Zfp804a (zinc finger protein 804A) - Rat Genome Database

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Gene: Zfp804a (zinc finger protein 804A) Rattus norvegicus
Analyze
Symbol: Zfp804a
Name: zinc finger protein 804A
RGD ID: 1305239
Description: Predicted to enable zinc ion binding activity. Involved in positive regulation of dendritic spine maintenance. Located in several cellular components, including dendrite; neuronal cell body; and presynapse. Orthologous to human ZNF804A (zinc finger protein 804A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; Cuprizon.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC295695; RGD1305239; similar to hypothetical protein; Znf804a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8387,440,496 - 87,670,872 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl387,197,582 - 87,670,869 (+)EnsemblGRCr8
mRatBN7.2367,033,481 - 67,267,769 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl367,034,170 - 67,263,607 (+)EnsemblmRatBN7.2
Rnor_6.0369,268,348 - 69,574,118 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl369,549,673 - 69,573,420 (+)Ensemblrn6Rnor6.0
Rnor_5.0375,809,140 - 76,117,092 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4365,030,107 - 65,285,045 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera366,430,262 - 66,661,181 (+)NCBICelera
RGSC_v3.1364,925,908 - 65,181,457 (+)NCBI
Cytogenetic Map3q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IDA)
cytoplasm  (IEA,ISO)
dendritic microtubule  (IEA,ISO)
dendritic shaft  (IDA,IEA,ISO)
dendritic spine  (IDA,IEA,ISO)
growth cone  (IEA,ISO)
neuronal cell body  (IDA,IEA,ISO)
nucleus  (IBA,IDA,IEA,ISO)
plasma membrane  (IEA,ISO)
postsynapse  (IDA,IEA,ISO)
presynapse  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Psychosis Risk Candidate ZNF804A Localizes to Synapses and Regulates Neurite Formation and Dendritic Spine Structure. Deans PJM, etal., Biol Psychiatry. 2017 Jul 1;82(1):49-61. doi: 10.1016/j.biopsych.2016.08.038. Epub 2016 Sep 15.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22384243   PMID:26148198  


Genomics

Comparative Map Data
Zfp804a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8387,440,496 - 87,670,872 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl387,197,582 - 87,670,869 (+)EnsemblGRCr8
mRatBN7.2367,033,481 - 67,267,769 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl367,034,170 - 67,263,607 (+)EnsemblmRatBN7.2
Rnor_6.0369,268,348 - 69,574,118 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl369,549,673 - 69,573,420 (+)Ensemblrn6Rnor6.0
Rnor_5.0375,809,140 - 76,117,092 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4365,030,107 - 65,285,045 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera366,430,262 - 66,661,181 (+)NCBICelera
RGSC_v3.1364,925,908 - 65,181,457 (+)NCBI
Cytogenetic Map3q24NCBI
ZNF804A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382184,598,529 - 184,939,492 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2184,598,529 - 184,939,492 (+)Ensemblhg38GRCh38
GRCh372185,463,256 - 185,804,219 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362185,171,338 - 185,512,459 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342185,288,598 - 185,629,718NCBI
Celera2179,058,829 - 179,399,965 (+)NCBICelera
Cytogenetic Map2q32.1NCBI
HuRef2177,322,196 - 177,663,897 (+)NCBIHuRef
CHM1_12185,468,928 - 185,810,005 (+)NCBICHM1_1
T2T-CHM13v2.02185,087,218 - 185,428,482 (+)NCBIT2T-CHM13v2.0
Zfp804a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39281,880,473 - 82,090,223 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl281,883,566 - 82,090,223 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38282,050,129 - 82,259,879 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl282,053,222 - 82,259,879 (+)Ensemblmm10GRCm38
MGSCv37281,893,815 - 82,100,036 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36281,633,950 - 82,060,718 (+)NCBIMGSCv36mm8
Celera283,705,441 - 83,911,600 (+)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.06NCBI
Znf804a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540312,935,722 - 13,201,523 (-)NCBIChiLan1.0ChiLan1.0
ZNF804A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21387,260,489 - 87,603,791 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B87,275,467 - 87,618,771 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B71,872,807 - 72,216,720 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B189,676,332 - 190,019,736 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B189,942,181 - 190,019,736 (+)EnsemblpanPan2panpan1.1
ZNF804A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13627,453,839 - 27,527,770 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3627,458,938 - 27,527,362 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3627,151,586 - 27,424,517 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03627,411,020 - 27,684,844 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.13627,533,406 - 27,807,315 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03627,467,699 - 27,741,327 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03627,617,963 - 27,891,702 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Znf804a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303144,387,589 - 144,674,073 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650612,164,469 - 12,167,690 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650612,164,004 - 12,450,483 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZNF804A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1589,842,769 - 90,150,347 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11589,842,424 - 90,150,352 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21599,729,119 - 99,848,332 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZNF804A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11070,094,213 - 70,431,682 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040129,124,475 - 129,457,402 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znf804a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248446,417,102 - 6,482,516 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Znf804a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1559,149,393 - 59,369,509 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Zfp804a
1344 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:20
Count of miRNA genes:19
Interacting mature miRNAs:19
Transcripts:ENSRNOT00000043974
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 1 23 126 37 32 19 6 19 2 111 44 3 120 39 59 13 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000043974   ⟹   ENSRNOP00000049549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl387,441,168 - 87,670,869 (+)Ensembl
mRatBN7.2 Ensembl367,034,170 - 67,263,607 (+)Ensembl
Rnor_6.0 Ensembl369,549,673 - 69,573,420 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000167522   ⟹   ENSRNOP00000109556
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl387,197,582 - 87,670,869 (+)Ensembl
RefSeq Acc Id: XM_008761996   ⟹   XP_008760218
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8387,440,496 - 87,670,872 (+)NCBI
mRatBN7.2367,033,481 - 67,267,769 (+)NCBI
Rnor_6.0369,268,348 - 69,574,118 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001416774 (Get FASTA)   NCBI Sequence Viewer  
  XP_008760218 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL79288 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000049549
  ENSRNOP00000049549.6
  ENSRNOP00000109556.1
RefSeq Acc Id: XP_008760218   ⟸   XM_008761996
- Sequence:
Ensembl Acc Id: ENSRNOP00000049549   ⟸   ENSRNOT00000043974
Ensembl Acc Id: ENSRNOP00000109556   ⟸   ENSRNOT00000167522
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M078-F1-model_v2 AlphaFold F1M078 1-1164 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305239 AgrOrtholog
BioCyc Gene G2FUF-49212 BioCyc
Ensembl Genes ENSRNOG00000038004 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000043974 ENTREZGENE
  ENSRNOT00000043974.7 UniProtKB/TrEMBL
  ENSRNOT00000167522.1 UniProtKB/TrEMBL
InterPro ZnF-G_patch_domain UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
KEGG Report rno:295695 UniProtKB/TrEMBL
NCBI Gene 295695 ENTREZGENE
PANTHER ZINC FINGER PROTEIN 804A UniProtKB/TrEMBL
  ZINC FINGER-CONTAINING UniProtKB/TrEMBL
PhenoGen Zfp804a PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038004 RatGTEx
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0ABK0LTY8_RAT UniProtKB/TrEMBL
  A6HMN7 ENTREZGENE, UniProtKB/TrEMBL
  F1M078 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-19 Zfp804a  zinc finger protein 804A  Znf804a  zinc finger protein 804A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Znf804a  zinc finger protein 804A  Zfp804a  zinc finger protein 804A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Zfp804a  zinc finger protein 804A  RGD1305239_predicted  similar to hypothetical protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1305239_predicted  similar to hypothetical protein (predicted)  LOC295695_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC295695_predicted  similar to hypothetical protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL