Nr2f2 (nuclear receptor subfamily 2, group F, member 2) - Rat Genome Database

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Gene: Nr2f2 (nuclear receptor subfamily 2, group F, member 2) Rattus norvegicus
Analyze
Symbol: Nr2f2
Name: nuclear receptor subfamily 2, group F, member 2
RGD ID: 69305
Description: Enables sequence-specific DNA binding activity. Involved in positive regulation of systemic arterial blood pressure; regulation of DNA-templated transcription; and response to estradiol. Predicted to be located in cytosol and nucleoplasm. Used to study hypertension. Human ortholog(s) of this gene implicated in 46,XX sex reversal 5. Orthologous to human NR2F2 (nuclear receptor subfamily 2 group F member 2); PARTICIPATES IN forkhead class A signaling pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: apolipoprotein A-I regulatory protein 1; apolipoprotein AI regulatory protein 1; ARP-1; COUP transcription factor 2; COUP transcription factor II; COUP-TF II; COUP-TF2; COUPb; nuclear receptor subfamily 2 group F member 2; ovalbumin upstream promoter beta nuclear receptor; Tfcoup2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Nr2f2em1Mcwi  
Genetic Models: SS-Nr2f2em1Mcwi
Candidate Gene For: Bp313
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81133,419,161 - 133,434,290 (-)NCBIGRCr8
mRatBN7.21124,008,282 - 124,022,521 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1124,009,181 - 124,022,031 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1132,007,025 - 132,012,975 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01139,177,092 - 139,183,046 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01131,989,976 - 131,995,932 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01131,447,671 - 131,465,749 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1131,448,447 - 131,460,473 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01132,486,697 - 132,499,845 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41125,280,974 - 125,286,929 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11125,359,316 - 125,365,272 (-)NCBI
Celera1116,179,533 - 116,185,445 (-)NCBICelera
Cytogenetic Map1q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arotinoid acid  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CHIR 99021  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
cortisol  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP,ISO)
dinophysistoxin 1  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
genistein  (EXP,ISO)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
maneb  (ISO)
menadione  (ISO)
mercury dibromide  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nitric oxide  (ISO)
nitrofen  (EXP)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
prostaglandin E2  (ISO)
quercetin  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
topiramate  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. ARP-1/COUP-TF II determines hepatoma phenotype by acting as both a transcriptional repressor of microsomal triglyceride transfer protein and an inducer of CYP7A1. Kang S, etal., J Biol Chem 2003 Aug 15;278(33):30478-86. Epub 2003 May 30.
4. The expression of Hedgehog genes (Ihh, Dhh) and Hedgehog target genes (Ptc1, Gli1, Coup-TfII) is affected by estrogenic stimuli in the uterus of immature female rats. Katayama S, etal., Toxicol Appl Pharmacol. 2006 Dec 15;217(3):375-83. Epub 2006 Oct 6.
5. Mutation within the hinge region of the transcription factor Nr2f2 attenuates salt-sensitive hypertension. Kumarasamy S, etal., Nat Commun. 2015 Feb 17;6:6252. doi: 10.1038/ncomms7252.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:7823919   PMID:8910285   PMID:9343308   PMID:12972613   PMID:15546392   PMID:15548577   PMID:15572686   PMID:15829524   PMID:15875024   PMID:16251273   PMID:16721029   PMID:16912278  
PMID:17404209   PMID:18765640   PMID:18798693   PMID:18815287   PMID:19210544   PMID:19231526   PMID:19796622   PMID:20130170   PMID:21879463   PMID:23378030   PMID:24234421   PMID:24466353  
PMID:25372459   PMID:36648143  


Genomics

Comparative Map Data
Nr2f2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81133,419,161 - 133,434,290 (-)NCBIGRCr8
mRatBN7.21124,008,282 - 124,022,521 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1124,009,181 - 124,022,031 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1132,007,025 - 132,012,975 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01139,177,092 - 139,183,046 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01131,989,976 - 131,995,932 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01131,447,671 - 131,465,749 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1131,448,447 - 131,460,473 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01132,486,697 - 132,499,845 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41125,280,974 - 125,286,929 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11125,359,316 - 125,365,272 (-)NCBI
Celera1116,179,533 - 116,185,445 (-)NCBICelera
Cytogenetic Map1q31NCBI
NR2F2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381596,326,046 - 96,340,263 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1596,325,938 - 96,340,263 (+)EnsemblGRCh38hg38GRCh38
GRCh371596,869,275 - 96,883,492 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361594,674,950 - 94,683,048 (+)NCBINCBI36Build 36hg18NCBI36
Build 341594,674,949 - 94,683,045NCBI
Celera1573,285,358 - 73,299,693 (+)NCBICelera
Cytogenetic Map15q26.2NCBI
HuRef1572,999,792 - 73,013,983 (+)NCBIHuRef
CHM1_11596,711,246 - 96,725,580 (+)NCBICHM1_1
T2T-CHM13v2.01594,090,629 - 94,104,848 (+)NCBIT2T-CHM13v2.0
Nr2f2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39770,001,694 - 70,016,494 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl770,001,692 - 70,016,483 (-)EnsemblGRCm39 Ensembl
GRCm38770,351,946 - 70,366,746 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl770,351,944 - 70,366,735 (-)EnsemblGRCm38mm10GRCm38
MGSCv37777,496,836 - 77,511,632 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36770,226,952 - 70,240,235 (-)NCBIMGSCv36mm8
Celera767,807,423 - 67,836,911 (-)NCBICelera
Cytogenetic Map7CNCBI
cM Map738.66NCBI
Nr2f2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541624,141,888 - 24,168,585 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541624,148,052 - 24,154,406 (+)NCBIChiLan1.0ChiLan1.0
NR2F2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21685,870,526 - 85,903,632 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11589,569,489 - 89,582,674 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01575,008,879 - 75,021,981 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11594,196,494 - 94,210,599 (+)NCBIpanpan1.1PanPan1.1panPan2
NR2F2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1344,135,143 - 44,148,836 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl344,136,463 - 44,148,524 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha346,838,728 - 46,852,294 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0344,548,234 - 44,561,807 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl344,475,116 - 44,561,446 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1344,070,866 - 44,084,429 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0344,300,713 - 44,314,268 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0344,625,819 - 44,639,411 (-)NCBIUU_Cfam_GSD_1.0
Nr2f2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640139,433,402 - 139,446,616 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364836,886,153 - 6,900,997 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364836,886,447 - 6,900,986 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NR2F2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl783,076,124 - 83,090,535 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1783,076,119 - 83,090,250 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2788,960,806 - 88,972,751 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NR2F2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12914,889,526 - 14,901,848 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2914,891,737 - 14,903,813 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605931,706,856 - 31,720,520 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nr2f2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247687,701,674 - 7,728,408 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247687,713,771 - 7,728,102 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nr2f2
28 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:65
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000014152
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
2325726Eae30Experimental allergic encephalomyelitis QTL 30nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1123053310128593844Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123479780142990467Rat

Markers in Region
RH133250  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,014,364 - 124,014,551 (+)MAPPERmRatBN7.2
Rnor_6.01131,452,853 - 131,453,039NCBIRnor6.0
Rnor_5.01132,491,879 - 132,492,065UniSTSRnor5.0
RGSC_v3.41125,285,093 - 125,285,279UniSTSRGSC3.4
Celera1116,183,609 - 116,183,795UniSTS
RH 3.4 Map11451.09UniSTS
Cytogenetic Map1q31UniSTS
D1Bda25  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,010,253 - 124,010,462 (+)MAPPERmRatBN7.2
Rnor_6.01131,448,744 - 131,448,952NCBIRnor6.0
Rnor_5.01132,487,770 - 132,487,978UniSTSRnor5.0
RGSC_v3.41125,280,981 - 125,281,189UniSTSRGSC3.4
Celera1116,179,540 - 116,179,748UniSTS
Cytogenetic Map1q31UniSTS
RH141740  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,010,196 - 124,010,411 (+)MAPPERmRatBN7.2
Rnor_6.01131,448,687 - 131,448,901NCBIRnor6.0
Rnor_5.01132,487,713 - 132,487,927UniSTSRnor5.0
RGSC_v3.41125,280,924 - 125,281,138UniSTSRGSC3.4
Celera1116,179,483 - 116,179,697UniSTS
RH 3.4 Map11451.2UniSTS
Cytogenetic Map1q31UniSTS
PMC316637P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21124,013,509 - 124,013,975 (+)MAPPERmRatBN7.2
Rnor_6.01131,451,998 - 131,452,463NCBIRnor6.0
Rnor_5.01132,491,024 - 132,491,489UniSTSRnor5.0
RGSC_v3.41125,284,238 - 125,284,703UniSTSRGSC3.4
Celera1116,182,754 - 116,183,219UniSTS
Cytogenetic Map1q31UniSTS


Genetic Models
This gene Nr2f2 is modified in the following models/strains:
SS-Nr2f2em1Mcwi    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 30 38 31 11 31 2 64 35 34 11
Low 13 19 10 8 10 8 9 10 7 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014152   ⟹   ENSRNOP00000014152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1124,010,247 - 124,016,202 (-)Ensembl
Rnor_6.0 Ensembl1131,448,737 - 131,454,689 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084336   ⟹   ENSRNOP00000072005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1124,009,181 - 124,022,031 (-)Ensembl
Rnor_6.0 Ensembl1131,448,447 - 131,460,473 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100190   ⟹   ENSRNOP00000078685
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1124,009,181 - 124,014,705 (-)Ensembl
RefSeq Acc Id: NM_080778   ⟹   NP_542956
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81133,420,227 - 133,426,179 (-)NCBI
mRatBN7.21124,010,247 - 124,016,202 (-)NCBI
Rnor_6.01131,448,737 - 131,454,689 (-)NCBI
Rnor_5.01132,486,697 - 132,499,845 (-)NCBI
RGSC_v3.41125,280,974 - 125,286,929 (-)RGD
Celera1116,179,533 - 116,185,445 (-)RGD
Sequence:
RefSeq Acc Id: XM_006229366   ⟹   XP_006229428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81133,419,161 - 133,434,290 (-)NCBI
mRatBN7.21124,008,282 - 124,022,521 (-)NCBI
Rnor_6.01131,447,671 - 131,465,749 (-)NCBI
Rnor_5.01132,486,697 - 132,499,845 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017588643   ⟹   XP_017444132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81133,419,161 - 133,425,607 (-)NCBI
mRatBN7.21124,008,282 - 124,015,639 (-)NCBI
Rnor_6.01131,447,671 - 131,454,067 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105995   ⟹   XP_038961923
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81133,419,161 - 133,425,451 (-)NCBI
mRatBN7.21124,008,286 - 124,014,951 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_542956   ⟸   NM_080778
- UniProtKB: O09018 (UniProtKB/Swiss-Prot),   A6JBW1 (UniProtKB/TrEMBL),   A0A8I6A7N1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229428   ⟸   XM_006229366
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K1W0 (UniProtKB/TrEMBL),   A6JBW0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444132   ⟸   XM_017588643
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000014152   ⟸   ENSRNOT00000014152
RefSeq Acc Id: ENSRNOP00000072005   ⟸   ENSRNOT00000084336
RefSeq Acc Id: XP_038961923   ⟸   XM_039105995
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZLR6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000078685   ⟸   ENSRNOT00000100190
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O09018-F1-model_v2 AlphaFold O09018 1-414 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690115
Promoter ID:EPDNEW_R637
Type:initiation region
Name:Nr2f2_1
Description:nuclear receptor subfamily 2, group F, member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01131,460,507 - 131,460,567EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69305 AgrOrtholog
BioCyc Gene G2FUF-58933 BioCyc
Ensembl Genes ENSRNOG00000010308 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00000014795 UniProtKB/TrEMBL
  ENSRNOG00055021297 UniProtKB/Swiss-Prot
  ENSRNOG00060018105 UniProtKB/Swiss-Prot
  ENSRNOG00065024645 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014152 ENTREZGENE
  ENSRNOT00000014152.4 UniProtKB/Swiss-Prot
  ENSRNOT00000084336.2 UniProtKB/TrEMBL
  ENSRNOT00000100190.1 UniProtKB/TrEMBL
  ENSRNOT00000115926.1 UniProtKB/TrEMBL
  ENSRNOT00055036402 UniProtKB/Swiss-Prot
  ENSRNOT00060031047 UniProtKB/Swiss-Prot
  ENSRNOT00065042313 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:113984 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 113984 ENTREZGENE
PANTHER COUP TRANSCRIPTION FACTOR 1 UniProtKB/TrEMBL
  COUP TRANSCRIPTION FACTOR 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR HORMONE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB NR2F2 RGD
PhenoGen Nr2f2 PhenoGen
PRINTS COUPTNFACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010308 RatGTEx
  ENSRNOG00000014795 RatGTEx
  ENSRNOG00055021297 RatGTEx
  ENSRNOG00060018105 RatGTEx
  ENSRNOG00065024645 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC206011
UniProt A0A0G2K1W0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZLR6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A7N1 ENTREZGENE, UniProtKB/TrEMBL
  A6JBW0 ENTREZGENE, UniProtKB/TrEMBL
  A6JBW1 ENTREZGENE, UniProtKB/TrEMBL
  COT2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Nr2f2  nuclear receptor subfamily 2, group F, member 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process a transcriptional repressor for the microsomal triglyceride transfer protein gene but a transcriptional activator for the CYP7A1 gene 737636