Eya4 (EYA transcriptional coactivator and phosphatase 4) - Rat Genome Database

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Gene: Eya4 (EYA transcriptional coactivator and phosphatase 4) Rattus norvegicus
Analyze
Symbol: Eya4
Name: EYA transcriptional coactivator and phosphatase 4
RGD ID: 1307099
Description: Predicted to enable protein tyrosine phosphatase activity. Involved in inner ear development. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 10; congestive heart failure; dilated cardiomyopathy; dilated cardiomyopathy 1J; and sensorineural hearing loss. Orthologous to human EYA4 (EYA transcriptional coactivator and phosphatase 4); INTERACTS WITH alpha-Zearalanol; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: eyes absent 4 homolog (Drosophila); eyes absent homolog 4; eyes absent homolog 4 (Drosophila); LOC292172
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8123,991,431 - 24,235,132 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl123,991,431 - 24,235,131 (+)EnsemblGRCr8
mRatBN7.2122,172,275 - 22,415,978 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl122,172,275 - 22,415,976 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx121,951,272 - 22,193,056 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0127,951,044 - 28,192,834 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0122,148,296 - 22,390,083 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0123,237,617 - 23,611,580 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl123,409,408 - 23,610,164 (+)Ensemblrn6Rnor6.0
Rnor_5.0125,068,884 - 25,080,689 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0124,707,171 - 24,911,188 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4122,814,568 - 22,914,973 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera120,901,953 - 21,143,929 (+)NCBICelera
RGSC_v3.1122,817,512 - 22,917,918 (+)NCBI
Cytogenetic Map1p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
carbamazepine  (ISO)
CGP 52608  (ISO)
chromium atom  (ISO)
clofibrate  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
fonofos  (ISO)
genistein  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
nickel atom  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP)
parathion  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
terbufos  (ISO)
testosterone  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss. Schonberger J, etal., Nat Genet. 2005 Apr;37(4):418-22. Epub 2005 Feb 27.
9. Mutations in the transcriptional activator EYA4 cause late-onset deafness at the DFNA10 locus. Wayne S, etal., Hum Mol Genet. 2001 Feb 1;10(3):195-200.
10. Eya4 Induces Hypertrophy via Regulation of p27kip1. Williams T, etal., Circ Cardiovasc Genet. 2015 Dec;8(6):752-64. doi: 10.1161/CIRCGENETICS.115.001134. Epub 2015 Oct 23.
Additional References at PubMed
PMID:12477932   PMID:18219393  


Genomics

Comparative Map Data
Eya4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8123,991,431 - 24,235,132 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl123,991,431 - 24,235,131 (+)EnsemblGRCr8
mRatBN7.2122,172,275 - 22,415,978 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl122,172,275 - 22,415,976 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx121,951,272 - 22,193,056 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0127,951,044 - 28,192,834 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0122,148,296 - 22,390,083 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0123,237,617 - 23,611,580 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl123,409,408 - 23,610,164 (+)Ensemblrn6Rnor6.0
Rnor_5.0125,068,884 - 25,080,689 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0124,707,171 - 24,911,188 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4122,814,568 - 22,914,973 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera120,901,953 - 21,143,929 (+)NCBICelera
RGSC_v3.1122,817,512 - 22,917,918 (+)NCBI
Cytogenetic Map1p12NCBI
EYA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386133,240,593 - 133,532,128 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6133,240,514 - 133,532,128 (+)Ensemblhg38GRCh38
GRCh376133,562,495 - 133,853,266 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366133,604,188 - 133,894,358 (+)NCBIBuild 36Build 36hg18NCBI36
Build 346133,604,205 - 133,892,353NCBI
Celera6134,303,566 - 134,594,492 (+)NCBICelera
Cytogenetic Map6q23.2NCBI
HuRef6131,131,517 - 131,422,316 (+)NCBIHuRef
CHM1_16133,824,722 - 134,116,529 (+)NCBICHM1_1
