACTCATCAACACCAACCTTAGGCGGGATGCCCTGCGCCA
CTGCCTTGACACCTCAAAGGCACGAGCCCTCATCTTTGGCAGCGAGATGGCCTCAGCTGTCTAT
GAGATCCAGGCTATCCTGGACCCCACACTCACCCTCTTCTGCTCTGGTTCCTGGGAGCCCAGCA
CCGTGCCTGCCAACACAGAGCATCTGGACCCTCTGCTGGAAGATGCCCCGAAGCACCTGCCCAG
CATCCCAGACAAGGGTTTTACAGATAAGCTCTTCTATATCTACACGTCGGGCACCACGGGGCTA
CCCAAAGCTGCCATTGTGGTGCACAGCAGGTATTACCGAATGGCTGCCCTGGTGTACTATGGAT
TCCGCATGCGGCCTGATGACATTGTCTATGACTGCCTCCCCCTCTACCACTCAGCAGGAAACAT
TGTGGGGATTGGCCAGTGCGTACTCCACGGCATGACTGTGGTGATCCGGAAGAAGTTTTCAGCC
TCCCGGTTCTGGGATGACTGTATCAAGTACAACTGCACAATTGTACAGTACATTGGTGAGCTTT
GCCGCTACCTCCTGAACCAGCCACCCCGTGAGGCTGAGTCTCGGCACAAGGTGCGCATGGCACT
GGGCAACGGTCTCCGGCAGTCCATCTGGACCGACTTCTCCAGCCGTTTCCACATTCCCCAAGTG
GCCGAGTTCTACGGGGCCACCGAGTGCAACTGTAGCTTGGGCAACTTTGACAGCCAGGTGGGGG
CCTGTGGCTTCAATAGCCGCATCCTGTCCTTTGTGTACCCCATCCGCTTGGTACGAGTCAATGA
GGATACCATGGAACTGATCCGGGGACCCGATGGCGTCTGCATTCCCTGTCAACCAGGCCAGCCA
GGCCAGCTGGTGGGTCGCATCATCCAGCAGGACCCCCTACGCCGTTTTGATGGCTACCTCAACC
AGGGTGCCAACAACAAGAAGATTGCTAGTGATGTCTTCAAGAAAGGGGACCAAGCCTACCTCAC
TGGTGACGTGCTGGTGATGGATGAGCTGGGCTACCTGTACTTCCGAGACCGCACAGGGGACACG
TTCCGCTGGAAAGGGGAGAATGTGTCTACCACTGAAGTGGAGGGCACACTCAGCCGCCTGCTTC
AGATGGCAGATGTGGCTGTTTATGGTGTTGAGGTGCCAGGAGCTGAGGGCCGAGCAGGAATGGC
TGCTGTGGCAAGCCCCACTAGCAACTGTGACCTGGAGAGCTTTGCACAGACCTTGAAAAAGGAG
CTGCCCCTGTACGCCCGCCCCATCTTCCTCCGCTTCTTGCCTGAGCTGCACAAAACAGGAACCT
TCAAGTTCCAGAAGACAGAGTTGCGGAAGGAGGGCTTTGACCCGTCTGTTGTGAAAGACCCACT
CTTCTATTTGGATGCCCGGACAGGCTGCTATGTTGCACTGGACCAAGAGGCCTATACCCGCATC
CAGGCAGGCGAGGAGAAGCTGTGATTTCCCCCACATCCCTCTGAGGGCCAGAGGATGCTGGATT
CAGAGCCCCAGCTTCCACCCCAGAGGGGTCCTGGGCAAGGCCAGACCAAAGCTAGCAGGGCCCG
CACCTCCACCCCTAGGTGCTGATCCCCCTCTCCCAAACTGCCAAGTGACTGACTCACTGCCGCT
TCCCCCACCCTCCAGAGGCTTTCTGTGAAAGTCTCATCCAAGCTGTGTCTTCTGGTCCAGGCGT
GGCCCCTGGCTCCAGGCTTACTGACAGGCACCTTTAGGATGATGTCTTGGGTCCAGCGGGCCAG
GATGTGGGAGAGGAGTCACTGAGATCCCTCCAAAAAGAAGGGAGCTTACAAATGAACCAAGACA
AAAGCCTCTCGACTCAGGAAGCTAAGTGGCCAGAGACTGAAGTGGCCAGCCATCCCGTGTCCAC
AGAGGATCTTGGTCCAAAGCTGCCAAAGTGTCACCTAGCCCTGTCTGCACCTCTGGGGAAAGGA
GGACAGCATGTGGCCAAAGTGTCACTTAGCCCTGTCTGCACCTCTGGGGAAAGGAGGACAGCAT
GTGGCCACTGGGCCCCTGTCTCAAGAAGTCGGGATCGCACACACACACACACTCCTTGTTTCTC
CAGATTCCCTTGTCCTTGTCTTAGGGAGGGAGGGGGGTGTCCTGTCTGTCTCTCAGATGCAGGC
TTCCTGCCTGTCTGTGAGTCTGTCCCTGTGTGTTGCCTTCTCCATCTGTCCTAGCCTGACTGTG
GGTGGAGAGGGCATGAGGGGAGGCTCAGGGGCTAATAAACTCTGCCTTGACTCCTCTTA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001094176	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH91430	(Get FASTA)	NCBI Sequence Viewer
	EDL93373	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000019500
	ENSRNOP00000019500.4

