Gene: Rab5b (RAB5B, member RAS oncogene family) Rattus norvegicus
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Symbol:
Rab5b
Name:
RAB5B, member RAS oncogene family
RGD ID:
1306489
Description:
Predicted to enable G protein activity; GDP binding activity; and GTP-dependent protein binding activity. Predicted to be involved in several processes, including endosomal transport; intracellular protein transport; and plasma membrane to endosome transport. Predicted to act upstream of or within endosome organization and regulation of endocytosis. Is active in synaptic vesicle membrane. Orthologous to human RAB5B (RAB5B, member RAS oncogene family); PARTICIPATES IN endocytosis pathway; Entamoebiasis pathway; phagocytosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; bisphenol A.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
LOC288779; ras-related protein Rab-5B
RGD Orthologs
Alliance Orthologs
More Info
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Species
Gene symbol and name
Data Source
Assertion derived from
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Orthologs 1
Homo sapiens (human):
RAB5B (RAB5B, member RAS oncogene family)
HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):
Rab5b (RAB5B, member RAS oncogene family)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):
Rab5b (RAB5B, member RAS oncogene family)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
RAB5B (RAB5B, member RAS oncogene family)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
RAB5B (RAB5B, member RAS oncogene family)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Rab5b (RAB5B, member RAS oncogene family)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
RAB5B (RAB5B, member RAS oncogene family)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
RAB5B (RAB5B, member RAS oncogene family)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Rab5b (RAB5B, member RAS oncogene family)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Rattus rattus (black rat):
Rab5b (RAB5B, member RAS oncogene family)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
TSKS (testis specific serine kinase substrate)
HGNC
OMA
Alliance orthologs 3
Homo sapiens (human):
RAB5B (RAB5B, member RAS oncogene family)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Rab5b (RAB5B, member RAS oncogene family)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
rab5b (RAB5B, member RAS oncogene family)
Alliance
DIOPT (OrthoFinder|PANTHER|PhylomeDB)
Caenorhabditis elegans (roundworm):
rab-5
Alliance
DIOPT (Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Caenorhabditis elegans (roundworm):
rab-5
Alliance
DIOPT (Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|SonicParanoid)
Drosophila melanogaster (fruit fly):
Rab5
Alliance
DIOPT (Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Drosophila melanogaster (fruit fly):
Rab5
Alliance
DIOPT (Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):
VPS21
Alliance
DIOPT (InParanoid|OMA|OrthoFinder|OrthoInspector|PhylomeDB|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):
VPS21
Alliance
DIOPT (InParanoid|OMA|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):
YPT52
Alliance
DIOPT (Ensembl Compara|Hieranoid|OMA)
Saccharomyces cerevisiae (baker's yeast):
YPT52
Alliance
DIOPT (Ensembl Compara|Hieranoid|OMA|PANTHER|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):
YPT53
Alliance
DIOPT (InParanoid|OMA|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):
YPT53
Alliance
DIOPT (InParanoid|OMA|OrthoInspector|PhylomeDB|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):
rab5b
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):
rab5b
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PhylomeDB|SonicParanoid)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 7 1,693,971 - 1,712,936 (-) NCBI GRCr8 GRCr8 GRCr8 GRCr8 Ensembl 7 1,693,989 - 1,712,780 (-) Ensembl GRCr8 mRatBN7.2 7 1,109,449 - 1,128,348 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 7 1,109,454 - 1,128,268 (-) Ensembl mRatBN7.2 UTH_Rnor_SHR_Utx 7 3,872,624 - 3,891,374 (-) NCBI UTH_Rnor_SHR_Utx UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 7 5,748,296 - 5,767,046 (-) NCBI UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 7 6,045,368 - 6,063,861 (-) NCBI UTH_Rnor_WKY_Bbb_1.0 UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 7 3,104,530 - 3,123,384 (-) NCBI Rnor_6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 7 3,104,551 - 3,123,297 (-) Ensembl rn6 Rnor6.0 Rnor_5.0 7 3,077,228 - 3,096,075 (-) NCBI Rnor_5.0 Rnor_5.0 rn5 RGSC_v3.4 7 1,979,776 - 1,998,540 (-) NCBI RGSC_v3.4 RGSC_v3.4 rn4 Celera 7 979,663 - 998,427 (-) NCBI Celera RGSC_v3.1 7 1,980,577 - 1,998,878 (-) NCBI Cytogenetic Map 7 q11 NCBI
JBrowse:
Imported Disease Annotations - ClinVar
Only show annotations with direct experimental evidence (0 objects hidden)
Rab5b Rat 1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene multiple interactions ISO Rab5b (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Rab5b Rat 1,2-dimethylhydrazine increases expression ISO Rab5b (Mus musculus) 6480464 1,2-Dimethylhydrazine results in increased expression of RAB5B mRNA CTD PMID:22206623 Rab5b Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Rab5b (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Rab5b Rat 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO Rab5b (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Rab5b Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of RAB5B mRNA CTD PMID:21215274|PMID:33387578 Rab5b Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Rab5b (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of RAB5B mRNA CTD PMID:21570461 Rab5b Rat 2,4,4'-trichlorobiphenyl multiple interactions ISO Rab5b (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Rab5b Rat 3,4-methylenedioxymethamphetamine increases expression ISO Rab5b (Mus musculus) 6480464 N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of RAB5B mRNA CTD PMID:20188158 Rab5b Rat 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RAB5B (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... CTD PMID:28628672 Rab5b Rat 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1,2-dithiol-3-thione results in decreased expression of RAB5B mRNA CTD PMID:19162173 Rab5b Rat 4,4'-diaminodiphenylmethane increases expression ISO Rab5b (Mus musculus) 6480464 4,4'-diaminodiphenylmethane results in increased expression of RAB5B mRNA CTD PMID:18648102 Rab5b Rat 4,4'-sulfonyldiphenol multiple interactions ISO RAB5B (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] more ... CTD PMID:28628672 Rab5b Rat acrylamide decreases expression ISO Rab5b (Mus musculus) 6480464 Acrylamide results in decreased expression of RAB5B mRNA CTD PMID:30807115 Rab5b Rat benzo[a]pyrene decreases expression ISO Rab5b (Mus musculus) 6480464 Benzo(a)pyrene results in decreased expression of RAB5B mRNA CTD PMID:22228805 Rab5b Rat benzo[e]pyrene decreases methylation ISO RAB5B (Homo sapiens) 6480464 benzo(e)pyrene results in decreased methylation of RAB5B intron CTD PMID:30157460 Rab5b Rat beta-lapachone decreases expression ISO RAB5B (Homo sapiens) 6480464 beta-lapachone results in decreased expression of RAB5B mRNA CTD PMID:38218311 Rab5b Rat bis(2-ethylhexyl) phthalate increases expression ISO Rab5b (Mus musculus) 6480464 Diethylhexyl Phthalate results in increased expression of RAB5B mRNA CTD PMID:34319233 Rab5b Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of RAB5B mRNA CTD PMID:25181051 Rab5b Rat bisphenol A increases expression ISO RAB5B (Homo sapiens) 6480464 bisphenol A results in increased expression of RAB5B protein CTD PMID:34186270|PMID:37567409 Rab5b Rat bisphenol A decreases expression ISO Rab5b (Mus musculus) 6480464 bisphenol A results in decreased expression of RAB5B mRNA CTD PMID:33221593 Rab5b Rat bisphenol F multiple interactions ISO RAB5B (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... CTD PMID:28628672 Rab5b Rat bisphenol F increases expression ISO Rab5b (Mus musculus) 6480464 bisphenol F results in increased expression of RAB5B mRNA CTD PMID:38685157 Rab5b Rat cadmium dichloride increases methylation EXP 6480464 Cadmium Chloride results in increased methylation of RAB5B promoter CTD PMID:22457795 Rab5b Rat cadmium dichloride increases expression ISO RAB5B (Homo sapiens) 6480464 Cadmium Chloride results in increased expression of RAB5B protein CTD PMID:24527689 Rab5b Rat carbon nanotube decreases expression ISO Rab5b (Mus musculus) 6480464 Nanotubes, Carbon analog results in decreased expression of RAB5B mRNA CTD PMID:25554681 Rab5b Rat chlordecone increases expression ISO Rab5b (Mus musculus) 6480464 Chlordecone results in increased expression of RAB5B mRNA CTD PMID:33711761 Rab5b Rat choline multiple interactions ISO Rab5b (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression more ... CTD PMID:20938992 Rab5b Rat cisplatin decreases expression ISO RAB5B (Homo sapiens) 6480464 Cisplatin results in decreased expression of RAB5B mRNA CTD PMID:27594783 Rab5b Rat cisplatin increases expression ISO RAB5B (Homo sapiens) 6480464 Cisplatin results in increased expression of RAB5B mRNA CTD PMID:27392435 Rab5b Rat cytarabine increases expression ISO RAB5B (Homo sapiens) 6480464 Cytarabine results in increased expression of RAB5B mRNA CTD PMID:19194470 Rab5b Rat DDE decreases expression ISO RAB5B (Homo sapiens) 6480464 Dichlorodiphenyl Dichloroethylene results in decreased expression of RAB5B mRNA CTD PMID:38568856 Rab5b Rat dexamethasone multiple interactions ISO RAB5B (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... CTD PMID:28628672 Rab5b Rat diquat decreases expression ISO Rab5b (Mus musculus) 6480464 Diquat results in decreased expression of RAB5B protein CTD PMID:36851058 Rab5b Rat diuron decreases expression EXP 6480464 Diuron results in decreased expression of RAB5B mRNA CTD PMID:21551480 Rab5b Rat fluvastatin multiple interactions ISO RAB5B (Homo sapiens) 6480464 [zoledronic acid co-treated with fluvastatin] results in increased expression of RAB5B mRNA CTD PMID:16996129 Rab5b Rat folic acid multiple interactions ISO Rab5b (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression more ... CTD PMID:20938992 Rab5b Rat glyphosate increases expression ISO RAB5B (Homo sapiens) 6480464 Glyphosate results in increased expression of RAB5B mRNA CTD PMID:31295307 Rab5b Rat hexane decreases methylation EXP 6480464 n-hexane results in decreased methylation of RAB5B promoter CTD PMID:23740543 Rab5b Rat indometacin multiple interactions ISO RAB5B (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] more ... CTD PMID:28628672 Rab5b Rat ivermectin decreases expression ISO RAB5B (Homo sapiens) 6480464 Ivermectin results in decreased expression of RAB5B protein CTD PMID:32959892 Rab5b Rat L-methionine multiple interactions ISO Rab5b (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression more ... CTD PMID:20938992 Rab5b Rat leflunomide decreases expression ISO RAB5B (Homo sapiens) 6480464 leflunomide results in decreased expression of RAB5B mRNA CTD PMID:28988120 Rab5b Rat methapyrilene decreases methylation ISO RAB5B (Homo sapiens) 6480464 Methapyrilene results in decreased methylation of RAB5B intron CTD PMID:30157460 Rab5b Rat N-methyl-4-phenylpyridinium affects expression ISO RAB5B (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium affects the expression of RAB5B mRNA CTD PMID:12710931 Rab5b Rat nickel dichloride decreases expression ISO RAB5B (Homo sapiens) 6480464 nickel chloride results in decreased expression of RAB5B mRNA CTD PMID:17312168 Rab5b Rat paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of RAB5B mRNA CTD PMID:33387578 Rab5b Rat PCB138 multiple interactions ISO Rab5b (Mus musculus) 6480464 [2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ... CTD PMID:25510870 Rab5b Rat perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of RAB5B mRNA CTD PMID:19162173 Rab5b Rat pirinixic acid decreases expression ISO Rab5b (Mus musculus) 6480464 pirinixic acid results in decreased expression of RAB5B mRNA CTD PMID:20813756 Rab5b Rat potassium dichromate increases expression ISO RAB5B (Homo sapiens) 6480464 Potassium Dichromate results in increased expression of RAB5B protein CTD PMID:23718831 Rab5b Rat resveratrol increases expression ISO Rab5b (Mus musculus) 6480464 resveratrol results in increased expression of RAB5B protein CTD PMID:25505154 Rab5b Rat resveratrol multiple interactions ISO RAB5B (Homo sapiens) 6480464 [Plant Extracts co-treated with Resveratrol] results in decreased expression of RAB5B mRNA CTD PMID:23557933 Rab5b Rat rotenone increases expression ISO RAB5B (Homo sapiens) 6480464 Rotenone results in increased expression of RAB5B protein CTD PMID:39603559 Rab5b Rat SB 431542 multiple interactions ISO RAB5B (Homo sapiens) 6480464 [LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in increased expression of RAB5B more ... CTD PMID:37664457 Rab5b Rat silver atom decreases expression ISO RAB5B (Homo sapiens) 6480464 Silver results in decreased expression of RAB5B mRNA CTD PMID:26551752 Rab5b Rat silver(0) decreases expression ISO RAB5B (Homo sapiens) 6480464 Silver results in decreased expression of RAB5B mRNA CTD PMID:26551752 Rab5b Rat sodium arsenate increases expression ISO Rab5b (Mus musculus) 6480464 sodium arsenate results in increased expression of RAB5B mRNA CTD PMID:21795629 Rab5b Rat sodium arsenate decreases expression ISO RAB5B (Homo sapiens) 6480464 sodium arsenate results in decreased expression of RAB5B protein CTD PMID:38348393 Rab5b Rat sodium arsenite increases expression ISO RAB5B (Homo sapiens) 6480464 sodium arsenite results in increased expression of RAB5B mRNA CTD PMID:38568856 Rab5b Rat tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of RAB5B mRNA CTD PMID:31150632 Rab5b Rat titanium dioxide increases expression ISO Rab5b (Mus musculus) 6480464 titanium dioxide results in increased expression of RAB5B mRNA CTD PMID:29264374 Rab5b Rat titanium dioxide decreases methylation ISO Rab5b (Mus musculus) 6480464 titanium dioxide results in decreased methylation of RAB5B gene CTD PMID:35295148 Rab5b Rat titanium dioxide increases methylation ISO Rab5b (Mus musculus) 6480464 titanium dioxide results in increased methylation of RAB5B gene CTD PMID:35295148 Rab5b Rat triphenyl phosphate affects expression ISO RAB5B (Homo sapiens) 6480464 triphenyl phosphate affects the expression of RAB5B mRNA CTD PMID:37042841 Rab5b Rat valproic acid decreases expression ISO RAB5B (Homo sapiens) 6480464 Valproic Acid results in decreased expression of RAB5B mRNA CTD PMID:23179753 Rab5b Rat valproic acid affects expression ISO RAB5B (Homo sapiens) 6480464 Valproic Acid affects the expression of RAB5B mRNA CTD PMID:25979313 Rab5b Rat vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of RAB5B mRNA CTD PMID:19015723 Rab5b Rat zoledronic acid multiple interactions ISO RAB5B (Homo sapiens) 6480464 [zoledronic acid co-treated with fluvastatin] results in increased expression of RAB5B mRNA CTD PMID:16996129