T2T-CHM13v2.06134,429,416 - 134,720,956 (+)NCBIT2T-CHM13v2.0
Eya4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391022,978,861 - 23,226,785 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1022,978,862 - 23,226,684 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381023,102,962 - 23,350,838 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1023,102,963 - 23,350,786 (-)Ensemblmm10GRCm38
MGSCv371022,823,974 - 23,069,709 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361022,793,584 - 23,039,319 (-)NCBIMGSCv36mm8
Celera1024,041,931 - 24,287,692 (-)NCBICelera
Cytogenetic Map10A3NCBI
cM Map1010.44NCBI
Eya4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543613,709,806 - 13,982,380 (+)Ensembl
ChiLan1.0NW_00495543613,710,366 - 13,982,379 (+)NCBIChiLan1.0ChiLan1.0
EYA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25153,222,778 - 153,512,494 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16151,130,319 - 151,419,079 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06131,016,143 - 131,306,251 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16135,116,275 - 135,405,295 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6135,116,978 - 135,404,403 (+)EnsemblpanPan2panpan1.1
EYA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1126,208,514 - 26,514,601 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl126,272,448 - 26,514,201 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha127,152,034 - 27,458,428 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0126,357,606 - 26,664,658 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl126,357,638 - 26,682,163 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1126,237,173 - 26,542,727 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0126,128,663 - 26,434,309 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0126,431,940 - 26,737,964 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Eya4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946121,558,662 - 121,686,404 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365601,337,842 - 1,462,285 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365601,325,521 - 1,466,216 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EYA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl130,261,917 - 30,533,604 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1130,260,784 - 30,575,593 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2133,764,541 - 34,092,713 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EYA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11339,988,427 - 40,271,862 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1340,001,261 - 40,272,592 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604012,166,253 - 12,454,567 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eya4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247537,548,694 - 7,677,472 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247537,536,654 - 7,680,671 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Eya4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12209,196,464 - 209,314,180 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Eya4
1727 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:62
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000022362
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1529322934184556Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)1143965634Rat
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1126564886Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1529322934184556Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11731537851816258Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1126564886Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)1134184556Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat
1300170Rf6Renal function QTL 63.14renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)1128483164Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1529322934184556Rat

Markers in Region
D1Mgh2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2122,340,647 - 22,340,797 (+)MAPPERmRatBN7.2
Rnor_6.0123,406,428 - 23,406,577NCBIRnor6.0
Rnor_5.0124,875,821 - 24,875,970UniSTSRnor5.0
RGSC_v3.4122,842,962 - 22,843,111UniSTSRGSC3.4
RGSC_v3.4122,842,898 - 22,843,363RGDRGSC3.4
Celera121,070,514 - 21,070,663UniSTS
RGSC_v3.1122,845,906 - 22,846,056RGD
RH 3.4 Map1220.6UniSTS
RH 3.4 Map1220.6RGD
RH 2.0 Map1147.3RGD
SHRSP x BN Map115.98RGD
FHH x ACI Map119.52RGD
Cytogenetic Map1p12UniSTS
