Mrtfa (myocardin related transcription factor A) - Rat Genome Database

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Gene: Mrtfa (myocardin related transcription factor A) Rattus norvegicus
Analyze
Symbol: Mrtfa
Name: myocardin related transcription factor A
RGD ID: 1304873
Description: Predicted to enable several functions, including actin monomer binding activity; leucine zipper domain binding activity; and transcription coactivator activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of cell differentiation; and positive regulation of collagen biosynthetic process. Located in cytosol and nucleus. Is active in glutamatergic synapse; postsynapse; and presynapse. Biomarker of Alzheimer's disease and transient cerebral ischemia. Human ortholog(s) of this gene implicated in acute megakaryocytic leukemia and immunodeficiency 66. Orthologous to human MRTFA (myocardin related transcription factor A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: basic, SAP, and coiled-coil domain containing protein; BSAC; FLMKL1; LOC315151; megakaryoblastic leukemia (translocation) 1; megakaryoblastic leukemia 1 met; MELODY; MKL/myocardin-like protein 1; Mkl1; MKL1-elongated derivative of yield protein; MKL1met; Mrtf-a; myocardin-related transcription factor A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87114,424,481 - 114,594,594 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7114,424,481 - 114,594,594 (-)EnsemblGRCr8
mRatBN7.27112,544,305 - 112,714,418 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7112,544,312 - 112,714,418 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7114,306,865 - 114,477,102 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07116,530,410 - 116,700,653 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07116,499,783 - 116,670,016 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07122,233,196 - 122,403,661 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7122,234,012 - 122,403,667 (-)Ensemblrn6Rnor6.0
Rnor_5.07122,217,533 - 122,387,766 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47119,306,220 - 119,415,012 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7108,866,997 - 109,036,998 (-)NCBICelera
RGSC_v3.17119,340,456 - 119,511,326 (-)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IDA,IEA,ISO)
cytosol  (IDA)
glutamatergic synapse  (IDA,IEP,IMP)
nuclear membrane  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IDA,IEA,ISO)
postsynapse  (IDA,IEP)
presynapse  (IDA,IEP)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Nuclear translocation of myocardin-related transcription factor-A during transforming growth factor beta-induced epithelial to mesenchymal transition of lens epithelial cells. Gupta M, etal., Mol Vis. 2013 May 6;19:1017-28. Print 2013.
4. Role of megakaryoblastic acute leukemia-1 in ERK1/2-dependent stimulation of serum response factor-driven transcription by BDNF or increased synaptic activity. Kalita K, etal., J Neurosci. 2006 Sep 27;26(39):10020-32.
5. Synaptic localisation of SRF coactivators, MKL1 and MKL2, and their role in dendritic spine morphology. Kaneda M, etal., Sci Rep. 2018 Jan 15;8(1):727. doi: 10.1038/s41598-017-18905-7.
6. C1q/tumor necrosis factor-related protein-6 attenuates post-infarct cardiac fibrosis by targeting RhoA/MRTF-A pathway and inhibiting myofibroblast differentiation. Lei H, etal., Basic Res Cardiol. 2015;110(4):35. doi: 10.1007/s00395-015-0492-7. Epub 2015 May 12.
7. Opposite effects of HDAC5 and p300 on MRTF-A-related neuronal apoptosis during ischemia/reperfusion injury in rats. Li N, etal., Cell Death Dis. 2017 Feb 23;8(2):e2624. doi: 10.1038/cddis.2017.16.
8. Myocardin-related transcription factor-A induces cardiomyocyte hypertrophy. Liao XH, etal., IUBMB Life. 2011 Jan;63(1):54-61. doi: 10.1002/iub.415.
9. Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Ma Z, etal., Nat Genet. 2001 Jul;28(3):220-1.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Deletion of Fn14 receptor protects from right heart fibrosis and dysfunction. Novoyatleva T, etal., Basic Res Cardiol. 2013 Mar;108(2):325. doi: 10.1007/s00395-012-0325-x. Epub 2013 Jan 17.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Myocardin and myocardin-related transcription factor-A synergistically mediate actin cytoskeletal-dependent inhibition of liver fibrogenesis. Shi Z, etal., Am J Physiol Gastrointest Liver Physiol. 2020 Mar 1;318(3):G504-G517. doi: 10.1152/ajpgi.00302.2019. Epub 2020 Jan 13.
17. Myocardin-related transcription factor A (MRTF-A) plays an essential role in hepatic stellate cell activation by epigenetically modulating TGF-beta signaling. Tian W, etal., Int J Biochem Cell Biol. 2016 Feb;71:35-43. doi: 10.1016/j.biocel.2015.12.005. Epub 2015 Dec 13.
18. Myocardin-related transcription factor-A is a key regulator in retinoic acid-induced neural-like differentiation of adult bone marrow-derived mesenchymal stem cells. Wang N, etal., Gene. 2013 Jul 10;523(2):178-86. doi: 10.1016/j.gene.2013.03.043. Epub 2013 Mar 27.
19. Vascular endothelial growth factor stimulates endothelial differentiation from mesenchymal stem cells via Rho/myocardin-related transcription factor--a signaling pathway. Wang N, etal., Int J Biochem Cell Biol. 2013 Jul;45(7):1447-56. doi: 10.1016/j.biocel.2013.04.021. Epub 2013 Apr 24.
20. KLF15 is an essential negative regulatory factor for the cardiac remodeling response to pressure overload. Yu Y, etal., Cardiology. 2015;130(3):143-52. doi: 10.1159/000369382. Epub 2015 Jan 24.
21. The role of myocardin-related transcription factor-A in Aβ25-35 induced neuron apoptosis and synapse injury. Zhang Y, etal., Brain Res. 2016 Oct 1;1648(Pt A):27-34. doi: 10.1016/j.brainres.2016.07.003. Epub 2016 Jul 5.
22. Anti-apoptotic effects of myocardin-related transcription factor-A on rat cardiomyocytes following hypoxia-induced injury. Zhong Z, etal., Can J Physiol Pharmacol. 2016 Apr;94(4):379-87. doi: 10.1139/cjpp-2014-0461. Epub 2015 Sep 11.
Additional References at PubMed
PMID:12019265   PMID:12732141   PMID:14970199   PMID:15292266   PMID:15798203   PMID:16987998   PMID:17588931   PMID:17991879   PMID:18945672   PMID:19350017   PMID:20016002   PMID:20534669  
PMID:20847050   PMID:21333636   PMID:21776010   PMID:21984612   PMID:22049076   PMID:23283978   PMID:24251100   PMID:24440334   PMID:24589521   PMID:24647044   PMID:24732378   PMID:25106095  
PMID:25446180   PMID:26719331   PMID:26759173   PMID:28712960   PMID:29391067   PMID:32125053   PMID:34205257   PMID:35829871   PMID:36046946  


Genomics

Comparative Map Data
Mrtfa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87114,424,481 - 114,594,594 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7114,424,481 - 114,594,594 (-)EnsemblGRCr8
mRatBN7.27112,544,305 - 112,714,418 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7112,544,312 - 112,714,418 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7114,306,865 - 114,477,102 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07116,530,410 - 116,700,653 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07116,499,783 - 116,670,016 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07122,233,196 - 122,403,661 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7122,234,012 - 122,403,667 (-)Ensemblrn6Rnor6.0
Rnor_5.07122,217,533 - 122,387,766 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47119,306,220 - 119,415,012 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7108,866,997 - 109,036,998 (-)NCBICelera
RGSC_v3.17119,340,456 - 119,511,326 (-)NCBI
Cytogenetic Map7q34NCBI
MRTFA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382240,410,289 - 40,636,719 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2240,410,281 - 40,636,719 (-)Ensemblhg38GRCh38
GRCh372240,806,293 - 41,032,723 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362239,136,238 - 39,362,636 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342239,130,791 - 39,357,190NCBI
Celera2224,608,353 - 24,836,358 (-)NCBICelera
Cytogenetic Map22q13.1-q13.2NCBI
HuRef2223,769,395 - 23,994,500 (-)NCBIHuRef
CHM1_12240,765,195 - 40,992,703 (-)NCBICHM1_1
T2T-CHM13v2.02240,880,672 - 41,108,683 (-)NCBIT2T-CHM13v2.0
Mrtfa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391580,896,482 - 81,074,937 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1580,896,482 - 81,074,958 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381581,012,281 - 81,190,736 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1581,012,281 - 81,190,757 (-)Ensemblmm10GRCm38
MGSCv371580,842,711 - 81,021,187 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361580,840,540 - 80,932,073 (-)NCBIMGSCv36mm8
Celera1583,132,403 - 83,308,218 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.98NCBI
Mrtfa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541326,139,843 - 26,222,580 (-)Ensembl
ChiLan1.0NW_00495541326,139,060 - 26,311,272 (-)NCBIChiLan1.0ChiLan1.0
MRTFA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22350,247,445 - 50,469,280 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12252,950,372 - 53,172,160 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02221,314,829 - 21,536,673 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12239,411,890 - 39,581,958 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2239,413,002 - 39,467,402 (-)EnsemblpanPan2panpan1.1
MRTFA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11024,561,161 - 24,759,586 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1024,561,161 - 24,759,081 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1024,496,201 - 24,694,602 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01025,311,403 - 25,509,948 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1025,311,348 - 25,509,944 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11025,024,155 - 25,222,271 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01025,346,404 - 25,544,515 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01025,520,463 - 25,718,833 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mrtfa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049458,223,715 - 8,374,424 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364921,282,674 - 1,383,696 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364921,234,025 - 1,384,838 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRTFA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl57,959,312 - 7,972,574 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.157,751,350 - 7,975,927 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.254,981,649 - 5,208,382 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MRTFA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11922,980,071 - 23,197,199 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1922,981,216 - 23,034,179 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666045102,390,890 - 102,610,530 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mrtfa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247527,878,876 - 8,050,274 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247527,836,545 - 8,050,176 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mrtfa
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11250,766,542 - 250,939,413 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mrtfa
934 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:50
Interacting mature miRNAs:54
Transcripts:ENSRNOT00000032232, ENSRNOT00000064515
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
RH138158  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27112,630,466 - 112,630,678 (+)MAPPERmRatBN7.2
Rnor_6.07122,319,607 - 122,319,818NCBIRnor6.0
Rnor_5.07122,303,718 - 122,303,929UniSTSRnor5.0
RGSC_v3.47119,392,559 - 119,392,770UniSTSRGSC3.4
Celera7108,953,157 - 108,953,368UniSTS
RH 3.4 Map7876.7UniSTS
Cytogenetic Map7q34UniSTS
AW821984  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27112,544,379 - 112,544,531 (+)MAPPERmRatBN7.2
Rnor_6.07122,233,264 - 122,233,415NCBIRnor6.0
Rnor_5.07122,217,601 - 122,217,752UniSTSRnor5.0
RGSC_v3.47119,306,294 - 119,306,445UniSTSRGSC3.4
Celera7108,867,065 - 108,867,216UniSTS
Cytogenetic Map7q34UniSTS
RH128003  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27112,544,490 - 112,544,706 (+)MAPPERmRatBN7.2
Rnor_6.07122,233,375 - 122,233,590NCBIRnor6.0
Rnor_5.07122,217,712 - 122,217,927UniSTSRnor5.0
RGSC_v3.47119,306,405 - 119,306,620UniSTSRGSC3.4
Celera7108,867,176 - 108,867,391UniSTS
Cytogenetic Map7q34UniSTS
RH131243  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27112,543,882 - 112,544,063 (+)MAPPERmRatBN7.2
Rnor_6.07122,232,767 - 122,232,947NCBIRnor6.0
Rnor_5.07122,217,104 - 122,217,284UniSTSRnor5.0
RGSC_v3.47119,305,797 - 119,305,977UniSTSRGSC3.4
Celera7108,866,568 - 108,866,748UniSTS
RH 3.4 Map7876.7UniSTS
Cytogenetic Map7q34UniSTS
BF388535  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27112,546,360 - 112,546,555 (+)MAPPERmRatBN7.2
Rnor_6.07122,235,245 - 122,235,439NCBIRnor6.0
Rnor_5.07122,219,582 - 122,219,776UniSTSRnor5.0
RGSC_v3.47119,308,275 - 119,308,469UniSTSRGSC3.4
Celera7108,869,046 - 108,869,240UniSTS
RH 3.4 Map7876.6UniSTS
Cytogenetic Map7q34UniSTS
Mkl1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27112,550,522 - 112,552,060 (+)MAPPERmRatBN7.2
Rnor_6.07122,239,407 - 122,240,944NCBIRnor6.0
Rnor_5.07122,223,744 - 122,225,281UniSTSRnor5.0
RGSC_v3.47119,312,437 - 119,313,974UniSTSRGSC3.4
Celera7108,873,208 - 108,874,745UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 92 59 6 356 192 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000032232   ⟹   ENSRNOP00000029616
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7114,424,481 - 114,520,539 (-)Ensembl
mRatBN7.2 Ensembl7112,544,314 - 112,640,313 (-)Ensembl
Rnor_6.0 Ensembl7122,234,012 - 122,329,443 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000064515   ⟹   ENSRNOP00000062311
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7114,424,481 - 114,520,483 (-)Ensembl
mRatBN7.2 Ensembl7112,544,312 - 112,555,314 (-)Ensembl
Rnor_6.0 Ensembl7122,234,210 - 122,247,139 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078345   ⟹   ENSRNOP00000070219
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7114,425,411 - 114,531,985 (-)Ensembl
mRatBN7.2 Ensembl7112,545,235 - 112,651,807 (-)Ensembl
Rnor_6.0 Ensembl7122,234,119 - 122,340,943 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088814   ⟹   ENSRNOP00000072830
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7114,424,481 - 114,594,594 (-)Ensembl
mRatBN7.2 Ensembl7112,544,312 - 112,714,418 (-)Ensembl
Rnor_6.0 Ensembl7122,234,119 - 122,403,667 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097041   ⟹   ENSRNOP00000076559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7114,424,481 - 114,594,594 (-)Ensembl
mRatBN7.2 Ensembl7112,544,312 - 112,714,418 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099618   ⟹   ENSRNOP00000078244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7114,424,481 - 114,435,470 (-)Ensembl
mRatBN7.2 Ensembl7112,544,312 - 112,555,294 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108877   ⟹   ENSRNOP00000087120
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7114,424,481 - 114,456,144 (-)Ensembl
mRatBN7.2 Ensembl7112,544,312 - 112,575,968 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000113613   ⟹   ENSRNOP00000076961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7114,424,481 - 114,466,594 (-)Ensembl
mRatBN7.2 Ensembl7112,544,312 - 112,553,841 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117655   ⟹   ENSRNOP00000078054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7114,424,481 - 114,594,594 (-)Ensembl
mRatBN7.2 Ensembl7112,544,312 - 112,714,418 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117917   ⟹   ENSRNOP00000088123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7114,424,481 - 114,469,989 (-)Ensembl
mRatBN7.2 Ensembl7112,544,312 - 112,590,012 (-)Ensembl
RefSeq Acc Id: NM_001401049   ⟹   NP_001387978
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87114,424,481 - 114,594,594 (-)NCBI
mRatBN7.27112,544,305 - 112,714,418 (-)NCBI
Ensembl Acc Id: ENSRNOP00000070219   ⟸   ENSRNOT00000078345
Ensembl Acc Id: ENSRNOP00000029616   ⟸   ENSRNOT00000032232
Ensembl Acc Id: ENSRNOP00000072830   ⟸   ENSRNOT00000088814
Ensembl Acc Id: ENSRNOP00000062311   ⟸   ENSRNOT00000064515
Ensembl Acc Id: ENSRNOP00000087120   ⟸   ENSRNOT00000108877
Ensembl Acc Id: ENSRNOP00000088123   ⟸   ENSRNOT00000117917
Ensembl Acc Id: ENSRNOP00000076559   ⟸   ENSRNOT00000097041
Ensembl Acc Id: ENSRNOP00000078244   ⟸   ENSRNOT00000099618
Ensembl Acc Id: ENSRNOP00000076961   ⟸   ENSRNOT00000113613
Ensembl Acc Id: ENSRNOP00000078054   ⟸   ENSRNOT00000117655
RefSeq Acc Id: NP_001387978   ⟸   NM_001401049
- UniProtKB: A0A0G2K3Y9 (UniProtKB/TrEMBL)
Protein Domains
SAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JXC5-F1-model_v2 AlphaFold A0A0G2JXC5 1-1038 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695505
Promoter ID:EPDNEW_R6029
Type:multiple initiation site
Name:Mkl1_1
Description:megakaryoblastic leukemia 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6030  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07122,329,452 - 122,329,512EPDNEW
RGD ID:13695506
Promoter ID:EPDNEW_R6030
Type:multiple initiation site
Name:Mkl1_2
Description:megakaryoblastic leukemia 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6029  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07122,403,765 - 122,403,825EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304873 AgrOrtholog
BioCyc Gene G2FUF-32687 BioCyc
Ensembl Genes ENSRNOG00000018803 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032232.9 UniProtKB/TrEMBL
  ENSRNOT00000064515.3 UniProtKB/TrEMBL
  ENSRNOT00000078345.3 UniProtKB/TrEMBL
  ENSRNOT00000088814 ENTREZGENE
  ENSRNOT00000088814.3 UniProtKB/TrEMBL
  ENSRNOT00000097041.2 UniProtKB/TrEMBL
  ENSRNOT00000099618.2 UniProtKB/TrEMBL
  ENSRNOT00000108877.2 UniProtKB/TrEMBL
  ENSRNOT00000113613.2 UniProtKB/TrEMBL
  ENSRNOT00000117655.2 UniProtKB/TrEMBL
  ENSRNOT00000117917.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.720.30 UniProtKB/TrEMBL
  6.10.140.2040 UniProtKB/TrEMBL
  6.10.150.10 UniProtKB/TrEMBL
InterPro Myocardin-like UniProtKB/TrEMBL
  RPEL_repeat UniProtKB/TrEMBL
  SAP_DNA-bd UniProtKB/TrEMBL
  SAP_dom_sf UniProtKB/TrEMBL
NCBI Gene 315151 ENTREZGENE
PANTHER PTHR22793 UniProtKB/TrEMBL
  PTHR22793:SF6 UniProtKB/TrEMBL
Pfam RPEL UniProtKB/TrEMBL
  SAP UniProtKB/TrEMBL
PhenoGen Mrtfa PhenoGen
PROSITE RPEL UniProtKB/TrEMBL
  SAP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018803 RatGTEx
SMART RPEL UniProtKB/TrEMBL
  SAP UniProtKB/TrEMBL
Superfamily-SCOP SSF68906 UniProtKB/TrEMBL
UniProt A0A0G2JXC5_RAT UniProtKB/TrEMBL
  A0A0G2K3Y9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y2C3_RAT UniProtKB/TrEMBL
  A0A8I5Y4Q9_RAT UniProtKB/TrEMBL
  A0A8I5Y983_RAT UniProtKB/TrEMBL
  A0A8I5ZKI6_RAT UniProtKB/TrEMBL
  A0A8I6AI47_RAT UniProtKB/TrEMBL
  A0A8I6GFP9_RAT UniProtKB/TrEMBL
  F1LV40_RAT UniProtKB/TrEMBL
  F1LVR8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-07-20 Mrtfa  myocardin related transcription factor A  Mkl1  megakaryoblastic leukemia (translocation) 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Mkl1  megakaryoblastic leukemia (translocation) 1  Mkl1_predicted  megakaryoblastic leukemia (translocation) 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Mkl1_predicted  megakaryoblastic leukemia (translocation) 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED