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Gene: Pa2g4 (proliferation-associated 2G4) Rattus norvegicus

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Symbol:

Pa2g4

Name:

proliferation-associated 2G4

RGD ID:

1302994

Description:

Predicted to enable nucleic acid binding activity; transcription corepressor activity; and ubiquitin protein ligase binding activity. Involved in negative regulation of apoptotic process and positive regulation of cell differentiation. Located in cytoplasm and nucleolus. Orthologous to human PA2G4 (proliferation-associated 2G4); INTERACTS WITH (+)-schisandrin B; 2,4-dibromophenyl 2,4,5-tribromophenyl ether; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

Ebp1; ErbB3-binding protein 1; MGC94070; proliferation-associated 2G4, 38kDa; proliferation-associated protein 2G4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PA2G4 (proliferation-associated 2G4)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Pa2g4 (proliferation-associated 2G4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pa2g4 (proliferation-associated 2G4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PA2G4 (proliferation-associated 2G4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PA2G4 (proliferation-associated 2G4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pa2g4 (proliferation-associated 2G4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PA2G4 (proliferation-associated 2G4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PA2G4 (proliferation-associated 2G4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pa2g4 (proliferation-associated 2G4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Pa2g4 (proliferation-associated 2G4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	PYROXD2 (pyridine nucleotide-disulphide oxidoreductase domain 2)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Pa2g4 (proliferation-associated 2G4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pa2g4 (proliferation-associated 2G4)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PA2G4 (proliferation-associated 2G4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Homo sapiens (human):	PA2G4 (proliferation-associated 2G4)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pa2g4a (proliferation-associated 2G4, a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pa2g4a (proliferation-associated 2G4, a)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pa2g4b (proliferation-associated 2G4, b)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG10576	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	ARX1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	ARX1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Caenorhabditis elegans (roundworm):	W08E12.7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pa2g4	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	pa2g4	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	1,569,326 - 1,576,794 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	1,569,327 - 1,576,802 (-)	Ensembl				GRCr8
mRatBN7.2	7	984,795 - 992,264 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	983,971 - 992,331 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	3,746,905 - 3,754,373 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	5,622,896 - 5,630,363 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	5,920,502 - 5,927,971 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	2,979,587 - 2,987,055 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	2,979,588 - 2,987,055 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	2,952,383 - 2,960,679 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	1,846,628 - 1,854,096 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	855,183 - 862,626 (-)	NCBI		Celera
RGSC_v3.1	7	1,846,628 - 1,854,096 (-)	NCBI
Cytogenetic Map	7	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Disease Progression (ISO)

Stomach Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(-)-epigallocatechin 3-gallate (ISO)

1,2-dichloroethane (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (EXP)

2,4-dinitrotoluene (EXP)

2,6-dimethoxyphenol (ISO)

2,6-dinitrotoluene (EXP)

2-amino-14,16-dimethyloctadecan-3-ol (ISO)

2-hydroxypropanoic acid (ISO)

3,3',4,4'-tetrachlorobiphenyl (ISO)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

4-hydroxynon-2-enal (ISO)

6-propyl-2-thiouracil (EXP)

actinomycin D (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ampicillin (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

belinostat (ISO)

benzatropine (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

beta-naphthoflavone (ISO)

bicalutamide (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloropicrin (ISO)

chlorpyrifos (ISO)

choline (ISO)

chromium(6+) (ISO)

chrysene (ISO)

cisplatin (ISO)

clofibric acid (EXP)

cobalt dichloride (ISO)

cocaine (EXP)

copper atom (ISO)

copper(0) (ISO)

Cuprizon (ISO)

cycloheximide (ISO)

cyclosporin A (ISO)

cyproterone acetate (ISO)

DDE (ISO)

deoxynivalenol (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (EXP,ISO)

diethylstilbestrol (ISO)

dioxygen (ISO)

doxorubicin (EXP)

elemental selenium (ISO)

enzyme inhibitor (ISO)

fenthion (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

FR900359 (ISO)

fulvestrant (ISO)

furfural (ISO)

genistein (ISO)

gentamycin (EXP)

geraniol (ISO)

glafenine (EXP)

graphite (ISO)

hydrogen peroxide (ISO)

hydroquinone (ISO)

ivermectin (ISO)

L-methionine (ISO)

lead diacetate (ISO)

lovastatin (ISO)

methidathion (ISO)

miconazole (ISO)

N-methyl-N'-nitro-N-nitrosoguanidine (ISO)

N-nitrosodiethylamine (EXP)

nefazodone (EXP)

nimesulide (EXP)

nitrates (ISO)

Nutlin-3 (ISO)

oxaliplatin (EXP)

ozone (ISO)

paraquat (EXP)

phenobarbital (ISO)

piroxicam (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

sodium dichromate (EXP)

sunitinib (ISO)

T-2 toxin (EXP)

tamoxifen (ISO)

tanespimycin (ISO)

Tetrachlorobisphenol A (EXP,ISO)

tetrachloromethane (EXP,ISO)

tetraphene (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

topotecan (EXP)

trimellitic anhydride (ISO)

valproic acid (ISO)

vitamin E (ISO)

warfarin (ISO)

wortmannin (ISO)

zinc sulfate (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA-templated transcription (IEA)

negative regulation of apoptotic process (IDA)

negative regulation of DNA-templated transcription (ISO)

positive regulation of cell differentiation (IDA)

regulation of translation (IEA)

rRNA processing (IEA)

Cellular Component

cytoplasm (IDA,IEA,ISO)

cytosol (ISO)

nucleolus (IDA,IEA,ISO)

nucleus (ISO)

ribonucleoprotein complex (IEA)

Molecular Function

nucleic acid binding (ISO)

protein binding (IPI,ISO)

RNA binding (IEA)

transcription corepressor activity (ISO)

ubiquitin protein ligase binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Ebp1 isoforms distinctively regulate cell survival and differentiation.	Liu Z, etal., Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10917-22. Epub 2006 Jul 10.
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes.	Squatrito M, etal., Oncogene 2004 May 27;23(25):4454-65.
8.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
9.	The long non-coding RNA H19 promotes cardiomyocyte apoptosis in dilated cardiomyopathy.	Zhang Y, etal., Oncotarget. 2017 Apr 25;8(17):28588-28594. doi: 10.18632/oncotarget.15544.

Additional References at PubMed

PMID:15073182	PMID:16642037	PMID:17316401	PMID:17951246	PMID:19037095	PMID:19946888	PMID:20458337	PMID:22082260	PMID:22658674	PMID:24878627	PMID:29476059

Genomics

Comparative Map Data

Pa2g4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	1,569,326 - 1,576,794 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	7	1,569,327 - 1,576,802 (-)	Ensembl				GRCr8
mRatBN7.2	7	984,795 - 992,264 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	983,971 - 992,331 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	7	3,746,905 - 3,754,373 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	5,622,896 - 5,630,363 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	5,920,502 - 5,927,971 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	2,979,587 - 2,987,055 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	2,979,588 - 2,987,055 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	7	2,952,383 - 2,960,679 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	7	1,846,628 - 1,854,096 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	7	855,183 - 862,626 (-)	NCBI		Celera
RGSC_v3.1	7	1,846,628 - 1,854,096 (-)	NCBI
Cytogenetic Map	7	q11	NCBI

PA2G4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	56,104,559 - 56,113,910 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	56,104,349 - 56,116,329 (+)	Ensembl			hg38	GRCh38
GRCh37	12	56,498,343 - 56,507,694 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	54,784,370 - 54,793,961 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	54,784,691 - 54,793,353	NCBI
Celera	12	56,150,290 - 56,159,843 (+)	NCBI		Celera
Cytogenetic Map	12	q13.2	NCBI
HuRef	12	53,537,242 - 53,546,835 (+)	NCBI		HuRef
CHM1_1	12	56,465,468 - 56,475,059 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	56,072,163 - 56,081,516 (+)	NCBI		T2T-CHM13v2.0

