Naaa (N-acylethanolamine acid amidase) - Rat Genome Database

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Gene: Naaa (N-acylethanolamine acid amidase) Rattus norvegicus
Analyze
Symbol: Naaa
Name: N-acylethanolamine acid amidase
RGD ID: 1307267
Description: Enables N-(long-chain-acyl)ethanolamine deacylase activity. Involved in N-acylethanolamine metabolic process. Predicted to be located in lysosome and membrane. Orthologous to human NAAA (N-acylethanolamine acid amidase); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: acylsphingosine deacylase NAAA; ASAH-like protein; Asahl; Asahl_predicted; LOC305237; MGC124515; N-acylethanolamine-hydrolyzing acid amidase; N-acylsphingosine amidohydrolase (acid ceramidase)-like; N-acylsphingosine amidohydrolase (acid ceramidase)-like (predicted); N-acylsphingosine amidohydrolase-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81416,061,599 - 16,080,703 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1416,061,583 - 16,080,702 (+)EnsemblGRCr8
mRatBN7.21415,777,306 - 15,796,411 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1415,777,306 - 15,796,410 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1415,786,134 - 15,805,104 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01417,104,987 - 17,123,957 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01415,800,429 - 15,819,399 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01417,283,262 - 17,302,364 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1417,283,124 - 17,302,366 (+)Ensemblrn6Rnor6.0
Rnor_5.01417,199,739 - 17,218,991 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41417,338,759 - 17,358,274 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1415,171,712 - 15,190,788 (+)NCBICelera
RGSC_v3.11417,338,760 - 17,356,973 (+)NCBI
Cytogenetic Map14p22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO)
lysosome  (IEA,ISO,ISS)
membrane  (IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Endogenous molecules stimulating N-acylethanolamine-hydrolyzing acid amidase (NAAA). Tai T, etal., ACS Chem Neurosci. 2012 May 16;3(5):379-85. doi: 10.1021/cn300007s. Epub 2012 Jan 27.
Additional References at PubMed
PMID:10610717   PMID:11463796   PMID:12477932   PMID:15655246   PMID:17462942   PMID:17980170   PMID:21106534   PMID:23376485   PMID:23533145   PMID:29514215   PMID:30301806   PMID:31063807  


Genomics

Comparative Map Data
Naaa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81416,061,599 - 16,080,703 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1416,061,583 - 16,080,702 (+)EnsemblGRCr8
mRatBN7.21415,777,306 - 15,796,411 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1415,777,306 - 15,796,410 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1415,786,134 - 15,805,104 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01417,104,987 - 17,123,957 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01415,800,429 - 15,819,399 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01417,283,262 - 17,302,364 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1417,283,124 - 17,302,366 (+)Ensemblrn6Rnor6.0
Rnor_5.01417,199,739 - 17,218,991 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41417,338,759 - 17,358,274 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1415,171,712 - 15,190,788 (+)NCBICelera
RGSC_v3.11417,338,760 - 17,356,973 (+)NCBI
Cytogenetic Map14p22NCBI
NAAA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38475,910,655 - 75,941,013 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl475,910,655 - 75,941,013 (-)Ensemblhg38GRCh38
GRCh37476,831,808 - 76,862,166 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36477,050,832 - 77,081,190 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34477,195,814 - 77,219,325NCBI
Celera474,132,297 - 74,162,693 (-)NCBICelera
Cytogenetic Map4q21.1NCBI
HuRef472,584,423 - 72,614,591 (-)NCBIHuRef
CHM1_1476,808,474 - 76,838,830 (-)NCBICHM1_1
T2T-CHM13v2.0479,251,154 - 79,281,501 (-)NCBIT2T-CHM13v2.0
Naaa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39592,405,519 - 92,426,040 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl592,405,518 - 92,426,029 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38592,257,660 - 92,278,181 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl592,257,659 - 92,278,170 (-)Ensemblmm10GRCm38
MGSCv37592,686,686 - 92,707,207 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36593,333,459 - 93,353,381 (-)NCBIMGSCv36mm8
Celera590,401,548 - 90,422,177 (-)NCBICelera
Cytogenetic Map5E2NCBI
cM Map546.35NCBI
Naaa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955433630,483 - 674,675 (-)Ensembl
ChiLan1.0NW_004955433630,627 - 674,675 (-)NCBIChiLan1.0ChiLan1.0
NAAA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2354,131,808 - 54,162,106 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1454,321,585 - 54,351,911 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0448,264,567 - 48,294,872 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1454,102,384 - 54,133,725 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl454,102,384 - 54,128,776 (+)EnsemblpanPan2panpan1.1
NAAA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.132483,317 - 504,304 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3241,379,385 - 41,398,991 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.032507,696 - 527,349 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.132507,868 - 527,523 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.032460,034 - 485,704 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03239,688,753 - 39,708,408 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Naaa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528511,590,682 - 11,604,990 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493659842,751 - 56,261 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NAAA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl871,573,788 - 71,603,338 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1871,573,783 - 71,603,256 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2875,709,382 - 75,738,808 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NAAA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1724,420,378 - 24,450,010 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl724,423,052 - 24,449,793 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660372,765,526 - 2,792,410 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Naaa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475715,074,189 - 15,099,876 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475715,074,137 - 15,101,342 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Naaa
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1115,107,481 - 5,125,297 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Naaa
121 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:192
Count of miRNA genes:144
Interacting mature miRNAs:155
Transcripts:ENSRNOT00000003102
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14395787821572472Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14395787818558812Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141133490630674469Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141133471628389666Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14117877928Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141513759431238250Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000003102   ⟹   ENSRNOP00000003102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1416,061,583 - 16,080,702 (+)Ensembl
mRatBN7.2 Ensembl1415,777,306 - 15,796,410 (+)Ensembl
Rnor_6.0 Ensembl1417,283,124 - 17,302,366 (+)Ensembl
RefSeq Acc Id: NM_001010967   ⟹   NP_001010967
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81416,061,599 - 16,080,703 (+)NCBI
mRatBN7.21415,777,306 - 15,796,411 (+)NCBI
Rnor_6.01417,283,262 - 17,302,364 (+)NCBI
Rnor_5.01417,199,739 - 17,218,991 (+)NCBI
RGSC_v3.41417,338,759 - 17,358,274 (+)RGD
Celera1415,171,712 - 15,190,788 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001010967 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI05772 (Get FASTA)   NCBI Sequence Viewer  
  BAD88529 (Get FASTA)   NCBI Sequence Viewer  
  EDL88611 (Get FASTA)   NCBI Sequence Viewer  
  EDL88612 (Get FASTA)   NCBI Sequence Viewer  
  EDL88613 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003102
  ENSRNOP00000003102.5
GenBank Protein Q5KTC7 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001010967   ⟸   NM_001010967
- Peptide Label: precursor
- UniProtKB: Q5KTC7 (UniProtKB/Swiss-Prot),   Q3KRD3 (UniProtKB/Swiss-Prot),   A6KK97 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003102   ⟸   ENSRNOT00000003102
Protein Domains
Acid ceramidase N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5KTC7-F1-model_v2 AlphaFold Q5KTC7 1-362 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699215
Promoter ID:EPDNEW_R9740
Type:multiple initiation site
Name:Naaa_1
Description:N-acylethanolamine acid amidase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01417,283,266 - 17,283,326EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307267 AgrOrtholog
BioCyc Gene G2FUF-16256 BioCyc
Ensembl Genes ENSRNOG00000002273 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003102 ENTREZGENE
  ENSRNOT00000003102.7 UniProtKB/Swiss-Prot
Gene3D-CATH Penicillin V Acylase, Chain A UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7930474 IMAGE-MGC_LOAD
InterPro Acid_ceramidase-like UniProtKB/Swiss-Prot
  Acid_ceramidase_N UniProtKB/Swiss-Prot
KEGG Report rno:497009 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124515 IMAGE-MGC_LOAD
NCBI Gene Naaa ENTREZGENE
PANTHER ACID AMIDASE UniProtKB/Swiss-Prot
  N-ACYLETHANOLAMINE-HYDROLYZING ACID AMIDASE UniProtKB/Swiss-Prot
Pfam NAAA-beta UniProtKB/Swiss-Prot
PhenoGen Naaa PhenoGen
PIRSF Acid_ceramidase-like UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002273 RatGTEx
UniProt A6KK97 ENTREZGENE, UniProtKB/TrEMBL
  NAAA_RAT UniProtKB/Swiss-Prot
  Q3KRD3 ENTREZGENE
  Q5KTC7 ENTREZGENE
UniProt Secondary Q3KRD3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-06-27     Naaa  N-acylethanolamine acid amidase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Naaa  N-acylethanolamine acid amidase  Asahl  N-acylsphingosine amidohydrolase (acid ceramidase)-like   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Asahl  N-acylsphingosine amidohydrolase (acid ceramidase)-like   Asahl_predicted  N-acylsphingosine amidohydrolase (acid ceramidase)-like (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Asahl_predicted  N-acylsphingosine amidohydrolase (acid ceramidase)-like (predicted)      Symbol and Name status set to approved 70820 APPROVED