Slit2 (slit guidance ligand 2) - Rat Genome Database

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Gene: Slit2 (slit guidance ligand 2) Rattus norvegicus
Analyze
Symbol: Slit2
Name: slit guidance ligand 2
RGD ID: 69310
Description: Enables heparan sulfate proteoglycan binding activity. Involved in several processes, including cellular response to platelet-derived growth factor stimulus; negative regulation of monocyte chemotaxis; and nervous system development. Located in axon; dendrite; and neuronal cell body. Biomarker of anti-basement membrane glomerulonephritis; congenital diaphragmatic hernia; diabetic retinopathy; and transient cerebral ischemia. Orthologous to human SLIT2 (slit guidance ligand 2); PARTICIPATES IN glypican signaling pathway; INTERACTS WITH (+)-pilocarpine; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: slit (Drosophila) homolog 2; slit homolog 2 (Drosophila); slit homolog 2 protein; slit-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81466,829,661 - 67,168,517 (-)NCBIGRCr8
mRatBN7.21462,616,337 - 62,955,934 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1462,617,067 - 62,955,948 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1467,016,997 - 67,353,404 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01468,330,637 - 68,667,055 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01464,727,393 - 65,063,822 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01466,831,848 - 67,171,491 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1466,831,848 - 67,170,361 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01466,864,065 - 67,202,691 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41467,546,283 - 67,891,840 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11467,624,799 - 67,894,206 (-)NCBI
Celera1461,665,582 - 62,001,006 (-)NCBICelera
Cytogenetic Map14q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetaldehyde  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyproconazole  (ISO)
cytarabine  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
dimethylarsinous acid  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enniatin  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
flusilazole  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
hexaconazole  (ISO)
iron dichloride  (ISO)
ketoconazole  (ISO)
L-methionine  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
mercury dibromide  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
mifepristone  (EXP)
Muraglitazar  (EXP)
N-acetyl-1,4-benzoquinone imine  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
oxaliplatin  (EXP)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PD 0325901  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
pyrimidifen  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
temozolomide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aortic valve morphogenesis  (ISO)
apoptotic process involved in luteolysis  (IEA,ISO)
axon extension involved in axon guidance  (IEA,ISO)
axon guidance  (IEA,ISO)
axonogenesis  (ISO)
branching morphogenesis of an epithelial tube  (IEA,ISO)
cell migration involved in sprouting angiogenesis  (IEA,ISO)
cell-cell adhesion  (ISO)
cellular response to heparin  (IEA,ISO)
cellular response to hormone stimulus  (IEA,ISO)
cellular response to hypoxia  (IEP)
cellular response to platelet-derived growth factor stimulus  (IEP)
chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration  (ISO)
chemorepulsion involved in postnatal olfactory bulb interneuron migration  (IEA,ISO)
corticospinal neuron axon guidance through spinal cord  (IEA,ISO)
dorsal/ventral axon guidance  (ISO)
follicle-stimulating hormone signaling pathway  (IEA)
in utero embryonic development  (ISO)
induction of negative chemotaxis  (IEA,ISO)
kidney development  (ISO)
mammary duct terminal end bud growth  (ISO)
mammary gland duct morphogenesis  (ISO)
metanephros development  (ISO)
motor neuron axon guidance  (IEA,ISO)
negative chemotaxis  (IEA,ISO)
negative regulation of actin filament polymerization  (IEA,ISO)
negative regulation of axon extension  (ISO)
negative regulation of cell growth  (IEA,ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cellular response to growth factor stimulus  (IEA,ISO)
negative regulation of chemokine-mediated signaling pathway  (IEA,ISO)
negative regulation of endothelial cell migration  (IEA,ISO)
negative regulation of gene expression  (ISO)
negative regulation of lamellipodium assembly  (IEA,ISO)
negative regulation of leukocyte chemotaxis  (ISO)
negative regulation of monocyte chemotaxis  (IDA)
negative regulation of mononuclear cell migration  (IEA,ISO)
negative regulation of neutrophil chemotaxis  (IEA,ISO)
negative regulation of protein phosphorylation  (IEA,ISO)
negative regulation of retinal ganglion cell axon guidance  (IEA,ISO)
negative regulation of small GTPase mediated signal transduction  (IEA,ISO)
negative regulation of smooth muscle cell chemotaxis  (IEA,ISO)
negative regulation of smooth muscle cell migration  (ISO)
negative regulation of vascular permeability  (IEA,ISO)
neuron projection extension  (IMP)
neuron projection morphogenesis  (ISO)
olfactory bulb development  (ISO)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of synapse assembly  (IMP)
pulmonary valve morphogenesis  (ISO)
response to cortisol  (IEA,ISO)
response to nutrient levels  (IEP)
retinal ganglion cell axon guidance  (IEA,ISO)
Roundabout signaling pathway  (IEA,ISO)
spinal cord development  (IEP)
telencephalon cell migration  (ISO)
ureteric bud development  (IEA,ISO)
ventricular septum morphogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Brose K, etal., Cell 1999 Mar 19;96(6):795-806.
2. A Study Based on the Correlation Between Slit2/Robo1 Signaling Pathway Proteins and Polymyositis/Dermatomyositis. Chai KX, etal., Curr Mol Med. 2020;20(9):717-722. doi: 10.2174/1566524020666200326102837.
3. Cutting edge: bone morphogenetic protein antagonists Drm/Gremlin and Dan interact with Slits and act as negative regulators of monocyte chemotaxis. Chen B, etal., J Immunol. 2004 Nov 15;173(10):5914-7.
4. Upregulation of Slit-2 and Slit-3 gene expressions in the nitrofen-induced hypoplastic lung. Doi T, etal., J Pediatr Surg. 2009 Nov;44(11):2092-5. doi: 10.1016/j.jpedsurg.2009.02.068.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Increased Expression of Slit2 and its Robo Receptors During Astroglial Scar Formation After Transient Focal Cerebral Ischemia in Rats. Jin X, etal., Neurochem Res. 2016 Dec;41(12):3373-3385. doi: 10.1007/s11064-016-2072-0. Epub 2016 Sep 29.
8. Modulation of inflammation by slit protein in vivo in experimental crescentic glomerulonephritis. Kanellis J, etal., Am J Pathol. 2004 Jul;165(1):341-52.
9. Recombinant Slit2 attenuates neuronal apoptosis via the Robo1-srGAP1 pathway in a rat model of neonatal HIE. Kaur H, etal., Neuropharmacology. 2019 Nov 1;158:107727. doi: 10.1016/j.neuropharm.2019.107727. Epub 2019 Jul 26.
10. Slit2/Robo1 Mediation of Synaptic Plasticity Contributes to Bone Cancer Pain. Ke C, etal., Mol Neurobiol. 2017 Jan;54(1):295-307. doi: 10.1007/s12035-015-9564-9. Epub 2016 Jan 6.
11. Slit2/Robo1 promotes synaptogenesis and functional recovery of spinal cord injury. Li Y, etal., Neuroreport. 2017 Jan 18;28(2):75-81. doi: 10.1097/WNR.0000000000000715.
12. Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain. Liang Y, etal., J Biol Chem 1999 Jun 18;274(25):17885-92.
13. Potential Role of Axonal Chemorepellent Slit2 in Modulating Adventitial Inflammation in a Rat Carotid Artery Balloon Injury Model. Liu D, etal., J Cardiovasc Pharmacol. 2016 May;67(5):433-41. doi: 10.1097/FJC.0000000000000369.
14. Expression of Slit2 and Robo1 after traumatic lesions of the rat spinal cord. Liu JB, etal., Acta Histochem. 2009 Sep 22.
15. Crosstalk between the activated Slit2-Robo1 pathway and TGF-β1 signalling promotes cardiac fibrosis. Liu Y, etal., ESC Heart Fail. 2021 Feb;8(1):447-460. doi: 10.1002/ehf2.13095. Epub 2020 Nov 24.
16. Spatiotemporal expression patterns of slit and robo genes in the rat brain. Marillat V, etal., J Comp Neurol. 2002 Jan 7;442(2):130-55.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Maternal perinatal undernutrition alters neuronal and neuroendocrine differentiation in the rat adrenal medulla at weaning. Molendi-Coste O, etal., Endocrinology. 2006 Jun;147(6):3050-9. Epub 2006 Feb 23.
19. Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves. Mommersteeg MT, etal., Cardiovasc Res. 2015 Apr 1;106(1):55-66. doi: 10.1093/cvr/cvv040. Epub 2015 Feb 17.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Slit2-N inhibits PDGF-induced migration in rat airway smooth muscle cells: WASP and Arp2/3 involved. Ning Y, etal., Toxicology. 2011 Apr 28;283(1):32-40. doi: 10.1016/j.tox.2011.01.026. Epub 2011 Feb 17.
22. Increased expression of Slit2 and its receptors Robo1 and Robo4 in reactive astrocytes of the rat hippocampus after transient forebrain ischemia. Park JH, etal., Brain Res. 2016 Mar 1;1634:45-56. doi: 10.1016/j.brainres.2015.12.056. Epub 2016 Jan 4.
23. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Recombinant Slit2 attenuates neuroinflammation after surgical brain injury by inhibiting peripheral immune cell infiltration via Robo1-srGAP1 pathway in a rat model. Sherchan P, etal., Neurobiol Dis. 2016 Jan;85:164-173. doi: 10.1016/j.nbd.2015.11.003. Epub 2015 Nov 10.
28. The expression of the Slit-Robo signal in the retina of diabetic rats and the vitreous or fibrovascular retinal membranes of patients with proliferative diabetic retinopathy. Zhou W, etal., PLoS One. 2017 Oct 3;12(10):e0185795. doi: 10.1371/journal.pone.0185795. eCollection 2017.
Additional References at PubMed
PMID:10197527   PMID:10864954   PMID:10975526   PMID:11309622   PMID:11375980   PMID:11748139   PMID:11804570   PMID:11804571   PMID:12097499   PMID:12879062   PMID:12954717   PMID:14605369  
PMID:14960623   PMID:15091338   PMID:15130495   PMID:15207848   PMID:15737744   PMID:16377904   PMID:16439476   PMID:16439689   PMID:16828733   PMID:16840550   PMID:16885222   PMID:17062560  
PMID:17848514   PMID:18345009   PMID:18566128   PMID:18755265   PMID:18829537   PMID:19005219   PMID:19033678   PMID:19056867   PMID:19351956   PMID:19498462   PMID:19759280   PMID:20153733  
PMID:21187345   PMID:22206666   PMID:22433866   PMID:22677040   PMID:23361995   PMID:23376485   PMID:24006456   PMID:26026792   PMID:28260032   PMID:31964527   PMID:34652618   PMID:38122948  


Genomics

Comparative Map Data
Slit2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81466,829,661 - 67,168,517 (-)NCBIGRCr8
mRatBN7.21462,616,337 - 62,955,934 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1462,617,067 - 62,955,948 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1467,016,997 - 67,353,404 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01468,330,637 - 68,667,055 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01464,727,393 - 65,063,822 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01466,831,848 - 67,171,491 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1466,831,848 - 67,170,361 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01466,864,065 - 67,202,691 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41467,546,283 - 67,891,840 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11467,624,799 - 67,894,206 (-)NCBI
Celera1461,665,582 - 62,001,006 (-)NCBICelera
Cytogenetic Map14q11NCBI
SLIT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38420,251,905 - 20,620,561 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl420,251,905 - 20,620,561 (+)EnsemblGRCh38hg38GRCh38
GRCh37420,253,528 - 20,622,184 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36419,864,333 - 20,229,886 (+)NCBINCBI36Build 36hg18NCBI36
Build 34419,931,503 - 20,297,057NCBI
Celera420,712,350 - 21,077,291 (+)NCBICelera
Cytogenetic Map4p15.31NCBI
HuRef419,604,199 - 19,969,514 (+)NCBIHuRef
CHM1_1420,253,276 - 20,618,733 (+)NCBICHM1_1
T2T-CHM13v2.0420,234,597 - 20,602,238 (+)NCBIT2T-CHM13v2.0
Slit2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39548,138,633 - 48,465,077 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl548,140,480 - 48,465,075 (+)EnsemblGRCm39 Ensembl
GRCm38547,981,291 - 48,307,735 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl547,983,138 - 48,307,733 (+)EnsemblGRCm38mm10GRCm38
MGSCv37548,374,394 - 48,697,017 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36548,273,041 - 48,593,759 (+)NCBIMGSCv36mm8
Celera545,381,658 - 45,708,133 (+)NCBICelera
Cytogenetic Map5B3NCBI
cM Map526.05NCBI
Slit2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554803,984,586 - 4,313,908 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554803,982,977 - 4,314,160 (-)NCBIChiLan1.0ChiLan1.0
SLIT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2320,490,764 - 20,869,771 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1420,698,666 - 21,066,091 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0414,654,448 - 15,023,708 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1419,946,369 - 20,314,656 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl420,158,952 - 20,314,656 (+)Ensemblpanpan1.1panPan2
SLIT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1388,964,707 - 89,311,817 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl388,966,232 - 89,312,955 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha391,423,926 - 91,773,328 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0389,948,981 - 90,297,465 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl389,948,988 - 90,298,073 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1389,094,518 - 89,443,898 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0389,179,097 - 89,528,769 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0389,562,948 - 89,912,569 (-)NCBIUU_Cfam_GSD_1.0
Slit2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528554,409,516 - 54,746,912 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364778,109,228 - 8,446,653 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364778,111,212 - 8,448,567 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLIT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl814,758,335 - 15,149,510 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1814,758,426 - 15,149,515 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2814,998,769 - 15,257,500 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLIT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12729,650,589 - 30,020,105 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2729,650,337 - 29,803,612 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604776,267,556 - 76,654,726 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slit2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475511,472,377 - 11,819,266 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475511,470,810 - 11,819,800 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slit2
1581 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:577
Count of miRNA genes:279
Interacting mature miRNAs:355
Transcripts:ENSRNOT00000005477
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141854133263541332Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143999825175582726Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat

Markers in Region
D14Got156  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21462,921,501 - 62,921,630 (+)MAPPERmRatBN7.2
Rnor_6.01467,136,878 - 67,137,006NCBIRnor6.0
Rnor_5.01467,168,120 - 67,168,248UniSTSRnor5.0
RGSC_v3.41467,858,616 - 67,858,744UniSTSRGSC3.4
Celera1461,967,928 - 61,968,056UniSTS
Cytogenetic Map14q11UniSTS
BE116869  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21462,912,713 - 62,912,877 (+)MAPPERmRatBN7.2
Rnor_6.01467,128,141 - 67,128,304NCBIRnor6.0
Rnor_5.01467,159,383 - 67,159,546UniSTSRnor5.0
RGSC_v3.41467,848,360 - 67,848,523UniSTSRGSC3.4
Celera1461,959,747 - 61,959,910UniSTS
RH 3.4 Map14475.6UniSTS
Cytogenetic Map14q11UniSTS
RH134686  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21462,617,915 - 62,618,105 (+)MAPPERmRatBN7.2
Rnor_6.01466,832,697 - 66,832,886NCBIRnor6.0
Rnor_5.01466,864,914 - 66,865,103UniSTSRnor5.0
RGSC_v3.41467,547,132 - 67,547,321UniSTSRGSC3.4
Celera1461,666,431 - 61,666,620UniSTS
RH 3.4 Map14478.1UniSTS
Cytogenetic Map14q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 20 60 35 27 11
Low 1 20 24 10 17 10 7 7 14 10 7
Below cutoff 2 3 32 30 2 30 1 4 4 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005477   ⟹   ENSRNOP00000005477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1462,617,067 - 62,954,577 (-)Ensembl
Rnor_6.0 Ensembl1466,831,848 - 67,170,361 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081601   ⟹   ENSRNOP00000075258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1462,617,067 - 62,954,577 (-)Ensembl
Rnor_6.0 Ensembl1466,831,877 - 66,978,499 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098728   ⟹   ENSRNOP00000094520
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1462,617,067 - 62,954,577 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101023   ⟹   ENSRNOP00000089142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1462,618,940 - 62,955,948 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117062   ⟹   ENSRNOP00000096652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1462,787,996 - 62,955,948 (-)Ensembl
RefSeq Acc Id: NM_022632   ⟹   NP_072154
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81466,829,661 - 67,167,146 (-)NCBI
mRatBN7.21462,617,067 - 62,954,577 (-)NCBI
Rnor_6.01466,831,848 - 67,170,361 (-)NCBI
Rnor_5.01466,864,065 - 67,202,691 (-)NCBI
RGSC_v3.41467,546,283 - 67,891,840 (-)RGD
Celera1461,665,582 - 62,001,006 (-)RGD
Sequence:
RefSeq Acc Id: XM_017599277   ⟹   XP_017454766
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81466,830,428 - 67,168,517 (-)NCBI
mRatBN7.21462,616,337 - 62,955,934 (-)NCBI
Rnor_6.01466,831,849 - 67,171,491 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599278   ⟹   XP_017454767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81466,830,428 - 67,168,511 (-)NCBI
mRatBN7.21462,616,337 - 62,955,934 (-)NCBI
Rnor_6.01466,831,849 - 67,171,491 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039092141   ⟹   XP_038948069
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81466,830,428 - 67,168,517 (-)NCBI
mRatBN7.21462,616,337 - 62,955,934 (-)NCBI
RefSeq Acc Id: XM_063273311   ⟹   XP_063129381
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81466,830,428 - 67,168,511 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_072154   ⟸   NM_022632
- Peptide Label: precursor
- UniProtKB: A0A8I6A6K5 (UniProtKB/TrEMBL),   F1MA79 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454767   ⟸   XM_017599278
- Peptide Label: isoform X4
- UniProtKB: A0A8I6A6K5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454766   ⟸   XM_017599277
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A6K5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075258   ⟸   ENSRNOT00000081601
RefSeq Acc Id: ENSRNOP00000005477   ⟸   ENSRNOT00000005477
RefSeq Acc Id: XP_038948069   ⟸   XM_039092141
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A6K5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000094520   ⟸   ENSRNOT00000098728
RefSeq Acc Id: ENSRNOP00000089142   ⟸   ENSRNOT00000101023
RefSeq Acc Id: ENSRNOP00000096652   ⟸   ENSRNOT00000117062
RefSeq Acc Id: XP_063129381   ⟸   XM_063273311
- Peptide Label: isoform X2
Protein Domains
CTCK   EGF-like   Laminin G   LRRCT   LRRNT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WVC1-F1-model_v2 AlphaFold Q9WVC1 1-766 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69310 AgrOrtholog
BioCyc Gene G2FUF-15565 BioCyc
Ensembl Genes ENSRNOG00000003840 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005477 ENTREZGENE
  ENSRNOT00000005477.8 UniProtKB/TrEMBL
  ENSRNOT00000081601.2 UniProtKB/TrEMBL
  ENSRNOT00000098728.1 UniProtKB/TrEMBL
  ENSRNOT00000101023.1 UniProtKB/TrEMBL
  ENSRNOT00000117062.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro ConA-like_subgrp UniProtKB/TrEMBL
  Cys-rich_flank_reg_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cys_knot_C UniProtKB/TrEMBL
  EG-like_dom UniProtKB/TrEMBL
  EGF-like_Ca-bd UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Fol_N UniProtKB/TrEMBL
  FSH_rcpt UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Laminin_G UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:360272 UniProtKB/TrEMBL
NCBI Gene Slit2 ENTREZGENE
PANTHER ANTIGEN BSP, PUTATIVE-RELATED UniProtKB/TrEMBL
  KEKKON 5, ISOFORM A UniProtKB/Swiss-Prot
  LRRCT DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  SLIT HOMOLOG UniProtKB/TrEMBL
  SLIT HOMOLOG 2 PROTEIN UniProtKB/TrEMBL
  SLIT1B UniProtKB/TrEMBL
  SYNAPTIC ADHESION-LIKE MOLECULE SALM UniProtKB/Swiss-Prot
Pfam EGF UniProtKB/TrEMBL
  hEGF UniProtKB/TrEMBL
  Laminin_G_1 UniProtKB/TrEMBL
  LRR_1 UniProtKB/TrEMBL
  LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slit2 PhenoGen
PRINTS FSHRECEPTOR UniProtKB/Swiss-Prot
  LEURICHRPT UniProtKB/Swiss-Prot
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  CTCK_1 UniProtKB/TrEMBL
  CTCK_2 UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LAM_G_DOMAIN UniProtKB/TrEMBL
  LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000003840 RatGTEx
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  FOLN UniProtKB/TrEMBL
  LamG UniProtKB/TrEMBL
  LRR_SD22 UniProtKB/TrEMBL
  LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00041 UniProtKB/TrEMBL
Superfamily-SCOP ConA_like_lec_gl UniProtKB/TrEMBL
  EGF/Laminin UniProtKB/TrEMBL
  L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A0G2KA49_RAT UniProtKB/TrEMBL
  A0A8I6A6K5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AMD5_RAT UniProtKB/TrEMBL
  A0A8I6B4I9_RAT UniProtKB/TrEMBL
  A6IJK6_RAT UniProtKB/TrEMBL
  F1MA79 ENTREZGENE, UniProtKB/TrEMBL
  Q9WVC1 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-01 Slit2  slit guidance ligand 2  Slit2  slit homolog 2 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Slit2  slit homolog 2 (Drosophila)      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference