Acss1 (acyl-CoA synthetase short-chain family member 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Acss1 (acyl-CoA synthetase short-chain family member 1) Rattus norvegicus
Analyze
Symbol: Acss1
Name: acyl-CoA synthetase short-chain family member 1
RGD ID: 1306246
Description: Enables acetate-CoA ligase activity. Involved in acetate biosynthetic process and propionate biosynthetic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to human ACSS1 (acyl-CoA synthetase short chain family member 1); PARTICIPATES IN disulfiram pharmacodynamics pathway; fatty acid beta degradation pathway; malonic aciduria pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Acas2l; acetyl-Coenzyme A synthetase 2 (AMP forming)-like; acetyl-coenzyme A synthetase 2-like, mitochondrial; LOC296259
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83159,910,809 - 159,960,748 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3159,910,809 - 159,960,748 (-)EnsemblGRCr8
mRatBN7.23139,450,383 - 139,500,325 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3139,450,383 - 139,500,325 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3143,346,852 - 143,396,694 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03151,930,593 - 151,980,423 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03149,678,658 - 149,728,584 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03146,420,346 - 146,470,293 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3146,420,346 - 146,470,293 (-)Ensemblrn6Rnor6.0
Rnor_5.03152,779,621 - 152,829,324 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43141,259,016 - 141,308,871 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3138,212,667 - 138,262,509 (-)NCBICelera
RGSC_v3.13141,164,598 - 141,235,812 (-)NCBI
Cytogenetic Map3q41NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,6-tribromophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
isoniazide  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
MeIQx  (ISO)
menadione  (ISO)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium acetate trihydrate  (ISO)
sodium arsenite  (ISO)
streptozocin  (ISO)
sunitinib  (ISO)
tebuconazole  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
trichloroethene  (EXP)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrial matrix  (IEA,ISO)
mitochondrion  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The subcellular distribution of short-chain fatty acyl-CoA synthetase activity in rat tissues. Barth C, etal., Biochim Biophys Acta. 1971 Oct 5;248(1):24-33.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Glucose-independent Acetate Metabolism Promotes Melanoma Cell Survival and Tumor Growth. Lakhter AJ, etal., J Biol Chem. 2016 Oct 14;291(42):21869-21879. doi: 10.1074/jbc.M115.712166. Epub 2016 Aug 18.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2. Sakakibara I, etal., Cell Metab. 2009 Feb;9(2):191-202. doi: 10.1016/j.cmet.2008.12.008.
10. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. Watkins PA, etal., J Lipid Res. 2007 Dec;48(12):2736-50. Epub 2007 Aug 30.
Additional References at PubMed
PMID:11150295   PMID:16788062   PMID:16790548   PMID:18614015   PMID:26945066   PMID:34800366  


Genomics

Comparative Map Data
Acss1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83159,910,809 - 159,960,748 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3159,910,809 - 159,960,748 (-)EnsemblGRCr8
mRatBN7.23139,450,383 - 139,500,325 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3139,450,383 - 139,500,325 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3143,346,852 - 143,396,694 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03151,930,593 - 151,980,423 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03149,678,658 - 149,728,584 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03146,420,346 - 146,470,293 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3146,420,346 - 146,470,293 (-)Ensemblrn6Rnor6.0
Rnor_5.03152,779,621 - 152,829,324 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43141,259,016 - 141,308,871 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3138,212,667 - 138,262,509 (-)NCBICelera
RGSC_v3.13141,164,598 - 141,235,812 (-)NCBI
Cytogenetic Map3q41NCBI
ACSS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382025,006,237 - 25,058,139 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2025,006,230 - 25,058,980 (-)Ensemblhg38GRCh38
GRCh372024,986,873 - 25,038,775 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362024,934,873 - 24,987,616 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342024,934,873 - 24,987,616NCBI
Celera2025,060,679 - 25,113,427 (-)NCBICelera
Cytogenetic Map20p11.21NCBI
HuRef2024,943,703 - 24,995,659 (-)NCBIHuRef
CHM1_12024,987,355 - 25,039,309 (-)NCBICHM1_1
T2T-CHM13v2.02025,070,421 - 25,122,324 (-)NCBIT2T-CHM13v2.0
Acss1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392150,460,031 - 150,510,160 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2150,460,025 - 150,510,420 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382150,618,111 - 150,668,240 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2150,618,105 - 150,668,500 (-)Ensemblmm10GRCm38
MGSCv372150,443,847 - 150,493,976 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362150,309,552 - 150,359,670 (-)NCBIMGSCv36mm8
Celera2151,852,988 - 151,903,233 (-)NCBICelera
Cytogenetic Map2G3NCBI
cM Map274.74NCBI
Acss1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541531,117,303 - 31,154,654 (-)Ensembl
ChiLan1.0NW_00495541531,117,542 - 31,154,654 (-)NCBIChiLan1.0ChiLan1.0
ACSS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22125,877,357 - 25,932,094 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12025,874,190 - 25,928,929 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02024,946,629 - 25,001,311 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12025,294,186 - 25,348,109 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2025,293,511 - 25,349,017 (-)EnsemblpanPan2panpan1.1
