Sh3glb2 (SH3 domain-containing GRB2-like endophilin B2) - Rat Genome Database

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Gene: Sh3glb2 (SH3 domain-containing GRB2-like endophilin B2) Rattus norvegicus
Analyze
Symbol: Sh3glb2
Name: SH3 domain-containing GRB2-like endophilin B2
RGD ID: 1305886
Description: Predicted to enable identical protein binding activity. Involved in postsynaptic neurotransmitter receptor internalization. Is active in glutamatergic synapse and postsynaptic endocytic zone. Orthologous to human SH3GLB2 (SH3 domain containing GRB2 like, endophilin B2); PARTICIPATES IN endocytosis pathway; INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: endophilin-B2; LOC311848; MGC105723; SH3 domain-containing GRB2-like protein B2; SH3-containing protein SH3GLB2; SH3-domain GRB2-like endophilin B2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8334,014,746 - 34,029,607 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl334,014,746 - 34,029,566 (-)EnsemblGRCr8
mRatBN7.2313,616,936 - 13,631,785 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl313,616,938 - 13,631,757 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx316,688,459 - 16,703,281 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0325,273,425 - 25,288,245 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0323,519,111 - 23,533,963 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.038,909,231 - 8,924,066 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl38,909,236 - 8,924,032 (-)Ensemblrn6Rnor6.0
Rnor_5.0314,262,005 - 14,276,841 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.439,388,827 - 9,403,628 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera38,383,439 - 8,398,287 (-)NCBICelera
RGSC_v3.139,389,126 - 9,403,928 (-)NCBI
Cytogenetic Map3p12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO)
glutamatergic synapse  (IDA,IEP,IMP)
membrane  (IBA)
postsynaptic endocytic zone  (IDA,IMP)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. CPG2 Recruits Endophilin B2 to the Cytoskeleton for Activity-Dependent Endocytosis of Synaptic Glutamate Receptors. Loebrich S, etal., Curr Biol. 2016 Feb 8;26(3):296-308. doi: 10.1016/j.cub.2015.11.071. Epub 2016 Jan 14.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11161816   PMID:12477932   PMID:20562859   PMID:25468996   PMID:27107012   PMID:28131823   PMID:28235806   PMID:29476059  


Genomics

Comparative Map Data
Sh3glb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8334,014,746 - 34,029,607 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl334,014,746 - 34,029,566 (-)EnsemblGRCr8
mRatBN7.2313,616,936 - 13,631,785 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl313,616,938 - 13,631,757 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx316,688,459 - 16,703,281 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0325,273,425 - 25,288,245 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0323,519,111 - 23,533,963 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.038,909,231 - 8,924,066 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl38,909,236 - 8,924,032 (-)Ensemblrn6Rnor6.0
Rnor_5.0314,262,005 - 14,276,841 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.439,388,827 - 9,403,628 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera38,383,439 - 8,398,287 (-)NCBICelera
RGSC_v3.139,389,126 - 9,403,928 (-)NCBI
Cytogenetic Map3p12NCBI
SH3GLB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389129,007,036 - 129,028,331 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9129,007,036 - 129,028,369 (-)Ensemblhg38GRCh38
GRCh379131,769,315 - 131,790,610 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369130,810,134 - 130,830,400 (-)NCBIBuild 36Build 36hg18NCBI36
Build 349128,849,867 - 128,870,133NCBI
Celera9102,422,625 - 102,442,892 (-)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9101,377,634 - 101,397,864 (-)NCBIHuRef
CHM1_19131,921,341 - 131,941,566 (-)NCBICHM1_1
T2T-CHM13v2.09141,210,470 - 141,231,788 (-)NCBIT2T-CHM13v2.0
Sh3glb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39230,234,789 - 30,249,380 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl230,234,821 - 30,249,349 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38230,344,777 - 30,359,358 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl230,344,809 - 30,359,337 (-)Ensemblmm10GRCm38
MGSCv37230,200,329 - 30,214,751 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36230,166,818 - 30,181,240 (-)NCBIMGSCv36mm8
Celera230,049,844 - 30,064,263 (-)NCBICelera
Cytogenetic Map2BNCBI
cM Map221.6NCBI
Sh3glb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555701,370,106 - 1,379,408 (-)Ensembl
ChiLan1.0NW_0049555701,370,106 - 1,379,405 (-)NCBIChiLan1.0ChiLan1.0
SH3GLB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21110,324,917 - 10,345,291 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1910,327,264 - 10,347,635 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09100,131,458 - 100,151,869 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19128,791,970 - 128,806,576 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9128,791,948 - 128,806,578 (-)EnsemblpanPan2panpan1.1
SH3GLB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1954,636,610 - 54,656,724 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl954,635,870 - 54,656,720 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha953,832,165 - 53,852,272 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0955,557,623 - 55,577,763 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl955,557,506 - 55,577,761 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1954,319,184 - 54,339,329 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0954,631,394 - 54,651,531 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0954,724,706 - 54,744,838 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sh3glb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947196,695,178 - 196,715,246 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648716,463,666 - 16,474,969 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648716,463,705 - 16,474,699 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SH3GLB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1269,312,825 - 269,332,344 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11269,313,788 - 269,332,351 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21303,329,912 - 303,348,485 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SH3GLB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1129,131,906 - 9,149,674 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl129,131,929 - 9,149,032 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666096408,001 - 426,673 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sh3glb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247606,047,411 - 6,060,425 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247606,047,388 - 6,060,425 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Sh3glb2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v155,272,500 - 5,286,944 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sh3glb2
154 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:85
Count of miRNA genes:59
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000023527
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32905627547904329Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10450811Scl73Serum cholesterol level QTL 734.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat
10450808Scl72Serum cholesterol level QTL 724.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
10450806Scl71Serum cholesterol level QTL 715.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)3290432947904329Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)3612543751125437Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)33083238444921701Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3136721849Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3655634751556347Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)32267715050766390Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)31527234860272348Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)3576639050766390Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)32905627547904329Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3655634751556347Rat

Markers in Region
RH134009  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2313,616,943 - 13,617,144 (+)MAPPERmRatBN7.2
Rnor_6.038,909,239 - 8,909,439NCBIRnor6.0
Rnor_5.0314,262,013 - 14,262,213UniSTSRnor5.0
RGSC_v3.439,388,835 - 9,389,035UniSTSRGSC3.4
Celera38,383,447 - 8,383,647UniSTS
Cytogenetic Map3p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 356 192 11 140 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001393780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001393781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_172010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC098064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000023527   ⟹   ENSRNOP00000023527
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl313,616,941 - 13,631,738 (-)Ensembl
Rnor_6.0 Ensembl38,909,236 - 8,924,032 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085042   ⟹   ENSRNOP00000075076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl313,616,938 - 13,631,756 (-)Ensembl
Rnor_6.0 Ensembl38,909,540 - 8,924,032 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100859   ⟹   ENSRNOP00000085000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl334,014,746 - 34,029,566 (-)Ensembl
mRatBN7.2 Ensembl313,616,941 - 13,631,738 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103772   ⟹   ENSRNOP00000077030
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl334,014,746 - 34,029,566 (-)Ensembl
mRatBN7.2 Ensembl313,616,943 - 13,631,757 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107109   ⟹   ENSRNOP00000089795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl334,014,751 - 34,029,547 (-)Ensembl
mRatBN7.2 Ensembl313,616,943 - 13,631,757 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109601   ⟹   ENSRNOP00000097875
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl313,616,941 - 13,631,738 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116005   ⟹   ENSRNOP00000079486
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl313,616,941 - 13,631,738 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116758   ⟹   ENSRNOP00000084372
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl334,014,746 - 34,029,566 (-)Ensembl
mRatBN7.2 Ensembl313,616,943 - 13,631,757 (-)Ensembl
RefSeq Acc Id: NM_001393780   ⟹   NP_001380709
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8334,014,746 - 34,029,566 (-)NCBI
mRatBN7.2313,616,936 - 13,631,757 (-)NCBI
RefSeq Acc Id: NM_001393781   ⟹   NP_001380710
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8334,014,746 - 34,029,566 (-)NCBI
mRatBN7.2313,616,936 - 13,631,757 (-)NCBI
RefSeq Acc Id: NR_172010
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8334,014,746 - 34,029,566 (-)NCBI
mRatBN7.2313,616,936 - 13,631,757 (-)NCBI
RefSeq Acc Id: XM_006233819   ⟹   XP_006233881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8334,014,746 - 34,029,607 (-)NCBI
mRatBN7.2313,616,936 - 13,631,780 (-)NCBI
Rnor_6.038,909,231 - 8,924,064 (-)NCBI
Rnor_5.0314,262,005 - 14,276,841 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233822   ⟹   XP_006233884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8334,014,746 - 34,029,607 (-)NCBI
mRatBN7.2313,616,936 - 13,631,780 (-)NCBI
Rnor_6.038,909,231 - 8,924,063 (-)NCBI
Rnor_5.0314,262,005 - 14,276,841 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761661   ⟹   XP_008759883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8334,014,746 - 34,029,607 (-)NCBI
mRatBN7.2313,616,936 - 13,631,781 (-)NCBI
Rnor_6.038,909,231 - 8,924,066 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761662   ⟹   XP_008759884
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8334,014,746 - 34,029,607 (-)NCBI
mRatBN7.2313,616,936 - 13,631,780 (-)NCBI
Rnor_6.038,909,231 - 8,924,063 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105239   ⟹   XP_038961167
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8334,015,723 - 34,029,607 (-)NCBI
mRatBN7.2313,617,904 - 13,631,780 (-)NCBI
RefSeq Acc Id: XM_063283947   ⟹   XP_063140017
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8334,014,746 - 34,029,607 (-)NCBI
RefSeq Acc Id: XM_063283948   ⟹   XP_063140018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8334,014,746 - 34,025,639 (-)NCBI
RefSeq Acc Id: XM_063283949   ⟹   XP_063140019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8334,015,723 - 34,029,607 (-)NCBI
RefSeq Acc Id: XM_063283950   ⟹   XP_063140020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8334,018,485 - 34,029,607 (-)NCBI
RefSeq Acc Id: XP_006233884   ⟸   XM_006233822
- Peptide Label: isoform X4
- UniProtKB: A6JTX1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233881   ⟸   XM_006233819
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K9P4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759883   ⟸   XM_008761661
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZZ43 (UniProtKB/TrEMBL),   A0A8I6GM93 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759884   ⟸   XM_008761662
- Peptide Label: isoform X5
- UniProtKB: A0A8I6GHN4 (UniProtKB/TrEMBL),   A6JTX3 (UniProtKB/TrEMBL),   A6JTX1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023527   ⟸   ENSRNOT00000023527
Ensembl Acc Id: ENSRNOP00000075076   ⟸   ENSRNOT00000085042
RefSeq Acc Id: XP_038961167   ⟸   XM_039105239
- Peptide Label: isoform X8
Ensembl Acc Id: ENSRNOP00000089795   ⟸   ENSRNOT00000107109
Ensembl Acc Id: ENSRNOP00000079486   ⟸   ENSRNOT00000116005
Ensembl Acc Id: ENSRNOP00000077030   ⟸   ENSRNOT00000103772
Ensembl Acc Id: ENSRNOP00000097875   ⟸   ENSRNOT00000109601
Ensembl Acc Id: ENSRNOP00000085000   ⟸   ENSRNOT00000100859
Ensembl Acc Id: ENSRNOP00000084372   ⟸   ENSRNOT00000116758
RefSeq Acc Id: NP_001380710   ⟸   NM_001393781
- Peptide Label: isoform 1
- UniProtKB: A6JTX4 (UniProtKB/TrEMBL),   A0A0G2K9P4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001380709   ⟸   NM_001393780
- Peptide Label: isoform 2
- UniProtKB: A0A0G2K9P4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140017   ⟸   XM_063283947
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GM93 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140018   ⟸   XM_063283948
- Peptide Label: isoform X6
- UniProtKB: A6JTX6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140019   ⟸   XM_063283949
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063140020   ⟸   XM_063283950
- Peptide Label: isoform X9
- UniProtKB: A6JTX9 (UniProtKB/TrEMBL)
Protein Domains
BAR   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5PPJ9-F1-model_v2 AlphaFold Q5PPJ9 1-404 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691957
Promoter ID:EPDNEW_R2481
Type:initiation region
Name:Sh3glb2_1
Description:SH3 domain-containing GRB2-like endophilin B2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.038,924,112 - 8,924,172EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305886 AgrOrtholog
BioCyc Gene G2FUF-50220 BioCyc
Ensembl Genes ENSRNOG00000017295 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000100859 ENTREZGENE
  ENSRNOT00000103772 ENTREZGENE
  ENSRNOT00000107109 ENTREZGENE
  ENSRNOT00000116758 ENTREZGENE
Gene3D-CATH 1.20.1270.60 UniProtKB/Swiss-Prot
  SH3 Domains UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7312960 IMAGE-MGC_LOAD
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot
  BAR_dom UniProtKB/Swiss-Prot
  Endophilin_B2_SH3 UniProtKB/Swiss-Prot
  Endophilin_SH3RF UniProtKB/Swiss-Prot
  SH3-like_dom_sf UniProtKB/Swiss-Prot
  SH3_domain UniProtKB/Swiss-Prot
MGC_CLONE MGC:105723 IMAGE-MGC_LOAD
NCBI Gene 311848 ENTREZGENE
PANTHER DREBRIN-LIKE PROTEIN-RELATED UniProtKB/Swiss-Prot
  SH3 DOMAIN-CONTAINING UniProtKB/Swiss-Prot
Pfam BAR UniProtKB/Swiss-Prot
  SH3_9 UniProtKB/Swiss-Prot
PhenoGen Sh3glb2 PhenoGen
PROSITE BAR UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017295 RatGTEx
SMART BAR UniProtKB/Swiss-Prot
  SH3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF103657 UniProtKB/Swiss-Prot
  SSF50044 UniProtKB/Swiss-Prot
UniProt A0A0G2K9P4 ENTREZGENE
  A0A8I5Y0M5_RAT UniProtKB/TrEMBL
  A0A8I5ZYB8_RAT UniProtKB/TrEMBL
  A0A8I5ZZ43 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GHN4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GM93 ENTREZGENE
  A6JTX1 ENTREZGENE, UniProtKB/TrEMBL
  A6JTX3 ENTREZGENE, UniProtKB/TrEMBL
  A6JTX4 ENTREZGENE, UniProtKB/TrEMBL
  A6JTX6 ENTREZGENE, UniProtKB/TrEMBL
  A6JTX7_RAT UniProtKB/TrEMBL
  A6JTX8_RAT UniProtKB/TrEMBL
  A6JTX9 ENTREZGENE, UniProtKB/TrEMBL
  Q5PPJ9 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Sh3glb2  SH3 domain-containing GRB2-like endophilin B2  Sh3glb2  SH3-domain GRB2-like endophilin B2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Sh3glb2  SH3-domain GRB2-like endophilin B2  Sh3glb2_predicted  SH3-domain GRB2-like endophilin B2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Sh3glb2_predicted  SH3-domain GRB2-like endophilin B2 (predicted)      Symbol and Name status set to approved 70820 APPROVED