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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:Notch signaling pathway
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Accession:PW:0000204 term browser browse the term
Definition:The Notch signaling pathway regulates processes involved in early embryonic development. It plays an important role in cell fate determination. Target genes of Notch have been implicated in angiogenesis, somitogenesis and gliogenesis. Deregulation of the Notch signaling pathway underlies a broad spectrum of diseases and clinical conditions.
Synonyms:related_synonym: Signaling by NOTCH
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show annotations for term's descendants           Sort by:
Notch signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam10 ADAM metallopeptidase domain 10 ISS
ISO		 PID
RGD		 PMID:12354787 PMID:17761886 PID:200015, RGD:1300252, RGD:2302204 NCBI chr 8:71,346,008...71,477,889
Ensembl chr 8:71,345,837...71,477,889 		JBrowse link
G Adam12 ADAM metallopeptidase domain 12 ISO PID PID:200015 NCBI chr 1:188,686,984...189,014,206
Ensembl chr 1:188,686,989...189,020,667 		JBrowse link
G Adam17 ADAM metallopeptidase domain 17 ISO
IEA		 KEGG
RGD		 PMID:17761886 rno:04330, RGD:2302204 NCBI chr 6:40,872,936...40,920,700
Ensembl chr 6:40,872,856...40,920,639 		JBrowse link
G Aph1a aph-1 homolog A, gamma secretase subunit ISO
IEA		 KEGG
PID
RGD		 PMID:17761886 PID:200015 rno:04330, RGD:2302204 NCBI chr 2:183,437,676...183,443,113
Ensembl chr 2:183,438,434...183,441,955 		JBrowse link
G Aph1b aph-1 homolog B, gamma secretase subunit ISO
IEA		 KEGG
PID
RGD		 PMID:17761886 PID:200015 rno:04330, RGD:2302204 NCBI chr 8:67,429,198...67,454,735
Ensembl chr 8:67,429,198...67,450,243 		JBrowse link
G Cbl Cbl proto-oncogene ISO PID PID:200015 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176 		JBrowse link
G Ccnd1 cyclin D1 ISO PID PID:200015 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO PID PID:200015 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cir1 corepressor interacting with RBPJ, 1 IEA KEGG rno:04330 NCBI chr 3:58,158,923...58,188,799
Ensembl chr 3:58,158,951...58,188,789 		JBrowse link
G Cntn1 contactin 1 ISO PID PID:200015 NCBI chr 7:123,263,146...123,560,896
Ensembl chr 7:123,372,792...123,558,541 		JBrowse link
G Cntn6 contactin 6 ISO PID PID:200015 NCBI chr 4:137,354,886...137,751,712
Ensembl chr 4:137,355,367...137,751,119 		JBrowse link
G Crebbp CREB binding protein IEA KEGG rno:04330 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Ctbp1 C-terminal binding protein 1 ISO
IEA		 PID
KEGG		 PID:200015 rno:04330 NCBI chr14:77,455,580...77,482,821
Ensembl chr14:77,455,696...77,482,821 		JBrowse link
G Ctbp2 C-terminal binding protein 2 IEA KEGG rno:04330 NCBI chr 1:187,782,064...187,918,115
Ensembl chr 1:187,782,682...187,920,222 		JBrowse link
G Cul1 cullin 1 ISO PID PID:200015 NCBI chr 4:76,551,952...76,625,830
Ensembl chr 4:76,551,983...76,627,980 		JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 ISO PID PID:200015 NCBI chr 6:128,410,216...128,417,518
Ensembl chr 6:128,410,316...128,417,522 		JBrowse link
G Dll1 delta like canonical Notch ligand 1 TAS
IEA
ISO		 KEGG
PID
RGD		 PMID:14743446 PMID:17761886 PID:200015 rno:04330, RGD:1304491, RGD:2302204 NCBI chr 1:56,312,062...56,320,177
Ensembl chr 1:56,312,066...56,320,179 		JBrowse link
G Dll3 delta like canonical Notch ligand 3 TAS
IEA
ISO		 KEGG
PID
RGD		 PMID:14743446 PMID:17761886 PID:200015 rno:04330, RGD:1304491, RGD:2302204 NCBI chr 1:83,562,011...83,570,008
Ensembl chr 1:83,562,014...83,569,750 		JBrowse link
G Dll4 delta like canonical Notch ligand 4 ISO
IEA		 KEGG
PID
RGD		 PMID:17761886 PID:200015 rno:04330, RGD:2302204 NCBI chr 3:106,317,114...106,327,004
Ensembl chr 3:106,316,986...106,326,931 		JBrowse link
