Arhgap44 (Rho GTPase activating protein 44) - Rat Genome Database

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Gene: Arhgap44 (Rho GTPase activating protein 44) Rattus norvegicus
Analyze
Symbol: Arhgap44
Name: Rho GTPase activating protein 44
RGD ID: 1305664
Description: Enables GTPase activator activity. Involved in negative regulation of filopodium assembly. Located in dendrite; postsynapse; and presynapse. Is active in glutamatergic synapse; postsynaptic density; and presynaptic active zone. Human ortholog(s) of this gene implicated in acquired immunodeficiency syndrome and skin melanoma. Orthologous to human ARHGAP44 (Rho GTPase activating protein 44); INTERACTS WITH 1,3-dinitrobenzene; alpha-Zearalanol; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC303222; RGD1305664; rho GTPase-activating protein 44; rho-type GTPase-activating protein RICH2; rhoGAP interacting with CIP4 homologs protein 2; RICH-2; similar to KIAA0672 gene product
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81050,154,724 - 50,322,027 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1050,154,724 - 50,321,897 (-)EnsemblGRCr8
mRatBN7.21049,655,583 - 49,822,876 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1049,655,584 - 49,824,297 (-)EnsemblmRatBN7.2
Rnor_6.01051,501,547 - 51,669,546 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1051,502,894 - 51,669,297 (-)Ensemblrn6Rnor6.0
Rnor_5.01051,259,533 - 51,425,933 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41051,313,035 - 51,479,556 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1048,871,532 - 49,038,827 (-)NCBICelera
RGSC_v3.11051,328,436 - 51,494,957 (-)NCBI
Cytogenetic Map10q24NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Dynamic recruitment of the curvature-sensitive protein ArhGAP44 to nanoscale membrane deformations limits exploratory filopodia initiation in neurons. Galic M, etal., Elife. 2014 Dec 15;3:e03116. doi: 10.7554/eLife.03116.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Screening low-frequency SNPS from genome-wide association study reveals a new risk allele for progression to AIDS. Le Clerc S, etal., J Acquir Immune Defic Syndr. 2011 Mar 1;56(3):279-84. doi: 10.1097/QAI.0b013e318204982b.
4. Genetic variants in the genes encoding rho GTPases and related regulators predict cutaneous melanoma-specific survival. Liu S, etal., Int J Cancer. 2017 Aug 15;141(4):721-730. doi: 10.1002/ijc.30785. Epub 2017 Jun 1.
5. A comprehensive landscape of transcription profiles and data resources for human leukemia. Luo M, etal., Blood Adv. 2023 Jul 25;7(14):3435-3449. doi: 10.1182/bloodadvances.2022008410.
6. RICH2 is implicated in viraemic control of HIV-1 in black South African individuals. Paximadis M, etal., Infect Genet Evol. 2017 Apr;49:78-87. doi: 10.1016/j.meegid.2017.01.007. Epub 2017 Jan 6.
7. Shank3-Rich2 interaction regulates AMPA receptor recycling and synaptic long-term potentiation. Raynaud F, etal., J Neurosci. 2013 Jun 5;33(23):9699-715. doi: 10.1523/JNEUROSCI.2725-12.2013.
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Mutant p53 promotes cell spreading and migration via ARHGAP44. Xu J, etal., Sci China Life Sci. 2017 Sep;60(9):1019-1029. doi: 10.1007/s11427-016-9040-8. Epub 2017 May 16.
11. RICH2, a potential tumor suppressor in hepatocellular carcinoma. Zhang J, etal., Front Biosci (Landmark Ed). 2019 Jun 1;24(8):1363-1376. doi: 10.2741/4784.