RefSeq Acc Id:

NP_001094176 ⟸ NM_001100706

- UniProtKB:

G3V7V3 (UniProtKB/TrEMBL), A6JTS4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLLGASLVGALLFSKLVLKLPWTQVGFSLLLLYLGSGGWRFIRVFIKTVRRDVFGGMVLLKVKT
KVRRYLQERKTVPLLFASVVRRHPDKTALIFEGTNTHWTFRQLDDYSSSVANFLQARGLVSGNV
VALFMENRNEFVGLWLGMAKLGVEAALINTNLRRDALRHCLDTSKARALIFGSEMASAVYEIQA
ILDPTLTLFCSGSWEPSTVPANTEHLDPLLEDAPKHLPSIPDKGFTDKLFYIYTSGTTGLPKAA
IVVHSRYYRMAALVYYGFRMRPDDIVYDCLPLYHSAGNIVGIGQCVLHGMTVVIRKKFSASRFW
DDCIKYNCTIVQYIGELCRYLLNQPPREAESRHKVRMALGNGLRQSIWTDFSSRFHIPQVAEFY
GATECNCSLGNFDSQVGACGFNSRILSFVYPIRLVRVNEDTMELIRGPDGVCIPCQPGQPGQLV
GRIIQQDPLRRFDGYLNQGANNKKIASDVFKKGDQAYLTGDVLVMDELGYLYFRDRTGDTFRWK
GENVSTTEVEGTLSRLLQMADVAVYGVEVPGAEGRAGMAAVASPTSNCDLESFAQTLKKELPLY
ARPIFLRFLPELHKTGTFKFQKTELRKEGFDPSVVKDPLFYLDARTGCYVALDQEAYTRIQAGE
EKL

hide sequence

Ensembl Acc Id:

ENSRNOP00000019500 ⟸ ENSRNOT00000019500

Protein Domains

AMP-binding enzyme C-terminal AMP-dependent synthetase/ligase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V7V3-F1-model_v2	AlphaFold	G3V7V3	1-643	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691943

Promoter ID:

EPDNEW_R2468

Type:

initiation region

Name:

Slc27a4_1

Description:

solute carrier family 27 member 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	8,363,937 - 8,363,997	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307383	AgrOrtholog
BioCyc Gene	G2FUF-50253	BioCyc
BioCyc Pathway	PWY-8042 [acylceramide biosynthesis]	BioCyc
BioCyc Pathway Image	PWY-8042	BioCyc
Ensembl Genes	ENSRNOG00000014369	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000019500	ENTREZGENE
	ENSRNOT00000019500.8	UniProtKB/TrEMBL
Gene3D-CATH	3.30.300.30	UniProtKB/TrEMBL
	3.40.50.12780	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7367192	IMAGE-MGC_LOAD
InterPro	AMP-bd_C	UniProtKB/TrEMBL
	AMP-bd_C_sf	UniProtKB/TrEMBL
	AMP-binding_CS	UniProtKB/TrEMBL
	AMP-dep_Synth/Lig	UniProtKB/TrEMBL
	AMP-dep_Synthh-like_sf	UniProtKB/TrEMBL
	Lipocalin_CS	UniProtKB/TrEMBL
KEGG Report	rno:311839	UniProtKB/TrEMBL
MGC_CLONE	MGC:109622	IMAGE-MGC_LOAD
NCBI Gene	311839	ENTREZGENE
PANTHER	LONG-CHAIN FATTY ACID TRANSPORT PROTEIN	UniProtKB/TrEMBL
	PTHR43107:SF11	UniProtKB/TrEMBL
Pfam	AMP-binding	UniProtKB/TrEMBL
	AMP-binding_C	UniProtKB/TrEMBL
PhenoGen	Slc27a4	PhenoGen
PROSITE	AMP_BINDING	UniProtKB/TrEMBL
	LIPOCALIN	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000014369	RatGTEx
Superfamily-SCOP	Acetyl-CoA synthetase-like	UniProtKB/TrEMBL
UniProt	A6JTS4	ENTREZGENE, UniProtKB/TrEMBL
	G3V7V3	ENTREZGENE, UniProtKB/TrEMBL
	Q5BJL7_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-09	Slc27a4	solute carrier family 27 member 4	Slc27a4	solute carrier family 27 (fatty acid transporter), member 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Slc27a4	solute carrier family 27 (fatty acid transporter), member 4	Slc27a4_predicted	solute carrier family 27 (fatty acid transporter), member 4 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Slc27a4_predicted	solute carrier family 27 (fatty acid transporter), member 4 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

BioCyc Pathways

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

BioCyc Pathways