Tmprss11g (transmembrane protease, serine 11G) - Rat Genome Database

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Gene: Tmprss11g (transmembrane protease, serine 11G) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Tmprss11g
Name: transmembrane protease, serine 11G
RGD ID: 1306446
Description: Predicted to enable serine-type peptidase activity. Predicted to be involved in proteolysis. Located in plasma membrane; INTERACTS WITH 17beta-estradiol; bisphenol A; N,N-diethyl-m-toluamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Desc4; LOC289546; RGD1306446; serine protease Desc4; similar to RIKEN cDNA 9930032O22 gene; transmembrane protease serine 11G
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81421,901,004 - 21,942,064 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1421,900,975 - 21,942,064 (+)EnsemblGRCr8
mRatBN7.21421,546,087 - 21,587,258 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1421,546,189 - 21,587,258 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1421,893,220 - 21,934,001 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01423,212,148 - 23,252,927 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01421,743,216 - 21,784,008 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01423,166,633 - 23,207,327 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1423,166,633 - 23,207,327 (+)Ensemblrn6Rnor6.0
Rnor_5.01423,058,672 - 23,097,346 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41423,196,890 - 23,240,419 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1421,020,752 - 21,060,937 (+)NCBICelera
RGSC_v3.11423,196,889 - 23,240,419 (+)NCBI
Cytogenetic Map14p21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
extracellular region  (IEA)
membrane  (IEA)
plasma membrane  (IBA,IDA,IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and characterisation of DESC4, a new transmembrane serine protease. Behrens M, etal., Cell Mol Life Sci. 2004 Nov;61(22):2866-77.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19149666  


Genomics

Variants

.
Variants in Tmprss11g
106 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:296
Count of miRNA genes:110
Interacting mature miRNAs:132
Transcripts:ENSRNOT00000042727, ENSRNOT00000060109
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141787564536079022Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141133490630674469Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141133471628389666Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141891545442433608Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141513759431238250Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
2 7 7 10 24 1 6 1 6 27 13 7 11 38 23

Sequence


Ensembl Acc Id: ENSRNOT00000060109   ⟹   ENSRNOP00000056857
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1421,900,975 - 21,942,041 (+)Ensembl
mRatBN7.2 Ensembl1421,546,189 - 21,587,258 (+)Ensembl
Rnor_6.0 Ensembl1423,166,633 - 23,207,327 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094471   ⟹   ENSRNOP00000083178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1421,923,085 - 21,942,064 (+)Ensembl
mRatBN7.2 Ensembl1421,568,274 - 21,587,258 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100035   ⟹   ENSRNOP00000082644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1421,901,004 - 21,942,064 (+)Ensembl
mRatBN7.2 Ensembl1421,546,189 - 21,587,258 (+)Ensembl
RefSeq Acc Id: NM_001008554   ⟹   NP_001008554
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81421,901,004 - 21,942,064 (+)NCBI
mRatBN7.21421,546,189 - 21,587,258 (+)NCBI
Rnor_6.01423,166,633 - 23,207,327 (+)NCBI
Rnor_5.01423,058,672 - 23,097,346 (+)NCBI
RGSC_v3.41423,196,890 - 23,240,419 (+)RGD
Celera1421,020,752 - 21,060,937 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001008554 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE84572 (Get FASTA)   NCBI Sequence Viewer  
  CAE84986 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000056857
GenBank Protein Q5QSK2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001008554   ⟸   NM_001008554
- UniProtKB: Q5NJM5 (UniProtKB/Swiss-Prot),   Q5QSK2 (UniProtKB/Swiss-Prot),   D3ZIU4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000056857   ⟸   ENSRNOT00000060109
Ensembl Acc Id: ENSRNOP00000082644   ⟸   ENSRNOT00000100035
Ensembl Acc Id: ENSRNOP00000083178   ⟸   ENSRNOT00000094471
Protein Domains
Peptidase S1   SEA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5QSK2-F1-model_v2 AlphaFold Q5QSK2 1-417 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306446 AgrOrtholog
BioCyc Gene G2FUF-16074 BioCyc
Ensembl Genes ENSRNOG00000029964 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000060109 ENTREZGENE
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
  3.30.70.960 UniProtKB/Swiss-Prot
InterPro Pept_S1A_HAT/DESC1 UniProtKB/Swiss-Prot
  Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  SEA_dom UniProtKB/Swiss-Prot
  SEA_dom_sf UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
KEGG Report rno:289546 UniProtKB/Swiss-Prot
NCBI Gene 289546 ENTREZGENE
PANTHER ACROSIN-RELATED UniProtKB/Swiss-Prot
  TRANSMEMBRANE PROTEASE SERINE 11C ISOFORM X1 UniProtKB/Swiss-Prot
Pfam SEA UniProtKB/Swiss-Prot
  Trypsin UniProtKB/Swiss-Prot
PhenoGen Tmprss11g PhenoGen
PIRSF TMPRSS11ABCDE UniProtKB/Swiss-Prot
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE SEA UniProtKB/Swiss-Prot
  TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000029964 RatGTEx
SMART Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot
  SSF82671 UniProtKB/Swiss-Prot
UniProt A0A8I5ZUB5_RAT UniProtKB/TrEMBL
  A0A8I5ZVE5_RAT UniProtKB/TrEMBL
  D3ZIU4 ENTREZGENE, UniProtKB/TrEMBL
  Q5NJM5 ENTREZGENE
  Q5QSK2 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q5NJM5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-09-13 Tmprss11g  transmembrane protease, serine 11G  RGD1306446  similar to RIKEN cDNA 9930032O22 gene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1306446  similar to RIKEN cDNA 9930032O22 gene  RGD1306446_predicted  similar to RIKEN cDNA 9930032O22 gene (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1306446_predicted  similar to RIKEN cDNA 9930032O22 gene (predicted)  LOC289546_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC289546_predicted  similar to RIKEN cDNA 9930032O22 gene (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL