Cacybp (calcyclin binding protein) - Rat Genome Database

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Gene: Cacybp (calcyclin binding protein) Rattus norvegicus
Analyze
Symbol: Cacybp
Name: calcyclin binding protein
RGD ID: 1303146
Description: Predicted to enable several functions, including protein domain specific binding activity; protein homodimerization activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to calcium ion; positive regulation of DNA replication; and response to growth hormone. Located in cell body. Biomarker of myocardial infarction. Orthologous to human CACYBP (calcyclin binding protein); PARTICIPATES IN Wnt signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: calcyclin-binding protein; MGC93921; similar to calcyclin binding protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81374,970,917 - 74,981,298 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1374,970,923 - 74,981,505 (-)EnsemblGRCr8
mRatBN7.21372,437,485 - 72,447,810 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1372,437,490 - 72,450,177 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1375,022,046 - 75,032,407 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01376,314,548 - 76,324,870 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01373,574,097 - 73,584,419 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01377,948,771 - 77,959,089 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1377,948,771 - 77,959,110 (-)Ensemblrn6Rnor6.0
Rnor_5.01382,855,945 - 82,866,235 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41375,623,161 - 75,633,644 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1372,243,269 - 72,253,676 (-)NCBICelera
RGSC_v3.11375,637,349 - 75,647,832 (-)NCBI
Cytogenetic Map13q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
daidzein  (ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
DDE  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
gedunin  (ISO)
genistein  (ISO)
genistein 7-O-beta-D-glucoside  (ISO)
gentamycin  (EXP)
glycitein  (ISO)
glycitin  (ISO)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
leflunomide  (EXP)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dichloride  (EXP)
methamphetamine  (EXP)
methidathion  (ISO)
methylisothiazolinone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-methylformamide  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
nitrates  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenytoin  (EXP)
pirinixic acid  (ISO)
piroxicam  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thiram  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
troglitazone  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Calcyclin binding protein promotes DNA synthesis and differentiation in rat neonatal cardiomyocytes. Au KW, etal., J Cell Biochem. 2006 Jun 1;98(3):555-66.
2. Growth hormone-dependent changes in the rat lung proteome during alveorization. Beyea JA, etal., Mol Cell Biochem. 2009 Jan;321(1-2):197-204. Epub 2008 Nov 5.
3. Expression and clinical significance of CacyBP/SIP in pancreatic cancer. Chen X, etal., Pancreatology. 2008;8(4-5):470-7. Epub 2008 Sep 3.
4. CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family. Filipek A, etal., J Biol Chem 2002 Aug 9;277(32):28848-52. Epub 2002 May 31.
5. Ca2+-dependent translocation of the calcyclin-binding protein in neurons and neuroblastoma NB-2a cells. Filipek A, etal., J Biol Chem 2002 Jun 7;277(23):21103-9.
6. Age-dependent changes in neuronal distribution of CacyBP/SIP: comparison to tubulin and the tau protein. Filipek A, etal., J Neural Transm. 2008 Sep;115(9):1257-64. Epub 2008 May 28.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Calcyclin (S100A6) binding protein (CacyBP) is highly expressed in brain neurons. Jastrzebska B, etal., J Histochem Cytochem. 2000 Sep;48(9):1195-202.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:15996101   PMID:16085652   PMID:20439489   PMID:20458337   PMID:22926504   PMID:28131823   PMID:32544715   PMID:36042446   PMID:38203261   PMID:38780511  


Genomics

Comparative Map Data
Cacybp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81374,970,917 - 74,981,298 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1374,970,923 - 74,981,505 (-)EnsemblGRCr8
mRatBN7.21372,437,485 - 72,447,810 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1372,437,490 - 72,450,177 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1375,022,046 - 75,032,407 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01376,314,548 - 76,324,870 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01373,574,097 - 73,584,419 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01377,948,771 - 77,959,089 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1377,948,771 - 77,959,110 (-)Ensemblrn6Rnor6.0
Rnor_5.01382,855,945 - 82,866,235 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41375,623,161 - 75,633,644 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1372,243,269 - 72,253,676 (-)NCBICelera
RGSC_v3.11375,637,349 - 75,647,832 (-)NCBI
Cytogenetic Map13q22NCBI
CACYBP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381174,999,435 - 175,012,027 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1174,999,163 - 175,012,027 (+)Ensemblhg38GRCh38
GRCh371174,968,571 - 174,981,163 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361173,235,194 - 173,247,786 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341171,700,548 - 171,712,820NCBI
Celera1148,078,240 - 148,090,832 (+)NCBICelera
Cytogenetic Map1q25.1NCBI
HuRef1146,194,908 - 146,207,494 (+)NCBIHuRef
CHM1_11176,391,539 - 176,404,132 (+)NCBICHM1_1
T2T-CHM13v2.01174,353,190 - 174,365,783 (+)NCBIT2T-CHM13v2.0
Cacybp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391160,029,171 - 160,040,391 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1160,029,937 - 160,040,445 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381160,202,367 - 160,212,892 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1160,202,367 - 160,212,875 (-)Ensemblmm10GRCm38
MGSCv371162,133,052 - 162,142,908 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361162,039,598 - 162,049,454 (-)NCBIMGSCv36mm8
Celera1162,614,677 - 162,624,538 (-)NCBICelera
Cytogenetic Map1H2.1NCBI
cM Map169.61NCBI
Cacybp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540614,823,509 - 14,840,127 (+)NCBIChiLan1.0ChiLan1.0
CACYBP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2174,721,125 - 74,732,212 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1174,394,759 - 74,405,832 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01150,511,021 - 150,522,369 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11154,209,195 - 154,220,583 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1154,210,001 - 154,220,583 (+)EnsemblpanPan2panpan1.1
CACYBP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1724,372,599 - 24,384,084 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl724,372,596 - 24,383,926 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha723,898,801 - 23,910,323 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0724,120,354 - 24,131,864 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl724,120,357 - 24,131,667 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1724,033,026 - 24,044,547 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0724,124,108 - 24,135,611 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0724,269,151 - 24,280,676 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cacybp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934495,351,995 - 95,356,739 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493648113,198,744 - 13,203,518 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CACYBP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9117,064,187 - 117,123,126 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.19117,062,303 - 117,077,442 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29128,738,082 - 128,751,826 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CACYBP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12554,246,331 - 54,258,273 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2554,247,057 - 54,257,660 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605555,820,181 - 55,833,649 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cacybp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247716,982,255 - 6,993,867 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247716,982,248 - 6,993,661 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cacybp
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11039,490,152 - 39,500,799 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cacybp
52 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:62
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000003586
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134874981487285480Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133996821183286298Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13742179187286911Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133708798382087983Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134098358585983585Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133379409678794096Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133992469384924693Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133483494779834947Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133981472684814726Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133996821184968211Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
11530006Niddm72Non-insulin dependent diabetes mellitus QTL 720.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)133828629883286298Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
BF393780  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21372,438,014 - 72,438,133 (+)MAPPERmRatBN7.2
Rnor_6.01377,949,301 - 77,949,419NCBIRnor6.0
Rnor_5.01382,856,472 - 82,856,590UniSTSRnor5.0
RGSC_v3.41375,623,688 - 75,623,806UniSTSRGSC3.4
Celera1372,243,796 - 72,243,914UniSTS
RH 3.4 Map13449.6UniSTS
Cytogenetic Map13q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000003586   ⟹   ENSRNOP00000003586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1374,970,923 - 74,981,505 (-)Ensembl
mRatBN7.2 Ensembl1372,437,490 - 72,450,177 (-)Ensembl
Rnor_6.0 Ensembl1377,948,771 - 77,959,089 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076334
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1377,954,174 - 77,959,110 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076990   ⟹   ENSRNOP00000068249
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1372,437,505 - 72,443,986 (-)Ensembl
Rnor_6.0 Ensembl1377,949,603 - 77,958,910 (-)Ensembl
RefSeq Acc Id: NM_001004208   ⟹   NP_001004208
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81374,970,917 - 74,981,239 (-)NCBI
mRatBN7.21372,437,488 - 72,447,810 (-)NCBI
Rnor_6.01377,948,774 - 77,959,089 (-)NCBI
Rnor_5.01382,855,945 - 82,866,235 (-)NCBI
RGSC_v3.41375,623,161 - 75,633,644 (-)RGD
Celera1372,243,269 - 72,253,676 (-)RGD
Sequence:
RefSeq Acc Id: XM_017598707   ⟹   XP_017454196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81374,970,919 - 74,981,298 (-)NCBI
mRatBN7.21372,437,485 - 72,447,626 (-)NCBI
Rnor_6.01377,948,771 - 77,958,905 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001004208 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454196 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79007 (Get FASTA)   NCBI Sequence Viewer  
  EDM09437 (Get FASTA)   NCBI Sequence Viewer  
  EDM09438 (Get FASTA)   NCBI Sequence Viewer  
  EDM09439 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003586.3
GenBank Protein Q6AYK6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001004208   ⟸   NM_001004208
- UniProtKB: Q6AYK6 (UniProtKB/Swiss-Prot),   A6ID58 (UniProtKB/TrEMBL),   A0A096MJT0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454196   ⟸   XM_017598707
- Peptide Label: isoform X1
- UniProtKB: A6ID59 (UniProtKB/TrEMBL),   A0A096MJT0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068249   ⟸   ENSRNOT00000076990
Ensembl Acc Id: ENSRNOP00000003586   ⟸   ENSRNOT00000003586
Protein Domains
CS   SGS   Siah interacting protein N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYK6-F1-model_v2 AlphaFold Q6AYK6 1-229 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698926
Promoter ID:EPDNEW_R9451
Type:initiation region
Name:Cacybp_1
Description:calcyclin binding protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01377,959,090 - 77,959,150EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303146 AgrOrtholog
BioCyc Gene G2FUF-17763 BioCyc
Ensembl Genes ENSRNOG00000002572 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003586.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.790 UniProtKB/Swiss-Prot
  UVR domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7113129 IMAGE-MGC_LOAD
InterPro CacyBP_N UniProtKB/Swiss-Prot
  Calcyclin-binding_UBL-bridge UniProtKB/Swiss-Prot
  CS_CacyBP UniProtKB/Swiss-Prot
  CS_dom UniProtKB/Swiss-Prot
  HSP20-like_chaperone UniProtKB/Swiss-Prot
  SGS_dom UniProtKB/Swiss-Prot
  Siah-Interact_N UniProtKB/Swiss-Prot
KEGG Report rno:289144 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93921 IMAGE-MGC_LOAD
NCBI Gene 289144 ENTREZGENE
PANTHER CALCYCLIN-BINDING PROTEIN UniProtKB/Swiss-Prot
  CALICYLIN BINDING PROTEIN UniProtKB/Swiss-Prot
Pfam PF04969 UniProtKB/Swiss-Prot
  SGS UniProtKB/Swiss-Prot
  Siah-Interact_N UniProtKB/Swiss-Prot
PhenoGen Cacybp PhenoGen
PROSITE PS51203 UniProtKB/Swiss-Prot
  SGS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002572 RatGTEx
Superfamily-SCOP SSF140106 UniProtKB/Swiss-Prot
  SSF49764 UniProtKB/Swiss-Prot
UniProt A0A096MJT0 ENTREZGENE
  A6ID58 ENTREZGENE, UniProtKB/TrEMBL
  A6ID59 ENTREZGENE, UniProtKB/TrEMBL
  A6ID60_RAT UniProtKB/TrEMBL
  CYBP_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Cacybp  calcyclin binding protein  MGC93921  similar to calcyclin binding protein  Symbol and Name updated 1299863 APPROVED
2005-02-14 MGC93921  similar to calcyclin binding protein      Symbol and Name status set to provisional 70820 PROVISIONAL