Fbxw8 (F-box and WD repeat domain containing 8) - Rat Genome Database

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Gene: Fbxw8 (F-box and WD repeat domain containing 8) Rattus norvegicus
Analyze
Symbol: Fbxw8
Name: F-box and WD repeat domain containing 8
RGD ID: 1306032
Description: Predicted to contribute to ubiquitin-protein transferase activity. Involved in Golgi organization and positive regulation of dendrite morphogenesis. Located in Golgi apparatus and perinuclear region of cytoplasm. Orthologous to human FBXW8 (F-box and WD repeat domain containing 8); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: F-box and WD-40 domain protein 8; F-box and WD-40 domain-containing protein 8; F-box/WD repeat-containing protein 8; LOC304522
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81244,087,375 - 44,177,985 (+)NCBIGRCr8
mRatBN7.21238,426,466 - 38,517,076 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1238,426,444 - 38,516,424 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1239,601,817 - 39,692,425 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01240,215,614 - 40,306,221 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01239,268,570 - 39,359,182 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01244,046,204 - 44,138,138 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1244,046,217 - 44,138,138 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01245,877,860 - 45,969,762 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41239,574,258 - 39,666,586 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11239,437,667 - 39,526,703 (+)NCBI
Celera1240,085,063 - 40,177,071 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning. Litterman N, etal., PLoS Biol. 2011 May;9(5):e1001060. doi: 10.1371/journal.pbio.1001060. Epub 2011 May 10.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15057822   PMID:16880526   PMID:18498745   PMID:19028597   PMID:24362026   PMID:24793695   PMID:29153991  


Genomics

Comparative Map Data
Fbxw8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81244,087,375 - 44,177,985 (+)NCBIGRCr8
mRatBN7.21238,426,466 - 38,517,076 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1238,426,444 - 38,516,424 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1239,601,817 - 39,692,425 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01240,215,614 - 40,306,221 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01239,268,570 - 39,359,182 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01244,046,204 - 44,138,138 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1244,046,217 - 44,138,138 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01245,877,860 - 45,969,762 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41239,574,258 - 39,666,586 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11239,437,667 - 39,526,703 (+)NCBI
Celera1240,085,063 - 40,177,071 (+)NCBICelera
Cytogenetic Map12q16NCBI
FBXW8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812116,910,950 - 117,031,148 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12116,910,950 - 117,032,498 (+)EnsemblGRCh38hg38GRCh38
GRCh3712117,348,755 - 117,468,953 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612115,833,144 - 115,953,336 (+)NCBINCBI36Build 36hg18NCBI36
Celera12116,978,296 - 117,098,473 (+)NCBICelera
Cytogenetic Map12q24.22NCBI
HuRef12114,357,862 - 114,477,782 (+)NCBIHuRef
CHM1_112117,316,410 - 117,436,644 (+)NCBICHM1_1
T2T-CHM13v2.012116,892,024 - 117,012,205 (+)NCBIT2T-CHM13v2.0
Fbxw8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395118,203,046 - 118,293,523 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5118,203,030 - 118,293,529 (-)EnsemblGRCm39 Ensembl
GRCm385118,064,981 - 118,155,458 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5118,064,965 - 118,155,464 (-)EnsemblGRCm38mm10GRCm38
MGSCv375118,514,990 - 118,605,467 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365118,326,029 - 118,416,415 (-)NCBIMGSCv36mm8
Celera5115,159,806 - 115,250,279 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map557.92NCBI
Fbxw8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545514,100,636 - 14,204,792 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545514,099,888 - 14,204,889 (-)NCBIChiLan1.0ChiLan1.0
FBXW8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210124,972,139 - 125,093,431 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112124,968,537 - 125,089,813 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012114,487,476 - 114,607,384 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112117,863,254 - 117,983,269 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12117,863,254 - 117,983,269 (+)Ensemblpanpan1.1panPan2
FBXW8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12613,520,605 - 13,640,975 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2613,412,189 - 13,638,258 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2613,515,165 - 13,635,427 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02613,780,524 - 13,901,191 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2613,780,556 - 13,901,188 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12613,742,170 - 13,863,012 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02613,820,084 - 13,940,246 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02613,854,501 - 13,975,455 (+)NCBIUU_Cfam_GSD_1.0
Fbxw8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118153,955,104 - 154,055,611 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365585,421,976 - 5,523,676 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365585,423,815 - 5,523,649 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXW8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1435,444,281 - 35,575,705 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11435,445,020 - 35,613,725 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21437,665,000 - 37,833,502 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FBXW8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111112,226,545 - 112,337,164 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11112,226,594 - 112,341,225 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037132,740,395 - 132,851,867 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbxw8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474716,233,312 - 16,343,824 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474716,226,025 - 16,343,839 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fbxw8
325 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:89
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000064756
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134044726024Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)122806443340130419Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134043551788Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)122806455740218380Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat

Markers in Region
D12Wox8  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,478,649 - 38,478,808 (+)MAPPERmRatBN7.2
Rnor_6.01244,098,086 - 44,098,244NCBIRnor6.0
Rnor_5.01245,929,729 - 45,929,887UniSTSRnor5.0
RGSC_v3.41239,626,553 - 39,626,712RGDRGSC3.4
RGSC_v3.41239,626,554 - 39,626,712UniSTSRGSC3.4
RGSC_v3.11239,489,942 - 39,490,100RGD
Celera1240,136,979 - 40,137,137UniSTS
RH 3.4 Map12707.3UniSTS
RH 3.4 Map12707.3RGD
RH 2.0 Map12532.5RGD
Cytogenetic Map12q16UniSTS
RH128116  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,516,777 - 38,516,957 (+)MAPPERmRatBN7.2
Rnor_6.01244,136,204 - 44,136,383NCBIRnor6.0
Rnor_5.01245,967,828 - 45,968,007UniSTSRnor5.0
RGSC_v3.41239,664,652 - 39,664,831UniSTSRGSC3.4
Celera1240,175,137 - 40,175,316UniSTS
RH 3.4 Map12706.1UniSTS
Cytogenetic Map12q16UniSTS
BE113888  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,513,714 - 38,513,903 (+)MAPPERmRatBN7.2
Rnor_6.01244,133,151 - 44,133,339NCBIRnor6.0
Rnor_5.01245,964,794 - 45,964,982UniSTSRnor5.0
RGSC_v3.41239,661,623 - 39,661,811UniSTSRGSC3.4
RH 3.4 Map12720.4UniSTS
Cytogenetic Map12q16UniSTS
RH138531  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,469,742 - 38,469,878 (+)MAPPERmRatBN7.2
Rnor_6.01244,089,179 - 44,089,314NCBIRnor6.0
Rnor_5.01245,920,822 - 45,920,957UniSTSRnor5.0
RGSC_v3.41239,617,647 - 39,617,782UniSTSRGSC3.4
Celera1240,128,072 - 40,128,207UniSTS
RH 3.4 Map12707.4UniSTS
Cytogenetic Map12q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000064756   ⟹   ENSRNOP00000059618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1244,046,454 - 44,134,844 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079510   ⟹   ENSRNOP00000069282
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1238,426,444 - 38,516,424 (+)Ensembl
Rnor_6.0 Ensembl1244,046,239 - 44,134,674 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080853   ⟹   ENSRNOP00000069117
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1244,046,217 - 44,138,138 (+)Ensembl
RefSeq Acc Id: NM_001107145   ⟹   NP_001100615
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81244,087,375 - 44,177,985 (+)NCBI
mRatBN7.21238,426,466 - 38,517,076 (+)NCBI
Rnor_6.01244,046,217 - 44,138,138 (+)NCBI
Rnor_5.01245,877,860 - 45,969,762 (+)NCBI
RGSC_v3.41239,574,258 - 39,666,586 (+)RGD
Celera1240,085,063 - 40,177,071 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100615 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM13811 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069282.2
GenBank Protein P0DL28 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001100615   ⟸   NM_001107145
- UniProtKB: P0DL28 (UniProtKB/Swiss-Prot),   A0A8L2R0H0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069117   ⟸   ENSRNOT00000080853
Ensembl Acc Id: ENSRNOP00000069282   ⟸   ENSRNOT00000079510
Ensembl Acc Id: ENSRNOP00000059618   ⟸   ENSRNOT00000064756
Protein Domains
F-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0DL28-F1-model_v2 AlphaFold P0DL28 1-596 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698672
Promoter ID:EPDNEW_R9197
Type:initiation region
Name:Fbxw8_1
Description:F-box and WD repeat domain containing 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01244,046,220 - 44,046,280EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306032 AgrOrtholog
BioCyc Gene G2FUF-19077 BioCyc
Ensembl Genes ENSRNOG00000001126 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000079510.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1280.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro F-box-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  F-box_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:304522 UniProtKB/TrEMBL
NCBI Gene 304522 ENTREZGENE
PANTHER F-BOX DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40 REPEAT PROTEIN 12, 37 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam F-box-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fbxw8 PhenoGen
PROSITE FBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_1 UniProtKB/Swiss-Prot
  WD_REPEATS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001126 RatGTEx
SMART FBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81383 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2R0H0 ENTREZGENE, UniProtKB/TrEMBL
  A6J1M2_RAT UniProtKB/TrEMBL
  FBXW8_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-25 Fbxw8  F-box and WD repeat domain containing 8  Fbxw8  F-box and WD-40 domain protein 8   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Fbxw8  F-box and WD-40 domain protein 8   Fbxw8_predicted  F-box and WD-40 domain protein 8 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Fbxw8_predicted  F-box and WD-40 domain protein 8 (predicted)      Symbol and Name status set to approved 70820 APPROVED