Gnrhr (gonadotropin releasing hormone receptor)

Gene: Gnrhr (gonadotropin releasing hormone receptor) Rattus norvegicus

Analyze

Symbol:

Gnrhr

Name:

gonadotropin releasing hormone receptor

RGD ID:

70513

Description:

Enables growth hormone-releasing hormone receptor activity. Involved in G protein-coupled receptor signaling pathway; circadian rhythm; and negative regulation of cell population proliferation. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 7 with or without anosmia. Orthologous to human GNRHR (gonadotropin releasing hormone receptor); PARTICIPATES IN gonadotropin-releasing hormone signaling pathway; INTERACTS WITH (R)-lipoic acid; (S)-nicotine; 17alpha-ethynylestradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

GH1; gnRH receptor; gnRH-R; gonadotropin-releasing hormone receptor; growth hormone; Lhrhr

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GNRHR (gonadotropin releasing hormone receptor)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Gnrhr (gonadotropin releasing hormone receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GNRHR (gonadotropin releasing hormone receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GNRHR (gonadotropin releasing hormone receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gnrhr (gonadotropin releasing hormone receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GNRHR (gonadotropin releasing hormone receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gnrhr (gonadotropin releasing hormone receptor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	GNRHR (gonadotropin releasing hormone receptor)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gnrhr (gonadotropin releasing hormone receptor)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gnrhr1 (gonadotropin releasing hormone receptor 1)	Alliance	DIOPT (InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Danio rerio (zebrafish):	gnrhr4 (gonadotropin releasing hormone receptor 4)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	gnrhr2 (gonadotropin releasing hormone receptor 2)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	AkhR	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gnrr-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	gnrhr2	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gnrhr	Alliance	DIOPT (InParanoid\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	22,211,666 - 22,229,654 (+)	NCBI		GRCr8
mRatBN7.2	14	21,856,871 - 21,874,861 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	21,856,871 - 21,874,861 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	22,213,471 - 22,231,501 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	23,525,897 - 23,543,927 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	22,056,995 - 22,075,025 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	23,480,462 - 23,498,450 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	23,480,462 - 23,498,450 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	23,384,861 - 23,402,815 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	23,625,135 - 23,656,583 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	23,625,137 - 23,656,250 (+)	NCBI
Celera	14	21,327,308 - 21,348,471 (+)	NCBI		Celera
Cytogenetic Map	14	p21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Adrenal Gland Neoplasms (ISO)

amenorrhea (ISO)

Delayed Puberty (ISO)

genetic disease (ISO)

hypogonadism (ISO)

hypogonadotropic hypogonadism (ISO)

hypogonadotropic hypogonadism 12 with or without anosmia (ISO)

hypogonadotropic hypogonadism 7 with or without anosmia (ISO,ISS)

infertility (ISO)

Klinefelter syndrome (ISO)

Neurodevelopmental Disorders (ISO)

primary sclerosing cholangitis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(R)-lipoic acid (EXP)

(S)-nicotine (EXP)

1,2-dichloroethane (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrophenol (ISO)

2-hydroxypropanoic acid (ISO)

6-propyl-2-thiouracil (EXP)

ammonium chloride (EXP)

ammonium hexachloroplatinate (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

bifenthrin (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

buserelin (ISO)

cadmium dichloride (EXP)

calcidiol (EXP)

carmustine (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

decabromodiphenyl ether (EXP)

Deslorelin (ISO)

dibutyl phthalate (EXP)

diethylstilbestrol (EXP)

dipentyl phthalate (EXP)

doxorubicin (ISO)

equol (EXP)

ethanol (EXP)

ethylparaben (ISO)

flutamide (EXP)

galaxolide (EXP)

hexamethylene diisocyanate (ISO)

isoflavones (EXP)

lipoic acid (EXP)

maleic acid (ISO)

melatonin (EXP)

mono(2-ethylhexyl) phthalate (EXP,ISO)

N-ethyl-N-nitrosourea (ISO)

nickel atom (ISO)

nicotine (EXP)

paracetamol (ISO)

paraquat (EXP)

pentobarbital (EXP)

perfluorododecanoic acid (EXP)

perfluoroundecanoic acid (EXP)

phorbol 13-acetate 12-myristate (ISO)

picrotoxin (EXP)

potassium dichromate (ISO)

progesterone (ISO)

rac-lactic acid (ISO)

sophoraflavanone B (EXP)

T-2 toxin (EXP)

testosterone enanthate (EXP)

tetrachloromethane (EXP)

thimerosal (ISO)

trichostatin A (ISO)

trimellitic anhydride (ISO)

triptorelin (ISO)

tunicamycin (ISO)

vinclozolin (EXP)

zearalenone (EXP)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to gonadotropin-releasing hormone (IEA)

cellular response to hormone stimulus (IBA)

circadian rhythm (IEP)

G protein-coupled receptor signaling pathway (IBA,IDA,IEA)

negative regulation of cell population proliferation (IDA)

Cellular Component

plasma membrane (IEA)

Molecular Function

gonadotropin-releasing hormone receptor activity (IBA,IEA,ISO)

growth hormone-releasing hormone receptor activity (IDA)

peptide binding (IBA,IEA)

protein binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

gonadotropin-releasing hormone signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Calnexin regulated gonadotropin-releasing hormone receptor plasma membrane expression.	Brothers SP, etal., J Mol Endocrinol. 2006 Dec;37(3):479-88.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Isolation and characterization of cDNAs encoding the rat pituitary gonadotropin-releasing hormone receptor.	Kaiser UB, etal., Biochem Biophys Res Commun 1992 Dec 30;189(3):1645-52.
5.	Comparison of mechanisms of action of luteinizing hormone-releasing hormone (LHRH) antagonist cetrorelix and LHRH agonist triptorelin on the gene expression of pituitary LHRH receptors in rats.	Kovacs M and Schally AV, Proc Natl Acad Sci U S A 2001 Oct 9;98(21):12197-202.
6.	Isolation of rat GnRH receptor cDNA having different 5'-noncoding sequence.	Kudo A, etal., Zoolog Sci 1993 Oct;10(5):863-7.
7.	Knockdown of Hepatic Gonadotropin-Releasing Hormone by Vivo-Morpholino Decreases Liver Fibrosis in Multidrug Resistance Gene 2 Knockout Mice by Down-Regulation of miR-200b.	Kyritsi K, etal., Am J Pathol. 2017 Jul;187(7):1551-1565. doi: 10.1016/j.ajpath.2017.03.013. Epub 2017 May 12.
8.	Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells.	Liu F, etal., J Biol Chem 2002 Aug 30;277(35):32099-108.
9.	Subcellular localization of the receptor for gonadotropin-releasing hormone in pituitary and ovarian tissue.	Marian J and Conn PM, Endocrinology. 1983 Jan;112(1):104-12.
10.	Thyroid transcription factor 1, a homeodomain containing transcription factor, contributes to regulating periodic oscillations in GnRH gene expression.	Matagne V, etal., J Neuroendocrinol. 2012 Jun;24(6):916-29. doi: 10.1111/j.1365-2826.2012.02302.x.
11.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
12.	Gonadotropin-releasing hormone receptor-mediated growth suppression of immortalized LbetaT2 gonadotrope and stable HEK293 cell lines.	Miles LE, etal., Endocrinology. 2004 Jan;145(1):194-204. Epub 2003 Oct 9.
13.	Nucleotide sequence analysis of mRNAs predicts that rat pituitary and gonadal gonadotropin-releasing hormone receptor proteins have identical primary structure.	Moumni M, etal., Biochem Biophys Res Commun 1994 May 16;200(3):1359-66.
14.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
15.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
16.	Online Mendelian Inheritance in Man, OMIM (TM).	Online Mendelian Inheritance in Man, OMIM (TM).
17.	DNA sequence of the rat growth hormone gene: location of the 5' terminus of the growth hormone mRNA and identification of an internal transposon-like element.	Page GS, etal., Nucleic Acids Res 1981 May 11;9(9):2087-104.
18.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
19.	Digenic mutations account for variable phenotypes in idiopathic hypogonadotropic hypogonadism.	Pitteloud N, etal., J Clin Invest. 2007 Feb;117(2):457-63. Epub 2007 Jan 18.
20.	GOA pipeline	RGD automated data pipeline
21.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
23.	Cloning and nucleotide sequencing of rat lymphocyte growth hormone cDNA.	Rohn WM and Weigent DA, Neuroimmunomodulation 1995 Mar-Apr;2(2):108-14.
24.	Nucleotide sequence and amplification in bacteria of structural gene for rat growth hormone.	Seeburg PH, etal., Nature 1977 Dec 8;270(5637):486-94.

Additional References at PubMed

PMID:1338727	PMID:7916600	PMID:9220016	PMID:11278883	PMID:11897706	PMID:11997175	PMID:12062898	PMID:12479044	PMID:12697272	PMID:14525953	PMID:14561652	PMID:15188505
PMID:15563546	PMID:15886197	PMID:15908340	PMID:16613990	PMID:16672174	PMID:17674129	PMID:17875654	PMID:17935160	PMID:18024297	PMID:18319619	PMID:19228890	PMID:19539704
PMID:21123436	PMID:22414758	PMID:23211524	PMID:23233674	PMID:23906992	PMID:25048263	PMID:25556311	PMID:27349532	PMID:27569529	PMID:28032117	PMID:33576068

Genomics

Comparative Map Data

Gnrhr
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	22,211,666 - 22,229,654 (+)	NCBI		GRCr8
mRatBN7.2	14	21,856,871 - 21,874,861 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	21,856,871 - 21,874,861 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	22,213,471 - 22,231,501 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	23,525,897 - 23,543,927 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	22,056,995 - 22,075,025 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	23,480,462 - 23,498,450 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	23,480,462 - 23,498,450 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	23,384,861 - 23,402,815 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	23,625,135 - 23,656,583 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	14	23,625,137 - 23,656,250 (+)	NCBI
Celera	14	21,327,308 - 21,348,471 (+)	NCBI		Celera
Cytogenetic Map	14	p21	NCBI

GNRHR
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	67,737,118 - 67,754,388 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	67,737,118 - 67,754,388 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	68,602,836 - 68,620,106 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	68,285,688 - 68,304,399 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	68,434,963 - 68,450,570	NCBI
Celera	4	66,065,459 - 66,084,171 (-)	NCBI		Celera
Cytogenetic Map	4	q13.2	NCBI
HuRef	4	64,516,278 - 64,534,988 (-)	NCBI		HuRef
CHM1_1	4	68,640,204 - 68,658,910 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	71,180,228 - 71,197,499 (-)	NCBI		T2T-CHM13v2.0

Gnrhr
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	86,328,613 - 86,345,760 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	86,328,613 - 86,345,760 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	86,180,754 - 86,197,901 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	86,180,754 - 86,197,901 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	86,611,019 - 86,626,895 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	87,256,555 - 87,272,431 (-)	NCBI		MGSCv36	mm8
Celera	5	83,413,347 - 83,430,921 (-)	NCBI		Celera
Cytogenetic Map	5	E1	NCBI
cM Map	5	43.56	NCBI

GNRHR
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	62,141,365 - 62,155,225 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	62,351,392 - 62,367,764 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	56,295,425 - 56,314,962 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	62,687,474 - 62,706,179 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	62,687,474 - 62,706,167 (+)	Ensembl	panpan1.1		panPan2

GNRHR
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	58,253,112 - 58,266,600 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	58,253,027 - 58,266,705 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	58,168,278 - 58,181,765 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	58,865,514 - 58,878,973 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	13	58,865,514 - 58,878,973 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	13	58,590,137 - 58,603,620 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	58,080,483 - 58,093,952 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	59,090,982 - 59,104,477 (-)	NCBI		UU_Cfam_GSD_1.0

Gnrhr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	18,185,844 - 18,202,017 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936582	749,016 - 765,189 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936582	749,016 - 765,189 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GNRHR
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	1,205,294 - 1,225,105 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666066	1,294,292 - 1,311,901 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gnrhr
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624761	1,216,556 - 1,225,994 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624761	1,216,501 - 1,231,229 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Gnrhr
87 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	400
Count of miRNA genes:	220
Interacting mature miRNAs:	255
Transcripts:	ENSRNOT00000002755
Prediction methods:	Microtar, Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2300159	Bmd61	Bone mineral density QTL 61	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
2300183	Bmd60	Bone mineral density QTL 60	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	14	1	26541967	Rat
619619	Rf4	Renal disease susceptibility QTL 4	4.1	0.002	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	14	1	32754612	Rat
634352	Apr6	Acute phase response QTL 6	3.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	14	1	41131407	Rat
70195	Mcs8	Mammary carcinoma susceptibility QTL 8	4.28		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	14	3813074	24531477	Rat
1331740	Bw26	Body weight QTL 26	3.028		body mass (VT:0001259)	body weight (CMO:0000012)	14	3813074	30767156	Rat
1581500	Renag1	Renal agenesis QTL 1			kidney development trait (VT:0000527)	percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)	14	8170668	68298175	Rat
1358296	Ael3	Aortic elastin QTL 3	3.7	0.00051	aorta elastin amount (VT:0003905)	aortic elastin	14	8267090	53267090	Rat
2302045	Pia39	Pristane induced arthritis QTL 39	4.9	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G2a level (CMO:0002116)	14	8267090	53267090	Rat
731183	Pia20	Pristane induced arthritis QTL 20	3.55		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	9088978	39057237	Rat
2302277	Gluco38	Glucose level QTL 38	5.8		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11030622	28035204	Rat
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11030622	95876975	Rat
631212	Bw5	Body weight QTL5	5.43		retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	14	11030812	30320092	Rat
1300140	Srn3	Serum renin concentration QTL 3	3.19		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	14	14875168	30883947	Rat
71117	Niddm17	Non-insulin dependent diabetes mellitus QTL 17	2.35		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	14	17593761	42336881	Rat
631262	Tcas4	Tongue tumor susceptibility QTL 4	7.29		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	14	17622561	42337007	Rat
2313397	Coatc1	Coat color QTL1			coat/hair pigmentation trait (VT:0010463)	coat/hair color measurement (CMO:0001808)	14	18541332	63541332	Rat
61420	Pia6	Pristane induced arthritis QTL 6	4.9		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	14	18631345	42337007	Rat
10755459	Coatc15	Coat color QTL 15		0.01681	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	14	19836944	64836944	Rat

Markers in Region

RH142317

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	21,855,292 - 21,855,446 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	23,478,884 - 23,479,037	NCBI	Rnor6.0
Rnor_5.0	14	23,383,283 - 23,383,436	UniSTS	Rnor5.0
RGSC_v3.4	14	23,623,557 - 23,623,710	UniSTS	RGSC3.4
Celera	14	21,325,726 - 21,325,879	UniSTS
Cytogenetic Map	14	p21	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			2								4
Low	1		13		17				3	2	28	7
Below cutoff	1	12	11	10	1	10	8	8	23	8	6	3	8

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031038	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC117319	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AH005223	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB775870	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473981	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L07646	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X68980	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X76635	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000002755 ⟹ ENSRNOP00000002755

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	14	21,856,871 - 21,874,861 (+)	Ensembl
Rnor_6.0 Ensembl	14	23,480,462 - 23,498,450 (+)	Ensembl

RefSeq Acc Id:

NM_031038 ⟹ NP_112300

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	22,211,666 - 22,229,654 (+)	NCBI
mRatBN7.2	14	21,856,871 - 21,874,861 (+)	NCBI
Rnor_6.0	14	23,480,462 - 23,498,450 (+)	NCBI
Rnor_5.0	14	23,384,861 - 23,402,815 (+)	NCBI
RGSC_v3.4	14	23,625,135 - 23,656,583 (+)	RGD
Celera	14	21,327,308 - 21,348,471 (+)	RGD

Sequence:

show sequence

AGAAAGCAACAGCGCTTTGCGTTCAGTTACGATAAAAACATCAGCAGTAACAGAGACTCGACTC
TTGAAGCCCGTCCTTGGAGAAATATGGCTAACAATGCGTCTCTTGAGCAGGACCAAAATCACTG
CTCAGCCATCAACAACAGCATCCCCCTGACACAGGGCAAGCTCCCGACTCTAACCTTATCTGGA
AAGATCCGAGTGACGGTGACTTTCTTCCTTTTCCTACTCTCTACTGCCTTCAATGCCTCTTTCT
TGGTAAAGCTGCAGAGGTGGACCCAGAAGAGGAAGAAAGGAAAAAAGCTCTCAAGGATGAAGGT
GCTTTTAAAGCATTTGACCTTAGCCAACCTCCTTGAGACTCTAATCGTCATGCCGCTGGATGGG
ATGTGGAACATCACTGTTCAGTGGTATGCTGGAGAGTTCCTTTGCAAAGTTCTCAGCTATCTGA
AGCTCTTCTCTATGTATGCCCCAGCCTTCATGATGGTGGTGATTAGCCTGGATCGCTCCCTGGC
CGTCACTCAGCCCTTAGCTGTCCAAAGCAAGAGCAAGCTTGAACGGTCTATGACCAGCCTGGCC
TGGATTCTCAGCATTGTCTTTGCGGGACCACAGTTATATATCTTCAGGATGATCTACCTAGCCG
ACGGCTCTGGGCCAGCAGTTTTCTCGCAATGTGTGACCCACTGCAGCTTTCCGCAATGGTGGCA
TGAAGCCTTCTACAACTTTTTCACCTTCAGCTGCCTGTTCATCATCCCTCTTCTCATCATGCTA
ATCTGCAATGCCAAAATCATCTTCGCCCTCACACGAGTCCTTCATCAGGACCCACGCAAACTAC
AGCTGAATCAATCCAAGAATAATATCCCAAGAGCACGGCTGAGAACTCTAAAGATGACAGTGGC
ATTTGCCACCTCCTTTGTCATCTGCTGGACTCCCTACTACGTCCTAGGAATCTGGTACTGGTTT
GATCCGGAAATGTTAAACAGGGTGTCAGAGCCAGTCAATCACTTCTTCTTTCTCTTTGCTTTTC
TAAACCCGTGCTTCGACCCACTTATATATGGGTATTTCTCTTTGTAATTGGGAGACTACCCAAG
CACTTGTGCTGAAACCCATATACGGGATAACTTATGTCACCGGTTGAGAATAAGCTCAAAGCTT
GCAACATACCTATGTGCAAGCAAGGCAGGGTTTGGGCTCAGGTTAGCAGCCTTGTCCATATACA
GAGTTTGTTGTTAGCGCTTCGGAAGACCTTCCAAAATAACTGAAATCTGTCCTTAATCATAAGC
TTCTAAACTAGCCTCAGCCTTGTCTCATGTTTTATTGCATCCCATTTGGGATTCTTTACTTCCT
CCTTACATAATAATGTATAGATACTTTAAATGACTACATCCTAAGGTAAAAAGTACCAAAAAGT
AAGACCGGGAAAGCCCAACATATTCACAACATCAGCTTAGTTTGGGGAGTTGGTTTTTTTTTCT
CAAAGGGGGCTGAGCATCTATAACACCCCATCCCAACACCTAGAGCCCACAGAGAGCAGAATCG
CTGCCCATAGATCATCAGCAAAACCAGATGCTGCTCCAAGACCTAAAGCCCAGAGACAGAAGGA
TCCCTGTCCAGAGGTTAGCAGGAAATACTGGCTGACACTATCCCAGCCTAAGGCACAGAGATAG
TAGACTCCCTTACTGCCCATAGGTCAGCAGCAGTAGCAGCTGATGTTATCTATCCCAGCCTAGA
GCACAGACAGAAGAGAATCACTGTCCATGGGTCAAATTTTAACTGCAATGACTGAAAGACTTAA
TTTTCTATTTTACTTTAAAAGCCTTTCTGATTCTTATTCAGCAACAAATCCACCAGCCCACCAG
GATTATTTACATGATACAAATTAATCCCATTTACATGCTACATTGCGACACATCCCTACATAGT
GGGGGTATTTAAAAGGGATAGGTTTTTTTTCATGGGCTGTTAGAATATTTCACAGACTATACAA
CATGTGGGGTTTATGTCAACTGACTGCCATGAATAGTGTTTTAATATAATTCAGAAAATGCCTA
TAATAATTATCTTGCAAGCATAATATACAATCCACTTTAACAATATGGTGGAACGTTTGTCTAT
CTTAACTTGCCGAGTCATGCCCCACAGATAAATGAGGAAAGTCAATAAAAACAGTAAGCAAATA
TATAAACAAAAAGAGGGGCTTTGATGTATTAAAGGAGCTCAAGGCAGGAAGCCATACAATTTCC
CCTATACAGACCAACAGCACAGAATATTAGGGAGGAGAATAGTAAAACTGTACATGTGAAAGAA
AAAAAAATGCAGTCCCCAAAAATATGTCCGCAGAATACCACATACTTCATTCAACTCAGCTCAG
ATCTTTGTCATGAAAGACCAGAGGTGAAGTTAAGATTGCGATATCCACTCACTGGGGAAAGCAT
ATGAACGCACATTCAATAATTATCTAATAGACATTGATGTGAGCTACATAATGCCACACCAGGC
TATGTGTGACTATAGAAAGCTGACCAGAGGGGTTGGGGATTTAGTTTAGTGGTAGAGCGCTTGC
CTAGCAAGCGCAAGGCCCTGGGTTCTGTCCTCAGCTCAAAAGAAAGAAAGAAAGAAAGAGAGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_112300	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41274	(Get FASTA)	NCBI Sequence Viewer
	AAB58038	(Get FASTA)	NCBI Sequence Viewer
	CAA48776	(Get FASTA)	NCBI Sequence Viewer
	CAA54083	(Get FASTA)	NCBI Sequence Viewer
	EDL89838	(Get FASTA)	NCBI Sequence Viewer
	EDL89839	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000002755
	ENSRNOP00000002755.3
GenBank Protein	P30969	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_112300 ⟸ NM_031038

- UniProtKB:

P30969 (UniProtKB/Swiss-Prot), A6JCR6 (UniProtKB/TrEMBL), G3V693 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWT
QKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAP
AFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVF
SQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNN
IPRARLRTLKMTVAFATSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPL
IYGYFSL

hide sequence

RefSeq Acc Id:

ENSRNOP00000002755 ⟸ ENSRNOT00000002755

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P30969-F1-model_v2	AlphaFold	P30969	1-327	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:70513	AgrOrtholog
BioCyc Gene	G2FUF-16066	BioCyc
Ensembl Genes	ENSRNOG00000002011	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000002755	ENTREZGENE
	ENSRNOT00000002755.5	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	GPCR_Rhodpsn	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GphnRH_fam_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:81668	UniProtKB/Swiss-Prot
NCBI Gene	81668	ENTREZGENE
PANTHER	GONADOTROPIN-RELEASING HORMONE RECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Gnrhr	PhenoGen
PRINTS	GNADOTRPHINR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCRRHODOPSN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000002011	RatGTEx
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6JCR6	ENTREZGENE, UniProtKB/TrEMBL
	A6JCR7_RAT	UniProtKB/TrEMBL
	G3V693	ENTREZGENE, UniProtKB/TrEMBL
	GNRHR_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-12-14	Gnrhr	gonadotropin releasing hormone receptor		gonadotropin-releasing hormone receptor	Name updated	1299863	APPROVED
2002-06-10	Gnrhr	gonadotropin-releasing hormone receptor			Symbol and Name status set to provisional	70585	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	mRNA level increased by exposure of pituitary cells in vitro to GNRH or triptorelin	69669
gene_function	high-affinity, G protein-coupled receptor	69669
gene_regulation	pituitary expression inhibited by cetrorelix, a GNRH antagonist, by counteracting GNHR stimulatory effect	69669

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)