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Gene: Usp8 (ubiquitin specific peptidase 8) Rattus norvegicus

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Symbol:

Usp8

Name:

ubiquitin specific peptidase 8

RGD ID:

1304979

Description:

Predicted to enable K48-linked deubiquitinase activity; K63-linked deubiquitinase activity; and cysteine-type deubiquitinase activity. Involved in cellular response to dexamethasone stimulus; cellular response to nerve growth factor stimulus; and regulation of protein catabolic process at postsynapse, modulating synaptic transmission. Located in early endosome. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in ACTH-secreting pituitary adenoma. Orthologous to human USP8 (ubiquitin specific peptidase 8); PARTICIPATES IN mitochondrial autophagy pathway; endocytosis pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC296121; ubiquitin carboxyl-terminal hydrolase 8; ubiquitin specific protease 8

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	USP8 (ubiquitin specific peptidase 8)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Usp8 (ubiquitin specific peptidase 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Usp8 (ubiquitin specific peptidase 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	USP8 (ubiquitin specific peptidase 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	USP8 (ubiquitin specific peptidase 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Usp8 (ubiquitin specific peptidase 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	USP8 (ubiquitin specific peptidase 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	USP8 (ubiquitin specific peptidase 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Usp8 (ubiquitin specific peptidase 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Usp8 (ubiquitin specific peptidase 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	USP8 (ubiquitin specific peptidase 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Usp8 (ubiquitin specific peptidase 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	usp8 (ubiquitin specific peptidase 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	DOA4	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	usp-50	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	usp-50	Alliance	DIOPT (OrthoInspector\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	UBP5	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	UBP5	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	Usp8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Usp8	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	usp8	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	usp8	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	134,413,832 - 134,463,040 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	134,415,391 - 134,463,032 (+)	Ensembl				GRCr8
mRatBN7.2	3	113,962,136 - 114,009,683 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	113,962,164 - 114,009,666 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	117,845,850 - 117,893,311 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	126,441,377 - 126,488,837 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	124,101,758 - 124,149,218 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	119,173,818 - 119,222,499 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	119,173,818 - 119,222,484 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	125,699,400 - 125,747,055 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	114,237,065 - 114,284,543 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	112,804,623 - 112,852,132 (+)	NCBI		Celera
RGSC_v3.1	3	114,103,490 - 114,189,451 (+)	NCBI
Cytogenetic Map	3	q36	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

ACTH-secreting pituitary adenoma (ISO)

esophagus squamous cell carcinoma (ISO)

hereditary spastic paraplegia (ISO)

hereditary spastic paraplegia 59 (ISO)

pituitary-dependent Cushing's disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrobenzenesulfonic acid (EXP)

2-hydroxypropanoic acid (ISO)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

Aroclor 1254 (ISO)

bafilomycin A1 (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

chloroquine (ISO)

choline (ISO)

coumarin (ISO)

dexamethasone (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

doxorubicin (ISO)

ethanol (ISO)

folic acid (ISO)

FR900359 (ISO)

indometacin (ISO)

L-methionine (ISO)

methapyrilene (EXP)

methyl methanesulfonate (ISO)

nonanoic acid (ISO)

paracetamol (EXP,ISO)

pifithrin-alpha hydrobromide (ISO)

rac-lactic acid (ISO)

raloxifene (ISO)

resveratrol (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

tetrachloromethane (EXP)

titanium dioxide (ISO)

toluene 2,4-diisocyanate (ISO)

triptonide (ISO)

tungsten (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to dexamethasone stimulus (IEP)

cellular response to nerve growth factor stimulus (IDA)

endosome organization (IBA,IEA,ISO)

mitotic cytokinesis (ISO)

negative regulation of lysosomal protein catabolic process (IEA,ISO)

positive regulation of amyloid fibril formation (IEA,ISO)

positive regulation of canonical Wnt signaling pathway (IEA,ISO)

protein deubiquitination (IEA,ISO)

protein K48-linked deubiquitination (IEA,ISO)

protein K63-linked deubiquitination (IEA,ISO)

proteolysis (IEA)

Ras protein signal transduction (IBA,ISO)

regulation of protein catabolic process at postsynapse, modulating synaptic transmission (IDA,IEP,IMP)

regulation of protein localization (IEA,ISO)

regulation of protein stability (IEA,ISO)

Cellular Component

acrosomal membrane (IEA,ISO)

cytoplasm (IEA,ISO)

cytosol (IBA,IEA,ISO)

early endosome (IDA,IEA,ISO)

endosome (IEA)

endosome membrane (IEA,ISO)

glutamatergic synapse (IDA,IEP,IMP)

midbody (IBA,IEA,ISO)

nucleus (IEA)

plasma membrane (IEA)

postsynaptic density (IBA,IDA,IEP)

Molecular Function

cysteine-type deubiquitinase activity (IBA,IEA,ISO)

cysteine-type peptidase activity (IEA)

hydrolase activity (IEA)

K48-linked deubiquitinase activity (IEA,ISO)

K63-linked deubiquitinase activity (IEA,ISO)

peptidase activity (IEA)

protein binding (ISO)

SH3 domain binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

endocytosis pathway (IEA)

mitochondrial autophagy pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	The deubiquitinating enzyme UBPy/USP8 interacts with TrkA and inhibits neuronal differentiation in PC12 cells.	Ceriani M, etal., Exp Cell Res. 2015 Apr 10;333(1):49-59. doi: 10.1016/j.yexcr.2015.01.019. Epub 2015 Feb 4.
2.	The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications.	Durcan TM and Fon EA, Genes Dev. 2015 May 15;29(10):989-99. doi: 10.1101/gad.262758.115.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Comprehensive gene review and curation	RGD comprehensive gene curation
10.	Synaptic strength is bidirectionally controlled by opposing activity-dependent regulation of Nedd4-1 and USP8.	Scudder SL, etal., J Neurosci. 2014 Dec 10;34(50):16637-49. doi: 10.1523/JNEUROSCI.2452-14.2014.
11.	Dexamethasone regulates expression of BRUCE/Apollon and the proliferation of neural progenitor cells.	Sippel M, etal., FEBS Lett. 2009 Jul 7;583(13):2213-7. doi: 10.1016/j.febslet.2009.06.018. Epub 2009 Jun 13.

Additional References at PubMed

PMID:11500497	PMID:15314180	PMID:15342353	PMID:16120644	PMID:16520378	PMID:16771824	PMID:18388320	PMID:20495530	PMID:25468996	PMID:27302062	PMID:29735556	PMID:31904090

Genomics

Comparative Map Data

Usp8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	134,413,832 - 134,463,040 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	134,415,391 - 134,463,032 (+)	Ensembl				GRCr8
mRatBN7.2	3	113,962,136 - 114,009,683 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	113,962,164 - 114,009,666 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	117,845,850 - 117,893,311 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	126,441,377 - 126,488,837 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	124,101,758 - 124,149,218 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	119,173,818 - 119,222,499 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	119,173,818 - 119,222,484 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	125,699,400 - 125,747,055 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	114,237,065 - 114,284,543 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	112,804,623 - 112,852,132 (+)	NCBI		Celera
RGSC_v3.1	3	114,103,490 - 114,189,451 (+)	NCBI
Cytogenetic Map	3	q36	NCBI

USP8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	50,424,405 - 50,514,421 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	50,424,372 - 50,514,421 (+)	Ensembl			hg38	GRCh38
GRCh37	15	50,716,602 - 50,806,618 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	48,503,871 - 48,579,265 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	15	48,503,870 - 48,579,263	NCBI
Celera	15	27,609,144 - 27,685,855 (+)	NCBI		Celera
Cytogenetic Map	15	q21.2	NCBI
HuRef	15	27,547,372 - 27,623,683 (+)	NCBI		HuRef
CHM1_1	15	50,834,671 - 50,911,286 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	48,232,513 - 48,322,500 (+)	NCBI		T2T-CHM13v2.0

Usp8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	126,549,280 - 126,601,234 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	126,549,248 - 126,601,217 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	126,707,201 - 126,759,314 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	126,707,328 - 126,759,297 (+)	Ensembl			mm10	GRCm38
MGSCv37	2	126,533,099 - 126,585,033 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	126,398,804 - 126,450,738 (+)	NCBI		MGSCv36	mm8
Celera	2	127,946,958 - 127,999,152 (+)	NCBI		Celera
Cytogenetic Map	2	F1	NCBI
cM Map	2	61.76	NCBI

Usp8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	3,840,007 - 3,891,284 (-)	Ensembl
ChiLan1.0	NW_004955409	3,839,308 - 3,903,595 (-)	NCBI	ChiLan1.0	ChiLan1.0

USP8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	39,669,333 - 39,746,278 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	43,850,502 - 43,939,848 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	29,374,945 - 29,451,235 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	47,699,282 - 47,790,624 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	47,713,997 - 47,790,624 (+)	Ensembl			panPan2	panpan1.1

USP8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	16,341,970 - 16,408,246 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	16,342,009 - 16,408,012 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	16,268,046 - 16,334,339 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	16,485,884 - 16,552,179 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	16,485,928 - 16,552,172 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	16,408,382 - 16,474,666 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	16,525,850 - 16,592,342 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	16,632,281 - 16,698,545 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Usp8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	94,615,145 - 94,673,337 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	12,463,120 - 12,520,674 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	12,463,189 - 12,524,148 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

USP8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	121,306,032 - 121,413,223 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	121,306,031 - 121,376,154 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	134,747,956 - 134,815,830 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

USP8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	32,829,627 - 32,906,493 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	32,829,523 - 32,866,073 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666048	108,247,584 - 108,324,662 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Usp8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624731	9,613,227 - 9,679,404 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624731	9,615,963 - 9,678,969 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Usp8
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	5	105,555,495 - 105,593,457 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Usp8
239 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	410
Count of miRNA genes:	215
Interacting mature miRNAs:	253
Transcripts:	ENSRNOT00000015124
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1582233	Insul10	Insulin level QTL 10	5.4	0.0015	blood insulin amount (VT:0001560)	serum insulin level times blood glucose level (CMO:0002040)	3	133259579	178259579	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	96509147	141509147	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	73592512	136118980	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	129154923	182114333	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	73592512	136118980	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	51581665	184004958	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	67641776	167835660	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	58601291	153936591	Rat
1582216	Bw65	Body weight QTL 65	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	122654702	136118980	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	49872657	138829559	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	73592512	136118980	Rat
1582219	Bw63	Body weight QTL 63	3.8	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	3	116582412	136118980	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	85062224	136118980	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	85062224	136118980	Rat
7387306	Bw124	Body weight QTL 124	3.2	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	3	104545086	149545086	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	133134628	178134628	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	81425008	141509147	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	70845569	136091483	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	longest distance run on treadmill (CMO:0001406)	3	93829559	138829559	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	112250810	157250810	Rat
2302273	Gluco35	Glucose level QTL 35	5.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	101255536	134750886	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	79649560	177741895	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	96509147	141509147	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	117537367	162537367	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	125116475	170116475	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	110225882	155225882	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	90755164	141509147	Rat
5686842	Rf59	Renal function QTL 59			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	3	122395989	167395989	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	131036586	176036586	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	1	141509147	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	131036586	176036586	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	98651826	167012663	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	125814931	139636791	Rat
1331758	Bp207	Blood pressure QTL 207	2.848		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	110634702	155634702	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	5675975	141509147	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	116188400	161188400	Rat

Markers in Region

RH139756

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	113,962,427 - 113,962,613 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	119,174,087 - 119,174,272	NCBI	Rnor6.0
Rnor_5.0	3	125,699,669 - 125,699,854	UniSTS	Rnor5.0
RGSC_v3.4	3	114,237,334 - 114,237,519	UniSTS	RGSC3.4
Celera	3	112,804,892 - 112,805,077	UniSTS
RH 3.4 Map	3	988.5	UniSTS
Cytogenetic Map	3	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106502	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001430101	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006234916	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008762155	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063283328	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ231922	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ235333	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000015124 ⟹ ENSRNOP00000015124

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	134,415,391 - 134,463,032 (+)	Ensembl
mRatBN7.2 Ensembl	3	113,962,164 - 114,009,665 (+)	Ensembl
Rnor_6.0 Ensembl	3	119,173,818 - 119,222,484 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000120063 ⟹ ENSRNOP00000086524

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	113,962,164 - 114,009,666 (+)	Ensembl

RefSeq Acc Id:

NM_001106502 ⟹ NP_001099972

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	134,415,526 - 134,463,025 (+)	NCBI
mRatBN7.2	3	113,962,159 - 114,009,661 (+)	NCBI
Rnor_6.0	3	119,173,818 - 119,222,484 (+)	NCBI
Rnor_5.0	3	125,699,400 - 125,747,055 (+)	NCBI
RGSC_v3.4	3	114,237,065 - 114,284,543 (+)	RGD
Celera	3	112,804,623 - 112,852,132 (+)	RGD

Sequence:

show sequence

CCGTCGCACGCAATGCGAATCGGGAAGAGGGGATGATCTGCGCTGCTTTGCGTCTGAGAACGGA
GGCTCGTTCTCCTTCTGGTGGTGGGCGATGGGCGTCAGGCGAGAAGGCCGGCGTTAGCGGAGCG
CGGGCGCTGCGCAAGAATCATTCATCATGCCTGCTGTAGCTTCAGTTCCTAAAGAACTCTACCT
CAGTTCTTCACTCAAAGACCTCAATAAGAAGACAGAAGTTAAACCTGAGAAAACCAGCACCAAG
AATTATATACACAGCGCTCAGAAGATTTTCAAGGCAGCAGAAGAATGCAGACTAGATCGTGATG
AGGAAAGGGCCTATGTGCTTTATATGAAATATGTGGCGGTTTATAATCTTATCAAAAAGAGACC
TGATTTCAAGCAACAGCAGGACTATTACCTTTCAATACTTGGACCTGCAAACATCAAAAAGGCT
ATTGAAGAAGCTGAAAGACTCTCTGAGAGCCTCAAACTGAGATACGAAGAGGCTGAAGTTCGGA
AACAGCTTGAAGAAAAGGACAGACGGGAGGAAGAACAGCTGCAGCAACAGAAAAGGCAGGAGAT
GGGAAGAGAGGATAGTGGTGCGGCGGCCAAACGCTCCGTGGAAAATTTACTGGATTCCAAAACC
AAAATCCAAAGGGTCAATGGAGAGAAGAGCGAAGGAGGTGCAGCAGCAGAGAGAGGAGCAGTCA
CAGCAAAGGAGCTATATACAATGATGATGGATAAAAACACAAGCCTGATTATAATGGATGCTCG
GAAAATACAGGATTATCAGCATTCCTGTATCTTGGGCTCTCTCAGTGTTCCTGAAGAAGCTATC
AGTCCAGGAGTCACTGCCAATTGGATTGAAGCAAAGCTTTCAGATGATTCTAAAGACACGTGGA
AAAAAAGGGGGAGTGTGGACTATGTGGTCCTGCTGGACTGGTTTAGTTCAGCGAAAGATTTGCT
GCTCGGGACCACGCTACGGAGTCTGAAAGATGCTCTTTTCAAGTGGGAAAGTAAAGCTGTCCTG
CACCATGAGCCCTTGGTGCTGGAGGGCGGCTATGAGAACTGGCTCCTGTGCTATCCACAGTTCA
CAACAAATGCTAAGGTTACTCCACCCCCTCGGAGCAGGCCTGAAGAGGTGTCTGTCTCATTGGA
TTTTACTTATCCCTCACTGGAAGAACCAGTTCCTTCCAAACTTCCTGCCCAGATGCCACCTCCT
CCTTTAGAAGCAAATGAGAAGGCACAGTTGGTAACTGATCAAGATGGTAAACCGAGACCGTTAG
TCCAGTCGGCTCTAGCCGGACCCAGTGTGGCTCCCAAAGCTGAAGCTTCACCCATAATTCAGCC
AGTGCCTGCTACAAAGAATGTTCCACAGGTTGATCGTACAAAAAAACCAGCAGTTAAGTTGCCT
GAAGATCATAGAATGAAATCTGAAAGTACAGATCAGAGTGGAAGAGTTCTTTCTGACCGATCCA
CCAAGCCAGTATTTACCTCTCCAGCCACCATGCTAACAGATGAAGAAAAGGCTCGCATTCATGA
AGAAACAGCCCTTCTTATGGAAAAGAATAGACAGGAGAAGGAACTGTGGGAAAGGCAGCAGAAG
GAACAGAAAGAGAAGCTGAGAAGGGAGGAACAAGAGCGCAAAGCTGGAAAGACCCAGGATGCAG
AAGAACGGGACTTCACTGAGAATCAGCACAAAGCAAAGGATGGACAAGAGAAGAGAGACAGCAA
ACAGACCAAGGCAGAAGACAGAGAGCCCCCAGCAGATGGGGCCCAGGACGCCACAGGAACGCAA
AGACAAAGTAAGAGTGAACACGATGCTTCCGATGCTAAGGTATCTGTGGAAGGTAAAAGGTGTC
CCATGTCAGAAGTGCAGAAGAGGCCAGCAGATGTGTCGTCTGCATCCTCCATGTCGGGAGAGCT
GAGTGCAGGCAAGGCTCAGCGAGAACCTTTGACAAGAGCAAGAAGTGAAGAAATGGGGAGAATT
GTGCCAGGACTGCCTTTAGGCTGGGCCAAGTTTCTTGATCCAATCACTGGGACTTTTCGTTACT
ACCATTCACCCACAAACACGGTTCACATGTATCCGCCTGAGATGGCTCCTTCGTCTGTGCCTCC
TTCCACCCCTCCCACTCACAAAGTCAAGCCCCAGATCCCTGCTGAGCGGGACAGGGAGCCATCC
AAACTGAAGCGCTCCTACTCCTCACCAGACATCACTCAGGCCCTGCAGGAGGAGGAGAAGAGGA
GGCCAGCAGTGACCCCGACAGTCAACCGGGAGAACAAGCCGCCGTGTTACCCTAAAGCTGAGAT
CTCGAGGCTTTCTGCTTCTCAGATTCGGAACCTCAATCCCGTTTTTGGAGGATCTGGACCAGCT
CTTACTGGACTTCGTAATTTGGGAAATACTTGTTACATGAACTCAATATTACAGTGCCTGTGCA
ATGCTCCACATTTGGCTGATTATTTCAACCGAAACTGCTACCAGGACGATATCAACAGGTCAAA
TTTGTTGGGGCATAAAGGTGAAGTGGCAGAAGAATTTGGTATAATCATGAAGGCACTGTGGACA
GGACAGTATAGATACATCAGTCCAAAAGACTTTAAAGTCACCATTGGTAAGATTAATGACCAGT
TTGCAGGATCCAGCCAGCAAGATTCACAAGAGCTGCTGCTTTTCCTCATGGATGGCCTCCACGA
GGATCTAAATAAGGCTGACAATCGGAAGAGGCATAAGGAAGAGAACAATGACCACCTCGATGAC
TTTAAAGCGGCAGAACATGCCTGGCAGAAGCACAAGCAGCTCAATGAGTCCATTATTGTCGCAC
TCTTTCAGGGTCAGTTCAAATCCACAGTGCAGTGCCTCACCTGTCACAAGAAGTCTCGGACATT
CGAGGCTTTCATGTATTTGTCTTTGCCACTAGCATCCACAAGTAAATGTACTTTACAGGACTGC
CTTAGATTATTTTCCAAAGAAGAAAAGCTTACAGATAACAACAGATTTTACTGCAGCCATTGCC
GAGCTCGGCGGGATTCTCTAAAGAAAATAGAAATCTGGAAATTGCCTCCTGTGCTGTTAGTACA
CCTGAAACGATTCTCCTATGACGGCAGGTGGAAGCAGAAACTGCAAACGTCCGTGGATTTCCCA
TTAGAAAATCTTGACCTGTCACAGTATGTTATTGGCCCAAAAAGCAGTTTGAAGAAATATAACT
TGTTTTCTGTTTCAAACCACTACGGCGGGCTCGATGGAGGCCACTACACGGCCTATTGTAAAAA
CGCGGCGAGGCAGCGCTGGTTTAAGTTTGATGACCACGAGGTTTCGGACATCTCCGTGTCTTCT
GTGAGGTCGTCAGCAGCTTATATCCTGTTTTACACCTCCCTGGGGCCACGCGTGACTGAGGCAG
CCACATAACAAGGCGTAGGGTATGGGGTGACATTTCTACATTGCAGCAGCACATCTAATGCTTA
GAGATCATGGCTCGCTGCAGCCGCTATGCAGAGGAGCCCAGAACACTGGGGGCTGTGCTACTAG
CACCATAGAATTCAGGTCAGTGCTGTTTATCAAAAAAGAAAGAAAAAACCCTGACATTTAACAA
CTATCATAGTGCACATTCCTTACAGGAATCATTTATTTCAAAACAACTTTTTGAGTCTGCCCCA
AAGTTAAATAATTCATTAGCCAGACATTTATTATTCTATTGGTACCAAACCATTGTAACCTCCA
TTTTCCTATCCACTGCTCTAGCCTCTTCCTACTTCTGTCCCAGCTCGACCCACTGAACTCTCTA
GAATGGCCTAACCCAGATAGGAATGTATGTGTACATATTTACTGCACTGCTGCACATCAGACCA
CTGTACATACTTAACAGATCCTCTGTGGACGCCTAGAAAGCATCCGTCCTTTTTCTTCCCACCT
CTTCTAGGTAGCTGCAATGCTTCCTTAGGGAAATGACAGGGCAAAATTATTTTTCTGTTGGCTT
CCGGCTGTATTTGTGCACTAAATCTTTATTCTAAAAAATGGAAACTTTAATTTTTTAAAAATAA
TTCATTTACATCTACATTAAAATCTTAACGAGG

hide sequence

RefSeq Acc Id:

XM_006234916 ⟹ XP_006234978

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	134,413,832 - 134,463,040 (+)	NCBI
mRatBN7.2	3	113,962,140 - 114,009,683 (+)	NCBI
Rnor_6.0	3	119,173,823 - 119,222,499 (+)	NCBI
Rnor_5.0	3	125,699,400 - 125,747,055 (+)	NCBI

Sequence:

show sequence

GCACGCAATGCGAATCGGGAAGAGGGGATGATCTGCGCTGCTTTGCGTCTGAGAACGGAGGCTC
GTTCTCCTTCTGGTGGTGGGCGATGGGCGTCAGGCGAGAAGGCCGGCGTTAGCGGAGCGCGGGC
GCTGCGGAAAGAACTACTTTTCATGAACCACATTATCCGTTTGTTGAAGTAGAAAAGCAAGAAT
CATTCATCATGCCTGCTGTAGCTTCAGTTCCTAAAGAACTCTACCTCAGTTCTTCACTCAAAGA
CCTCAATAAGAAGACAGAAGTTAAACCTGAGAAAACCAGCACCAAGAATTATATACACAGCGCT
CAGAAGATTTTCAAGGCAGCAGAAGAATGCAGACTAGATCGTGATGAGGAAAGGGCCTATGTGC
TTTATATGAAATATGTGGCGGTTTATAATCTTATCAAAAAGAGACCTGATTTCAAGCAACAGCA
GGACTATTACCTTTCAATACTTGGACCTGCAAACATCAAAAAGGCTATTGAAGAAGCTGAAAGA
CTCTCTGAGAGCCTCAAACTGAGATACGAAGAGGCTGAAGTTCGGAAACAGCTTGAAGAAAAGG
ACAGACGGGAGGAAGAACAGCTGCAGCAACAGAAAAGGCAGGAGATGGGAAGAGAGGATAGTGG
TGCGGCGGCCAAACGCTCCGTGGAAAATTTACTGGATTCCAAAACCAAAATCCAAAGGGTCAAT
GGAGAGAAGAGCGAAGGAGGTGCAGCAGCAGAGAGAGGAGCAGTCACAGCAAAGGAGCTATATA
CAATGATGATGGATAAAAACACAAGCCTGATTATAATGGATGCTCGGAAAATACAGGATTATCA
GCATTCCTGTATCTTGGGCTCTCTCAGTGTTCCTGAAGAAGCTATCAGTCCAGGAGTCACTGCC
AATTGGATTGAAGCAAAGCTTTCAGATGATTCTAAAGACACGTGGAAAAAAAGGGGGAGTGTGG
ACTATGTGGTCCTGCTGGACTGGTTTAGTTCAGCGAAAGATTTGCTGCTCGGGACCACGCTACG
GAGTCTGAAAGATGCTCTTTTCAAGTGGGAAAGTAAAGCTGTCCTGCACCATGAGCCCTTGGTG
CTGGAGGGCGGCTATGAGAACTGGCTCCTGTGCTATCCACAGTTCACAACAAATGCTAAGGTTA
CTCCACCCCCTCGGAGCAGGCCTGAAGAGGTGTCTGTCTCATTGGATTTTACTTATCCCTCACT
GGAAGAACCAGTTCCTTCCAAACTTCCTGCCCAGATGCCACCTCCTCCTTTAGAAGCAAATGAG
AAGGCACAGTTGGTAACTGATCAAGATGGTAAACCGAGACCGTTAGTCCAGTCGGCTCTAGCCG
GACCCAGTGTGGCTCCCAAAGCTGAAGCTTCACCCATAATTCAGCCAGTGCCTGCTACAAAGAA
TGTTCCACAGGTTGATCGTACAAAAAAACCAGCAGTTAAGTTGCCTGAAGATCATAGAATGAAA
TCTGAAAGTACAGATCAGAGTGGAAGAGTTCTTTCTGACCGATCCACCAAGCCAGTATTTACCT
CTCCAGCCACCATGCTAACAGATGAAGAAAAGGCTCGCATTCATGAAGAAACAGCCCTTCTTAT
GGAAAAGAATAGACAGGAGAAGGAACTGTGGGAAAGGCAGCAGAAGGAACAGAAAGAGAAGCTG
AGAAGGGAGGAACAAGAGCGCAAAGCTGGAAAGACCCAGGATGCAGAAGAACGGGACTTCACTG
AGAATCAGCACAAAGCAAAGGATGGACAAGAGAAGAGAGACAGCAAACAGACCAAGGCAGAAGA
CAGAGAGCCCCCAGCAGATGGGGCCCAGGACGCCACAGGAACGCAAAGACAAAGTAAGAGTGAA
CACGATGCTTCCGATGCTAAGGTATCTGTGGAAGGTAAAAGGTGTCCCATGTCAGAAGTGCAGA
AGAGGCCAGCAGATGTGTCGTCTGCATCCTCCATGTCGGGAGAGCTGAGTGCAGGCAAGGCTCA
GCGAGAACCTTTGACAAGAGCAAGAAGTGAAGAAATGGGGAGAATTGTGCCAGGACTGCCTTTA
GGCTGGGCCAAGTTTCTTGATCCAATCACTGGGACTTTTCGTTACTACCATTCACCCACAAACA
CGGTTCACATGTATCCGCCTGAGATGGCTCCTTCGTCTGTGCCTCCTTCCACCCCTCCCACTCA
CAAAGTCAAGCCCCAGATCCCTGCTGAGCGGGACAGGGAGCCATCCAAACTGAAGCGCTCCTAC
TCCTCACCAGACATCACTCAGGCCCTGCAGGAGGAGGAGAAGAGGAGGCCAGCAGTGACCCCGA
CAGTCAACCGGGAGAACAAGCCGCCGTGTTACCCTAAAGCTGAGATCTCGAGGCTTTCTGCTTC
TCAGATTCGGAACCTCAATCCCGTTTTTGGAGGATCTGGACCAGCTCTTACTGGACTTCGTAAT
TTGGGAAATACTTGTTACATGAACTCAATATTACAGTGCCTGTGCAATGCTCCACATTTGGCTG
ATTATTTCAACCGAAACTGCTACCAGGACGATATCAACAGGTCAAATTTGTTGGGGCATAAAGG
TGAAGTGGCAGAAGAATTTGGTATAATCATGAAGGCACTGTGGACAGGACAGTATAGATACATC
AGTCCAAAAGACTTTAAAGTCACCATTGGTAAGATTAATGACCAGTTTGCAGGATCCAGCCAGC
AAGATTCACAAGAGCTGCTGCTTTTCCTCATGGATGGCCTCCACGAGGATCTAAATAAGGCTGA
CAATCGGAAGAGGCATAAGGAAGAGAACAATGACCACCTCGATGACTTTAAAGCGGCAGAACAT
GCCTGGCAGAAGCACAAGCAGCTCAATGAGTCCATTATTGTCGCACTCTTTCAGGGTCAGTTCA
AATCCACAGTGCAGTGCCTCACCTGTCACAAGAAGTCTCGGACATTCGAGGCTTTCATGTATTT
GTCTTTGCCACTAGCATCCACAAGTAAATGTACTTTACAGGACTGCCTTAGATTATTTTCCAAA
GAAGAAAAGCTTACAGATAACAACAGATTTTACTGCAGCCATTGCCGAGCTCGGCGGGATTCTC
TAAAGAAAATAGAAATCTGGAAATTGCCTCCTGTGCTGTTAGTACACCTGAAACGATTCTCCTA
TGACGGCAGGTGGAAGCAGAAACTGCAAACGTCCGTGGATTTCCCATTAGAAAATCTTGACCTG
TCACAGTATGTTATTGGCCCAAAAAGCAGTTTGAAGAAATATAACTTGTTTTCTGTTTCAAACC
ACTACGGCGGGCTCGATGGAGGCCACTACACGGCCTATTGTAAAAACGCGGCGAGGCAGCGCTG
GTTTAAGTTTGATGACCACGAGGTTTCGGACATCTCCGTGTCTTCTGTGAGGTCGTCAGCAGCT
TATATCCTGTTTTACACCTCCCTGGGGCCACGCGTGACTGAGGCAGCCACATAACAAGGCGTAG
GGTATGGGGTGACATTTCTACATTGCAGCAGCACATCTAATGCTTAGAGATCATGGCTCGCTGC
AGCCGCTATGCAGAGGAGCCCAGAACACTGGGGGCTGTGCTACTAGCACCATAGAATTCAGGTC
AGTGCTGTTTATCAAAAAAGAAAGAAAAAACCCTGACATTTAACAACTATCATAGTGCACATTC
CTTACAGGAATCATTTATTTCAAAACAACTTTTTGAGTCTGCCCCAAAGTTAAATAATTCATTA
GCCAGACATTTATTATTCTATTGGTACCAAACCATTGTAACCTCCATTTTCCTATCCACTGCTC
TAGCCTCTTCCTACTTCTGTCCCAGCTCGACCCACTGAACTCTCTAGAATGGCCTAACCCAGAT
AGGAATGTATGTGTACATATTTACTGCACTGCTGCACATCAGACCACTGTACATACTTAACAGA
TCCTCTGTGGACGCCTAGAAAGCATCCGTCCTTTTTCTTCCCACCTCTTCTAGGTAGCTGCAAT
GCTTCCTTAGGGAAATGACAGGGCAAAATTATTTTTCTGTTGGCTTCCGGCTGTATTTGTGCAC
TAAATCTTTATTCTAAAAAATGGAAACTTTAATTTTTTAAAAATAATTCATTTACATCTACATT
AAAATCTTAACGAGGAAAACTCATTTGAAA

hide sequence

RefSeq Acc Id:

XM_063283328 ⟹ XP_063139398

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	134,413,832 - 134,456,180 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001099972	(Get FASTA)	NCBI Sequence Viewer
	NP_001417030	(Get FASTA)	NCBI Sequence Viewer
	XP_006234978	(Get FASTA)	NCBI Sequence Viewer
	XP_063139398	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL80091	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000015124
	ENSRNOP00000015124.6

RefSeq Acc Id:

NP_001099972 ⟸ NM_001106502

- UniProtKB:

D3ZN39 (UniProtKB/TrEMBL), A6HPZ0 (UniProtKB/TrEMBL), A0A8I6A1E0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPAVASVPKELYLSSSLKDLNKKTEVKPEKTSTKNYIHSAQKIFKAAEECRLDRDEERAYVLYM
KYVAVYNLIKKRPDFKQQQDYYLSILGPANIKKAIEEAERLSESLKLRYEEAEVRKQLEEKDRR
EEEQLQQQKRQEMGREDSGAAAKRSVENLLDSKTKIQRVNGEKSEGGAAAERGAVTAKELYTMM
MDKNTSLIIMDARKIQDYQHSCILGSLSVPEEAISPGVTANWIEAKLSDDSKDTWKKRGSVDYV
VLLDWFSSAKDLLLGTTLRSLKDALFKWESKAVLHHEPLVLEGGYENWLLCYPQFTTNAKVTPP
PRSRPEEVSVSLDFTYPSLEEPVPSKLPAQMPPPPLEANEKAQLVTDQDGKPRPLVQSALAGPS
VAPKAEASPIIQPVPATKNVPQVDRTKKPAVKLPEDHRMKSESTDQSGRVLSDRSTKPVFTSPA
TMLTDEEKARIHEETALLMEKNRQEKELWERQQKEQKEKLRREEQERKAGKTQDAEERDFTENQ
HKAKDGQEKRDSKQTKAEDREPPADGAQDATGTQRQSKSEHDASDAKVSVEGKRCPMSEVQKRP
ADVSSASSMSGELSAGKAQREPLTRARSEEMGRIVPGLPLGWAKFLDPITGTFRYYHSPTNTVH
MYPPEMAPSSVPPSTPPTHKVKPQIPAERDREPSKLKRSYSSPDITQALQEEEKRRPAVTPTVN
RENKPPCYPKAEISRLSASQIRNLNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYF
NRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKVTIGKINDQFAGSSQQDS
QELLLFLMDGLHEDLNKADNRKRHKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKST
VQCLTCHKKSRTFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKK
IEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKSSLKKYNLFSVSNHYG
GLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVRSSAAYILFYTSLGPRVTEAAT

hide sequence

RefSeq Acc Id:

XP_006234978 ⟸ XM_006234916

- Peptide Label:

isoform X1

- Sequence:

show sequence

MPAVASVPKELYLSSSLKDLNKKTEVKPEKTSTKNYIHSAQKIFKAAEECRLDRDEERAYVLYM
KYVAVYNLIKKRPDFKQQQDYYLSILGPANIKKAIEEAERLSESLKLRYEEAEVRKQLEEKDRR
EEEQLQQQKRQEMGREDSGAAAKRSVENLLDSKTKIQRVNGEKSEGGAAAERGAVTAKELYTMM
MDKNTSLIIMDARKIQDYQHSCILGSLSVPEEAISPGVTANWIEAKLSDDSKDTWKKRGSVDYV
VLLDWFSSAKDLLLGTTLRSLKDALFKWESKAVLHHEPLVLEGGYENWLLCYPQFTTNAKVTPP
PRSRPEEVSVSLDFTYPSLEEPVPSKLPAQMPPPPLEANEKAQLVTDQDGKPRPLVQSALAGPS
VAPKAEASPIIQPVPATKNVPQVDRTKKPAVKLPEDHRMKSESTDQSGRVLSDRSTKPVFTSPA
TMLTDEEKARIHEETALLMEKNRQEKELWERQQKEQKEKLRREEQERKAGKTQDAEERDFTENQ
HKAKDGQEKRDSKQTKAEDREPPADGAQDATGTQRQSKSEHDASDAKVSVEGKRCPMSEVQKRP
ADVSSASSMSGELSAGKAQREPLTRARSEEMGRIVPGLPLGWAKFLDPITGTFRYYHSPTNTVH
MYPPEMAPSSVPPSTPPTHKVKPQIPAERDREPSKLKRSYSSPDITQALQEEEKRRPAVTPTVN
RENKPPCYPKAEISRLSASQIRNLNPVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYF
NRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKVTIGKINDQFAGSSQQDS
QELLLFLMDGLHEDLNKADNRKRHKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKST
VQCLTCHKKSRTFEAFMYLSLPLASTSKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKK
IEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLENLDLSQYVIGPKSSLKKYNLFSVSNHYG
GLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSVRSSAAYILFYTSLGPRVTEAAT

hide sequence

Ensembl Acc Id:

ENSRNOP00000015124 ⟸ ENSRNOT00000015124

Ensembl Acc Id:

ENSRNOP00000086524 ⟸ ENSRNOT00000120063

RefSeq Acc Id:	XP_063139398 ⟸ XM_063283328
- Peptide Label:	isoform X2

Protein Domains

Rhodanese USP

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZN39-F1-model_v2	AlphaFold	D3ZN39	1-1081	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692391

Promoter ID:

EPDNEW_R2916

Type:

initiation region

Name:

Usp8_1

Description:

ubiquitin specific peptidase 8

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	119,173,852 - 119,173,912	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1304979	AgrOrtholog
BioCyc Gene	G2FUF-48018	BioCyc
Ensembl Genes	ENSRNOG00000010729	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000015124	ENTREZGENE
	ENSRNOT00000015124.8	UniProtKB/TrEMBL
Gene3D-CATH	3.40.250.10	UniProtKB/TrEMBL
	Cysteine proteinases	UniProtKB/TrEMBL
	Phosphotransferase system, lactose/cellobiose-type IIA subunit	UniProtKB/TrEMBL
InterPro	DUF1873	UniProtKB/TrEMBL
	Papain_like_cys_pep_sf	UniProtKB/TrEMBL
	Pept_C19ubi-hydrolase_C_CS	UniProtKB/TrEMBL
	Peptidase_C19	UniProtKB/TrEMBL
	Rhodanese-like_dom	UniProtKB/TrEMBL
	Rhodanese-like_dom_sf	UniProtKB/TrEMBL
	Ub_carboxyl-term_hydrolase	UniProtKB/TrEMBL
	UCH/PAN2	UniProtKB/TrEMBL
	WW_USP8	UniProtKB/TrEMBL
KEGG Report	rno:296121	UniProtKB/TrEMBL
NCBI Gene	296121	ENTREZGENE
PANTHER	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE	UniProtKB/TrEMBL
	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 8	UniProtKB/TrEMBL
Pfam	DUF1873	UniProtKB/TrEMBL
	Rhodanese	UniProtKB/TrEMBL
	UCH	UniProtKB/TrEMBL
	WW_USP8	UniProtKB/TrEMBL
PhenoGen	Usp8	PhenoGen
PROSITE	RHODANESE_3	UniProtKB/TrEMBL
	UCH_2_1	UniProtKB/TrEMBL
	UCH_2_2	UniProtKB/TrEMBL
	UCH_2_3	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000010729	RatGTEx
SMART	RHOD	UniProtKB/TrEMBL
Superfamily-SCOP	Rhodanese-like	UniProtKB/TrEMBL
	SSF54001	UniProtKB/TrEMBL
	USP8 N-terminal domain-like	UniProtKB/TrEMBL
UniProt	A0A8I6A1E0	ENTREZGENE
	A6HPZ0	ENTREZGENE, UniProtKB/TrEMBL
	D3ZN39	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-04	Usp8	ubiquitin specific peptidase 8	Usp8_predicted	ubiquitin specific protease 8 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-12	Usp8_predicted	ubiquitin specific protease 8 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)