Cdk7 (cyclin-dependent kinase 7) - Rat Genome Database

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Gene: Cdk7 (cyclin-dependent kinase 7) Rattus norvegicus
Analyze
Symbol: Cdk7
Name: cyclin-dependent kinase 7
RGD ID: 621124
Description: Enables cyclin-dependent protein serine/threonine kinase activity. Involved in transcription by RNA polymerase II. Part of transcription factor TFIIH holo complex. Orthologous to human CDK7 (cyclin dependent kinase 7); PARTICIPATES IN RNA polymerase II transcription initiation pathway; RNA polymerase II transcription pathway; cell cycle pathway, mitotic; INTERACTS WITH 2,4-dinitrotoluene; ammonium chloride; dibutyl phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 39 protein kinase; CAK; CDK-activating kinase; CDK-activating kinase 1; cell division protein kinase 7; cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase); cyclin-dependent kinase 7 (MO15 homolog Xenopus laevis cdk-activating kinase); cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase); P39 Mo15; TFIIH basal transcription factor complex kinase subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8233,574,623 - 33,599,485 (-)NCBIGRCr8
mRatBN7.2231,840,558 - 31,865,422 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl231,840,558 - 31,865,383 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx238,974,607 - 38,999,466 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0237,015,603 - 37,040,504 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0231,873,480 - 31,898,638 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0230,710,642 - 30,735,522 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl230,710,643 - 30,735,514 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0249,869,631 - 49,894,108 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4231,500,629 - 31,525,590 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1231,422,411 - 31,445,843 (-)NCBI
Celera227,854,542 - 27,879,123 (-)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
caffeine  (ISO)
calycosin  (ISO)
carbamazepine  (ISO)
carbofuran  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chlorpromazine  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
divanadium pentaoxide  (ISO)
epoxiconazole  (ISO)
fipronil  (EXP)
flutamide  (EXP)
folpet  (ISO)
FR900359  (ISO)
gallic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hypochlorous acid  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lamivudine  (ISO)
lycopene  (ISO)
metformin  (ISO)
myristicin  (ISO)
N-acetyl-L-cysteine  (ISO)
nefazodone  (EXP)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
sodium arsenite  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
thapsigargin  (ISO)
triazoles  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
Triptolide  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
wogonin  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Updating the RNA polymerase CTD code: adding gene-specific layers. Egloff S, etal., Trends Genet. 2012 Jul;28(7):333-41. doi: 10.1016/j.tig.2012.03.007. Epub 2012 May 21.
2. A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor. Egly JM and Coin F, DNA Repair (Amst). 2011 Jul 15;10(7):714-21. doi: 10.1016/j.dnarep.2011.04.021. Epub 2011 May 17.
3. Changes in cyclin dependent kinase expression and activity accompanying lens fiber cell differentiation. Gao CY, etal., Exp Eye Res 1999 Dec;69(6):695-703.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. The writers, readers, and functions of the RNA polymerase II C-terminal domain code. Jeronimo C, etal., Chem Rev. 2013 Nov 13;113(11):8491-522. doi: 10.1021/cr4001397. Epub 2013 Jul 10.
7. An alliance between Ras GTPase-activating protein, filamin C, and Ras GTPase-activating protein SH3 domain-binding protein regulates myocyte growth. Lypowy J, etal., J Biol Chem. 2005 Jul 8;280(27):25717-28. Epub 2005 May 9.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. A mammalian RNA polymerase II holoenzyme containing all components required for promoter-specific transcription initiation. Ossipow V, etal., Cell. 1995 Oct 6;83(1):137-46.
11. An RNA polymerase II complex containing all essential initiation factors binds to the activation domain of PAR leucine zipper transcription factor thyroid embryonic factor. Ossipow V, etal., Mol Cell Biol. 1999 Feb;19(2):1242-50.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Association of Cdk-activating kinase subunits with transcription factor TFIIH. Serizawa H, etal., Nature. 1995 Mar 16;374(6519):280-2.
17. CR16, a novel proline-rich protein expressed in rat brain neurons, binds to SH3 domains and is a MAP kinase substrate. Weiler MC, etal., J Mol Neurosci 1996 Fall;7(3):203-15.
18. Neuronal CDK7 in hippocampus is related to aging and Alzheimer disease. Zhu X, etal., Neurobiol Aging. 2000 Nov-Dec;21(6):807-13.
Additional References at PubMed
PMID:8692841   PMID:9852112   PMID:10801852   PMID:11319144   PMID:12721286   PMID:12748294   PMID:16109376   PMID:17416350   PMID:21778139   PMID:23393140  


Genomics

Comparative Map Data
Cdk7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8233,574,623 - 33,599,485 (-)NCBIGRCr8
mRatBN7.2231,840,558 - 31,865,422 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl231,840,558 - 31,865,383 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx238,974,607 - 38,999,466 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0237,015,603 - 37,040,504 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0231,873,480 - 31,898,638 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0230,710,642 - 30,735,522 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl230,710,643 - 30,735,514 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0249,869,631 - 49,894,108 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4231,500,629 - 31,525,590 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1231,422,411 - 31,445,843 (-)NCBI
Celera227,854,542 - 27,879,123 (-)NCBICelera
Cytogenetic Map2q12NCBI
CDK7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38569,234,795 - 69,277,430 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl569,234,795 - 69,277,430 (+)EnsemblGRCh38hg38GRCh38
GRCh37568,530,622 - 68,573,257 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36568,566,471 - 68,609,006 (+)NCBINCBI36Build 36hg18NCBI36
Build 34568,566,470 - 68,609,004NCBI
Celera565,533,029 - 65,575,634 (+)NCBICelera
Cytogenetic Map5q13.2NCBI
HuRef565,486,830 - 65,529,452 (+)NCBIHuRef
CHM1_1568,530,362 - 68,573,002 (+)NCBICHM1_1
T2T-CHM13v2.0570,060,554 - 70,103,173 (+)NCBIT2T-CHM13v2.0
Cdk7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913100,833,532 - 100,867,454 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13100,839,139 - 100,867,447 (-)EnsemblGRCm39 Ensembl
GRCm3813100,697,024 - 100,730,942 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl13100,702,631 - 100,730,939 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713101,466,979 - 101,500,897 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613101,803,572 - 101,831,180 (-)NCBIMGSCv36mm8
Celera13104,306,673 - 104,340,748 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1353.23NCBI
Cdk7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544654,448 - 90,191 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544654,401 - 87,884 (+)NCBIChiLan1.0ChiLan1.0
CDK7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2444,642,445 - 44,687,453 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1542,796,052 - 42,841,438 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0544,723,268 - 44,765,711 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1546,292,831 - 46,334,912 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl546,292,838 - 46,334,912 (-)Ensemblpanpan1.1panPan2
CDK7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1254,317,472 - 54,350,633 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl254,317,534 - 54,350,742 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha251,283,814 - 51,347,207 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0254,828,202 - 54,891,625 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl254,828,210 - 54,867,999 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1251,887,194 - 51,950,489 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0252,662,280 - 52,725,915 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0253,550,125 - 53,613,994 (+)NCBIUU_Cfam_GSD_1.0
Cdk7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213191,370,593 - 191,403,111 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936480307,069 - 339,521 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936480307,089 - 339,515 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDK7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1647,410,145 - 47,449,364 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11647,410,136 - 47,445,795 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21651,303,672 - 51,329,266 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDK7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1465,329,490 - 65,375,269 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl465,329,585 - 65,374,989 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604914,060,456 - 14,106,755 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdk7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624905123,318 - 176,168 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624905123,365 - 175,776 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdk7
199 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:150
Count of miRNA genes:112
Interacting mature miRNAs:119
Transcripts:ENSRNOT00000025026, ENSRNOT00000071234
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22699957143154682Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22997159351729300Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 57 41 19 41 8 9 74 35 41 11 8
Low 2 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025026   ⟹   ENSRNOP00000025026
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl231,840,558 - 31,865,383 (-)Ensembl
Rnor_6.0 Ensembl230,710,643 - 30,735,514 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099935   ⟹   ENSRNOP00000091862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl231,840,558 - 31,865,383 (-)Ensembl
RefSeq Acc Id: NM_001398656   ⟹   NP_001385585
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,574,623 - 33,599,485 (-)NCBI
mRatBN7.2231,840,558 - 31,865,422 (-)NCBI
RefSeq Acc Id: NM_001398657   ⟹   NP_001385586
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8233,574,623 - 33,599,485 (-)NCBI
mRatBN7.2231,840,558 - 31,865,422 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001385585 (Get FASTA)   NCBI Sequence Viewer  
  NP_001385586 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA58562 (Get FASTA)   NCBI Sequence Viewer  
  EDM10209 (Get FASTA)   NCBI Sequence Viewer  
  EDM10210 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025026
  ENSRNOP00000025026.8
  ENSRNOP00000091862.1
GenBank Protein P51952 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000025026   ⟸   ENSRNOT00000025026
RefSeq Acc Id: ENSRNOP00000091862   ⟸   ENSRNOT00000099935
RefSeq Acc Id: NP_001385586   ⟸   NM_001398657
- Peptide Label: isoform 2
- UniProtKB: A6I5A2 (UniProtKB/TrEMBL),   F1LQC8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001385585   ⟸   NM_001398656
- Peptide Label: isoform 1
- UniProtKB: P51952 (UniProtKB/Swiss-Prot)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51952-F1-model_v2 AlphaFold P51952 1-329 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691111
Promoter ID:EPDNEW_R1634
Type:initiation region
Name:Cdk7_1
Description:cyclin-dependent kinase 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0230,735,454 - 30,735,514EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621124 AgrOrtholog
BioCyc Gene G2FUF-54653 BioCyc
Ensembl Genes ENSRNOG00000018510 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025026 ENTREZGENE
  ENSRNOT00000025026.9 UniProtKB/TrEMBL
  ENSRNOT00000099935.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CDK7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 171150 ENTREZGENE
PANTHER CELL DIVISION PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYCLIN-DEPENDENT KINASE 7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cdk7 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018510 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ACJ6_RAT UniProtKB/TrEMBL
  A6I5A1_RAT UniProtKB/TrEMBL
  A6I5A2 ENTREZGENE, UniProtKB/TrEMBL
  CDK7_RAT UniProtKB/Swiss-Prot
  F1LQC8 ENTREZGENE, UniProtKB/TrEMBL
  P51952 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-09 Cdk7  cyclin-dependent kinase 7  Cdk7  cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Cdk7  cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase)    cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)  Name updated 1299863 APPROVED
2002-08-07 Cdk7  cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)      Symbol and Name status set to provisional 70820 PROVISIONAL