D1Arb3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2122,340,598 - 22,340,924 (+)MAPPERmRatBN7.2
Rnor_6.0123,406,379 - 23,406,704NCBIRnor6.0
Rnor_5.0124,875,772 - 24,876,097UniSTSRnor5.0
RGSC_v3.4122,842,913 - 22,843,238UniSTSRGSC3.4
Celera121,070,465 - 21,070,790UniSTS
RGSC_v3.1122,845,857 - 22,846,184RGD
RH 3.4 Map1222.9UniSTS
RH 3.4 Map1222.9RGD
RH 2.0 Map1145.5RGD
SHRSP x BN Map115.98RGD
Cytogenetic Map1p12UniSTS
D1Rat463  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8124,021,321 - 24,021,426 (+)Marker Load Pipeline
mRatBN7.2122,202,166 - 22,202,271 (+)MAPPERmRatBN7.2
Rnor_6.0123,267,931 - 23,268,035NCBIRnor6.0
Rnor_5.0124,737,485 - 24,737,589UniSTSRnor5.0
Celera120,931,787 - 20,931,891UniSTS
FHH x ACI Map119.52UniSTS
FHH x ACI Map119.52RGD
Cytogenetic Map1p12UniSTS
D1Got29  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2122,321,222 - 22,321,426 (+)MAPPERmRatBN7.2
Rnor_6.0123,387,004 - 23,387,205NCBIRnor6.0
Rnor_5.0124,856,564 - 24,856,765UniSTSRnor5.0
RGSC_v3.4122,823,522 - 22,823,723UniSTSRGSC3.4
RGSC_v3.4122,823,521 - 22,823,721RGDRGSC3.4
Celera121,051,115 - 21,051,316UniSTS
RGSC_v3.1122,826,466 - 22,826,666RGD
RH 3.4 Map1222.6UniSTS
RH 3.4 Map1222.6RGD
RH 2.0 Map1150.0RGD
Cytogenetic Map1p12UniSTS
BI301357  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2122,250,539 - 22,250,731 (+)MAPPERmRatBN7.2
Rnor_6.0123,316,321 - 23,316,512NCBIRnor6.0
Rnor_5.0124,785,881 - 24,786,072UniSTSRnor5.0
Celera120,980,431 - 20,980,622UniSTS
RH 3.4 Map1224.1UniSTS
Cytogenetic Map1p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 12 67 147 65 64 33 27 33 6 253 127 11 126 78 91 31 10 10

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001271317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008758600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039103338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282827 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282831 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063282833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC107460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000022362   ⟹   ENSRNOP00000022362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl123,991,431 - 24,233,279 (+)Ensembl
mRatBN7.2 Ensembl122,172,275 - 22,414,734 (+)Ensembl
Rnor_6.0 Ensembl123,409,408 - 23,610,164 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102230   ⟹   ENSRNOP00000089077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl123,992,036 - 24,235,131 (+)Ensembl
mRatBN7.2 Ensembl122,173,039 - 22,415,976 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113193   ⟹   ENSRNOP00000097961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl123,992,036 - 24,235,131 (+)Ensembl
mRatBN7.2 Ensembl122,351,120 - 22,415,976 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116083   ⟹   ENSRNOP00000096314
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl123,992,036 - 24,235,131 (+)Ensembl
mRatBN7.2 Ensembl122,173,039 - 22,415,976 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000129366   ⟹   ENSRNOP00000099830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl123,992,119 - 24,234,415 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000153564   ⟹   ENSRNOP00000112543
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl123,992,354 - 24,233,279 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000167396   ⟹   ENSRNOP00000107060
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl124,170,295 - 24,232,055 (+)Ensembl
RefSeq Acc Id: NM_001271317   ⟹   NP_001258246
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8123,991,431 - 24,233,279 (+)NCBI
mRatBN7.2122,172,275 - 22,414,125 (+)NCBI
Rnor_6.0123,237,617 - 23,611,580 (+)NCBI
Rnor_5.0124,707,171 - 24,911,188 (+)NCBI
Rnor_5.0125,068,884 - 25,080,689 (+)NCBI
Celera120,901,953 - 21,143,929 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039103304   ⟹   XP_038959232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8123,992,029 - 24,235,132 (+)NCBI
mRatBN7.2122,172,692 - 22,415,978 (+)NCBI
RefSeq Acc Id: XM_039103306   ⟹   XP_038959234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8124,009,885 - 24,235,132 (+)NCBI
mRatBN7.2122,189,879 - 22,415,978 (+)NCBI
RefSeq Acc Id: XM_039103308   ⟹   XP_038959236
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8123,992,029 - 24,235,132 (+)NCBI
mRatBN7.2122,172,689 - 22,415,978 (+)NCBI
RefSeq Acc Id: XM_039103311   ⟹   XP_038959239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8123,992,029 - 24,235,132 (+)NCBI
mRatBN7.2122,172,691 - 22,415,978 (+)NCBI
RefSeq Acc Id: XM_039103312   ⟹   XP_038959240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8123,992,029 - 24,235,132 (+)NCBI
mRatBN7.2122,172,695 - 22,415,978 (+)NCBI
RefSeq Acc Id: XM_039103313   ⟹   XP_038959241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8123,992,029 - 24,235,132 (+)NCBI
mRatBN7.2122,172,692 - 22,415,978 (+)NCBI
RefSeq Acc Id: XM_039103315   ⟹   XP_038959243
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8123,992,029 - 24,235,132 (+)NCBI
mRatBN7.2122,172,694 - 22,415,978 (+)NCBI
RefSeq Acc Id: XM_039103316   ⟹   XP_038959244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8123,992,029 - 24,235,132 (+)NCBI
mRatBN7.2122,172,696 - 22,415,978 (+)NCBI
RefSeq Acc Id: XM_039103321   ⟹   XP_038959249
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8124,170,168 - 24,235,132 (+)NCBI
mRatBN7.2122,348,065 - 22,415,978 (+)NCBI
RefSeq Acc Id: XM_039103331   ⟹   XP_038959259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8124,170,168 - 24,235,132 (+)NCBI
mRatBN7.2122,348,065 - 22,415,978 (+)NCBI
RefSeq Acc Id: XM_039103335   ⟹   XP_038959263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8123,992,029 - 24,224,398 (+)NCBI
mRatBN7.2122,172,688 - 22,405,244 (+)NCBI
RefSeq Acc Id: XM_039103338   ⟹   XP_038959266
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8123,992,029 - 24,235,132 (+)NCBI
mRatBN7.2122,172,692 - 22,415,978 (+)NCBI
RefSeq Acc Id: XM_063282825   ⟹   XP_063138895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8123,992,033 - 24,235,132 (+)NCBI
RefSeq Acc Id: XM_063282826   ⟹   XP_063138896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8123,992,033 - 24,235,132 (+)NCBI
RefSeq Acc Id: XM_063282827   ⟹   XP_063138897
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8123,992,033 - 24,235,132 (+)NCBI
RefSeq Acc Id: XM_063282828   ⟹   XP_063138898
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8124,009,893 - 24,235,132 (+)NCBI
RefSeq Acc Id: XM_063282831   ⟹   XP_063138901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8124,170,168 - 24,235,132 (+)NCBI
RefSeq Acc Id: XM_063282832   ⟹   XP_063138902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8124,170,168 - 24,235,132 (+)NCBI
RefSeq Acc Id: XM_063282833   ⟹   XP_063138903
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8124,176,415 - 24,235,132 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001258246 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959232 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959234 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959236 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959239 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959240 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959241 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959243 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959244 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959249 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959259 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959263 (Get FASTA)   NCBI Sequence Viewer  
  XP_038959266 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138895 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138896 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138897 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138898 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138901 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138902 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138903 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022362
  ENSRNOP00000022362.8
  ENSRNOP00000089077
  ENSRNOP00000089077.2
  ENSRNOP00000096314
  ENSRNOP00000096314.2
  ENSRNOP00000097961
  ENSRNOP00000097961.2
  ENSRNOP00000099830
  ENSRNOP00000099830.1
  ENSRNOP00000107060
  ENSRNOP00000107060.1
  ENSRNOP00000112543
  ENSRNOP00000112543.1
RefSeq Acc Id: NP_001258246   ⟸   NM_001271317
- UniProtKB: A0A8I6B402 (UniProtKB/TrEMBL),   A6JUP2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022362   ⟸   ENSRNOT00000022362
RefSeq Acc Id: XP_038959263   ⟸   XM_039103335
- Peptide Label: isoform X17
RefSeq Acc Id: XP_038959236   ⟸   XM_039103308
- Peptide Label: isoform X2
- UniProtKB: F1LX86 (UniProtKB/TrEMBL),   A6JUP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959239   ⟸   XM_039103311
- Peptide Label: isoform X4
- UniProtKB: A6JUP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959232   ⟸   XM_039103304
- Peptide Label: isoform X3
- UniProtKB: A6JUP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959241   ⟸   XM_039103313
- Peptide Label: isoform X6
- UniProtKB: A6JUP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959266   ⟸   XM_039103338
- Peptide Label: isoform X1
- UniProtKB: A6JUP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959243   ⟸   XM_039103315
- Peptide Label: isoform X8
- UniProtKB: A6JUP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959240   ⟸   XM_039103312
- Peptide Label: isoform X5
- UniProtKB: A0A8I6B402 (UniProtKB/TrEMBL),   A6JUP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959244   ⟸   XM_039103316
- Peptide Label: isoform X11
- UniProtKB: A0A8I6A7V1 (UniProtKB/TrEMBL),   A6JUP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959234   ⟸   XM_039103306
- Peptide Label: isoform X3
- UniProtKB: A6JUP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959249   ⟸   XM_039103321
- Peptide Label: isoform X12
- UniProtKB: A0A8I6AS60 (UniProtKB/TrEMBL),   A6JUP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038959259   ⟸   XM_039103331
- Peptide Label: isoform X15
- UniProtKB: A6JUP2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096314   ⟸   ENSRNOT00000116083
Ensembl Acc Id: ENSRNOP00000089077   ⟸   ENSRNOT00000102230
Ensembl Acc Id: ENSRNOP00000097961   ⟸   ENSRNOT00000113193
RefSeq Acc Id: XP_063138895   ⟸   XM_063282825
- Peptide Label: isoform X7
- UniProtKB: A6JUP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138896   ⟸   XM_063282826
- Peptide Label: isoform X9
- UniProtKB: A6JUP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138897   ⟸   XM_063282827
- Peptide Label: isoform X10
- UniProtKB: A6JUP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138898   ⟸   XM_063282828
- Peptide Label: isoform X11
- UniProtKB: A6JUP2 (UniProtKB/TrEMBL),   A0A8I6A7V1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138901   ⟸   XM_063282831
- Peptide Label: isoform X13
- UniProtKB: A6JUP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138902   ⟸   XM_063282832
- Peptide Label: isoform X14
- UniProtKB: A6JUP2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138903   ⟸   XM_063282833
- Peptide Label: isoform X16
Ensembl Acc Id: ENSRNOP00000112543   ⟸   ENSRNOT00000153564
Ensembl Acc Id: ENSRNOP00000099830   ⟸   ENSRNOT00000129366
Ensembl Acc Id: ENSRNOP00000107060   ⟸   ENSRNOT00000167396

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LX86-F1-model_v2 AlphaFold F1LX86 1-589 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307099 AgrOrtholog
BioCyc Gene G2FUF-62057 BioCyc
Ensembl Genes ENSRNOG00000016627 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022362 ENTREZGENE
  ENSRNOT00000022362.9 UniProtKB/TrEMBL
  ENSRNOT00000102230 ENTREZGENE
  ENSRNOT00000102230.2 UniProtKB/TrEMBL
  ENSRNOT00000113193 ENTREZGENE
  ENSRNOT00000113193.2 UniProtKB/TrEMBL
  ENSRNOT00000116083 ENTREZGENE
  ENSRNOT00000116083.2 UniProtKB/TrEMBL
  ENSRNOT00000129366 ENTREZGENE
  ENSRNOT00000129366.1 UniProtKB/TrEMBL
  ENSRNOT00000153564 ENTREZGENE
  ENSRNOT00000153564.1 UniProtKB/TrEMBL
  ENSRNOT00000167396 ENTREZGENE
  ENSRNOT00000167396.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.12350 UniProtKB/TrEMBL
InterPro EYA_dom UniProtKB/TrEMBL
  EYA_dom_metazoan UniProtKB/TrEMBL
  EYA_dom_sf UniProtKB/TrEMBL
  EYA_fam UniProtKB/TrEMBL
KEGG Report rno:292172 UniProtKB/TrEMBL
NCBI Gene 292172 ENTREZGENE
PANTHER PTHR10190 UniProtKB/TrEMBL
  PTHR10190:SF17 UniProtKB/TrEMBL
Pfam Hydrolase UniProtKB/TrEMBL
PhenoGen Eya4 PhenoGen
RatGTEx ENSRNOG00000016627 RatGTEx
UniProt A0A8I6A7V1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AS60 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6B402 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0KY58_RAT UniProtKB/TrEMBL
  A0ABK0M115_RAT UniProtKB/TrEMBL
  A0ABK0M2M6_RAT UniProtKB/TrEMBL
  A6JUP2 ENTREZGENE, UniProtKB/TrEMBL
  F1LX86 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-06-25 Eya4  EYA transcriptional coactivator and phosphatase 4  Eya4  eyes absent homolog 4 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Eya4  eyes absent homolog 4 (Drosophila)  Eya4  eyes absent 4 homolog (Drosophila)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Eya4  eyes absent 4 homolog (Drosophila)   Eya4_predicted  eyes absent 4 homolog (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Eya4_predicted  eyes absent 4 homolog (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED