Ca12 (carbonic anhydrase 12) - Rat Genome Database

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Gene: Ca12 (carbonic anhydrase 12) Rattus norvegicus
Analyze
Symbol: Ca12 (Ensembl: Car12)
Name: carbonic anhydrase 12
RGD ID: 1306612
Description: Predicted to enable carbonate dehydratase activity. Involved in estrous cycle. Located in apical plasma membrane and basolateral plasma membrane. Human ortholog(s) of this gene implicated in isolated hyperchlorhidrosis and lung non-small cell carcinoma. Orthologous to human CA12 (carbonic anhydrase 12); INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Car12; carbonic anyhydrase 12; LOC363085; membrane-bound carbonic anhydrase 12
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8876,169,723 - 76,225,465 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl876,169,815 - 76,225,465 (+)EnsemblGRCr8
mRatBN7.2867,274,739 - 67,330,428 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl867,274,359 - 67,330,440 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx872,787,939 - 72,840,890 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0871,060,751 - 71,113,710 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0868,930,478 - 68,983,460 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0872,405,770 - 72,461,425 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl872,405,748 - 72,460,240 (+)Ensemblrn6Rnor6.0
Rnor_5.0872,071,988 - 72,127,646 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4871,017,732 - 71,070,729 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera866,660,144 - 66,713,076 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4-hydroxynon-2-enal  (ISO)
4-methylumbelliferyl beta-D-galactoside  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acetazolamide  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bosentan  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clomiphene  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
estrone  (ISO)
famotidine  (ISO)
fipronil  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
glyphosate  (EXP)
hexestrol  (ISO)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
indometacin  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
mestranol  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
oryzalin  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
PCB138  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
SLC-0111  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
thiram  (ISO)
topiramate  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Prognostic value of carbonic anhydrase XII (CA XII) overexpression in hepatocellular carcinoma. null
2. Integrative Proteo-Genomic Analysis for Recurrent Survival Prognosis in Colon Adenocarcinoma. Ai F, etal., Front Oncol. 2022 Jun 30;12:871568. doi: 10.3389/fonc.2022.871568. eCollection 2022.
3. Comprehensive analysis of The Cancer Genome Atlas reveals a unique gene and non-coding RNA signature of fibrolamellar carcinoma. Dinh TA, etal., Sci Rep. 2017 Mar 17;7:44653. doi: 10.1038/srep44653.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. In-vivo functional study on the involvement of CFTR, SLC26A6, NHE-1 and CA isoenzymes II and XII in uterine fluid pH, volume and electrolyte regulation in rats under different sex-steroid influence. Gholami K, etal., Int J Med Sci. 2013 Jul 5;10(9):1121-34. doi: 10.7150/ijms.5918. Print 2013.
6. Region- and cell-specific differences in the distribution of carbonic anhydrases II, III, XII, and XIV in the adult rat epididymis. Hermo L, etal., J Histochem Cytochem. 2005 Jun;53(6):699-713. doi: 10.1369/jhc.4A6575.2005.
7. Response of CAIX and CAXII to in vitro re-oxygenation and clinical significance of the combined expression in NSCLC patients. Ilie M, etal., Lung Cancer. 2013 Oct;82(1):16-23. doi: 10.1016/j.lungcan.2013.07.005. Epub 2013 Jul 30.
8. Expression of von Hippel-Lindau tumor suppressor and tumor-associated carbonic anhydrases IX and XII in normal and neoplastic colorectal mucosa. Kivela AJ, etal., World J Gastroenterol. 2005 May 7;11(17):2616-25. doi: 10.3748/wjg.v11.i17.2616.
9. Expression of a novel transmembrane carbonic anhydrase isozyme XII in normal human gut and colorectal tumors. Kivelä A, etal., Am J Pathol. 2000 Feb;156(2):577-84. doi: 10.1016/S0002-9440(10)64762-1.
10. CAXII Is a sero-diagnostic marker for lung cancer. Kobayashi M, etal., PLoS One. 2012;7(3):e33952. doi: 10.1371/journal.pone.0033952. Epub 2012 Mar 16.
11. pH regulators to target the tumor immune microenvironment in human hepatocellular carcinoma. Kuchuk O, etal., Oncoimmunology. 2018 Mar 26;7(7):e1445452. doi: 10.1080/2162402X.2018.1445452. eCollection 2018.
12. Localization of carbonic anhydrase XII to the basolateral membrane of H+-secreting cells of mouse and rat kidney. Kyllönen MS, etal., J Histochem Cytochem. 2003 Sep;51(9):1217-24. doi: 10.1177/002215540305100912.
13. Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer. Niemelä AM, etal., Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1760-6. doi: 10.1158/1055-9965.EPI-07-0080.
14. Carbonic anhydrase XII mediates the survival and prometastatic functions of macrophages in human hepatocellular carcinoma. Ning WR, etal., J Clin Invest. 2022 Apr 1;132(7). pii: 153110. doi: 10.1172/JCI153110.
15. Carbonic Anhydrase XII as an Independent Prognostic Factor in Advanced Esophageal Squamous Cell Carcinoma. Ochi F, etal., J Cancer. 2015 Jul 29;6(10):922-9. doi: 10.7150/jca.11269. eCollection 2015.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Carbonic anhydrase enzymes II, VII, IX and XII in colorectal carcinomas. Viikilä P, etal., World J Gastroenterol. 2016 Sep 28;22(36):8168-77. doi: 10.3748/wjg.v22.i36.8168.
21. An inhibitory antibody targeting carbonic anhydrase XII abrogates chemoresistance and significantly reduces lung metastases in an orthotopic breast cancer model in vivo. von Neubeck B, etal., Int J Cancer. 2018 Oct 15;143(8):2065-2075. doi: 10.1002/ijc.31607. Epub 2018 Aug 10.
Additional References at PubMed
PMID:14660577   PMID:16271802   PMID:16831598   PMID:21035102   PMID:28940640   PMID:36846718  


Genomics

Comparative Map Data
Ca12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8876,169,723 - 76,225,465 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl876,169,815 - 76,225,465 (+)EnsemblGRCr8
mRatBN7.2867,274,739 - 67,330,428 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl867,274,359 - 67,330,440 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx872,787,939 - 72,840,890 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0871,060,751 - 71,113,710 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0868,930,478 - 68,983,460 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0872,405,770 - 72,461,425 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl872,405,748 - 72,460,240 (+)Ensemblrn6Rnor6.0
Rnor_5.0872,071,988 - 72,127,646 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4871,017,732 - 71,070,729 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera866,660,144 - 66,713,076 (+)NCBICelera
Cytogenetic Map8q24NCBI
CA12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381563,321,378 - 63,381,846 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1563,321,378 - 63,382,027 (-)Ensemblhg38GRCh38
GRCh371563,613,577 - 63,674,045 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361561,402,783 - 61,461,128 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1540,494,364 - 40,552,718 (-)NCBICelera
Cytogenetic Map15q22.2NCBI
HuRef1540,438,444 - 40,496,766 (-)NCBIHuRef
CHM1_11563,734,781 - 63,793,114 (-)NCBICHM1_1
T2T-CHM13v2.01561,126,049 - 61,186,532 (-)NCBIT2T-CHM13v2.0
Car12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39966,619,026 - 66,674,127 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl966,620,968 - 66,674,127 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38966,712,296 - 66,766,845 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl966,713,686 - 66,766,845 (+)Ensemblmm10GRCm38
MGSCv37966,561,493 - 66,614,652 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36966,512,886 - 66,565,989 (+)NCBIMGSCv36mm8
Celera963,948,029 - 64,000,964 (+)NCBICelera
Cytogenetic Map9CNCBI
cM Map936.09NCBI
Ca12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545011,943,340 - 11,975,928 (+)Ensembl
ChiLan1.0NW_00495545011,927,730 - 11,975,553 (+)NCBIChiLan1.0ChiLan1.0
CA12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21652,571,690 - 52,630,424 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11556,747,752 - 56,806,529 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01542,270,188 - 42,328,952 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11560,565,592 - 60,624,008 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1560,565,592 - 60,624,008 (-)EnsemblpanPan2panpan1.1
CA12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13027,903,460 - 27,957,162 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3027,905,837 - 27,957,742 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3027,822,431 - 27,876,096 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03028,075,321 - 28,129,041 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3028,077,699 - 28,129,047 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13028,012,749 - 28,066,343 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03028,074,625 - 28,128,260 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03028,311,867 - 28,365,995 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ca12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640106,028,826 - 106,081,389 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647123,876,812 - 23,929,987 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647123,876,889 - 23,929,720 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CA12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1108,649,271 - 108,710,651 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11108,649,277 - 108,710,658 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21119,822,275 - 119,904,112 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CA12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12620,162,706 - 20,221,680 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2620,162,926 - 20,224,502 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048121,178,247 - 121,238,609 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ca12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247819,140,837 - 9,196,400 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247819,140,753 - 9,195,651 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ca12
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1861,073,724 - 61,128,356 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ca12
301 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:73
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000023952
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat

Markers in Region
BE121257  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2867,324,477 - 67,324,688 (+)MAPPERmRatBN7.2
Rnor_6.0872,455,475 - 72,455,685NCBIRnor6.0
Rnor_5.0872,121,696 - 72,121,906UniSTSRnor5.0
RGSC_v3.4871,067,306 - 71,067,516UniSTSRGSC3.4
Celera866,709,653 - 66,709,863UniSTS
RH 3.4 Map8851.6UniSTS
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 64 158 91 90 59 84 59 6 345 181 10 133 81 92 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000023952   ⟹   ENSRNOP00000023952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl876,169,815 - 76,225,465 (+)Ensembl
mRatBN7.2 Ensembl867,274,359 - 67,330,440 (+)Ensembl
Rnor_6.0 Ensembl872,405,748 - 72,460,240 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105264   ⟹   ENSRNOP00000091938
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl876,169,816 - 76,225,462 (+)Ensembl
mRatBN7.2 Ensembl867,274,601 - 67,330,440 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116915   ⟹   ENSRNOP00000087370
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl867,274,899 - 67,330,440 (+)Ensembl
RefSeq Acc Id: NM_001080756   ⟹   NP_001074225
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8876,169,815 - 76,225,465 (+)NCBI
mRatBN7.2867,274,768 - 67,330,428 (+)NCBI
Rnor_6.0872,405,923 - 72,458,898 (+)NCBI
Rnor_5.0872,071,988 - 72,127,646 (+)NCBI
RGSC_v3.4871,017,732 - 71,070,729 (+)RGD
Celera866,660,144 - 66,713,076 (+)RGD
Sequence:
RefSeq Acc Id: XM_006243311   ⟹   XP_006243373
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8876,169,723 - 76,225,460 (+)NCBI
mRatBN7.2867,274,739 - 67,330,428 (+)NCBI
Rnor_6.0872,405,770 - 72,461,425 (+)NCBI
Rnor_5.0872,071,988 - 72,127,646 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063265771   ⟹   XP_063121841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8876,169,723 - 76,225,460 (+)NCBI
RefSeq Acc Id: XM_063265772   ⟹   XP_063121842
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8876,169,944 - 76,225,460 (+)NCBI
RefSeq Acc Id: XM_063265773   ⟹   XP_063121843
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8876,185,046 - 76,225,460 (+)NCBI
RefSeq Acc Id: XM_063265774   ⟹   XP_063121844
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8876,169,948 - 76,225,460 (+)NCBI
RefSeq Acc Id: NP_001074225   ⟸   NM_001080756
- Peptide Label: precursor
- UniProtKB: A2IBE2 (UniProtKB/TrEMBL),   A0A8I6A5P9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243373   ⟸   XM_006243311
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AH35 (UniProtKB/TrEMBL),   A0A8I6A5P9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023952   ⟸   ENSRNOT00000023952
Ensembl Acc Id: ENSRNOP00000091938   ⟸   ENSRNOT00000105264
Ensembl Acc Id: ENSRNOP00000087370   ⟸   ENSRNOT00000116915
RefSeq Acc Id: XP_063121841   ⟸   XM_063265771
- Peptide Label: isoform X1
- UniProtKB: F7FAJ9 (UniProtKB/TrEMBL),   A0A8I6A5P9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121842   ⟸   XM_063265772
- Peptide Label: isoform X3
- UniProtKB: A6J5I5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121844   ⟸   XM_063265774
- Peptide Label: isoform X4
- UniProtKB: A6J5I4 (UniProtKB/TrEMBL),   A6J5I5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121843   ⟸   XM_063265773
- Peptide Label: isoform X3
- UniProtKB: A6J5I5 (UniProtKB/TrEMBL)
Protein Domains
Alpha-carbonic anhydrase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A2IBE2-F1-model_v2 AlphaFold A2IBE2 1-354 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696090
Promoter ID:EPDNEW_R6614
Type:single initiation site
Name:Car12_1
Description:carbonic anhydrase 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0872,405,792 - 72,405,852EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306612 AgrOrtholog
BioCyc Gene G2FUF-30015 BioCyc
Ensembl Genes ENSRNOG00000017766 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023952 ENTREZGENE
  ENSRNOT00000023952.8 UniProtKB/TrEMBL
  ENSRNOT00000105264 ENTREZGENE
  ENSRNOT00000105264.2 UniProtKB/TrEMBL
Gene3D-CATH 3.10.200.10 UniProtKB/TrEMBL
InterPro Carbonic_anhydrase_a-class UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class_cat UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class_CS UniProtKB/TrEMBL
  Carbonic_anhydrase_a_sf UniProtKB/TrEMBL
KEGG Report rno:363085 UniProtKB/TrEMBL
NCBI Gene 363085 ENTREZGENE
PANTHER Euk_COanhd UniProtKB/TrEMBL
  PTHR18952:SF19 UniProtKB/TrEMBL
Pfam Carb_anhydrase UniProtKB/TrEMBL
PhenoGen Ca12 PhenoGen
PROSITE ALPHA_CA_1 UniProtKB/TrEMBL
  ALPHA_CA_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017766 RatGTEx
SMART Carb_anhydrase UniProtKB/TrEMBL
Superfamily-SCOP Euk_COanhd UniProtKB/TrEMBL
UniProt A0A8I6A5P9 ENTREZGENE
  A0A8I6AH35 ENTREZGENE, UniProtKB/TrEMBL
  A2IBE2 ENTREZGENE, UniProtKB/TrEMBL
  A6J5I4 ENTREZGENE, UniProtKB/TrEMBL
  A6J5I5 ENTREZGENE, UniProtKB/TrEMBL
  F7FAJ9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-04-28 Ca12  carbonic anhydrase 12  Car12  carbonic anhydrase 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2022-04-18 Car12  carbonic anhydrase 12  Ca12  carbonic anhydrase 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2019-04-16 Ca12  carbonic anhydrase 12  Car12  carbonic anhydrase 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-01 Car12  carbonic anhydrase 12  Car12  carbonic anyhydrase 12  Name changed 629549 APPROVED
2005-12-06 Car12  carbonic anyhydrase 12  Car12_predicted  carbonic anyhydrase 12 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Car12_predicted  carbonic anyhydrase 12 (predicted)      Symbol and Name status set to approved 70820 APPROVED