Rps21 (ribosomal protein S21) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Rps21 (ribosomal protein S21) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Rps21
Name: ribosomal protein S21
RGD ID: 621038
Description: Predicted to enable ribosome binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Part of cytosolic small ribosomal subunit. Orthologous to human RPS21 (ribosomal protein S21); PARTICIPATES IN ribosome biogenesis pathway; translation pathway; .
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 40S ribosomal protein S21; small ribosomal subunit protein eS21
RGD Orthologs
Alliance Genes
More Info homologs ...
Related Pseudogenes: Rps21-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83187,724,038 - 187,725,060 (+)NCBIGRCr8
mRatBN7.23167,346,437 - 167,347,459 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3167,346,201 - 167,347,470 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3171,722,880 - 171,723,902 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03180,681,969 - 180,682,991 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03177,347,380 - 177,348,402 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03175,629,176 - 175,630,198 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3175,629,374 - 175,630,048 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03181,484,784 - 181,485,902 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43169,311,205 - 169,312,227 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13169,217,240 - 169,218,262 (+)NCBI
Celera3165,232,803 - 165,233,825 (-)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Structures of the human and Drosophila 80S ribosome. Anger AM, etal., Nature. 2013 May 2;497(7447):80-5. doi: 10.1038/nature12104.
2. The primary structures of rat ribosomal proteins: the characterization of the cDNAs for S21 and L39, corrections in the sequences of L7 and L18a, and the identification of L33. Chan YL, etal., Biochem Biophys Res Commun 1995 Aug 24;213(3):1042-50.
3. Isolation of eukaryotic ribosomal proteins. Purification and characterization of the 40 S ribosomal subunit proteins Sa, Sc, S3a, S3b, S5', S9, S10, S11, S12, S14, S15, S15', S16, S17, S18, S19, S20, S21, S26, S27', and S29. Collatz E, etal., J Biol Chem. 1977 Dec 25;252(24):9071-80.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Functional dichotomy of ribosomal proteins during the synthesis of mammalian 40S ribosomal subunits. O'Donohue MF, etal., J Cell Biol. 2010 Sep 6;190(5):853-66. doi: 10.1083/jcb.201005117.
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:3910104   PMID:15489334   PMID:16751776   PMID:22871113  


Genomics

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:22
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000008458
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3161192952169034231Rat

Markers in Region
RH141919  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23167,347,605 - 167,347,820 (+)MAPPERmRatBN7.2
Rnor_6.03175,630,345 - 175,630,559NCBIRnor6.0
Rnor_5.03181,484,430 - 181,484,644UniSTSRnor5.0
RGSC_v3.43169,312,374 - 169,312,588UniSTSRGSC3.4
Celera3165,232,442 - 165,232,656UniSTS
RH 3.4 Map31527.8UniSTS
Cytogenetic Map3q43UniSTS
AI232413  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23167,346,584 - 167,347,027 (+)MAPPERmRatBN7.2
Rnor_6.03175,629,324 - 175,629,766NCBIRnor6.0
Rnor_5.03181,485,223 - 181,485,665UniSTSRnor5.0
RGSC_v3.43169,311,353 - 169,311,795UniSTSRGSC3.4
Celera3165,233,235 - 165,233,677UniSTS
RH 3.4 Map31525.0UniSTS
Cytogenetic Map3q43UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 12 14 14 2 14 32 14 28
Medium 3 31 43 27 17 27 8 11 42 21 13 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC115322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC058464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ610337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217300 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB462029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB867501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB868380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB871637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB879498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB889343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC924910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC925789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC929046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC936907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC946752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X79059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000084027   ⟹   ENSRNOP00000070217
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3167,346,201 - 167,347,470 (+)Ensembl
Rnor_6.0 Ensembl3175,629,374 - 175,630,048 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118161   ⟹   ENSRNOP00000096052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3167,346,334 - 167,347,468 (+)Ensembl
RefSeq Acc Id: NM_031111   ⟹   NP_112373
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83187,724,038 - 187,725,060 (+)NCBI
mRatBN7.23167,346,437 - 167,347,459 (+)NCBI
Rnor_6.03175,629,176 - 175,630,198 (+)NCBI
Rnor_5.03181,484,784 - 181,485,902 (-)NCBI
RGSC_v3.43169,311,205 - 169,312,227 (+)RGD
Celera3165,232,803 - 165,233,825 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_112373   ⟸   NM_031111
- UniProtKB: P05765 (UniProtKB/Swiss-Prot),   A6KMA7 (UniProtKB/TrEMBL),   D3ZSE0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070217   ⟸   ENSRNOT00000084027
RefSeq Acc Id: ENSRNOP00000096052   ⟸   ENSRNOT00000118161

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P05765-F1-model_v2 AlphaFold P05765 1-83 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621038 AgrOrtholog
BioCyc Gene G2FUF-46363 BioCyc
Ensembl Genes ENSRNOG00000033916 UniProtKB/TrEMBL
  ENSRNOG00000060449 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00055025079 UniProtKB/Swiss-Prot
  ENSRNOG00060030643 UniProtKB/Swiss-Prot
  ENSRNOG00065027897 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000051693.5 UniProtKB/TrEMBL
  ENSRNOT00000084027.2 UniProtKB/TrEMBL
  ENSRNOT00000118161.1 UniProtKB/TrEMBL
  ENSRNOT00055043214 UniProtKB/Swiss-Prot
  ENSRNOT00060053240 UniProtKB/Swiss-Prot
  ENSRNOT00065048101 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.1230.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6918340 IMAGE-MGC_LOAD
InterPro Ribosomal_S21e UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosomal_S21e_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosomal_S21e_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81775 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72789 IMAGE-MGC_LOAD
NCBI Gene 81775 ENTREZGENE
PANTHER 40S RIBOSOMAL PROTEIN S21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10442 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ribosomal_S21e UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rps21 PhenoGen
PIRSF Ribosomal_S21e UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RIBOSOMAL_S21E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033916 RatGTEx
  ENSRNOG00000060449 RatGTEx
  ENSRNOG00055025079 RatGTEx
  ENSRNOG00060030643 RatGTEx
  ENSRNOG00065027897 RatGTEx
UniProt A0A0G2JXC3_RAT UniProtKB/TrEMBL
  A0A8I6ARS2_RAT UniProtKB/TrEMBL
  A6KMA7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZSE0 ENTREZGENE, UniProtKB/TrEMBL
  P05765 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Rps21  ribosomal protein S21      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Rps21  ribosomal protein S21      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 83 amino acids and a molecular weight of 9,121 633962