Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-catechin | multiple interactions | ISO | RHOT2 (Homo sapiens) | 6480464 | [Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of RHOT2 mRNA | CTD | PMID:24763279 | 1,2-dimethylhydrazine | decreases expression | ISO | Rhot2 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of RHOT2 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | multiple interactions | ISO | Rhot2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RHOT2 mRNA | CTD | PMID:17942748 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of RHOT2 mRNA | CTD | PMID:32145629 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Rhot2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RHOT2 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of RHOT2 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Rhot2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of RHOT2 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of RHOT2 mRNA | CTD | PMID:21215274 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of RHOT2 mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 6-dinitrotoluene affects the expression of RHOT2 mRNA | CTD | PMID:21346803 | 4,4'-sulfonyldiphenol | affects expression | ISO | RHOT2 (Homo sapiens) | 6480464 | bisphenol S affects the expression of RHOT2 protein | CTD | PMID:31945527 | acrolein | multiple interactions | ISO | RHOT2 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of RHOT2 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of RHOT2 mRNA | CTD | PMID:32699268 | alpha-pinene | multiple interactions | ISO | RHOT2 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of RHOT2 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of RHOT2 mRNA | CTD | PMID:32699268 | benzo[a]pyrene | multiple interactions | ISO | Rhot2 (Mus musculus) | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of RHOT2 mRNA] and Benzo(a)pyrene promotes the reaction [AHR protein binds to RHOT2 promoter] | CTD | PMID:19654925 and PMID:22228805 | benzo[a]pyrene | affects methylation | ISO | RHOT2 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of RHOT2 promoter | CTD | PMID:27901495 | bisphenol A | increases expression | ISO | RHOT2 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of RHOT2 mRNA | CTD | PMID:25047013 | bisphenol A | decreases methylation | ISO | RHOT2 (Homo sapiens) | 6480464 | bisphenol A results in decreased methylation of RHOT2 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of RHOT2 mRNA | CTD | PMID:30816183 and PMID:32528016 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of RHOT2 gene | CTD | PMID:28505145 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of RHOT2 mRNA | CTD | PMID:25181051 | bortezomib | decreases expression | ISO | RHOT2 (Homo sapiens) | 6480464 | Bortezomib results in decreased expression of RHOT2 mRNA | CTD | PMID:20977926 | cadmium dichloride | increases methylation | EXP | | 6480464 | Cadmium Chloride results in increased methylation of RHOT2 promoter | CTD | PMID:22457795 | cannabidiol | increases expression | ISO | RHOT2 (Homo sapiens) | 6480464 | Cannabidiol results in increased expression of RHOT2 mRNA | CTD | PMID:27714895 | carbamazepine | affects expression | ISO | RHOT2 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of RHOT2 mRNA | CTD | PMID:24752500 | chrysene | increases expression | ISO | Rhot2 (Mus musculus) | 6480464 | chrysene results in increased expression of RHOT2 mRNA | CTD | PMID:26377693 | clobetasol | increases expression | ISO | Rhot2 (Mus musculus) | 6480464 | Clobetasol results in increased expression of RHOT2 mRNA | CTD | PMID:27462272 | cocaine | affects expression | EXP | | 6480464 | Cocaine affects the expression of RHOT2 mRNA | CTD | PMID:20187946 | diclofenac | affects expression | ISO | RHOT2 (Homo sapiens) | 6480464 | Diclofenac affects the expression of RHOT2 mRNA | CTD | PMID:24752500 | epoxiconazole | decreases expression | ISO | Rhot2 (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of RHOT2 mRNA | CTD | PMID:35436446 | ethanol | multiple interactions | ISO | Rhot2 (Mus musculus) | 6480464 | Ethanol affects the expression of and affects the splicing of RHOT2 mRNA | CTD | PMID:30319688 | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of RHOT2 gene | CTD | PMID:22079235 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of RHOT2 mRNA | CTD | PMID:22061828 | hydrogen peroxide | multiple interactions | ISO | RHOT2 (Homo sapiens) | 6480464 | [Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RHOT2 protein | CTD | PMID:18951874 | ivermectin | decreases expression | ISO | RHOT2 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of RHOT2 protein | CTD | PMID:32959892 | lead(0) | affects expression | ISO | RHOT2 (Homo sapiens) | 6480464 | Lead affects the expression of RHOT2 mRNA | CTD | PMID:28903495 | ozone | multiple interactions | ISO | RHOT2 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of RHOT2 mRNA more ... | CTD | PMID:32699268 and PMID:35430440 | paclitaxel | affects response to substance | ISO | RHOT2 (Homo sapiens) | 6480464 | RHOT2 protein affects the susceptibility to Paclitaxel | CTD | PMID:16217747 | paracetamol | affects expression | ISO | Rhot2 (Mus musculus) | 6480464 | Acetaminophen affects the expression of RHOT2 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of RHOT2 mRNA | CTD | PMID:33387578 | pirinixic acid | decreases expression | ISO | Rhot2 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of RHOT2 mRNA | CTD | PMID:23811191 | propiconazole | decreases expression | ISO | Rhot2 (Mus musculus) | 6480464 | propiconazole results in decreased expression of RHOT2 mRNA | CTD | PMID:21278054 | sodium arsenite | decreases expression | ISO | RHOT2 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of RHOT2 mRNA | CTD | PMID:34032870 | sodium fluoride | decreases expression | ISO | Rhot2 (Mus musculus) | 6480464 | Sodium Fluoride results in decreased expression of RHOT2 protein | CTD | PMID:28918527 | temozolomide | increases expression | ISO | RHOT2 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of RHOT2 mRNA | CTD | PMID:31758290 | theophylline | multiple interactions | ISO | RHOT2 (Homo sapiens) | 6480464 | [Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of RHOT2 protein | CTD | PMID:18951874 | triptonide | affects expression | ISO | Rhot2 (Mus musculus) | 6480464 | triptonide affects the expression of RHOT2 mRNA | CTD | PMID:33045310 | valproic acid | increases methylation | ISO | RHOT2 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of RHOT2 gene | CTD | PMID:29154799 | |