Additional References at PubMed
PMID:12477932   PMID:22750946   PMID:24352656   PMID:26969129   PMID:30053369  


Genomics

Comparative Map Data
Arhgap44
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81050,154,724 - 50,322,027 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1050,154,724 - 50,321,897 (-)EnsemblGRCr8
mRatBN7.21049,655,583 - 49,822,876 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1049,655,584 - 49,824,297 (-)EnsemblmRatBN7.2
Rnor_6.01051,501,547 - 51,669,546 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1051,502,894 - 51,669,297 (-)Ensemblrn6Rnor6.0
Rnor_5.01051,259,533 - 51,425,933 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41051,313,035 - 51,479,556 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1048,871,532 - 49,038,827 (-)NCBICelera
RGSC_v3.11051,328,436 - 51,494,957 (-)NCBI
Cytogenetic Map10q24NCBI
ARHGAP44
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381712,789,498 - 12,991,643 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1712,789,498 - 12,991,643 (+)Ensemblhg38GRCh38
GRCh371712,692,815 - 12,894,960 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361712,633,554 - 12,835,685 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1712,718,166 - 12,920,275 (+)NCBICelera
Cytogenetic Map17p12NCBI
HuRef1712,588,245 - 12,790,668 (+)NCBIHuRef
CHM1_11712,701,589 - 12,903,719 (+)NCBICHM1_1
T2T-CHM13v2.01712,696,985 - 12,899,110 (+)NCBIT2T-CHM13v2.0
Arhgap44
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391164,892,865 - 65,053,779 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1164,892,865 - 65,053,787 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381165,002,039 - 65,162,972 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1165,002,039 - 65,162,961 (-)Ensemblmm10GRCm38
MGSCv371164,815,541 - 64,976,463 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361164,818,234 - 64,979,156 (-)NCBIMGSCv36mm8
Celera1171,938,015 - 72,099,074 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1140.42NCBI
Arhgap44
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554674,430,087 - 4,522,611 (-)Ensembl
ChiLan1.0NW_0049554674,428,738 - 4,590,877 (-)NCBIChiLan1.0ChiLan1.0
ARHGAP44
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21960,757,445 - 60,959,269 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11765,564,061 - 65,765,878 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01738,657,824 - 38,859,591 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11743,357,438 - 43,558,355 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1743,357,438 - 43,453,457 (-)EnsemblpanPan2panpan1.1
ARHGAP44
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1536,790,059 - 36,957,932 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl536,789,814 - 36,957,411 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha536,933,812 - 37,101,416 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0536,898,675 - 37,066,421 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl536,898,649 - 37,066,421 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1536,871,586 - 37,039,378 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0536,818,449 - 36,986,578 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0537,008,878 - 37,176,525 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Arhgap44
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560251,899,406 - 52,068,726 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365955,373,476 - 5,543,073 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365955,373,645 - 5,542,915 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGAP44
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1257,049,895 - 57,206,889 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11257,049,900 - 57,206,706 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21260,167,786 - 60,195,211 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGAP44
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11612,125,543 - 12,328,203 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1612,125,574 - 12,330,501 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660598,910,762 - 9,113,230 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgap44
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624877661,998 - 850,431 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624877662,595 - 851,762 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Arhgap44
1009 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:731
Count of miRNA genes:246
Interacting mature miRNAs:305
Transcripts:ENSRNOT00000004829, ENSRNOT00000057583, ENSRNOT00000071595
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103589326352293000Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102937704652699134Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH131220  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21049,655,607 - 49,655,763 (+)MAPPERmRatBN7.2
Rnor_6.01051,501,572 - 51,501,727NCBIRnor6.0
Rnor_5.01051,259,558 - 51,259,713UniSTSRnor5.0
RGSC_v3.41051,313,511 - 51,313,666UniSTSRGSC3.4
Celera1048,871,557 - 48,871,712UniSTS
RH 3.4 Map10582.4UniSTS
Cytogenetic Map10q24UniSTS
RH137170  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21049,654,974 - 49,655,155 (+)MAPPERmRatBN7.2
Rnor_6.01051,500,939 - 51,501,119NCBIRnor6.0
Rnor_5.01051,258,925 - 51,259,105UniSTSRnor5.0
RGSC_v3.41051,312,878 - 51,313,058UniSTSRGSC3.4
Celera1048,870,924 - 48,871,104UniSTS
RH 3.4 Map10580.6UniSTS
Cytogenetic Map10q24UniSTS
RH138269  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21049,811,947 - 49,812,075 (+)MAPPERmRatBN7.2
Rnor_6.01051,658,597 - 51,658,724NCBIRnor6.0
Rnor_5.01051,415,000 - 51,415,127UniSTSRnor5.0
RGSC_v3.41051,470,537 - 51,470,664UniSTSRGSC3.4
Celera1049,027,911 - 49,028,038UniSTS
RH 3.4 Map10583.8UniSTS
Cytogenetic Map10q24UniSTS
RH11339  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21049,720,872 - 49,720,955 (+)MAPPERmRatBN7.2
Rnor_6.01051,566,835 - 51,566,917NCBIRnor6.0
Rnor_5.01051,324,821 - 51,324,903UniSTSRnor5.0
RGSC_v3.41051,378,775 - 51,378,857UniSTSRGSC3.4
Celera1048,936,838 - 48,936,920UniSTS
Cytogenetic Map10q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 66 59 6 330 166 11 140 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001419596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006220697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006220698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006246835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767896 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008774998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008774999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039087288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC089950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000004829   ⟹   ENSRNOP00000004829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1050,154,724 - 50,321,897 (-)Ensembl
mRatBN7.2 Ensembl1049,655,584 - 49,824,297 (-)Ensembl
Rnor_6.0 Ensembl1051,502,894 - 51,576,376 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000071595   ⟹   ENSRNOP00000066638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1050,154,724 - 50,321,897 (-)Ensembl
mRatBN7.2 Ensembl1049,656,070 - 49,824,297 (-)Ensembl
Rnor_6.0 Ensembl1051,505,137 - 51,669,297 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101528   ⟹   ENSRNOP00000096546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1050,154,724 - 50,321,897 (-)Ensembl
mRatBN7.2 Ensembl1049,655,584 - 49,824,297 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000167941   ⟹   ENSRNOP00000103825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1050,158,313 - 50,321,897 (-)Ensembl
RefSeq Acc Id: NM_001419596   ⟹   NP_001406525
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81050,154,724 - 50,322,009 (-)NCBI
mRatBN7.21049,655,583 - 49,822,872 (-)NCBI
RefSeq Acc Id: XM_039087288   ⟹   XP_038943216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81050,154,724 - 50,256,208 (-)NCBI
mRatBN7.21049,656,930 - 49,757,066 (-)NCBI
RefSeq Acc Id: XM_063269017   ⟹   XP_063125087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81050,154,724 - 50,322,027 (-)NCBI
RefSeq Acc Id: XM_063269018   ⟹   XP_063125088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81050,156,071 - 50,322,015 (-)NCBI
RefSeq Acc Id: XM_063269020   ⟹   XP_063125090
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81050,154,724 - 50,322,015 (-)NCBI
RefSeq Acc Id: XM_063269021   ⟹   XP_063125091
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81050,154,724 - 50,322,026 (-)NCBI
RefSeq Acc Id: XM_063269022   ⟹   XP_063125092
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81050,154,724 - 50,221,894 (-)NCBI
Ensembl Acc Id: ENSRNOP00000004829   ⟸   ENSRNOT00000004829
Ensembl Acc Id: ENSRNOP00000066638   ⟸   ENSRNOT00000071595
RefSeq Acc Id: XP_038943216   ⟸   XM_039087288
- Peptide Label: isoform X2
- UniProtKB: A0A0H2UHC0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000096546   ⟸   ENSRNOT00000101528
RefSeq Acc Id: NP_001406525   ⟸   NM_001419596
- UniProtKB: F1LST2 (UniProtKB/Swiss-Prot),   F1LQX4 (UniProtKB/Swiss-Prot),   M0RAT0 (UniProtKB/Swiss-Prot),   A0A0H2UHC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125087   ⟸   XM_063269017
- Peptide Label: isoform X1
- UniProtKB: A0A0H2UHC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125091   ⟸   XM_063269021
- Peptide Label: isoform X5
- UniProtKB: A0A0H2UHC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125090   ⟸   XM_063269020
- Peptide Label: isoform X4
- UniProtKB: A0A0H2UHC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125092   ⟸   XM_063269022
- Peptide Label: isoform X6
- UniProtKB: A6HFF2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125088   ⟸   XM_063269018
- Peptide Label: isoform X3
- UniProtKB: A0A8L2QXS1 (UniProtKB/TrEMBL),   A6HFF1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000103825   ⟸   ENSRNOT00000167941
Protein Domains
BAR   Rho-GAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LQX4-F1-model_v2 AlphaFold F1LQX4 1-814 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305664 AgrOrtholog
BioCyc Gene G2FUF-24716 BioCyc
Ensembl Genes ENSRNOG00000003603 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004829 ENTREZGENE
  ENSRNOT00000004829.9 UniProtKB/Swiss-Prot
  ENSRNOT00000071595 ENTREZGENE
  ENSRNOT00000101528 ENTREZGENE
  ENSRNOT00000101528.1 UniProtKB/Swiss-Prot
  ENSRNOT00000167941 ENTREZGENE
Gene3D-CATH 1.10.555.10 UniProtKB/Swiss-Prot
  1.20.1270.60 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7312152 IMAGE-MGC_LOAD
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot
  BAR_dom UniProtKB/Swiss-Prot
  RHG17/44/SH3BP1-like UniProtKB/Swiss-Prot
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot
  RhoGAP_dom UniProtKB/Swiss-Prot
MGC_CLONE MGC:109276 IMAGE-MGC_LOAD
NCBI Gene 303222 ENTREZGENE
PANTHER 3BP-1 RELATED RHOGAP UniProtKB/Swiss-Prot
  RHO GTPASE-ACTIVATING PROTEIN 44 UniProtKB/Swiss-Prot
Pfam BAR UniProtKB/Swiss-Prot
  RhoGAP UniProtKB/Swiss-Prot
PhenoGen Arhgap44 PhenoGen
PROSITE BAR UniProtKB/Swiss-Prot
  RHOGAP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003603 RatGTEx
SMART BAR UniProtKB/Swiss-Prot
  RhoGAP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF103657 UniProtKB/Swiss-Prot
  SSF48350 UniProtKB/Swiss-Prot
UniProt A0A0H2UHC0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QXS1 ENTREZGENE, UniProtKB/TrEMBL
  A6HFF1 ENTREZGENE, UniProtKB/TrEMBL
  A6HFF2 ENTREZGENE, UniProtKB/TrEMBL
  F1LQX4 ENTREZGENE
  F1LST2 ENTREZGENE
  M0RAT0 ENTREZGENE
  RHG44_RAT UniProtKB/Swiss-Prot
UniProt Secondary F1LST2 UniProtKB/Swiss-Prot
  M0RAT0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-10 Arhgap44  Rho GTPase activating protein 44  RGD1305664  similar to KIAA0672 gene product  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1305664  similar to KIAA0672 gene product  RGD1305664_predicted  similar to KIAA0672 gene product (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1305664_predicted  similar to KIAA0672 gene product (predicted)  LOC303222_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC303222_predicted  similar to KIAA0672 gene product (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL