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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:hexosamine biosynthetic pathway
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Accession:PW:0000559 term browser browse the term
Definition:The formation of nucleotide hexosamines, primarily UDP-N-acetylglucosamine, constitutes the final step in the hexosamine biosynthetic pathway which provides substrates for the O-linked glycosylation of proteins. Glycoproteins that are either secreted from the cell or inserted into the plasma membrane undergo N-linked glycosylation. The O-linked glycosylation of nuclear and/or cytosolic proteins confers a signaling dimension to the hexosamine biosynthetic pathway.
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hexosamine biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gfpt1 glutamine fructose-6-phosphate transaminase 1 IMP
ISO		 RGD PMID:10898949 PMID:15466941 RGD:1625426, RGD:1625539 NCBI chr 4:119,496,691...119,546,472
Ensembl chr 4:119,496,714...119,546,471 		JBrowse link
G Gnpnat1 glucosamine-phosphate N-acetyltransferase 1 ISO RGD PMID:15466941 RGD:1625539 NCBI chr15:18,596,180...18,608,854
Ensembl chr15:18,596,442...18,608,739 		JBrowse link
G Gpi glucose-6-phosphate isomerase ISO RGD PMID:15466941 RGD:1625539 NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086 		JBrowse link
G Oga O-GlcNAcase TAS RGD PMID:18445751 RGD:2311625 NCBI chr 1:244,598,285...244,633,835
Ensembl chr 1:244,598,292...244,634,359 		JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase ISO
TAS		 RGD PMID:15466941 PMID:18445751 RGD:1625539, RGD:2311625 NCBI chr  X:66,771,278...66,816,148
Ensembl chr  X:66,771,349...66,816,146 		JBrowse link
G Pgm3 phosphoglucomutase 3 ISO RGD PMID:15466941 RGD:1625539 NCBI chr 8:87,518,317...87,536,021
Ensembl chr 8:87,517,701...87,536,022 		JBrowse link
G Uap1 UDP-N-acetylglucosamine pyrophosphorylase 1 ISO RGD PMID:15466941 RGD:1625539 NCBI chr13:82,342,946...82,377,558
Ensembl chr13:82,342,946...82,377,469 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    classic metabolic pathway 1854
      carbohydrate metabolic pathway 526
        amino sugar metabolic pathway 50
          hexosamine metabolic pathway 7
            hexosamine biosynthetic pathway 7
Path 2
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3871
      homeostasis pathway 1773
        glucose homeostasis pathway 344
          glucose utilization pathway 121
            glucose conversion pathway 7
              hexosamine biosynthetic pathway 7
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