Gng5-ps3 (G protein subunit gamma 5, pseudogene 3) - Rat Genome Database

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Gene: Gng5-ps3 (G protein subunit gamma 5, pseudogene 3) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Gng5-ps3
Name: G protein subunit gamma 5, pseudogene 3
RGD ID: 11485321
Description: Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be part of heterotrimeric G-protein complex. Orthologous to human GNG5 (G protein subunit gamma 5).
Type: pseudo (Ensembl: protein-coding)
RefSeq Status: INFERRED
Previously known as: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5; heterotrimeric guanine nucleotide-binding protein 3l1; heterotrimeric guanine nucleotide-binding protein 3l2; Hg3l1; Hg3l2; LOC108349548
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Related Functional Gene: Gng5  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,420,149 - 86,420,633 (+)NCBIGRCr8
mRatBN7.2177,292,029 - 77,292,513 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1366,188,047 - 66,188,253 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0178,545,963 - 78,546,461 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,546,012 - 78,546,218 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl2252,359,976 - 252,368,473 (+)EnsemblRnor6.0rn6Rnor6.0
Celera171,777,349 - 71,777,847 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The heterotrimeric G protein subunits Galpha(q) and Gbeta(1) have lysophospholipase D activity. Aoyama C, etal., Biochem J. 2011 Dec 1;440(2):241-50. doi: 10.1042/BJ20110545.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.

Genomics

Variants

.
Variants in Gng5-ps3
4 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)15034351099980958Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
2 7 9 16 23 25 7 17 7 60 36 8 10 7 18

Sequence


Ensembl Acc Id: ENSRNOT00000021358   ⟹   ENSRNOP00000021358
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2252,359,976 - 252,368,473 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000058172   ⟹   ENSRNOP00000054976
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1366,188,047 - 66,188,253 (-)Ensembl
Rnor_6.0 Ensembl178,546,012 - 78,546,218 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105080   ⟹   ENSRNOP00000087679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl177,292,043 - 77,292,513 (+)Ensembl
RefSeq Acc Id: XM_017589994   ⟹   XP_017445483
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2177,292,033 - 77,292,502 (+)NCBI
Rnor_6.0178,545,963 - 78,546,461 (+)NCBI
Sequence:
Protein Sequences
GenBank Protein CAG9553629 (Get FASTA)   NCBI Sequence Viewer  
  CAG9553630 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054976.3
RefSeq Acc Id: XP_017445483   ⟸   XM_017589994
- Sequence:
Ensembl Acc Id: ENSRNOP00000021358   ⟸   ENSRNOT00000021358
Ensembl Acc Id: ENSRNOP00000054976   ⟸   ENSRNOT00000058172
Ensembl Acc Id: ENSRNOP00000087679   ⟸   ENSRNOT00000105080
Protein Domains
G protein gamma

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63219-F1-model_v2 AlphaFold P63219 1-68 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689736
Promoter ID:EPDNEW_R257
Type:multiple initiation site
Name:Gng5_1
Description:G protein subunit gamma 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0178,546,012 - 78,546,072EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:11485321 AgrOrtholog
BioCyc Gene G2FUF-60606 BioCyc
Ensembl Genes ENSRNOG00000015936 Ensembl
  ENSRNOG00000038205 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000063636 Ensembl
Ensembl Transcript ENSRNOT00000058172.4 UniProtKB/TrEMBL
Gene3D-CATH 4.10.260.10 UniProtKB/TrEMBL
InterPro G-protein_gamma-like_dom UniProtKB/TrEMBL
  GGL_sf UniProtKB/TrEMBL
  Gprotein-gamma UniProtKB/TrEMBL
NCBI Gene LOC108349548 ENTREZGENE
PANTHER GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)/G(S)/G(O) SUBUNIT GAMMA-5 UniProtKB/TrEMBL
  PTHR13809 UniProtKB/TrEMBL
Pfam G-gamma UniProtKB/TrEMBL
PhenoGen Gng5-ps3 PhenoGen
PRINTS GPROTEING UniProtKB/TrEMBL
PROSITE G_PROTEIN_GAMMA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015936 RatGTEx
  ENSRNOG00000038205 RatGTEx
  ENSRNOG00000063636 RatGTEx
SMART G_gamma UniProtKB/TrEMBL
  GGL UniProtKB/TrEMBL
Superfamily-SCOP SSF48670 UniProtKB/TrEMBL
UniProt A0A8L2QRU2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-07-14 Gng5-ps3  G protein subunit gamma 5, pseudogene 3  LOC108349548  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5  Name and Symbol and Type changed (type changed from [protein-coding] to [pseudo]) 629549 APPROVED
2016-08-02 LOC108349548  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5      Symbol and Name status set to provisional 70820 PROVISIONAL