Spink4 (serine peptidase inhibitor, Kazal type 4) - Rat Genome Database

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Gene: Spink4 (serine peptidase inhibitor, Kazal type 4) Rattus norvegicus
Analyze
Symbol: Spink4
Name: serine peptidase inhibitor, Kazal type 4
RGD ID: 1303188
Description: Predicted to enable serine-type endopeptidase inhibitor activity. Involved in response to xenobiotic stimulus. Predicted to be located in extracellular space. Orthologous to human SPINK4 (serine peptidase inhibitor Kazal type 4); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Kazal type serine protease inhibitor 4; PEC-60; serine protease inhibitor Kazal-type 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8560,811,899 - 60,860,823 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl560,849,060 - 60,860,823 (+)EnsemblGRCr8
mRatBN7.2556,043,936 - 56,064,841 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl555,981,624 - 56,064,795 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx558,010,977 - 58,031,900 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0559,830,126 - 59,851,051 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0559,824,235 - 59,845,122 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0557,238,221 - 57,252,654 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl557,239,086 - 57,250,662 (+)Ensemblrn6Rnor6.0
Rnor_5.0561,770,297 - 61,782,009 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4558,314,305 - 58,325,973 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera554,664,999 - 54,676,599 (+)NCBICelera
RGSC_v3.1558,314,483 - 58,326,152 (+)NCBI
Cytogenetic Map5q22NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Reserpine treatment increases PEC-60-like immunoreactivity in the substantia nigra of the male rat as determined by radioimmunoassay. Fuxe K, etal., Acta Physiol Scand. 1991 Nov;143(3):357-8.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. A genomic analysis of rat proteases and protease inhibitors. Puente XS and Lopez-Otin C, Genome Res 2004 Apr;14(4):609-22.
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Spink4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8560,811,899 - 60,860,823 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl560,849,060 - 60,860,823 (+)EnsemblGRCr8
mRatBN7.2556,043,936 - 56,064,841 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl555,981,624 - 56,064,795 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx558,010,977 - 58,031,900 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0559,830,126 - 59,851,051 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0559,824,235 - 59,845,122 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0557,238,221 - 57,252,654 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl557,239,086 - 57,250,662 (+)Ensemblrn6Rnor6.0
Rnor_5.0561,770,297 - 61,782,009 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4558,314,305 - 58,325,973 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera554,664,999 - 54,676,599 (+)NCBICelera
RGSC_v3.1558,314,483 - 58,326,152 (+)NCBI
Cytogenetic Map5q22NCBI
SPINK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38933,240,167 - 33,248,567 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl933,218,365 - 33,248,567 (+)Ensemblhg38GRCh38
GRCh37933,240,165 - 33,248,565 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36933,230,196 - 33,238,565 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34933,230,195 - 33,238,564NCBI
Celera933,170,395 - 33,178,768 (+)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef933,197,153 - 33,205,532 (+)NCBIHuRef
CHM1_1933,239,128 - 33,247,497 (+)NCBICHM1_1
T2T-CHM13v2.0933,258,882 - 33,267,284 (+)NCBIT2T-CHM13v2.0
Spink4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39440,920,056 - 40,931,395 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl440,920,052 - 40,931,395 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38440,920,056 - 40,931,395 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl440,920,052 - 40,931,395 (+)Ensemblmm10GRCm38
MGSCv37440,867,089 - 40,878,428 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36441,095,937 - 41,143,924 (+)NCBIMGSCv36mm8
Celera440,580,572 - 40,591,997 (+)NCBICelera
Cytogenetic Map4A5NCBI
cM Map420.64NCBI
Spink4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554722,406,279 - 2,415,668 (-)Ensembl
ChiLan1.0NW_0049554722,406,279 - 2,415,668 (-)NCBIChiLan1.0ChiLan1.0
SPINK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21191,353,771 - 91,358,753 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1991,359,713 - 91,364,695 (-)NCBINHGRI_mPanPan1
SPINK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11150,340,068 - 50,345,777 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1150,340,145 - 50,345,777 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1148,967,880 - 48,975,762 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01151,277,984 - 51,285,866 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1151,278,074 - 51,285,866 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11149,942,377 - 49,950,251 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01149,809,310 - 49,817,196 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01150,574,406 - 50,582,288 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Spink4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947165,237,296 - 165,243,461 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365241,785,415 - 1,790,954 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365241,784,805 - 1,789,464 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPINK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1033,246,247 - 33,255,688 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11033,246,260 - 33,255,617 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21037,503,380 - 37,512,763 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPINK4
(Chlorocebus sabaeus - green monkey)		 No map positions available.
Spink4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473637,998,891 - 38,008,535 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473637,988,002 - 38,010,277 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Spink4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11117,250,325 - 117,262,145 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Spink4
374 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:79
Count of miRNA genes:68
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000060714
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)55266537294894052Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51757663362576633Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)51748608062486080Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
61359EaexExperimental allergic encephalomyelitis QTL x3nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)560511627105511627Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51748608062486080Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2303577Gluco47Glucose level QTL 473blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51652001961520019Rat
2316959Gluco59Glucose level QTL 594.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)556546393101546393Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)52367149368671493Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 8 36 87 48 47 16 47 16 6 203 113 8 60 53 73 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000060714   ⟹   ENSRNOP00000057444
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl560,849,060 - 60,860,823 (+)Ensembl
mRatBN7.2 Ensembl556,053,103 - 56,064,795 (+)Ensembl
Rnor_6.0 Ensembl557,239,086 - 57,250,662 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102888   ⟹   ENSRNOP00000095176
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl556,043,980 - 56,064,795 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103589   ⟹   ENSRNOP00000088683
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl555,981,624 - 56,064,795 (+)Ensembl
RefSeq Acc Id: NM_001395750   ⟹   NP_001382679
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8560,849,060 - 60,860,823 (+)NCBI
mRatBN7.2556,053,078 - 56,064,841 (+)NCBI
RefSeq Acc Id: NR_172724
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8560,839,919 - 60,860,823 (+)NCBI
mRatBN7.2556,043,936 - 56,064,841 (+)NCBI
RefSeq Acc Id: XM_063288150   ⟹   XP_063144220
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8560,811,900 - 60,860,823 (+)NCBI
RefSeq Acc Id: XM_063288151   ⟹   XP_063144221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8560,811,899 - 60,858,737 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001382679 (Get FASTA)   NCBI Sequence Viewer  
  XP_063144220 (Get FASTA)   NCBI Sequence Viewer  
  XP_063144221 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE51397 (Get FASTA)   NCBI Sequence Viewer  
  EDL98647 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000057444
  ENSRNOP00000057444.3
Ensembl Acc Id: ENSRNOP00000057444   ⟸   ENSRNOT00000060714
Ensembl Acc Id: ENSRNOP00000095176   ⟸   ENSRNOT00000102888
Ensembl Acc Id: ENSRNOP00000088683   ⟸   ENSRNOT00000103589
RefSeq Acc Id: NP_001382679   ⟸   NM_001395750
- Peptide Label: precursor
- UniProtKB: E9PU35 (UniProtKB/TrEMBL),   A6IIS7 (UniProtKB/TrEMBL),   Q6IE48 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144221   ⟸   XM_063288151
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063144220   ⟸   XM_063288150
- Peptide Label: isoform X1
Protein Domains
Kazal-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PU35-F1-model_v2 AlphaFold E9PU35 1-75 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693638
Promoter ID:EPDNEW_R4162
Type:single initiation site
Name:Spink4_1
Description:serine peptidase inhibitor, Kazal type 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0557,239,062 - 57,239,122EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303188 AgrOrtholog
BioCyc Gene G2FUF-41585 BioCyc
Ensembl Genes ENSRNOG00000008252 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000060714 ENTREZGENE
  ENSRNOT00000060714.4 UniProtKB/TrEMBL
Gene3D-CATH 3.30.60.30 UniProtKB/TrEMBL
InterPro Kazal_dom_sf UniProtKB/TrEMBL
  Prot_inh_Kazal UniProtKB/TrEMBL
  Spink4-like UniProtKB/TrEMBL
NCBI Gene 408233 ENTREZGENE
PANTHER PTHR21179 UniProtKB/TrEMBL
  SERINE PROTEASE INHIBITOR KAZAL-TYPE 4 UniProtKB/TrEMBL
Pfam Kazal_1 UniProtKB/TrEMBL
PharmGKB SPINK4 RGD
PhenoGen Spink4 PhenoGen
PROSITE KAZAL_1 UniProtKB/TrEMBL
  KAZAL_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008252 RatGTEx
SMART KAZAL UniProtKB/TrEMBL
Superfamily-SCOP SSF100895 UniProtKB/TrEMBL
UniProt A6IIS7 ENTREZGENE, UniProtKB/TrEMBL
  E9PU35 ENTREZGENE, UniProtKB/TrEMBL
  Q6IE48 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Spink4  serine peptidase inhibitor, Kazal type 4  Spink4  Kazal type serine protease inhibitor 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-14 Spink4  Kazal type serine protease inhibitor 4      Symbol and Name status set to provisional 70820 PROVISIONAL