ONTOLOGY REPORT - ANNOTATIONS
Term: cholesterol biosynthetic process
Accession: GO:0006695
browse the term
Definition: The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
Synonyms: exact_synonym: cholesterol anabolism; cholesterol biosynthesis; cholesterol formation; cholesterol synthesis
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AABR07021955.1
involved_in
IEA IBA
GO_REF:0000041 GO_REF:0000033
UniProt GO_Central
GO_REF:0000033 GO_REF:0000041
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Acat2
acetyl-CoA acetyltransferase 2
involved_in
TAS
PMID:10806397
UniProt
PMID:10806397
RGD:2326086
NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821
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Apoa1
apolipoprotein A1
acts_upstream_of_or_within
ISO
MGI:2180783 (PMID:8647961)
RGD
PMID:8647961
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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Ces1d
carboxylesterase 1D
involved_in
ISO
(PMID:11015575)
RGD
PMID:11015575
NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
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Cftr
CF transmembrane conductance regulator
involved_in acts_upstream_of_or_within
IEA ISO
GO_REF:0000107 MGI:1856709 (PMID:17085523)
Ensembl RGD
PMID:17085523
GO_REF:0000107
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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Cyb5r3
cytochrome b5 reductase 3
involved_in
IEA
GO_REF:0000043
UniProt
GO_REF:0000043
NCBI chr 7:114,306,686...114,324,247
Ensembl chr 7:114,306,685...114,324,298
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Dhcr24
24-dehydrocholesterol reductase
involved_in acts_upstream_of_or_within
ISS ISO
GO_REF:0000024 MGI:3027024 (PMID:14684813), (PMID:16321981), (PMID:16513830) (PMID:11519011)
UniProt RGD
PMID:11519011 PMID:14684813 PMID:16321981 PMID:16513830
GO_REF:0000024
NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137
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Dhcr7
7-dehydrocholesterol reductase
involved_in
TAS IBA IEA ISO IMP IC IDA
GO_REF:0000033 GO_REF:0000041 (PMID:9465114)
GO_Central UniProt RGD
PMID:9465114 PMID:12031495 PMID:9831636 PMID:10666310 PMID:10329655
GO_REF:0000033 GO_REF:0000041, RGD:625561 , RGD:2316918 , RGD:2316916 , RGD:632010
NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
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Ebp
EBP, cholestenol delta-isomerase
involved_in
IDA IBA ISO IEA TAS
GO_REF:0000033 (PMID:9894009) GO_REF:0000041
GO_Central RGD UniProt
PMID:9894009 PMID:11171067 PMID:11171067
GO_REF:0000033 GO_REF:0000041, RGD:628445 , RGD:628445
NCBI chr X:14,299,427...14,305,826
Ensembl chr X:14,299,448...14,305,826
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ENSRNOG00000062441
involved_in
IEA
GO_REF:0000043
UniProt
GO_REF:0000043
Ensembl chr17:61,602,519...61,608,185
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Fdft1
farnesyl diphosphate farnesyl transferase 1
involved_in
TAS IBA IEA IMP
GO_REF:0000033 GO_REF:0000118
GO_Central TreeGrafter RGD
PMID:1400448 PMID:16440058
GO_REF:0000033 GO_REF:0000118, RGD:728402 , RGD:1626611
NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
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Fdps
farnesyl diphosphate synthase
TAS
RGD
PMID:1321149
RGD:728501
NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
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G6pd
glucose-6-phosphate dehydrogenase
involved_in
ISO
(PMID:12027950)
RGD
PMID:12027950
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
involved_in acts_upstream_of_or_within
ISO IEA
(PMID:23063590) (PMID:15845870), (PMID:7798939), (PMID:8647961) GO_REF:0000107 GO_REF:0000043
RGD Ensembl UniProt
PMID:7798939 PMID:8647961 PMID:15845870 PMID:23063590
GO_REF:0000043 GO_REF:0000107
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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Hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1
involved_in
IEA
GO_REF:0000043
UniProt
GO_REF:0000043
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
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Hmgcs2
3-hydroxy-3-methylglutaryl-CoA synthase 2
involved_in
IEA
GO_REF:0000043
UniProt
GO_REF:0000043
NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
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Hsd17b7
hydroxysteroid (17-beta) dehydrogenase 7
involved_in acts_upstream_of_or_within
ISO IEA IBA ISS
(PMID:12829805) GO_REF:0000118 GO_REF:0000033 GO_REF:0000024 GO_REF:0000107
RGD TreeGrafter GO_Central UniProt Ensembl
PMID:12829805
GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118
NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017
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Idi1
isopentenyl-diphosphate delta isomerase 1
involved_in
TAS IEA
GO_REF:0000043
UniProt RGD
PMID:9228075
GO_REF:0000043, RGD:729078
NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
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Idi2
isopentenyl-diphosphate delta isomerase 2
involved_in
IEA
GO_REF:0000043
UniProt
GO_REF:0000043
NCBI chr17:61,331,385...61,334,987
Ensembl chr17:61,331,669...61,334,285
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Idi2l2
isopentenyl-diphosphate delta isomerase 2 like 2
involved_in
IEA
GO_REF:0000043
UniProt
GO_REF:0000043
NCBI chr17:61,372,853...61,386,459
Ensembl chr17:61,373,678...61,386,454
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Idi2l3
isopentenyl-diphosphate delta isomerase 2 like 3
involved_in
IEA
GO_REF:0000043
UniProt
GO_REF:0000043
NCBI chr17:61,518,138...61,535,484
Ensembl chr17:61,519,390...61,531,603
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Insig1
insulin induced gene 1
involved_in acts_upstream_of_or_within
ISO IBA
(PMID:32322062) MGI:1920249 (PMID:16955138) GO_REF:0000033
RGD GO_Central
PMID:16955138 PMID:32322062
GO_REF:0000033
NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
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Insig2
insulin induced gene 2
involved_in acts_upstream_of_or_within
ISS ISO IBA IEA
GO_REF:0000024 MGI:1916289 (PMID:16955138) GO_REF:0000033 GO_REF:0000107 (PMID:32322062)
UniProt RGD GO_Central Ensembl
PMID:16955138 PMID:32322062
GO_REF:0000024 GO_REF:0000033 GO_REF:0000107
NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
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Lbr
lamin B receptor
involved_in
ISO IBA IEA ISS
(PMID:16784888), (PMID:27336722) GO_REF:0000033 (MGI:3822946|PMID:18785926), (MGI:5308142|PMID:22140257) GO_REF:0000041 GO_REF:0000024
RGD GO_Central UniProt
PMID:16784888 PMID:18785926 PMID:22140257 PMID:27336722
GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 MGI:3822946 MGI:5308142
NCBI chr13:93,539,386...93,564,026
Ensembl chr13:93,538,920...93,564,017
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Lipa
lipase A, lysosomal acid type
involved_in acts_upstream_of_or_within
IEA ISO
GO_REF:0000107 MGI:2451080 (PMID:25147230), (PMID:29599133)
Ensembl RGD
PMID:25147230 PMID:29599133
GO_REF:0000107
NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633
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LOC102551575
isopentenyl-diphosphate delta-isomerase 2-like
involved_in
IEA
GO_REF:0000043
UniProt
GO_REF:0000043
NCBI chr17:61,504,294...61,507,015
Ensembl chr17:61,504,535...61,507,015
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LOC120097764
isopentenyl-diphosphate delta-isomerase 2-like
involved_in
IEA
GO_REF:0000043
UniProt
GO_REF:0000043
NCBI chr17:61,338,622...61,349,795
Ensembl chr17:61,347,251...61,349,795 Ensembl chr17:61,347,251...61,349,795
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LOC120102490
insulin-induced gene 1 protein-like
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 4:67,330,399...67,331,371
Ensembl chr 4:67,330,588...67,331,346
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Lss
lanosterol synthase
involved_in
IMP IBA IEA IDA ISO
GO_REF:0000033 GO_REF:0000118 GO_REF:0000107 PMID:7568116 (PMID:17186944)
GO_Central TreeGrafter Ensembl RGD
PMID:17186944 PMID:16440058 PMID:7568116 PMID:1429550
GO_REF:0000033 GO_REF:0000107 GO_REF:0000118, RGD:1626611 , RGD:728996 , RGD:2316919
NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
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Msmo1
methylsterol monooxygenase 1
involved_in
IEA
GO_REF:0000041
UniProt
GO_REF:0000041
NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
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Mvd
mevalonate diphosphate decarboxylase
involved_in
NAS IEA
GO_REF:0000041
UniProt RGD
PMID:11767099
GO_REF:0000041, RGD:729305
NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971
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Mvk
mevalonate kinase
involved_in
TAS IEA IBA ISO
GO_REF:0000118 GO_REF:0000033 GO_REF:0000107 GO_REF:0000043 (PMID:1377680)
TreeGrafter GO_Central Ensembl UniProt RGD
PMID:1377680 PMID:2158094
GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118, RGD:728935
NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882
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Npc1l1
NPC1 like intracellular cholesterol transporter 1
involved_in
ISO
(PMID:17140581)
RGD
PMID:17140581
NCBI chr14:81,071,448...81,091,113
Ensembl chr14:81,071,451...81,091,113
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Nsdhl
NAD(P) dependent steroid dehydrogenase-like
involved_in
IEA
GO_REF:0000043
UniProt
GO_REF:0000043
NCBI chr X:150,775,034...150,807,161
Ensembl chr X:150,775,080...150,807,142
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Pmvk
phosphomevalonate kinase
involved_in
ISO IBA NAS
(PMID:8663599) GO_REF:0000033 PMID:10191291
RGD GO_Central
PMID:8663599 PMID:10191291
GO_REF:0000033, RGD:8553625
NCBI chr 2:174,876,586...174,886,365
Ensembl chr 2:174,876,657...174,886,364
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Prkaa1
protein kinase AMP-activated catalytic subunit alpha 1
involved_in
IEA
GO_REF:0000043
UniProt
GO_REF:0000043
NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
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Prkaa2
protein kinase AMP-activated catalytic subunit alpha 2
involved_in
IEA
GO_REF:0000043
UniProt
GO_REF:0000043
NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
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Srebf1
sterol regulatory element binding transcription factor 1
acts_upstream_of
ISO
MGI:2177958 (PMID:9329978)
RGD
PMID:9329978
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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Tm7sf2
transmembrane 7 superfamily member 2
involved_in
IEA IBA ISO
GO_REF:0000041 GO_REF:0000033 (MGI:3822946|PMID:18785926) (PMID:16784888)
UniProt GO_Central RGD
PMID:16784888 PMID:18785926
GO_REF:0000033 GO_REF:0000041 MGI:3822946
NCBI chr 1:203,355,930...203,360,287
Ensembl chr 1:203,355,931...203,360,270
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Cyp51
cytochrome P450, family 51
IDA
RGD
PMID:7581240
RGD:2316902
NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
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Dhcr24
24-dehydrocholesterol reductase
involved_in
ISO
(PMID:11519011)
RGD
PMID:11519011
NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137
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Msmo1
methylsterol monooxygenase 1
involved_in
IEA
GO_REF:0000118
TreeGrafter
GO_REF:0000118
NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
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Sc5d
sterol-C5-desaturase
involved_in
IDA IBA
GO_REF:0000033
GO_Central RGD
PMID:7961720
GO_REF:0000033, RGD:2316911
NCBI chr 8:42,629,649...42,641,257
Ensembl chr 8:42,632,672...42,641,273
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Apoe
apolipoprotein E
involved_in
IDA IEA ISO
GO_REF:0000107 (PMID:1917954)
Ensembl RGD
PMID:1917954 PMID:9225228
GO_REF:0000107, RGD:10059686
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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Erlin1
ER lipid raft associated 1
involved_in
ISO
(PMID:24217618)
RGD
PMID:24217618
NCBI chr 1:242,921,147...242,956,472
Ensembl chr 1:242,921,152...242,956,394
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Erlin2
ER lipid raft associated 2
involved_in
ISO
(PMID:24217618)
RGD
PMID:24217618
NCBI chr16:65,017,654...65,034,184
Ensembl chr16:65,018,532...65,033,671
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Idi2
isopentenyl-diphosphate delta isomerase 2
acts_upstream_of_or_within
ISO
(PMID:17202134)
RGD
PMID:17202134
NCBI chr17:61,331,385...61,334,987
Ensembl chr17:61,331,669...61,334,285
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Mir185
microRNA 185
acts_upstream_of
ISO
RNAcentral:URS00002367FA_9606|RNAcentral:URS00004176D4_9606 (PMID:23951060), (PMID:24296663)
RGD
PMID:23951060 PMID:24296663
NCBI chr11:82,664,716...82,664,795
Ensembl chr11:82,664,716...82,664,795
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Mir342
microRNA 342
acts_upstream_of
ISO
(PMID:23951060)
RGD
PMID:23951060
NCBI chr 6:127,565,269...127,565,367
Ensembl chr 6:127,565,269...127,565,367
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Mir98
microRNA 98
involved_in
ISO
(PMID:30195495)
RGD
PMID:30195495
NCBI chr X:20,981,235...20,981,342
Ensembl chr X:20,981,235...20,981,342
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Sod1
superoxide dismutase 1
involved_in
ISS IEA ISO
GO_REF:0000024 GO_REF:0000107 (PMID:15473258)
UniProt Ensembl RGD
PMID:15473258
GO_REF:0000024 GO_REF:0000107
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Abcg1
ATP binding cassette subfamily G member 1
involved_in
ISO
(MGI:3768186|PMID:17916878)
RGD
PMID:17916878
MGI:3768186
NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
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Abcg4
ATP binding cassette subfamily G member 4
involved_in
ISO IEA
(MGI:3768186|PMID:17916878) GO_REF:0000107
RGD Ensembl
PMID:17916878
GO_REF:0000107 MGI:3768186
NCBI chr 8:44,611,187...44,629,818
Ensembl chr 8:44,611,187...44,626,881
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Cyp7a1
cytochrome P450 family 7 subfamily A member 1
involved_in
IDA
PMID:23536474
BHF-UCL
PMID:23536474
RGD:13792517
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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Fdps
farnesyl diphosphate synthase
IMP
RGD
PMID:18637708
RGD:2316295
NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
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Fgf1
fibroblast growth factor 1
involved_in
ISS ISO
GO_REF:0000024 (PMID:19229075)
UniProt RGD
PMID:19229075
GO_REF:0000024
NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
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Mir96
microRNA 96
involved_in acts_upstream_of
ISO
RNAcentral:URS00001CC379_9606 (PMID:23823476) (PMID:30460077)
RGD
PMID:23823476 PMID:30460077
NCBI chr 4:58,788,411...58,788,516
Ensembl chr 4:58,788,411...58,788,516
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Npy1r
neuropeptide Y receptor Y1
IMP
RGD
PMID:32976883
RGD:405096663
NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759
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Por
cytochrome p450 oxidoreductase
IMP
RGD
PMID:19264869
RGD:2316785
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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Qki
QKI, KH domain containing RNA binding
involved_in
ISO
(MGI:6712091|PMID:33942715)
RGD
PMID:33942715
MGI:6712091
NCBI chr 1:50,387,716...50,501,568
Ensembl chr 1:50,387,698...50,498,831
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Scap
SREBF chaperone
involved_in
ISO
(PMID:32322062)
RGD
PMID:32322062
NCBI chr 8:110,306,026...110,360,677
Ensembl chr 8:110,306,031...110,360,666
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Scp2
sterol carrier protein 2
IDA
RGD
PMID:2554812
RGD:9850260
NCBI chr 5:122,806,949...122,881,259
Ensembl chr 5:122,776,549...122,881,287
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Sec14l2
SEC14-like lipid binding 2
IDA
RGD
PMID:11226224
RGD:727312
NCBI chr14:78,973,805...78,998,480
Ensembl chr14:78,973,808...78,993,788
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Srebf1
sterol regulatory element binding transcription factor 1
involved_in acts_upstream_of_or_within
ISO ISS
(MGI:3623165|PMID:9062341), (MGI:83216|PMID:8833906) (PMID:12177166) (PMID:32322062) GO_REF:0000024 MGI:2177958|MGI:2177959 (PMID:16046411), (PMID:9329978)
RGD UniProt
PMID:8833906 PMID:9062341 PMID:9329978 PMID:12177166 PMID:16046411 PMID:32322062 More...
GO_REF:0000024 MGI:3623165 MGI:83216
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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Srebf2
sterol regulatory element binding transcription factor 2
involved_in
IEA ISO ISS
GO_REF:0000107 (PMID:12177166) (PMID:32322062) GO_REF:0000024 (MGI:6712091|PMID:33942715), (MGI:6713934|PMID:34021134)
Ensembl RGD UniProt
PMID:12177166 PMID:32322062 PMID:33942715 PMID:34021134
GO_REF:0000024 GO_REF:0000107 MGI:6712091 MGI:6713934
NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
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Abca2
ATP binding cassette subfamily A member 2
NOT|involved_in
ISO
(PMID:21810484)
RGD
PMID:21810484
NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537
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Apob
apolipoprotein B
involved_in acts_upstream_of_or_within
IEA ISO
GO_REF:0000107 MGI:2183298 (PMID:16455790)
Ensembl RGD
PMID:16455790
GO_REF:0000107
NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
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Aqp8
aquaporin 8
involved_in
IEA ISO ISS
GO_REF:0000107 (PMID:30579780) GO_REF:0000024
Ensembl RGD UniProt
PMID:30579780
GO_REF:0000024 GO_REF:0000107
NCBI chr 1:177,993,313...177,999,158
Ensembl chr 1:177,993,305...177,999,158
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Cyp51
cytochrome P450, family 51
TAS
RGD
PMID:7665087
RGD:1298863
NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
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Dhcr7
7-dehydrocholesterol reductase
IDA
RGD
PMID:10329655
RGD:632010
NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
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Erlin1
ER lipid raft associated 1
involved_in
ISO
(PMID:24217618)
RGD
PMID:24217618
NCBI chr 1:242,921,147...242,956,472
Ensembl chr 1:242,921,152...242,956,394
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Erlin2
ER lipid raft associated 2
involved_in
ISO
(PMID:24217618)
RGD
PMID:24217618
NCBI chr16:65,017,654...65,034,184
Ensembl chr16:65,018,532...65,033,671
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Lpcat3
lysophosphatidylcholine acyltransferase 3
involved_in
ISS ISO
GO_REF:0000024 (MGI:6278041|PMID:29395055)
UniProt RGD
PMID:29395055
GO_REF:0000024 MGI:6278041
NCBI chr 4:157,468,397...157,509,889
Ensembl chr 4:157,468,290...157,509,880
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Mvk
mevalonate kinase
NAS
RGD
PMID:2158094
RGD:728935
NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882
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Pex2
peroxisomal biogenesis factor 2
acts_upstream_of_or_within
ISO
MGI:2180128 (PMID:14673138)
RGD
PMID:14673138
NCBI chr 2:96,050,380...96,072,928
Ensembl chr 2:96,045,958...96,073,404
G
Scap
SREBF chaperone
involved_in acts_upstream_of_or_within
IBA ISO
GO_REF:0000033 MGI:2148743|MGI:2180899 (PMID:16054043)
GO_Central RGD
PMID:16054043
GO_REF:0000033
NCBI chr 8:110,306,026...110,360,677
Ensembl chr 8:110,306,031...110,360,666
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all