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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:sterol regulatory element-binding protein signaling pathway
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Accession:PW:0000753 term browser browse the term
Definition:The sterol regulatory element-binding protein (SREBP) pathway has important roles in the control of lipid and cholesterol metabolism. SREBPs are sterol-regulated transcription factors that belong to the bHLH family.
Synonyms:related_synonym: SREBP signaling pathway
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sterol regulatory element-binding protein signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insig1 insulin induced gene 1 ISO RGD PMID:19933148 RGD:2317203 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Insig2 insulin induced gene 2 ISO RGD PMID:19933148 RGD:2317203 NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923 		JBrowse link
G Mbtps1 membrane-bound transcription factor peptidase, site 1 ISO RGD PMID:19933148 RGD:2317203 NCBI chr19:47,561,598...47,612,769
Ensembl chr19:47,561,598...47,612,791 		JBrowse link
G Mbtps2 membrane-bound transcription factor peptidase, site 2 ISO RGD PMID:19933148 RGD:2317203 NCBI chr  X:37,410,914...37,461,130
Ensembl chr  X:37,410,811...37,464,430 		JBrowse link
G Scap SREBF chaperone ISO RGD PMID:19933148 RGD:2317203 NCBI chr 8:110,306,026...110,360,677
Ensembl chr 8:110,306,031...110,360,666 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 ISO RGD PMID:19933148 RGD:2317203 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 ISO RGD PMID:19933148 RGD:2317203 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      transcription factor mediated signaling pathway 460
        basic helix-loop-helix signaling pathway 10
          sterol regulatory element-binding protein signaling pathway 7
Path 2
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3871
      pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis 1752
        transcription pathway 1074
          transcription pathway via transcription factor mediated signaling 460
            basic helix-loop-helix signaling pathway 10
              sterol regulatory element-binding protein signaling pathway 7
paths to the root