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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:protein kinase C (PKC) signaling pathway
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Accession:PW:0000840 term browser browse the term
Definition:Protein kinase C constitutes a family of serine/threonine kinases activated by diacylglycerol (DAG) and calcium whose signal transduction plays important roles in many cellular processes. Ligand-activated G protein-coupled receptors, via the Galphaq pathway, stimulate phospholipase C, which cleaves PIP2 into DAG and IP3. IP3 promotes calcium release.
Synonyms:related_synonym: protein kinase C signaling
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protein kinase C (PKC) signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btk Bruton tyrosine kinase ISO RGD PMID:15380937 RGD:5131492 NCBI chr  X:97,722,796...97,762,315
Ensembl chr  X:97,722,802...97,761,853 		JBrowse link
G Cdc37 cell division cycle 37, HSP90 cochaperone ISO RGD PMID:19934406 RGD:5131489 NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809 		JBrowse link
G Copb1 COPI coat complex subunit beta 1 ISO RGD PMID:18491053 RGD:5131491 NCBI chr 1:168,404,334...168,438,589
Ensembl chr 1:168,404,335...168,438,416 		JBrowse link
G Fscn1 fascin actin-bundling protein 1 ISO RGD PMID:15380937 RGD:5131492 NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211 		JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase ISO RGD PMID:15380937 RGD:5131492 NCBI chr20:42,767,733...42,960,903
Ensembl chr20:42,766,369...42,959,911 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO RGD PMID:19934406 RGD:5131489 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase ISO RGD PMID:15380937 RGD:5131492 NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794 		JBrowse link
G Ldb3 LIM domain binding 3 ISO RGD PMID:18491053 PMID:15380937 RGD:5131491, RGD:5131492 NCBI chr16:9,855,768...9,920,108
Ensembl chr16:9,855,927...9,918,532 		JBrowse link
G Pard3 par-3 family cell polarity regulator ISO RGD PMID:16525119 RGD:5132275 NCBI chr19:55,080,282...55,630,111
Ensembl chr19:55,080,282...55,629,778 		JBrowse link
G Pard6a par-6 family cell polarity regulator alpha ISO RGD PMID:16525119 RGD:5132275 NCBI chr19:33,589,531...33,591,900
Ensembl chr19:33,589,542...33,591,900 		JBrowse link
G Pard6b par-6 family cell polarity regulator beta ISO RGD PMID:16525119 RGD:5132275 NCBI chr 3:156,790,540...156,811,620
Ensembl chr 3:156,790,540...156,811,622 		JBrowse link
G Pard6g par-6 family cell polarity regulator gamma ISO RGD PMID:16525119 RGD:5132275 NCBI chr18:73,497,992...73,565,048
Ensembl chr18:73,498,021...73,565,029 		JBrowse link
G Pcnt pericentrin ISO RGD PMID:15380937 RGD:5131492 NCBI chr20:12,190,597...12,278,723
Ensembl chr20:12,191,648...12,278,710 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 ISO RGD PMID:19934406 RGD:5131489 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 IMP
ISO		 RGD PMID:20819118 PMID:18511290 RGD:8693633, RGD:5131497 NCBI chr13:22,308,532...22,530,978
Ensembl chr13:22,308,548...22,530,977 		JBrowse link
G Phlpp2 PH domain and leucine rich repeat protein phosphatase 2 ISO RGD PMID:18511290 RGD:5131497 NCBI chr19:37,835,125...37,901,804
Ensembl chr19:37,835,125...37,905,513 		JBrowse link
G Pick1 protein interacting with PRKCA 1 ISO RGD PMID:18491053 RGD:5131491 NCBI chr 7:110,796,623...110,816,850
Ensembl chr 7:110,797,117...110,816,848 		JBrowse link
G Plcb1 phospholipase C beta 1 ISO RGD PMID:17524618 RGD:5131502 NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869 		JBrowse link
G Plcb2 phospholipase C, beta 2 ISO RGD PMID:17524618 RGD:5131502 NCBI chr 3:105,683,676...105,704,384
Ensembl chr 3:105,684,815...105,704,302 		JBrowse link
G Plcb3 phospholipase C beta 3 ISO RGD PMID:17524618 RGD:5131502 NCBI chr 1:204,143,257...204,160,384
Ensembl chr 1:204,144,956...204,160,228 		JBrowse link
G Plcb4 phospholipase C, beta 4 ISO RGD PMID:17524618 RGD:5131502 NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392 		JBrowse link
G Prkca protein kinase C, alpha ISO RGD PMID:19934406 RGD:5131489 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkcb protein kinase C, beta ISO RGD PMID:19934406 RGD:5131489 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Prkcd protein kinase C, delta ISO RGD PMID:19934406 RGD:5131489 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Prkce protein kinase C, epsilon ISO RGD PMID:19934406 RGD:5131489 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719 		JBrowse link
G Prkcg protein kinase C, gamma ISO RGD PMID:19934406 RGD:5131489 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384 		JBrowse link
G Prkch protein kinase C, eta ISO
IMP		 RGD PMID:19934406 PMID:9677361 RGD:5131489, RGD:5131657 NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654 		JBrowse link
G Prkci protein kinase C, iota ISO RGD PMID:19934406 PMID:16525119 RGD:5131489, RGD:5132275 NCBI chr 2:112,321,919...112,382,305
Ensembl chr 2:112,321,929...112,382,352 		JBrowse link
G Prkcq protein kinase C, theta ISO RGD PMID:19934406 RGD:5131489 NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704 		JBrowse link
G Prkcz protein kinase C, zeta ISO
IMP		 RGD PMID:19934406 PMID:20570724 PMID:16525119 RGD:5131489, RGD:5131661, RGD:5132275 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
G Rack1 receptor for activated C kinase 1 ISO RGD PMID:18491053 RGD:5131491 NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975 		JBrowse link
G Rasa1 RAS p21 protein activator 1 IMP RGD PMID:7588705 RGD:10002727 NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      signaling pathway involving second messengers 358
        protein kinase C (PKC) signaling pathway 32
Path 2
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      kinase mediated signaling pathway 601
        serine/threonine-specific kinase mediated signaling pathway 475
          protein kinase C (PKC) signaling pathway 32
paths to the root