G Dner delta/notch-like EGF repeat containing ISO PID PID:200015 NCBI chr 9:85,586,985...85,902,461
Ensembl chr 9:85,586,987...85,902,637 		JBrowse link
G Dnm1 dynamin 1 ISO PID PID:200015 NCBI chr 3:15,604,782...15,648,654
Ensembl chr 3:15,604,784...15,648,538 		JBrowse link
G Dtx1 deltex E3 ubiquitin ligase 1 ISO PID PID:200015 NCBI chr12:35,849,647...35,880,835
Ensembl chr12:35,849,617...35,880,838 		JBrowse link
G Dtx2 deltex E3 ubiquitin ligase 2 IEA KEGG rno:04330 NCBI chr12:20,643,289...20,682,908
Ensembl chr12:20,643,297...20,682,885 		JBrowse link
G Dtx3 deltex E3 ubiquitin ligase 3 IEA KEGG rno:04330 NCBI chr 7:63,013,769...63,018,431
Ensembl chr 7:63,013,371...63,018,522 		JBrowse link
G Dtx3l deltex E3 ubiquitin ligase 3L IEA KEGG rno:04330 NCBI chr11:64,814,926...64,824,539
Ensembl chr11:64,814,926...64,824,538 		JBrowse link
G Dtx4 deltex E3 ubiquitin ligase 4 IEA KEGG rno:04330 NCBI chr 1:209,457,719...209,545,163
Ensembl chr 1:209,460,735...209,492,818 		JBrowse link
G Dvl1 dishevelled segment polarity protein 1 IEA KEGG rno:04330 NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664 		JBrowse link
G Dvl3 dishevelled segment polarity protein 3 IEA KEGG rno:04330 NCBI chr11:80,365,446...80,382,641
Ensembl chr11:80,366,117...80,382,462 		JBrowse link
G Eno1 enolase 1 ISO PID PID:200015 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 		JBrowse link
G Ep300 E1A binding protein p300 ISO
IEA		 PID
KEGG		 PID:200015 rno:04330 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Eps15 epidermal growth factor receptor pathway substrate 15 ISO PID PID:200015 NCBI chr 5:124,045,865...124,146,221
Ensembl chr 5:124,045,926...124,146,221 		JBrowse link
G Fbxw7 F-box and WD repeat domain containing 7 ISO PID PID:200015 NCBI chr 2:170,149,706...170,311,536
Ensembl chr 2:170,149,694...170,309,941 		JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) ISO PID PID:200015 NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314 		JBrowse link
G Gata3 GATA binding protein 3 ISO PID PID:200015 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Hdac1 histone deacetylase 1 ISO
IEA		 PID
KEGG		 PID:200015 rno:04330 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hdac1l histone deacetylase 1-like IEA KEGG rno:04330 NCBI chr 9:80,452,615...80,454,615
Ensembl chr 9:80,453,139...80,454,593 		JBrowse link
G Hdac2 histone deacetylase 2 IEA KEGG rno:04330 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 ISO
IEA		 KEGG
RGD		 PMID:17586813 rno:04330, RGD:5135539 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Hes5 hes family bHLH transcription factor 5 ISO
IEA		 KEGG
RGD		 PMID:17586813 rno:04330, RGD:5135539 NCBI chr 5:165,522,138...165,523,684
Ensembl chr 5:165,522,234...165,523,001 		JBrowse link
G Hes7 hes family bHLH transcription factor 7 ISO RGD PMID:17586813 RGD:5135539 NCBI chr10:53,824,124...53,828,934
Ensembl chr10:53,825,574...53,828,097 		JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 IDA
ISO		 RGD PMID:11741889 PMID:17586813 RGD:70528, RGD:5135539 NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312 		JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 ISO
IDA		 RGD PMID:17586813 PMID:11741889 RGD:5135539, RGD:70528 NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218 		JBrowse link
G Heyl hes-related family bHLH transcription factor with YRPW motif-like ISO RGD PMID:17586813 RGD:5135539 NCBI chr 5:135,508,160...135,525,152
Ensembl chr 5:135,508,160...135,525,152 		JBrowse link
G Il4 interleukin 4 ISO PID PID:200015 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Itch itchy E3 ubiquitin protein ligase ISO PID PID:200015 NCBI chr 3:143,642,348...143,733,745
Ensembl chr 3:143,645,637...143,733,543 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 IDA
IEA
ISO
IMP		 KEGG
PID
RGD		 PMID:7697721 PMID:15057910 PMID:17761886 PID:200015 rno:04330, RGD:69863, RGD:1334443, RGD:2302204 NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209 		JBrowse link
G Jag2 jagged canonical Notch ligand 2 TAS
IEA
ISO		 KEGG
PID
RGD		 PMID:8948600 PMID:17761886 PID:200015 rno:04330, RGD:69864, RGD:2302204 NCBI chr 6:131,983,059...132,005,665
Ensembl chr 6:131,983,056...132,005,818 		JBrowse link
G Kat2a lysine acetyltransferase 2A IEA KEGG rno:04330 NCBI chr10:85,632,216...85,640,561
Ensembl chr10:85,632,216...85,640,166 		JBrowse link
G Kat2b lysine acetyltransferase 2B IEA KEGG rno:04330 NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064 		JBrowse link
G Kdm1a lysine demethylase 1A ISO PID PID:200015 NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319 		JBrowse link
G Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase IDA
IEA
ISO		 KEGG
RGD		 PMID:12167404 PMID:17761886 rno:04330, RGD:727405, RGD:2302204 NCBI chr12:14,030,551...14,038,996
Ensembl chr12:14,018,333...14,039,008 		JBrowse link
G Lnx1 ligand of numb-protein X 1 ISO PID PID:200015 NCBI chr14:33,514,429...33,617,086
Ensembl chr14:33,514,436...33,617,086 		JBrowse link
G Maml1 mastermind-like transcriptional coactivator 1 ISO
IEA		 KEGG
PID
RGD		 PMID:17761886 PID:200015 rno:04330, RGD:2302204 NCBI chr10:34,588,639...34,623,024
Ensembl chr10:34,588,646...34,623,338 		JBrowse link
G Maml2 mastermind-like transcriptional coactivator 2 ISO
IEA		 KEGG
PID
RGD		 PMID:17761886 PID:200015 rno:04330, RGD:2302204 NCBI chr 8:10,268,611...10,588,307
Ensembl chr 8:10,268,665...10,587,107 		JBrowse link
G Maml3 mastermind-like transcriptional coactivator 3 ISO RGD PMID:17761886 RGD:2302204 NCBI chr 2:135,720,431...136,137,829
Ensembl chr 2:135,721,021...136,137,814 		JBrowse link
G Mark2 microtubule affinity regulating kinase 2 ISO PID PID:200015 NCBI chr 1:204,461,029...204,526,247
Ensembl chr 1:204,461,030...204,525,652 		JBrowse link
G Mfap2 microfibril associated protein 2 ISO PID PID:200015 NCBI chr 5:153,312,068...153,320,266
Ensembl chr 5:153,314,711...153,320,259 		JBrowse link
G Mfap5 microfibril associated protein 5 ISO PID PID:200015 NCBI chr 4:155,727,925...155,750,458
Ensembl chr 4:155,727,925...155,750,458 		JBrowse link
G Mfng MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase ISS
IEA
ISO		 KEGG
RGD		 PMID:9187150 PMID:17761886 rno:04330, RGD:1302739, RGD:2302204 NCBI chr 7:110,310,810...110,328,653
Ensembl chr 7:110,310,812...110,328,653 		JBrowse link
G Mib1 MIB E3 ubiquitin protein ligase 1 ISO PID
RGD		 PMID:12530964 PID:200015, RGD:1334454 NCBI chr18:1,802,519...1,926,988
Ensembl chr18:1,802,519...1,920,689 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor ISO PID PID:200015 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Mycbp Myc binding protein ISO PID PID:200015 NCBI chr 5:136,135,955...136,143,163
Ensembl chr 5:136,135,931...136,145,616 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 ISO PID PID:200015 NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 ISO
IEA		 PID
KEGG		 PID:200015 rno:04330 NCBI chr12:31,466,418...31,628,319
Ensembl chr12:31,466,412...31,628,319 		JBrowse link
G Ncstn nicastrin TAS
IEA
ISO		 KEGG
PID
RGD		 PMID:12736250 PMID:17761886 PID:200015 rno:04330, RGD:724403, RGD:2302204 NCBI chr13:84,530,442...84,546,454
Ensembl chr13:84,530,440...84,546,454 		JBrowse link
G Neurl1 neuralized E3 ubiquitin protein ligase 1 ISO RGD PMID:14986688 RGD:1334462 NCBI chr 1:246,066,830...246,152,890
Ensembl chr 1:246,067,100...246,152,903 		JBrowse link
G Neurl2 neuralized E3 ubiquitin protein ligase 2 ISO RGD PMID:14986688 RGD:1334462 NCBI chr 3:153,566,659...153,569,380
Ensembl chr 3:153,566,660...153,569,380 		JBrowse link
G Notch1 notch receptor 1 IDA
IEA
ISO
IMP		 KEGG
PID
RGD		 PMID:11900468 PMID:15247148 PMID:15057910 PMID:17761886 PMID:12853432 PID:200015 rno:04330, RGD:724389, RGD:2306423, RGD:1334443, RGD:2302204, RGD:1358543 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Notch2 notch receptor 2 TAS
IEA
ISO		 KEGG
PID
RGD		 PMID:1295745 PMID:17761886 PID:200015 rno:04330, RGD:69906, RGD:2302204 NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088 		JBrowse link
G Notch3 notch receptor 3 IDA
IEA
ISO		 KEGG
PID
RGD		 PMID:11971902 PMID:15247148 PMID:17761886 PID:200015 rno:04330, RGD:625426, RGD:2306423, RGD:2302204 NCBI chr 7:11,132,984...11,184,025
Ensembl chr 7:11,133,706...11,184,025 		JBrowse link
G Notch4 notch receptor 4 IDA
IEA
ISO		 KEGG
PID
RGD		 PMID:10964583 PMID:17761886 PID:200015 rno:04330, RGD:1304484, RGD:2302204 NCBI chr20:4,160,362...4,184,466
Ensembl chr20:4,160,445...4,184,465 		JBrowse link
G Numb NUMB, endocytic adaptor protein TAS
IEA
ISO		 KEGG
PID
RGD		 PMID:12500307 PID:200015 rno:04330, RGD:724390 NCBI chr 6:103,431,400...103,553,422
Ensembl chr 6:103,431,400...103,553,354 		JBrowse link
G Numbl NUMB-like, endocytic adaptor protein ISO
IEA		 KEGG
RGD		 PMID:15492044 rno:04330, RGD:1334451 NCBI chr 1:82,549,814...82,573,788
Ensembl chr 1:82,550,054...82,573,776 		JBrowse link
G Pofut1 protein O-fucosyltransferase 1 ISS
ISO		 RGD PMID:14570055 PMID:17761886 RGD:1334453, RGD:2302204 NCBI chr 3:141,708,618...141,735,558
Ensembl chr 3:141,708,644...141,734,786 		JBrowse link
G Psen1 presenilin 1 TAS
IEA
ISO		 KEGG
PID
RGD		 PMID:12736250 PMID:17761886 PID:200015 rno:04330, RGD:724403, RGD:2302204 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Psen2 presenilin 2 ISO
IEA		 KEGG
RGD		 PMID:17761886 rno:04330, RGD:2302204 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174 		JBrowse link
G Psenen presenilin enhancer gamma secretase subunit ISO
IEA		 KEGG
PID
RGD		 PMID:17761886 PID:200015 rno:04330, RGD:2302204 NCBI chr 1:85,814,905...85,816,654
Ensembl chr 1:85,814,905...85,816,192 		JBrowse link
G Ptcra pre T-cell antigen receptor alpha IEA KEGG rno:04330 NCBI chr 9:14,218,907...14,229,141
Ensembl chr 9:14,218,802...14,229,235 		JBrowse link
G Rab11a RAB11a, member RAS oncogene family ISO PID PID:200015 NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525 		JBrowse link
G Rbbp8 RB binding protein 8, endonuclease ISO PID PID:200015 NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846 		JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region IDA
IEA
ISO		 KEGG
PID
RGD		 PMID:15247148 PID:200015 rno:04330, RGD:2306423 NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353 		JBrowse link
G Rbpjl recombination signal binding protein for immunoglobulin kappa J region-like IEA KEGG rno:04330 NCBI chr 3:153,134,044...153,147,421
Ensembl chr 3:153,134,140...153,146,513 		JBrowse link
G Rbpjl2 recombination signal binding protein for immunoglobulin kappa J region-like 2 IEA KEGG rno:04330 NCBI chr 5:5,464,969...5,466,367
Ensembl chr 5:5,464,397...5,466,366 		JBrowse link
G Rfng RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase IMP
IEA
ISO		 KEGG
RGD		 PMID:11165380 PMID:17761886 rno:04330, RGD:633801, RGD:2302204 NCBI chr10:106,047,221...106,050,331
Ensembl chr10:106,047,221...106,050,345 		JBrowse link
G Skp1 S-phase kinase-associated protein 1 ISO PID PID:200015 NCBI chr10:36,401,987...36,417,066
Ensembl chr10:36,402,153...36,417,388 		JBrowse link
G Skp2 S-phase kinase associated protein 2 ISO PID PID:200015 NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338 		JBrowse link
G Snw1 SNW domain containing 1 IEA KEGG rno:04330 NCBI chr 6:107,095,450...107,119,536
Ensembl chr 6:107,095,457...107,119,536 		JBrowse link
G Spen spen family transcriptional repressor ISO PID PID:200015 NCBI chr 5:153,775,287...153,848,677
Ensembl chr 5:153,776,234...153,848,811 		JBrowse link
G Sspo SCO-spondin ISO PID PID:200015 NCBI chr 4:77,394,915...77,450,526
Ensembl chr 4:77,397,059...77,450,412 		JBrowse link
G Yy1 YY1 transcription factor ISO PID PID:200015 NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747 		JBrowse link
altered Notch signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll1 delta like canonical Notch ligand 1 ISS paper on the human protein which may be involved in disease RGD PMID:10079256 RGD:1304492 NCBI chr 1:56,312,062...56,320,177
Ensembl chr 1:56,312,066...56,320,179 		JBrowse link
G Dll3 delta like canonical Notch ligand 3 ISS paper mentions mutations and diseases, deletion in mice RGD PMID:12141422 RGD:1304493 NCBI chr 1:83,562,011...83,570,008
Ensembl chr 1:83,562,014...83,569,750 		JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 ISS RGD PMID:12548545 RGD:1334460 NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 ISS RGD PMID:10964583 RGD:1304484 NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209 		JBrowse link
G Jag2 jagged canonical Notch ligand 2 ISS RGD PMID:10079256 RGD:1304492 NCBI chr 6:131,983,059...132,005,665
Ensembl chr 6:131,983,056...132,005,818 		JBrowse link
G Notch1 notch receptor 1 ISS RGD PMID:11900468 RGD:724389 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Notch4 notch receptor 4 ISS RGD PMID:10964583 RGD:1304484 NCBI chr20:4,160,362...4,184,466
Ensembl chr20:4,160,445...4,184,465 		JBrowse link
G Numb NUMB, endocytic adaptor protein ISS RGD PMID:15492044 RGD:1334451 NCBI chr 6:103,431,400...103,553,422
Ensembl chr 6:103,431,400...103,553,354 		JBrowse link
G Pofut1 protein O-fucosyltransferase 1 ISS RGD PMID:14570055 RGD:1334453 NCBI chr 3:141,708,618...141,735,558
Ensembl chr 3:141,708,644...141,734,786 		JBrowse link
altered Notch signaling pathway involving promoters term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 ISS RGD PMID:12548545 RGD:1334460 NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312 		JBrowse link
altered Notch signaling pathway involving the macromolecules modifying the main players term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Numb NUMB, endocytic adaptor protein ISS In humans, loss of Numb regulation over Notch is involved in breast cancer. RGD PMID:15492044 RGD:1334451 NCBI chr 6:103,431,400...103,553,422
Ensembl chr 6:103,431,400...103,553,354 		JBrowse link
G Pofut1 protein O-fucosyltransferase 1 ISS RGD PMID:14570055 RGD:1334453 NCBI chr 3:141,708,618...141,735,558
Ensembl chr 3:141,708,644...141,734,786 		JBrowse link
G Psen2 presenilin 2 ISO C. elegans transgenics expressing human wild-type and mutant PSEN2 RGD PMID:16474849 RGD:2302525 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174 		JBrowse link
altered Notch signaling pathway involving the main players term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll3 delta like canonical Notch ligand 3 ISS RGD PMID:12141422 RGD:1304493 NCBI chr 1:83,562,011...83,570,008
Ensembl chr 1:83,562,014...83,569,750 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 ISS RGD PMID:15057910 RGD:1334443 NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209 		JBrowse link
G Notch1 notch receptor 1 ISS RGD PMID:15472075 RGD:1334450 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Notch3 notch receptor 3 ISS RGD PMID:14667809 RGD:1334442 NCBI chr 7:11,132,984...11,184,025
Ensembl chr 7:11,133,706...11,184,025 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      signaling pathway pertinent to development 536
        Notch signaling pathway 90
          altered Notch signaling pathway + 11
Path 2
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      cell adhesion signaling pathway 413
        cell-cell signaling pathway 253
          Notch signaling pathway 90
            altered Notch signaling pathway + 11
paths to the root