ACSS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1231,192,771 - 1,251,724 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl231,184,392 - 1,252,255 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha231,222,892 - 1,281,311 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0231,435,773 - 1,494,208 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl231,435,776 - 1,494,754 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1231,251,020 - 1,309,471 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0231,381,192 - 1,439,604 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0231,364,196 - 1,422,653 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Acss1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640147,319,248 - 147,380,019 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936620739,633 - 800,803 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936620739,633 - 800,472 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACSS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1730,800,427 - 30,839,742 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11730,800,536 - 30,839,799 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21734,949,412 - 34,988,665 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103247057
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_0236660872,048,170 - 2,100,706 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acss1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624939394,884 - 435,098 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624939384,003 - 431,485 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Acss1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15130,337,722 - 130,387,353 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Acss1
662 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:811
Count of miRNA genes:294
Interacting mature miRNAs:391
Transcripts:ENSRNOT00000009627
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3141508991166376254Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
D3Rat148  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83159,917,263 - 159,917,474 (+)Marker Load Pipeline
Rnor_6.03146,426,801 - 146,427,014NCBIRnor6.0
Rnor_5.03152,786,076 - 152,786,289UniSTSRnor5.0
RGSC_v3.43141,265,471 - 141,265,676UniSTSRGSC3.4
RGSC_v3.43141,265,470 - 141,265,676RGDRGSC3.4
Celera3138,219,122 - 138,219,291UniSTS
RGSC_v3.13141,171,043 - 141,171,249RGD
SHRSP x BN Map365.2999RGD
SHRSP x BN Map365.2999UniSTS
Cytogenetic Map3q41UniSTS
BF389773  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23139,463,124 - 139,463,298 (+)MAPPERmRatBN7.2
Rnor_6.03146,433,095 - 146,433,268NCBIRnor6.0
Rnor_5.03152,792,370 - 152,792,543UniSTSRnor5.0
RGSC_v3.43141,271,757 - 141,271,930UniSTSRGSC3.4
Celera3138,225,372 - 138,225,545UniSTS
RH 3.4 Map31197.32UniSTS
Cytogenetic Map3q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000009627   ⟹   ENSRNOP00000009627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3159,910,809 - 159,960,748 (-)Ensembl
mRatBN7.2 Ensembl3139,450,383 - 139,500,325 (-)Ensembl
Rnor_6.0 Ensembl3146,420,346 - 146,470,293 (-)Ensembl
RefSeq Acc Id: NM_001106524   ⟹   NP_001099994
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83159,910,809 - 159,960,748 (-)NCBI
mRatBN7.23139,450,383 - 139,500,325 (-)NCBI
Rnor_6.03146,420,346 - 146,470,293 (-)NCBI
Rnor_5.03152,779,621 - 152,829,324 (-)NCBI
RGSC_v3.43141,259,016 - 141,308,871 (-)RGD
Celera3138,212,667 - 138,262,509 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099994 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL86149 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009627
  ENSRNOP00000009627.4
RefSeq Acc Id: NP_001099994   ⟸   NM_001106524
- UniProtKB: D3ZZN3 (UniProtKB/TrEMBL),   A6KHF6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009627   ⟸   ENSRNOT00000009627
Protein Domains
Acetyl-coenzyme A synthetase N-terminal   AMP-binding enzyme C-terminal   AMP-dependent synthetase/ligase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZZN3-F1-model_v2 AlphaFold D3ZZN3 1-682 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692516
Promoter ID:EPDNEW_R3041
Type:multiple initiation site
Name:Acss1_1
Description:acyl-CoA synthetase short-chain family member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03146,470,278 - 146,470,338EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306246 AgrOrtholog
BioCyc Gene G2FUF-47349 BioCyc
Ensembl Genes ENSRNOG00000007102 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009627 ENTREZGENE
  ENSRNOT00000009627.7 UniProtKB/TrEMBL
Gene3D-CATH 3.30.300.30 UniProtKB/TrEMBL
  3.40.50.12780 UniProtKB/TrEMBL
InterPro Ac_CoA_lig_AcsA UniProtKB/TrEMBL
  ACAS_N UniProtKB/TrEMBL
  AMP-bd_C_sf UniProtKB/TrEMBL
  AMP-binding_CS UniProtKB/TrEMBL
  AMP-dep_Synth/Lig UniProtKB/TrEMBL
  AMP-dep_Synthh-like_sf UniProtKB/TrEMBL
  DUF4009 UniProtKB/TrEMBL
KEGG Report rno:296259 UniProtKB/TrEMBL
NCBI Gene 296259 ENTREZGENE
PANTHER ACETYL-COENZYME A SYNTHETASE UniProtKB/TrEMBL
  ACETYL-COENZYME A SYNTHETASE 2-LIKE, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam ACAS_N UniProtKB/TrEMBL
  AMP-binding UniProtKB/TrEMBL
  DUF4009 UniProtKB/TrEMBL
PhenoGen Acss1 PhenoGen
PROSITE AMP_BINDING UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007102 RatGTEx
Superfamily-SCOP Acetyl-CoA synthetase-like UniProtKB/TrEMBL
UniProt A6KHF6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZZN3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Acss1  acyl-CoA synthetase short-chain family member 1   Acss1_predicted  acyl-CoA synthetase short-chain family member 1 (predicted)  'predicted' is removed 2292626 APPROVED
2008-01-09 Acss1_predicted  acyl-CoA synthetase short-chain family member 1 (predicted)  LOC681886  similar to acetyl-CoA synthetase 2-like  Data merged from RGD:1590480 1643240 APPROVED
2006-11-20 LOC681886  similar to acetyl-CoA synthetase 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Acss1_predicted  acyl-CoA synthetase short-chain family member 1 (predicted)  Acas2l_predicted  acetyl-Coenzyme A synthetase 2 (AMP forming)-like (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Acas2l_predicted  acetyl-Coenzyme A synthetase 2 (AMP forming)-like (predicted)      Symbol and Name status set to approved 70820 APPROVED