Pa2g4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	128,393,635 - 128,401,803 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	128,393,635 - 128,401,856 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	10	128,557,766 - 128,565,934 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	128,557,766 - 128,565,987 (-)	Ensembl			mm10	GRCm38
MGSCv37	10	127,994,822 - 128,002,990 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	10	127,961,592 - 127,968,897 (-)	NCBI		MGSCv36	mm8
Celera	10	130,949,754 - 130,957,922 (-)	NCBI		Celera
Cytogenetic Map	10	D3	NCBI
cM Map	10	77.09	NCBI

Pa2g4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	3,705,704 - 3,717,403 (+)	Ensembl
ChiLan1.0	NW_004955458	3,705,704 - 3,715,782 (+)	NCBI	ChiLan1.0	ChiLan1.0

PA2G4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	38,218,516 - 38,227,001 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	38,214,527 - 38,224,146 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	32,801,085 - 32,810,441 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	33,051,672 - 33,061,262 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	33,051,672 - 33,061,262 (-)	Ensembl			panPan2	panpan1.1

PA2G4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	426,074 - 437,044 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	426,069 - 434,767 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	487,811 - 499,123 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	432,937 - 444,249 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	432,930 - 441,669 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	410,400 - 421,711 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	653,296 - 664,836 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	777,521 - 788,835 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Pa2g4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	58,345,893 - 58,353,962 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936646	516,265 - 524,481 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936646	516,273 - 523,572 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PA2G4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	5	21,495,997 - 21,503,297 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	23,103,723 - 23,106,699 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PA2G4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	52,044,845 - 52,054,545 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666037	193,930,133 - 193,940,436 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pa2g4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624802	11,896,285 - 11,904,756 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624802	11,896,285 - 11,904,989 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Pa2g4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	1	156,026,094 - 156,034,047 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Pa2g4
35 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	129
Count of miRNA genes:	99
Interacting mature miRNAs:	104
Transcripts:	ENSRNOT00000006578
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300176	Hrtrt10	Heart rate QTL 10	3.19		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	7	1	23748937	Rat
2298550	Neuinf6	Neuroinflammation QTL 6	3.3		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	7	1	29716167	Rat
2290372	Gluco33	Glucose level QTL 33	2.71		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	1	31777942	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	1	104117804	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	1509236	116977875	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	34650782	Rat
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	32612984	Rat
1582260	Bw72	Body weight QTL 72	3.2	0.0043	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
1582261	Bw69	Body weight QTL 69	3.2	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
1582262	Bw75	Body weight QTL 75	3	0.0038	body mass (VT:0001259)	body weight (CMO:0000012)	7	1	39960528	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	32612984	Rat

Markers in Region

RH139015

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	7	1,569,946 - 1,570,173 (+)	Marker Load Pipeline
mRatBN7.2	7	985,415 - 985,642 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	2,980,208 - 2,980,434	NCBI	Rnor6.0
Rnor_5.0	7	2,953,832 - 2,954,058	UniSTS	Rnor5.0
RGSC_v3.4	7	1,847,249 - 1,847,475	UniSTS	RGSC3.4
Celera	7	855,804 - 856,030	UniSTS
Cytogenetic Map	7	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001004206	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC128207	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC079095	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474104	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ233061	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000006578 ⟹ ENSRNOP00000006578

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	1,569,327 - 1,576,794 (-)	Ensembl
mRatBN7.2 Ensembl	7	984,807 - 992,331 (-)	Ensembl
Rnor_6.0 Ensembl	7	2,979,588 - 2,987,055 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000081125 ⟹ ENSRNOP00000069595

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	1,570,110 - 1,576,802 (-)	Ensembl
mRatBN7.2 Ensembl	7	985,579 - 992,286 (-)	Ensembl
Rnor_6.0 Ensembl	7	2,980,380 - 2,986,935 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096142 ⟹ ENSRNOP00000091838

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	983,971 - 992,331 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096767 ⟹ ENSRNOP00000085880

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	983,971 - 991,705 (-)	Ensembl

RefSeq Acc Id:

NM_001004206 ⟹ NP_001004206

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	1,569,326 - 1,576,794 (-)	NCBI
mRatBN7.2	7	984,795 - 992,264 (-)	NCBI
Rnor_6.0	7	2,979,587 - 2,987,055 (-)	NCBI
Rnor_5.0	7	2,952,383 - 2,960,679 (-)	NCBI
RGSC_v3.4	7	1,846,628 - 1,854,096 (-)	RGD
Celera	7	855,183 - 862,626 (-)	RGD

Sequence:

show sequence

CCCTTGCTAGCTCGCGCTTTCCTCGCGGATCGAAGAGACTCCGGCTACAGCTTGTGGCTGGGAA
GGGAGACGGAGGCCGCAGCTCAGGGAAAGTGAAGCTGCAGTAGTGGCAGTAGGAAGATGTCGGG
CGAAGACGAGCAGCAGGAGCAAACTATCGCCGAGGACCTGGTCGTGACCAAGTATAAGATGGGG
GGCGACATCGCCAACCGGGTGCTTCGATCTTTGGTGGAAGCTTCTAGCTCAGGTGTGTCTGTAC
TGAGCTTGTGTGAGAAAGGTGACGCCATGATTATGGAAGAGACAGGGAAGATCTTCAAGAAGGA
GAAGGAGATGAAGAAAGGTATTGCCTTTCCTACCAGCATTTCCGTAAATAACTGTGTGTGTCAC
TTCTCCCCTTTGAAGAGTGACCAGGACTATATACTCAAGGAAGGCGACTTGGTAAAAATTGACC
TTGGGGTTCATGTGGATGGCTTCATTGCCAACGTGGCTCACACTTTTGTAATTGGTGTAGCTCA
GGGGTCCCAGGTAACAGGTCGGAAAGCAGATGTCATTAAGGCTGCTCACTTATGTGCCGAAGCT
GCTTTACGACTGGTCAAACCTGGAAACCAGAACACACAAGTGACAGAAGCCTGGAACAAAGTCG
CTCATTCATTTAACTGCACGCCAATAGAAGGTATGCTGTCACACCAGTTGAAGCAGCATGTGAT
TGATGGAGAGAAAACCATTATCCAGAATCCTACAGACCAGCAGAAGAAGGACCACGAAAAGGCA
GAATTTGAAGTGCATGAGGTTTATGCTGTGGATGTCCTCGTCAGCTCAGGAGAAGGCAAGGCCA
AAGATGCAGGACAGAGAACCACCATTTACAAGCGAGACCCCTCTAAACAATATGGCCTGAAAAT
GAAAACTTCACGTGCCTTTTTCAGTGAGGTGGAAAGGCGTTTTGATGCTATGCCCTTTACTTTA
AGAGCATTTGAGGATGAGAAGAAGGCTCGAATGGGTGTGGTGGAGTGCGCCAAGCATGAGTTAC
TACAGCCATTCAACGTTCTCTATGAGAAGGAGGGTGAGTTTGTTGCCCAGTTTAAATTTACAGT
TCTACTCATGCCCAATGGCCCCATGCGGATAACCAGTGGTCCCTTTGAGCCCGACCTGTACAAG
TCTGAGATGGAGGTTCAGGATGCAGAGCTGAAGGCTCTTCTCCAGAGCTCTGCAAGTCGAAAAA
CCCAGAAAAAGAAGAAAAAGAAGGCCTCCAAGACTGCAGAGAACGCCACCAGTGGAGAGACATT
AGAGGAGAATGGAGCTGGGGACTGAGGTGGGTCCCCTCCCCAGCTTGTCACTCCTGCCTCACCC
CCTCCCACCGCACCCCAGGCTCTGTCAAGTGCAGTTCGTCTTCTCCACCCAAGACTACCAGCAG
AGCGGGGTTCTGCCCTCATCCCGGTCCCCCACCCACCCGCCCACTCCTTTCAACAAAAAAACCA
GCTCCGACTGACTCTGGTGTTGGGAGGCCAGGCTTCCCAACCACCGAAGACTACTTTTAGTAGA
AAAAGAAATTGAATAATAAAATCAGGAGTCAAAATCCAAAAAAAAAAAAAAAAAAAAAAAAAAA
AA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001004206	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79095	(Get FASTA)	NCBI Sequence Viewer
	EDL84836	(Get FASTA)	NCBI Sequence Viewer
	EDL84837	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000006578
	ENSRNOP00000091838.1
GenBank Protein	Q6AYD3	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001004206 ⟸ NM_001004206

- UniProtKB:

Q6AYD3 (UniProtKB/Swiss-Prot), A0A8L2UI00 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSGEDEQQEQTIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKIF
KKEKEMKKGIAFPTSISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVIG
VAQGSQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSHQLKQ
HVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAKDAGQRTTIYKRDPSKQYG
LKMKTSRAFFSEVERRFDAMPFTLRAFEDEKKARMGVVECAKHELLQPFNVLYEKEGEFVAQFK
FTVLLMPNGPMRITSGPFEPDLYKSEMEVQDAELKALLQSSASRKTQKKKKKKASKTAENATSG
ETLEENGAGD

hide sequence

Ensembl Acc Id:

ENSRNOP00000006578 ⟸ ENSRNOT00000006578

Ensembl Acc Id:

ENSRNOP00000069595 ⟸ ENSRNOT00000081125

Ensembl Acc Id:

ENSRNOP00000091838 ⟸ ENSRNOT00000096142

Ensembl Acc Id:

ENSRNOP00000085880 ⟸ ENSRNOT00000096767

Protein Domains

Peptidase M24

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6AYD3-F1-model_v2	AlphaFold	Q6AYD3	1-394	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694944

Promoter ID:

EPDNEW_R5469

Type:

initiation region

Name:

Pa2g4_1

Description:

proliferation-associated 2G4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	2,987,050 - 2,987,110	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1302994	AgrOrtholog
BioCyc Gene	G2FUF-35351	BioCyc
Ensembl Genes	ENSRNOG00000004904	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000006578	ENTREZGENE
	ENSRNOT00000096142.1	UniProtKB/Swiss-Prot
Gene3D-CATH	1.10.10.10	UniProtKB/Swiss-Prot
	3.90.230.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7124036	IMAGE-MGC_LOAD
InterPro	Creatinase/aminopeptidase-like	UniProtKB/Swiss-Prot
	PA2G4	UniProtKB/Swiss-Prot
	PA2G4/ARX1	UniProtKB/Swiss-Prot
	Pept_M24	UniProtKB/Swiss-Prot
	Pept_M24A_MAP2_BS	UniProtKB/Swiss-Prot
	WH-like_DNA-bd_sf	UniProtKB/Swiss-Prot
	WH_DNA-bd_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:288778	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94070	IMAGE-MGC_LOAD
NCBI Gene	288778	ENTREZGENE
PANTHER	PROLIFERATION-ASSOCIATED PROTEIN 2G4	UniProtKB/Swiss-Prot
	PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P	UniProtKB/Swiss-Prot
Pfam	Peptidase_M24	UniProtKB/Swiss-Prot
PhenoGen	Pa2g4	PhenoGen
PROSITE	MAP_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000004904	RatGTEx
Superfamily-SCOP	SSF46785	UniProtKB/Swiss-Prot
	SSF55920	UniProtKB/Swiss-Prot
UniProt	A0A0G2JVS2_RAT	UniProtKB/TrEMBL
	A0A8L2UI00	ENTREZGENE, UniProtKB/TrEMBL
	A6KSF5_RAT	UniProtKB/TrEMBL
	PA2G4_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-11-17	Pa2g4	proliferation-associated 2G4			Name updated	1299863	APPROVED
2005-02-14	Pa2g4	proliferation-associated 2G4, 38kDa			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD