Bdh1 (3-hydroxybutyrate dehydrogenase 1) - Rat Genome Database

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Gene: Bdh1 (3-hydroxybutyrate dehydrogenase 1) Rattus norvegicus
Analyze
Symbol: Bdh1
Name: 3-hydroxybutyrate dehydrogenase 1
RGD ID: 620131
Description: Enables 3-hydroxybutyrate dehydrogenase activity and phospholipid binding activity. Involved in several processes, including response to corticosterone; response to estradiol; and response to peptide hormone. Located in mitochondrial inner membrane. Biomarker of hyperthyroidism. Orthologous to human BDH1 (3-hydroxybutyrate dehydrogenase 1); PARTICIPATES IN forkhead class A signaling pathway; ketone bodies metabolic pathway; succinyl-CoA:3-oxoacid transferase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 3-hydroxybutyrate dehydrogenase (heart, mitochondrial); 3-hydroxybutyrate dehydrogenase, type 1; Bdh; D-beta-hydroxybutyrate dehydrogenase, mitochondrial; MGC94818
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81182,806,125 - 82,848,133 (-)NCBIGRCr8
mRatBN7.21169,302,534 - 69,343,173 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1169,302,534 - 69,337,671 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1178,139,549 - 78,174,678 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01170,799,406 - 70,827,976 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01169,828,637 - 69,863,770 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01172,577,547 - 72,619,435 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1172,578,533 - 72,614,176 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01175,651,886 - 75,693,764 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41171,130,561 - 71,165,695 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11171,188,149 - 71,223,284 (-)NCBI
Celera1168,723,790 - 68,758,851 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
5-Hydroxythalidomide  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
ciglitazone  (ISO)
ciprofibrate  (EXP)
cisplatin  (EXP)
clofibrate  (EXP)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP,ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (EXP)
fenthion  (ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
gallic acid  (ISO)
genistein  (ISO)
inulin  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
Lasiocarpine  (ISO)
Mesaconitine  (EXP)
methamphetamine  (ISO)
methapyrilene  (EXP,ISO)
methidathion  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triclosan  (ISO)
trimellitic anhydride  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
trovafloxacin  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Post-transcriptional analysis of rat mitochondrial D-3-hydroxybutyrate dehydrogenase control through development and physiological stages. Bailly A, etal., Biol Cell. 1991;73(2-3):121-9.
2. Effect of diabetes, adrenalectomy and hypophysectomy on D-3-hydroxybutyrate dehydrogenase activity and substrate oxidation by rat mitochondria. Bedetti CD, etal., Biochem Int. 1987 Jan;14(1):45-54.
3. Favourable, significant effect of the dose-dependent treatment with RU 38486 (RU) on the alterations of the hepatic mitochondrial function of diabetic rats. Brignone JA, etal., Diabetes Res Clin Pract. 1996 May;32(3):141-8.
4. Enzyme activity alteration by cadmium administration to rats: the possibility of iron involvement in lipid peroxidation. Casalino E, etal., Arch Biochem Biophys. 1997 Oct 15;346(2):171-9.
5. Primary structure of rat liver D-beta-hydroxybutyrate dehydrogenase from cDNA and protein analyses: a short-chain alcohol dehydrogenase. Churchill P, etal., Biochemistry 1992 Apr 21;31(15):3793-9.
6. Reactivation of D-beta-hydroxybutyrate dehydrogenase with short-chain lecithins: stoichiometry and kinetic mechanism. Cortese JD, etal., Biochemistry. 1982 Aug 3;21(16):3899-908.
7. Glycemia, ketonemia, and brain enzymes of ketone body utilization in suckling and adult rats undernourished from intrauterine life. Escriva F, etal., J Neurochem. 1985 May;44(5):1358-62.
8. Circulating glucose, insulin and ketone bodies and enzymes of ketone body utilization in brain mitochondria from suckling rats treated with high L-thyroxine doses. Escriva F, etal., Rev Esp Fisiol. 1983 Dec;39(4):363-71.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Decreased rate of ketone-body oxidation and decreased activity of D-3-hydroxybutyrate dehydrogenase and succinyl-CoA:3-oxo-acid CoA-transferase in heart mitochondria of diabetic rats. Grinblat L, etal., Biochem J. 1986 Nov 15;240(1):49-56.
12. Effect of streptozotocin-induced diabetes on oxidative energy metabolism in rat kidney mitochondria. A comparative study of early and late effects. Katyare SS and Satav JG, Diabetes Obes Metab. 2005 Sep;7(5):555-62.
13. Cardiovascular disease potentially contributes to the progression and poor prognosis of COVID-19. Li M, etal., Nutr Metab Cardiovasc Dis. 2020 Jun 25;30(7):1061-1067. doi: 10.1016/j.numecd.2020.04.013. Epub 2020 Apr 18.
14. Ketone-body metabolism in hyperthyroid rats: reduced activity of D-3-hydroxybutyrate dehydrogenase in both liver and heart and of succinyl-coenzyme A: 3-oxoacid coenzyme A-transferase in heart. Lippolis R, etal., Arch Biochem Biophys. 1988 Jan;260(1):94-101.
15. Utilization of ketone bodies by the rat liver, brain and heart in chronic alcohol intoxication. Lukivskaya OYa and Buko VU, Alcohol Alcohol. 1993 Jul;28(4):431-6.
16. Comparison of 3-hydroxybutyrate dehydrogenase from bovine heart and rat liver mitochondria. McIntyre JO, etal., Arch Biochem Biophys. 1988 Apr;262(1):85-98.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Proteomics analysis of cardiac muscle from rats with peroxisomal proliferator-activated receptor alpha (PPARalpha) stimulation. Miyazaki M, etal., J Toxicol Sci. 2010;35(1):131-5.
19. Cerebral ketone body metabolism. Morris AA J Inherit Metab Dis. 2005;28(2):109-21.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
23. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
24. Effects of digitonin on the intracellular content of rat hepatocytes: implications for its use in the study of intralobular heterogeneity. Racine L, etal., J Histochem Cytochem. 1993 Jul;41(7):991-1001.
25. GOA pipeline RGD automated data pipeline
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. [The effect of hepatotoxins on the activity of organelle-specific enzymes and metabolism of liver lipids] Vengerovskii AI and Saratikov AS, Vopr Med Khim. 1989 May-Jun;35(3):87-91.
28. Activities of enzymes of acetoacetate metabolism in rat brown adipose tissue during development. Williamson DH and Ilic V, Biochem J. 1985 Nov 1;231(3):773-5.
29. Developmental regulation of D-beta-hydroxybutyrate dehydrogenase in rat liver and brain. Zhang WW, etal., FEBS Lett. 1989 Oct 9;256(1-2):71-4.
Additional References at PubMed
PMID:8679568   PMID:12477932   PMID:12865426   PMID:14651853   PMID:15489334   PMID:18614015   PMID:26316108   PMID:29476059  


Genomics

Comparative Map Data
Bdh1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81182,806,125 - 82,848,133 (-)NCBIGRCr8
mRatBN7.21169,302,534 - 69,343,173 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1169,302,534 - 69,337,671 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1178,139,549 - 78,174,678 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01170,799,406 - 70,827,976 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01169,828,637 - 69,863,770 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01172,577,547 - 72,619,435 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1172,578,533 - 72,614,176 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01175,651,886 - 75,693,764 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41171,130,561 - 71,165,695 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11171,188,149 - 71,223,284 (-)NCBI
Celera1168,723,790 - 68,758,851 (-)NCBICelera
Cytogenetic Map11q22NCBI
BDH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383197,509,783 - 197,573,343 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3197,509,783 - 197,573,323 (-)EnsemblGRCh38hg38GRCh38
GRCh373197,236,654 - 197,300,214 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363198,721,051 - 198,784,591 (-)NCBINCBI36Build 36hg18NCBI36
Build 343198,726,756 - 198,788,504NCBI
Celera3195,829,052 - 195,891,752 (-)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3194,539,341 - 194,602,169 (-)NCBIHuRef
CHM1_13197,207,633 - 197,271,017 (-)NCBICHM1_1
T2T-CHM13v2.03200,242,414 - 200,306,032 (-)NCBIT2T-CHM13v2.0
Bdh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391631,241,115 - 31,277,719 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1631,241,098 - 31,277,719 (+)EnsemblGRCm39 Ensembl
GRCm381631,422,297 - 31,458,901 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1631,422,280 - 31,458,901 (+)EnsemblGRCm38mm10GRCm38
MGSCv371631,422,383 - 31,458,987 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361631,342,041 - 31,377,244 (+)NCBIMGSCv36mm8
Celera1631,928,539 - 31,964,764 (+)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1621.74NCBI
Bdh1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542013,452,166 - 13,486,565 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542013,454,379 - 13,486,700 (-)NCBIChiLan1.0ChiLan1.0
BDH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22195,408,886 - 195,455,045 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13195,416,692 - 195,462,850 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03194,917,904 - 194,979,451 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13204,797,765 - 204,862,387 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3204,797,757 - 204,863,889 (-)Ensemblpanpan1.1panPan2
BDH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13330,407,021 - 30,422,735 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3330,406,338 - 30,436,366 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3330,430,095 - 30,459,631 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03330,656,076 - 30,686,162 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3330,627,393 - 30,685,079 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13330,449,912 - 30,479,577 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03330,487,027 - 30,516,743 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03331,107,916 - 31,137,803 (-)NCBIUU_Cfam_GSD_1.0
Bdh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602143,527,823 - 143,574,972 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936833367,710 - 410,139 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936833367,790 - 409,966 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BDH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13132,605,489 - 132,645,937 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113132,602,372 - 132,647,271 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213142,184,212 - 142,203,863 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BDH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11589,678,844 - 89,741,848 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1589,707,046 - 89,742,434 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604163,463,989 - 63,508,519 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bdh1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473062,397,245 - 62,424,924 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473062,397,242 - 62,466,172 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bdh1
422 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:48
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000002366
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat

Markers in Region
RH132045  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21169,338,157 - 69,338,350 (+)MAPPERmRatBN7.2
Rnor_6.01172,614,411 - 72,614,603NCBIRnor6.0
Rnor_5.01175,688,750 - 75,688,942UniSTSRnor5.0
RGSC_v3.41171,166,182 - 71,166,374UniSTSRGSC3.4
Celera1168,759,338 - 68,759,530UniSTS
RH 3.4 Map11554.82UniSTS
Cytogenetic Map11q22UniSTS
RH143333  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21169,337,328 - 69,337,511 (+)MAPPERmRatBN7.2
Rnor_6.01172,613,582 - 72,613,764NCBIRnor6.0
Rnor_5.01175,687,921 - 75,688,103UniSTSRnor5.0
RGSC_v3.41171,165,353 - 71,165,535UniSTSRGSC3.4
Celera1168,758,509 - 68,758,691UniSTS
RH 3.4 Map11555.62UniSTS
Cytogenetic Map11q22UniSTS
AI169712  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21169,302,809 - 69,302,989 (+)MAPPERmRatBN7.2
Rnor_6.01172,579,201 - 72,579,380NCBIRnor6.0
Rnor_5.01175,653,540 - 75,653,719UniSTSRnor5.0
RGSC_v3.41171,130,837 - 71,131,016UniSTSRGSC3.4
Celera1168,724,066 - 68,724,245UniSTS
RH 3.4 Map11405.3UniSTS
Cytogenetic Map11q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 27 55 41 12 41 62 24 28
Low 16 2 7 8 9 12 11 13 11 8
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002366   ⟹   ENSRNOP00000002366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1169,302,534 - 69,337,671 (-)Ensembl
Rnor_6.0 Ensembl1172,578,533 - 72,614,176 (-)Ensembl
RefSeq Acc Id: NM_053995   ⟹   NP_446447
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,807,503 - 82,842,636 (-)NCBI
mRatBN7.21169,302,534 - 69,337,671 (-)NCBI
Rnor_6.01172,578,925 - 72,613,924 (-)NCBI
Rnor_5.01175,651,886 - 75,693,764 (-)NCBI
RGSC_v3.41171,130,561 - 71,165,695 (-)RGD
Celera1168,723,790 - 68,758,851 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248478   ⟹   XP_006248540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,806,125 - 82,848,133 (-)NCBI
mRatBN7.21169,302,632 - 69,343,173 (-)NCBI
Rnor_6.01172,577,547 - 72,619,435 (-)NCBI
Rnor_5.01175,651,886 - 75,693,764 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039087910   ⟹   XP_038943838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,806,125 - 82,841,075 (-)NCBI
mRatBN7.21169,302,632 - 69,335,507 (-)NCBI
RefSeq Acc Id: XM_039087911   ⟹   XP_038943839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,806,125 - 82,831,566 (-)NCBI
mRatBN7.21169,302,632 - 69,326,607 (-)NCBI
RefSeq Acc Id: XM_063270245   ⟹   XP_063126315
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,806,125 - 82,848,130 (-)NCBI
RefSeq Acc Id: XM_063270246   ⟹   XP_063126316
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,806,125 - 82,841,282 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_446447   ⟸   NM_053995
- UniProtKB: Q5U2Q2 (UniProtKB/Swiss-Prot),   P29147 (UniProtKB/Swiss-Prot),   A0A0G2JSH2 (UniProtKB/TrEMBL),   A6IRW3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248540   ⟸   XM_006248478
- Peptide Label: isoform X1
- UniProtKB: Q5U2Q2 (UniProtKB/Swiss-Prot),   P29147 (UniProtKB/Swiss-Prot),   A0A0G2JSH2 (UniProtKB/TrEMBL),   A6IRW3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002366   ⟸   ENSRNOT00000002366
RefSeq Acc Id: XP_038943838   ⟸   XM_039087910
- Peptide Label: isoform X1
- UniProtKB: Q5U2Q2 (UniProtKB/Swiss-Prot),   P29147 (UniProtKB/Swiss-Prot),   A0A0G2JSH2 (UniProtKB/TrEMBL),   A6IRW3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943839   ⟸   XM_039087911
- Peptide Label: isoform X1
- UniProtKB: Q5U2Q2 (UniProtKB/Swiss-Prot),   P29147 (UniProtKB/Swiss-Prot),   A0A0G2JSH2 (UniProtKB/TrEMBL),   A6IRW3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126315   ⟸   XM_063270245
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JSH2 (UniProtKB/TrEMBL),   A6IRW3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126316   ⟸   XM_063270246
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JSH2 (UniProtKB/TrEMBL),   A6IRW3 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P29147-F1-model_v2 AlphaFold P29147 1-343 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698222
Promoter ID:EPDNEW_R8745
Type:initiation region
Name:Bdh1_1
Description:3-hydroxybutyrate dehydrogenase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01172,613,936 - 72,613,996EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620131 AgrOrtholog
BioCyc Gene G2FUF-21056 BioCyc
BioCyc Pathway PWY66-367 [ketogenesis] BioCyc
  PWY66-368 [ketolysis] BioCyc
BioCyc Pathway Image PWY66-367 BioCyc
  PWY66-368 BioCyc
Ensembl Genes ENSRNOG00000001736 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002366 ENTREZGENE
  ENSRNOT00000002366.6 UniProtKB/TrEMBL
Gene3D-CATH NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7108483 IMAGE-MGC_LOAD
InterPro NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sc_DH/Rdtase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDR_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:117099 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:94818 IMAGE-MGC_LOAD
NCBI Gene 117099 ENTREZGENE
PANTHER D-BETA-HYDROXYBUTYRATE DEHYDROGENASE, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam adh_short UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bdh1 PhenoGen
PRINTS GDHRDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SDRFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ADH_SHORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001736 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSH2 ENTREZGENE, UniProtKB/TrEMBL
  A6IRW3 ENTREZGENE, UniProtKB/TrEMBL
  A6IRW4_RAT UniProtKB/TrEMBL
  BDH_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5U2Q2 ENTREZGENE
UniProt Secondary Q5U2Q2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-01-03 Bdh1  3-hydroxybutyrate dehydrogenase 1  Bdh1  3-hydroxybutyrate dehydrogenase, type 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Bdh1  3-hydroxybutyrate dehydrogenase, type 1  Bdh  3-hydroxybutyrate dehydrogenase (heart, mitochondrial)  Symbol and Name updated 1299863 APPROVED
2004-02-26 Bdh  3-hydroxybutyrate dehydrogenase (heart, mitochondrial)      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Bdh  3-hydroxybutyrate dehydrogenase (heart, mitochondrial)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_transcript transcripts of 3.2 kb and 1.7 kb are detected 631956