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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:FasL mediated signaling pathway
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Accession:PW:0000681 term browser browse the term
Definition:Fas ligand binding to its receptor triggers a conformational change that allows the receptor to assemble a signaling complex known as DISC, followed by recruitment of pro-caspase-8 and activation of caspase-3 and -7. It is believed that Fas-mediated signaling to elicit apoptosis follows two routes.
Synonyms:related_synonym: Fas signaling pathway;   FasL/ CD95L signaling
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FasL mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200080 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bid BH3 interacting domain death agonist IEP
ISO		 PID
RGD		 PMID:18090083 PMID:19239902 PID:200080, RGD:2314002, RGD:4143196 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 ISO PID PID:200080 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 ISO PID PID:200080 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Btk Bruton tyrosine kinase ISO PID PID:200080 NCBI chr  X:97,722,796...97,762,315
Ensembl chr  X:97,722,802...97,761,853 		JBrowse link
G Casp3 caspase 3 ISO PID
RGD		 PMID:19239902 PID:200080, RGD:4143196 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 ISO RGD PMID:19239902 RGD:4143196 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 IMP
ISO		 PID
RGD		 PMID:18090083 PMID:19239902 PID:200080, RGD:2314002, RGD:4143196 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator ISO
IEP		 PID
RGD		 PMID:19239902 PMID:19107989 PID:200080, RGD:4143196, RGD:8662854 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex ISO PID PID:200080 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Cltc clathrin heavy chain ISO PID PID:200080 NCBI chr10:71,517,661...71,574,591
Ensembl chr10:71,517,663...71,573,737 		JBrowse link
G Ezr ezrin ISO PID PID:200080 NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505 		JBrowse link
G Fadd Fas associated via death domain ISO PID
RGD		 PMID:19239902 PID:200080, RGD:4143196 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 ISO PID PID:200080 NCBI chr 7:130,632,368...130,659,353
Ensembl chr 7:130,633,348...130,659,168 		JBrowse link
G Fas Fas cell surface death receptor IEP
ISO		 PID
RGD		 PMID:18090083 PMID:19239902 PMID:19107989 PID:200080, RGD:2314002, RGD:4143196, RGD:8662854 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand IEP
ISO		 PID
RGD		 PMID:18090083 PMID:19239902 PID:200080, RGD:2314002, RGD:4143196 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta ISO PID PID:200080 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma ISO PID PID:200080 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 ISO PID PID:200080 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293 		JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 ISO PID PID:200080 NCBI chr12:2,591,312...2,600,534
Ensembl chr12:2,591,219...2,604,222 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 ISO PID PID:200080 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 ISO PID PID:200080 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 ISO PID PID:200080 NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 ISO PID PID:200080 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO PID PID:200080 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 ISO PID PID:200080 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 ISO PID PID:200080 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO PID PID:200080 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta ISO PID PID:200080 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta ISO PID PID:200080 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200080 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 ISO PID PID:200080 NCBI chr16:18,665,517...18,674,067
Ensembl chr16:18,665,457...18,674,065 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 ISO PID PID:200080 NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583 		JBrowse link
G Rfc1 replication factor C subunit 1 ISO PID PID:200080 NCBI chr14:42,966,279...43,041,372
Ensembl chr14:42,966,324...43,041,370 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 ISO PID PID:200080 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 ISO PID PID:200080 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO PID PID:200080 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Syk spleen associated tyrosine kinase ISO PID PID:200080 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      cytokine and chemokine mediated signaling pathway 570
        cytokine mediated signaling pathway 485
          tumor necrosis factor superfamily mediated signaling pathway 88
            FasL mediated signaling pathway 38
              altered FasL mediated signaling pathway 0
Path 2
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3871
      cell death pathway 243
        programmed cell death pathway 243
          apoptotic cell death pathway 162
            extrinsic apoptotic pathway 88
              FasL mediated signaling pathway 38
                altered FasL mediated signaling pathway 0
paths to the root