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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:leptin system pathway
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Accession:PW:0000363 term browser browse the term
Definition:Leptin acts on two populations of hypothalamic neurons that express orexigenic (feeding inducing) and anorexigenic genes, respectively. Leptin reduces the expression of genes from the former and enhances the expression of genes from the latter neurons. The leptin mediated response acts primarily via Jak-dependent activation of STAT.
Synonyms:related_synonym: Signaling by Leptin;   leptin-mediated signaling pathway
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leptin system pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Irs1 insulin receptor substrate 1 ISO RGD PMID:15316008 RGD:2302071 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Irs2 insulin receptor substrate 2 ISO RGD PMID:15316008 RGD:2302071 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482 		JBrowse link
G Jak2 Janus kinase 2 ISO RGD PMID:17010638 PMID:15316008 RGD:1625125, RGD:2302071 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Lep leptin TAS
IDA
ISO		 RGD PMID:11102451 PMID:9618284 PMID:9070213 PMID:17010638 RGD:61790, RGD:2290294, RGD:2290293, RGD:1625125 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lepr leptin receptor TAS
IDA
ISO		 RGD PMID:11102451 PMID:9618284 PMID:9070213 PMID:17010638 PMID:17229951 RGD:61790, RGD:2290294, RGD:2290293, RGD:1625125, RGD:1600611 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Lepr_v1 leptin receptor, variant 1 IDA RGD PMID:9070213 PMID:9618284 RGD:2290293, RGD:2290294
G Lepr_v2 leptin receptor, variant 2 ISO
IDA		 RGD PMID:17578380 PMID:9618284 PMID:9070213 RGD:2290292, RGD:2290294, RGD:2290293
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 ISO RGD PMID:15821101 RGD:2289366 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 ISO RGD PMID:17872473 RGD:2289807 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Sh2b1 SH2B adaptor protein 1 ISO RGD PMID:15316008 RGD:2302071 NCBI chr 1:181,048,622...181,057,036
Ensembl chr 1:181,048,623...181,056,579 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 ISO RGD PMID:17010638 RGD:1625125 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO RGD PMID:17229951 PMID:17010638 RGD:1600611, RGD:1625125 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
altered leptin system pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insr insulin receptor IMP increased basal hypothalamic leptin signaling without changes in leptin receptor expression after antisense-mediated hypothalamus-specific Insr knock-down RGD PMID:17585961 RGD:2290473 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Lep leptin TAS RGD PMID:11102451 RGD:61790 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lepr leptin receptor TAS
ISO		 RGD PMID:11102451 PMID:17229951 RGD:61790, RGD:1600611 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Lepr_v2 leptin receptor, variant 2 ISO RGD PMID:17578380 RGD:2290292
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      hormone signaling pathway 624
        peptide and protein hormone signaling pathway 439
          leptin system pathway 13
            altered leptin system pathway 4
paths to the root