Wdr62 (WD repeat domain 62) - Rat Genome Database

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Gene: Wdr62 (WD repeat domain 62) Rattus norvegicus
Analyze
Symbol: Wdr62
Name: WD repeat domain 62
RGD ID: 1306714
Description: Involved in several processes, including positive regulation of neuroblast proliferation; positive regulation of neuron migration; and regulation of centrosome cycle. Predicted to be located in centrosome; nucleus; and spindle pole. Human ortholog(s) of this gene implicated in intellectual disability; polymicrogyria; primary autosomal recessive microcephaly; and primary autosomal recessive microcephaly 2 with or without cortical malformations. Orthologous to human WDR62 (WD repeat domain 62); INTERACTS WITH 1-naphthyl isothiocyanate; bisphenol A; gentamycin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100911863; LOC308492; NEWGENE_1306714; RGD1306714; similar to hypothetical protein; WD repeat domain 62-like 1; WD repeat-containing protein 62; WD repeat-containing protein 62-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8194,618,992 - 94,658,097 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl194,618,992 - 94,658,223 (-)EnsemblGRCr8
mRatBN7.2185,491,531 - 85,530,643 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl185,491,533 - 85,530,637 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx190,908,116 - 90,947,153 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0199,375,488 - 99,414,640 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0192,666,377 - 92,705,415 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0190,995,545 - 91,034,592 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl188,694,824 - 88,734,223 (-)Ensemblrn6Rnor6.0
Rnor_5.0192,132,727 - 92,171,774 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4185,448,728 - 85,482,510 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera179,865,970 - 79,905,079 (-)NCBICelera
RGSC_v3.1185,526,838 - 85,560,621 (+)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centriolar satellite  (IBA,IEA,ISO)
centrosome  (IEA,ISO)
nucleus  (IEA,ISO)
spindle pole  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. WDR62 missense mutation in a consanguineous family with primary microcephaly. Bacino CA, etal., Am J Med Genet A. 2012 Mar;158A(3):622-5. doi: 10.1002/ajmg.a.34417. Epub 2012 Feb 3.
2. Novel splice-site mutation in WDR62 revealed by whole-exome sequencing in a Sudanese family with primary microcephaly. Bastaki F, etal., Congenit Anom (Kyoto). 2016 May;56(3):135-7. doi: 10.1111/cga.12144.
3. Mutations in WDR62, encoding a centrosomal and nuclear protein, in Indian primary microcephaly families with cortical malformations. Bhat V, etal., Clin Genet. 2011 Dec;80(6):532-40. doi: 10.1111/j.1399-0004.2011.01686.x. Epub 2011 May 16.
4. Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain size. Chen JF, etal., Nat Commun. 2014 May 30;5:3885. doi: 10.1038/ncomms4885.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Mutations in WDR62 gene in Pakistani families with autosomal recessive primary microcephaly. Kousar R, etal., BMC Neurol. 2011 Oct 1;11:119. doi: 10.1186/1471-2377-11-119.
7. The utility of exome sequencing for genetic diagnosis in a familial microcephaly epilepsy syndrome. McDonell LM, etal., BMC Neurol. 2014 Jan 31;14:22. doi: 10.1186/1471-2377-14-22.
8. Whole-exome sequencing identifies compound heterozygous mutations in WDR62 in siblings with recurrent polymicrogyria. Murdock DR, etal., Am J Med Genet A. 2011 Sep;155A(9):2071-7. doi: 10.1002/ajmg.a.34165. Epub 2011 Aug 10.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. A novel single base pair duplication in WDR62 causes primary microcephaly. Rupp V, etal., BMC Med Genet. 2014 Oct 11;15:107. doi: 10.1186/s12881-014-0107-4.
14. Microcephaly-associated protein WDR62 regulates neurogenesis through JNK1 in the developing neocortex. Xu D, etal., Cell Rep. 2014 Jan 16;6(1):104-16. doi: 10.1016/j.celrep.2013.12.016. Epub 2014 Jan 2.
Additional References at PubMed
PMID:12477932   PMID:20729831   PMID:20890278   PMID:20890279   PMID:26297806  


Genomics

Comparative Map Data
Wdr62
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8194,618,992 - 94,658,097 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl194,618,992 - 94,658,223 (-)EnsemblGRCr8
mRatBN7.2185,491,531 - 85,530,643 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl185,491,533 - 85,530,637 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx190,908,116 - 90,947,153 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0199,375,488 - 99,414,640 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0192,666,377 - 92,705,415 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0190,995,545 - 91,034,592 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl188,694,824 - 88,734,223 (-)Ensemblrn6Rnor6.0
Rnor_5.0192,132,727 - 92,171,774 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4185,448,728 - 85,482,510 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera179,865,970 - 79,905,079 (-)NCBICelera
RGSC_v3.1185,526,838 - 85,560,621 (+)NCBI
Cytogenetic Map1q21NCBI
WDR62
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381936,054,897 - 36,111,145 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1936,054,649 - 36,105,108 (+)Ensemblhg38GRCh38
GRCh371936,545,799 - 36,596,010 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361941,237,623 - 41,287,852 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1933,259,959 - 33,310,190 (+)NCBICelera
Cytogenetic Map19q13.12NCBI
HuRef1933,051,308 - 33,101,495 (+)NCBIHuRef
CHM1_11936,547,139 - 36,597,353 (+)NCBICHM1_1
T2T-CHM13v2.01938,600,696 - 38,656,963 (+)NCBIT2T-CHM13v2.0
Wdr62
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39729,939,563 - 29,980,243 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl729,939,563 - 29,979,844 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38730,240,138 - 30,281,908 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl730,240,138 - 30,280,419 (-)Ensemblmm10GRCm38
MGSCv37731,025,157 - 31,065,440 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36729,948,898 - 29,989,181 (-)NCBIMGSCv36mm8
Celera724,846,534 - 24,911,761 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map717.34NCBI
Wdr62
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554682,503,885 - 2,545,255 (-)Ensembl
ChiLan1.0NW_0049554682,504,181 - 2,545,982 (-)NCBIChiLan1.0ChiLan1.0
WDR62
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22042,056,064 - 42,106,920 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11944,039,672 - 44,090,489 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01932,973,725 - 33,030,297 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11941,721,289 - 41,777,038 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1941,721,281 - 41,777,038 (+)EnsemblpanPan2panpan1.1
WDR62
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11116,594,243 - 116,641,206 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1116,594,244 - 116,641,191 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1115,999,825 - 116,047,171 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01117,197,202 - 117,244,720 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1117,197,203 - 117,245,435 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11116,764,609 - 116,811,924 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01116,384,790 - 116,432,353 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01117,439,956 - 117,487,492 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Wdr62
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934911,309,957 - 11,349,593 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493692280,217 - 119,653 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493692280,136 - 119,702 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WDR62
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl645,419,015 - 45,474,050 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1645,418,966 - 45,477,619 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2640,820,975 - 40,876,258 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WDR62
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1630,964,219 - 31,010,692 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl630,964,319 - 31,011,403 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660738,758,742 - 8,810,706 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wdr62
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479410,310,129 - 10,348,686 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462479410,309,855 - 10,358,018 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Wdr62
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12165,729,950 - 165,768,904 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Wdr62
405 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:51
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000065011
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat

Markers in Region
AI235173  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2185,511,117 - 85,511,248 (+)MAPPERmRatBN7.2
mRatBN7.2185,511,117 - 85,511,248 (-)MAPPERmRatBN7.2
Rnor_6.0191,014,875 - 91,015,005NCBIRnor6.0
Rnor_6.0188,714,415 - 88,714,545NCBIRnor6.0
Rnor_5.0189,871,821 - 89,871,951UniSTSRnor5.0
Rnor_5.0192,152,057 - 92,152,187UniSTSRnor5.0
RGSC_v3.4185,462,793 - 85,462,923UniSTSRGSC3.4
Celera179,885,563 - 79,885,693UniSTS
RH 3.4 Map1845.1UniSTS
Cytogenetic Map1q21UniSTS
RH133836  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2185,532,060 - 85,532,247 (+)MAPPERmRatBN7.2
mRatBN7.2185,532,060 - 85,532,247 (-)MAPPERmRatBN7.2
Rnor_6.0190,993,860 - 90,994,046NCBIRnor6.0
Rnor_6.0188,735,722 - 88,735,908NCBIRnor6.0
Rnor_5.0189,891,740 - 89,891,926UniSTSRnor5.0
Rnor_5.0192,131,042 - 92,131,228UniSTSRnor5.0
RGSC_v3.4185,223,648 - 85,223,834UniSTSRGSC3.4
Celera179,906,578 - 79,906,764UniSTS
RH 3.4 Map1850.0UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 2 19 55 2 3 66 139 95 11 54 36 47 3 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000047120   ⟹   ENSRNOP00000047632
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl194,618,992 - 94,658,223 (-)Ensembl
mRatBN7.2 Ensembl185,491,533 - 85,530,587 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000065011   ⟹   ENSRNOP00000061740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl194,618,992 - 94,658,223 (-)Ensembl
mRatBN7.2 Ensembl185,491,533 - 85,530,587 (-)Ensembl
Rnor_6.0 Ensembl188,694,828 - 88,734,223 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081282   ⟹   ENSRNOP00000074579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl194,618,992 - 94,658,223 (-)Ensembl
mRatBN7.2 Ensembl185,491,533 - 85,530,587 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082555   ⟹   ENSRNOP00000071039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl194,618,992 - 94,658,220 (-)Ensembl
mRatBN7.2 Ensembl185,491,535 - 85,530,637 (-)Ensembl
Rnor_6.0 Ensembl188,694,824 - 88,723,973 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000141044   ⟹   ENSRNOP00000111670
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl194,618,992 - 94,658,128 (-)Ensembl
RefSeq Acc Id: NM_001191623   ⟹   NP_001178552
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8194,618,992 - 94,658,021 (-)NCBI
mRatBN7.2185,491,531 - 85,530,562 (-)NCBI
Rnor_6.0190,995,545 - 91,034,592 (+)NCBI
Rnor_5.0192,132,727 - 92,171,774 (+)NCBI
Celera179,865,970 - 79,905,079 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006228797   ⟹   XP_006228859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8194,618,992 - 94,658,096 (-)NCBI
mRatBN7.2185,491,531 - 85,530,643 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039111586   ⟹   XP_038967514
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8194,618,992 - 94,658,096 (-)NCBI
mRatBN7.2185,491,531 - 85,530,643 (-)NCBI
RefSeq Acc Id: XM_039111587   ⟹   XP_038967515
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8194,620,629 - 94,658,097 (-)NCBI
mRatBN7.2185,493,165 - 85,530,643 (-)NCBI
RefSeq Acc Id: NP_001178552   ⟸   NM_001191623
- UniProtKB: F1M5K2 (UniProtKB/TrEMBL),   F1LRR4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000061740   ⟸   ENSRNOT00000065011
Ensembl Acc Id: ENSRNOP00000071039   ⟸   ENSRNOT00000082555
RefSeq Acc Id: XP_006228859   ⟸   XM_006228797
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JZG6 (UniProtKB/TrEMBL),   F1LRR4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038967514   ⟸   XM_039111586
- Peptide Label: isoform X1
- UniProtKB: F1LRR4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038967515   ⟸   XM_039111587
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000047632   ⟸   ENSRNOT00000047120
Ensembl Acc Id: ENSRNOP00000074579   ⟸   ENSRNOT00000081282
Ensembl Acc Id: ENSRNOP00000111670   ⟸   ENSRNOT00000141044
Protein Domains
MABP1/WDR62 first WD40   MABP1/WDR62 second WD40   MABP1/WRD62 coiled-coil

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LRR4-F1-model_v2 AlphaFold F1LRR4 1-1551 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689956
Promoter ID:EPDNEW_R481
Type:initiation region
Name:Wdr62_1
Description:WD repeat domain 62
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0190,995,514 - 90,995,574EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306714 AgrOrtholog
BioCyc Gene G2FUF-60133 BioCyc
Ensembl Genes ENSRNOG00000020807 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000047120.7 UniProtKB/TrEMBL
  ENSRNOT00000065011 ENTREZGENE
  ENSRNOT00000065011.4 UniProtKB/TrEMBL
  ENSRNOT00000081282.3 UniProtKB/TrEMBL
  ENSRNOT00000082555 ENTREZGENE
  ENSRNOT00000082555.3 UniProtKB/TrEMBL
  ENSRNOT00000141044.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7133018 IMAGE-MGC_LOAD
  IMAGE:7457388 IMAGE-MGC_LOAD
InterPro CCD_WD-repeat_protein UniProtKB/TrEMBL
  Quinonprotein_ADH-like_supfam UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_MABP1-WDR62_1st UniProtKB/TrEMBL
  WD40_MABP1-WDR62_2nd UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
  WDR62-MABP1_CC UniProtKB/TrEMBL
KEGG Report rno:308492 UniProtKB/TrEMBL
MGC_CLONE MGC:125097 IMAGE-MGC_LOAD
  MGC:95237 IMAGE-MGC_LOAD
NCBI Gene 308492 ENTREZGENE
PANTHER WD REPEAT DOMAIN 62, ISOFORM G UniProtKB/TrEMBL
  WD REPEAT-CONTAINING PROTEIN 62 UniProtKB/TrEMBL
Pfam WD40_MABP1-WDR62_1st UniProtKB/TrEMBL
  WD40_MABP1-WDR62_2nd UniProtKB/TrEMBL
  WDR62-MABP1_CC UniProtKB/TrEMBL
PhenoGen Wdr62 PhenoGen
PROSITE WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020807 RatGTEx
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP Peptidase/esterase 'gauge' domain UniProtKB/TrEMBL
  Quin_alc_DH_like UniProtKB/TrEMBL
  SSF50978 UniProtKB/TrEMBL
  TolB, C-terminal domain UniProtKB/TrEMBL
UniProt A0A0G2JZG6 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K8E8_RAT UniProtKB/TrEMBL
  A0ABK0LYS2_RAT UniProtKB/TrEMBL
  F1LRR4 ENTREZGENE, UniProtKB/TrEMBL
  F1M5K2 ENTREZGENE, UniProtKB/TrEMBL
  Q3MHU0_RAT UniProtKB/TrEMBL
  Q5M9F2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Wdr62  WD repeat domain 62  NEWGENE_1306714  WD repeat domain 62-like 1  Data merged from RGD:11427960 737654 PROVISIONAL
2016-10-05 NEWGENE_1306714  WD repeat domain 62-like 1  NEWGENE_1306714  WD repeat domain 62  Name changed 629549 APPROVED
2015-07-29 Wdr62  WD repeat domain 62  LOC100911863  WD repeat-containing protein 62-like  Data merged from RGD:6490021 737654 PROVISIONAL
2012-07-05 LOC100911863  WD repeat-containing protein 62-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-07 Wdr62  WD repeat domain 62  RGD1306714  similar to hypothetical protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1306714  similar to hypothetical protein  RGD1306714_predicted  similar to hypothetical protein (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1306714_predicted  similar to hypothetical protein (predicted)  LOC308492_predicted  similar to hypothetical protein (predicted)  Symbol and Name status set to approved 1331353 APPROVED