Inhbe (inhibin subunit beta E) - Rat Genome Database

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Gene: Inhbe (inhibin subunit beta E) Rattus norvegicus
Analyze
Symbol: Inhbe
Name: inhibin subunit beta E
RGD ID: 621196
Description: Predicted to enable cytokine activity. Predicted to be involved in signal transduction. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human INHBE (inhibin subunit beta E); PARTICIPATES IN transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: activin beta E; activin beta-E chain; inhibin beta E; inhibin beta E chain; inhibin beta E subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8765,061,531 - 65,064,519 (-)NCBIGRCr8
mRatBN7.2763,176,221 - 63,179,209 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl763,176,219 - 63,179,172 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx765,066,840 - 65,068,267 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0767,269,266 - 67,270,691 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0767,070,582 - 67,072,002 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,641,423 - 70,642,848 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,640,075 - 70,643,169 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,815,702 - 70,817,127 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,308,713 - 67,310,138 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1767,328,105 - 67,331,057 (-)NCBI
Celera760,317,558 - 60,318,983 (-)NCBICelera
Cytogenetic Map7q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,4-dithiothreitol  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
amiodarone  (EXP,ISO)
amitriptyline  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bosentan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
citalopram  (ISO)
clarithromycin  (ISO)
clofibrate  (EXP)
clomipramine  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
corn oil  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
dimethylarsinic acid  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxepin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
erythromycin A  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fentin chloride  (EXP)
flecainide  (ISO)
fluoxetine  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (ISO)
genistein  (ISO)
gentamycin  (EXP)
haloperidol  (ISO)
hydrazine  (ISO)
hydroquinone  (ISO)
imipramine  (ISO)
inulin  (ISO)
iron dichloride  (ISO)
isoniazide  (ISO)
ketoconazole  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
L-ethionine  (EXP)
lead diacetate  (ISO)
leflunomide  (EXP,ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP,ISO)
loratadine  (ISO)
mercury dibromide  (ISO)
metacetamol  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nelfinavir  (ISO)
nevirapine  (EXP)
niclosamide  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
omeprazole  (EXP)
oxycodone  (EXP)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
PCB138  (ISO)
pentamidine  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
perhexiline  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
quinidine  (ISO)
quinolin-8-ol  (ISO)
ranitidine  (EXP)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sertraline  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sotalol  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tebuconazole  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thioridazine  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vincristine  (ISO)
zimeldine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Overexpression of activin beta(C) or activin beta(E) in the mouse liver inhibits regenerative deoxyribonucleic acid synthesis of hepatic cells. Chabicovsky M, etal., Endocrinology 2003 Aug;144(8):3497-504.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Cloning and regulation of the rat activin betaE subunit. O'Bryan MK, etal., J Mol Endocrinol 2000 Jun;24(3):409-18.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Expression and dimerization of the rat activin subunits betaC and betaE: evidence for the ormation of novel activin dimers. Vejda S, etal., J Mol Endocrinol 2002 Apr;28(2):137-48.
Additional References at PubMed
PMID:16935389  


Genomics

Comparative Map Data
Inhbe
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8765,061,531 - 65,064,519 (-)NCBIGRCr8
mRatBN7.2763,176,221 - 63,179,209 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl763,176,219 - 63,179,172 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx765,066,840 - 65,068,267 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0767,269,266 - 67,270,691 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0767,070,582 - 67,072,002 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0770,641,423 - 70,642,848 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,640,075 - 70,643,169 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,815,702 - 70,817,127 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,308,713 - 67,310,138 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1767,328,105 - 67,331,057 (-)NCBI
Celera760,317,558 - 60,318,983 (-)NCBICelera
Cytogenetic Map7q22NCBI
INHBE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381257,455,307 - 57,458,025 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1257,452,323 - 57,459,280 (+)EnsemblGRCh38hg38GRCh38
GRCh371257,849,090 - 57,851,808 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,135,363 - 56,138,058 (+)NCBINCBI36Build 36hg18NCBI36
Build 341256,135,362 - 56,138,056NCBI
Celera1257,503,083 - 57,505,778 (+)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1254,886,854 - 54,889,664 (+)NCBIHuRef
CHM1_11257,817,205 - 57,819,905 (+)NCBICHM1_1
T2T-CHM13v2.01257,423,596 - 57,426,314 (+)NCBIT2T-CHM13v2.0
Inhbe
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,185,271 - 127,187,717 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10127,184,726 - 127,190,280 (-)EnsemblGRCm39 Ensembl
GRCm3810127,349,402 - 127,351,848 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,348,857 - 127,354,411 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710126,786,458 - 126,788,828 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610126,752,351 - 126,754,721 (-)NCBIMGSCv36mm8
Celera10129,741,900 - 129,744,264 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1074.5NCBI
Inhbe
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554585,177,036 - 5,179,095 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554585,177,036 - 5,179,095 (+)NCBIChiLan1.0ChiLan1.0
INHBE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21036,882,466 - 36,884,975 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11236,877,499 - 36,881,728 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01231,467,974 - 31,470,700 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11231,724,247 - 31,726,978 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,724,252 - 31,726,978 (-)Ensemblpanpan1.1panPan2
INHBE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,558,876 - 1,563,370 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,559,770 - 1,562,885 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,622,273 - 1,626,266 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0101,568,055 - 1,572,048 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl101,568,174 - 1,572,796 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1101,546,151 - 1,550,142 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0101,787,658 - 1,791,648 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0101,912,977 - 1,916,971 (+)NCBIUU_Cfam_GSD_1.0
Inhbe
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494557,253,345 - 57,256,317 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366461,614,745 - 1,616,279 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366461,614,902 - 1,616,482 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INHBE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl522,732,516 - 22,734,083 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1522,732,774 - 22,734,716 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2524,808,794 - 24,811,612 (-)NCBISscrofa10.2Sscrofa10.2susScr3
INHBE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11153,367,304 - 53,369,205 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1153,367,423 - 53,370,322 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037192,597,371 - 192,599,709 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Inhbe
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480210,493,576 - 10,499,565 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480210,497,618 - 10,499,433 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Inhbe
12 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:234
Count of miRNA genes:152
Interacting mature miRNAs:182
Transcripts:ENSRNOT00000010106
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73111283276112832Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73429328279293282Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73429328279293282Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73796056982960569Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74725178365728867Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 23 23 23
Low 19 18 18 2 1
Below cutoff 15 7 6 6 6 21 26 20 6 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000010106   ⟹   ENSRNOP00000010106
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl763,176,219 - 63,179,172 (-)Ensembl
Rnor_6.0 Ensembl770,640,075 - 70,643,169 (-)Ensembl
RefSeq Acc Id: NM_031815   ⟹   NP_114003
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8765,061,531 - 65,064,519 (-)NCBI
mRatBN7.2763,176,221 - 63,179,209 (-)NCBI
Rnor_6.0770,641,423 - 70,642,848 (-)NCBI
Rnor_5.0770,815,702 - 70,817,127 (-)NCBI
RGSC_v3.4767,308,713 - 67,310,138 (-)RGD
Celera760,317,558 - 60,318,983 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_114003 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC36741 (Get FASTA)   NCBI Sequence Viewer  
  AAD30133 (Get FASTA)   NCBI Sequence Viewer  
  EDM16469 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010106
  ENSRNOP00000010106.2
GenBank Protein O88959 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_114003   ⟸   NM_031815
- Peptide Label: precursor
- UniProtKB: Q9R285 (UniProtKB/Swiss-Prot),   O88959 (UniProtKB/Swiss-Prot),   A0A0G2JSJ0 (UniProtKB/TrEMBL),   A6HQV3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010106   ⟸   ENSRNOT00000010106
Protein Domains
TGF-beta family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88959-F1-model_v2 AlphaFold O88959 1-350 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695259
Promoter ID:EPDNEW_R5784
Type:initiation region
Name:Inhbe_1
Description:inhibin beta E subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0770,643,074 - 70,643,134EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621196 AgrOrtholog
BioCyc Gene G2FUF-33749 BioCyc
Ensembl Genes ENSRNOG00000007601 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010106 ENTREZGENE
  ENSRNOT00000010106.5 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Inhibin_betaC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83711 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 83711 ENTREZGENE
PANTHER INHIBIN BETA E CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11848 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Inhbe PhenoGen
PRINTS INHIBINBC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007601 RatGTEx
SMART TGFB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSJ0 ENTREZGENE, UniProtKB/TrEMBL
  A6HQV3 ENTREZGENE, UniProtKB/TrEMBL
  INHBE_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9R285 ENTREZGENE
UniProt Secondary Q9R285 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-25 Inhbe  inhibin subunit beta E  Inhbe  inhibin beta E subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-06-01 Inhbe  inhibin beta E subunit  Inhbe  inhibin beta E  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Inhbe  inhibin beta E    activin beta E  Name updated 1299863 APPROVED
2002-08-07 Inhbe  activin beta E      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in hepatocytes 631972