Lrp4 (LDL receptor related protein 4) - Rat Genome Database

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Gene: Lrp4 (LDL receptor related protein 4) Rattus norvegicus
Analyze
Symbol: Lrp4
Name: LDL receptor related protein 4
RGD ID: 619731
Description: Enables apolipoprotein binding activity; receptor tyrosine kinase binding activity; and scaffold protein binding activity. Involved in dendrite morphogenesis and synapse organization. Located in several cellular components, including plasma membrane raft; postsynaptic density; and synaptic membrane. Human ortholog(s) of this gene implicated in Cenani-Lenz syndactyly syndrome; congenital myasthenic syndrome 17; and sclerosteosis 2. Orthologous to human LRP4 (LDL receptor related protein 4); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: low density lipoprotein receptor-related protein 4; low-density lipoprotein receptor-related protein 4; LRP-4; Megf7; multiple epidermal growth factor-like domains 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,885,373 - 97,939,366 (+)NCBIGRCr8
mRatBN7.2377,429,600 - 77,483,593 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,429,798 - 77,483,593 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx380,903,881 - 80,957,484 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,502,902 - 89,556,508 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,354,307 - 87,408,281 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0380,362,643 - 80,416,684 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,362,858 - 80,416,679 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0387,062,818 - 87,116,798 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,821,638 - 75,875,100 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1375,718,009 - 75,771,472 (+)NCBI
Celera376,634,746 - 76,688,537 (+)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
Cuprizon  (EXP)
cyclosporin A  (ISO)
deguelin  (ISO)
diarsenic trioxide  (ISO)
dibenzofurans  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenthion  (ISO)
folic acid  (ISO)
FR900359  (ISO)
genistein  (EXP)
gentamycin  (EXP)
lead diacetate  (ISO)
leflunomide  (ISO)
maneb  (ISO)
metacetamol  (ISO)
methidathion  (ISO)
methylmercury chloride  (EXP)
monosodium L-glutamate  (ISO)
nickel atom  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctanoic acid  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
pyridaben  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. A role for LRP4 in neuronal cell viability is related to apoE-binding. Lu Y, etal., Brain Res. 2007 Oct 26;1177:19-28. Epub 2007 Aug 25.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Interaction of LDL receptor-related protein 4 (LRP4) with postsynaptic scaffold proteins via its C-terminal PDZ domain-binding motif, and its regulation by Ca/calmodulin-dependent protein kinase II. Tian QB, etal., Eur J Neurosci. 2006 Jun;23(11):2864-76.
11. A novel low-density lipoprotein receptor-related protein with type II membrane protein-like structure is abundant in heart. Tomita Y, etal., J Biochem (Tokyo) 1998 Oct;124(4):784-9.
12. The neuromuscular junction: selective remodeling of synaptic regulators at the nerve/muscle interface. Witzemann V, etal., Mech Dev. 2013 Jun-Aug;130(6-8):402-11. doi: 10.1016/j.mod.2012.09.004. Epub 2012 Sep 29.
13. LRP4 serves as a coreceptor of agrin. Zhang B, etal., Neuron. 2008 Oct 23;60(2):285-97. doi: 10.1016/j.neuron.2008.10.006.
14. Structural basis of agrin-LRP4-MuSK signaling. Zong Y, etal., Genes Dev. 2012 Feb 1;26(3):247-58. doi: 10.1101/gad.180885.111.
Additional References at PubMed
PMID:9693030   PMID:15057822   PMID:16207730   PMID:16263759   PMID:16517118   PMID:17119023   PMID:18289866   PMID:18508042   PMID:18848351   PMID:20093106   PMID:20381006   PMID:20383322  
PMID:21471202   PMID:21969364   PMID:22038977   PMID:22854782   PMID:24140340   PMID:30699436  


Genomics

Comparative Map Data
Lrp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,885,373 - 97,939,366 (+)NCBIGRCr8
mRatBN7.2377,429,600 - 77,483,593 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,429,798 - 77,483,593 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx380,903,881 - 80,957,484 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,502,902 - 89,556,508 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,354,307 - 87,408,281 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0380,362,643 - 80,416,684 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,362,858 - 80,416,679 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0387,062,818 - 87,116,798 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,821,638 - 75,875,100 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1375,718,009 - 75,771,472 (+)NCBI
Celera376,634,746 - 76,688,537 (+)NCBICelera
Cytogenetic Map3q24NCBI
LRP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381146,856,717 - 46,918,550 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1146,856,717 - 46,918,642 (-)EnsemblGRCh38hg38GRCh38
GRCh371146,878,268 - 46,940,101 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361146,834,994 - 46,896,652 (-)NCBINCBI36Build 36hg18NCBI36
Build 341146,834,994 - 46,874,397NCBI
Celera1147,024,050 - 47,085,802 (-)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1146,584,196 - 46,645,441 (-)NCBIHuRef
CHM1_11146,876,690 - 46,938,585 (-)NCBICHM1_1
T2T-CHM13v2.01147,013,618 - 47,075,418 (-)NCBIT2T-CHM13v2.0
Lrp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39291,287,794 - 91,344,246 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl291,287,856 - 91,344,124 (+)EnsemblGRCm39 Ensembl
GRCm38291,457,456 - 91,513,901 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,457,511 - 91,513,779 (+)EnsemblGRCm38mm10GRCm38
MGSCv37291,297,688 - 91,354,058 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36291,258,540 - 91,314,618 (+)NCBIMGSCv36mm8
Celera292,845,990 - 92,902,350 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.63NCBI
Lrp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554221,191,338 - 1,238,227 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554221,191,338 - 1,238,227 (+)NCBIChiLan1.0ChiLan1.0
LRP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2949,062,785 - 49,123,346 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11149,082,564 - 49,143,094 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01146,808,090 - 46,868,649 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11147,364,195 - 47,409,143 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,366,321 - 47,411,105 (-)Ensemblpanpan1.1panPan2
LRP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,616,683 - 42,667,297 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1842,616,426 - 42,665,794 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1841,344,660 - 41,396,887 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01843,271,285 - 43,323,513 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1843,271,155 - 43,323,246 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11842,756,909 - 42,808,998 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01842,312,112 - 42,364,153 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01843,041,646 - 43,093,851 (+)NCBIUU_Cfam_GSD_1.0
Lrp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494720,100,527 - 20,153,707 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365622,211,514 - 2,263,937 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365622,211,519 - 2,262,899 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,616,131 - 15,672,874 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,616,137 - 15,672,876 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2216,979,254 - 17,017,635 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1118,393,489 - 18,474,514 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl118,413,513 - 18,471,444 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038115,697,194 - 115,757,957 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247671,708,866 - 1,757,629 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lrp4
173 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:319
Count of miRNA genes:197
Interacting mature miRNAs:255
Transcripts:ENSRNOT00000021353
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36113434889115068Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 28 3 3 3 1 1 74 25 25 11 1
Low 3 15 54 38 19 38 7 10 10 16 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021353   ⟹   ENSRNOP00000021353
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl377,429,798 - 77,483,593 (+)Ensembl
Rnor_6.0 Ensembl380,362,858 - 80,416,679 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086242   ⟹   ENSRNOP00000072367
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl377,441,988 - 77,483,593 (+)Ensembl
Rnor_6.0 Ensembl380,362,865 - 80,412,815 (+)Ensembl
RefSeq Acc Id: NM_031322   ⟹   NP_112612
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,885,571 - 97,939,366 (+)NCBI
mRatBN7.2377,429,798 - 77,483,593 (+)NCBI
Rnor_6.0380,362,858 - 80,416,679 (+)NCBI
Rnor_5.0387,062,818 - 87,116,798 (+)NCBI
RGSC_v3.4375,821,638 - 75,875,100 (+)RGD
Celera376,634,746 - 76,688,537 (+)RGD
Sequence:
RefSeq Acc Id: XM_063284643   ⟹   XP_063140713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,885,373 - 97,919,536 (+)NCBI
RefSeq Acc Id: XR_001837050
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,885,373 - 97,928,289 (+)NCBI
mRatBN7.2377,429,600 - 77,472,516 (+)NCBI
Rnor_6.0380,362,643 - 80,405,543 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_112612   ⟸   NM_031322
- Peptide Label: precursor
- UniProtKB: Q9QYP1 (UniProtKB/Swiss-Prot),   Q76LU2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021353   ⟸   ENSRNOT00000021353
RefSeq Acc Id: ENSRNOP00000072367   ⟸   ENSRNOT00000086242
RefSeq Acc Id: XP_063140713   ⟸   XM_063284643
- Peptide Label: isoform X1
Protein Domains
EGF-like   LDL-receptor class A

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QYP1-F1-model_v2 AlphaFold Q9QYP1 1-1905 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619731 AgrOrtholog
BioCyc Gene G2FUF-48734 BioCyc
Ensembl Genes ENSRNOG00000015285 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055015853 UniProtKB/Swiss-Prot
  ENSRNOG00060009568 UniProtKB/Swiss-Prot
  ENSRNOG00065023316 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021353 ENTREZGENE
  ENSRNOT00000021353.5 UniProtKB/Swiss-Prot
  ENSRNOT00000086242.2 UniProtKB/TrEMBL
  ENSRNOT00055027063 UniProtKB/Swiss-Prot
  ENSRNOT00060016316 UniProtKB/Swiss-Prot
  ENSRNOT00065040022 UniProtKB/Swiss-Prot
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83469 UniProtKB/TrEMBL
NCBI Gene 83469 ENTREZGENE
PANTHER LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MEGALIN, ISOFORM A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam cEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FXa_inhibition UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lrp4 PhenoGen
PRINTS LDLRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLRB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000015285 RatGTEx
  ENSRNOG00055015853 RatGTEx
  ENSRNOG00060009568 RatGTEx
  ENSRNOG00065023316 RatGTEx
SMART EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LDLa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00135 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  YWTD domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K2T4_RAT UniProtKB/TrEMBL
  A6HNC6_RAT UniProtKB/TrEMBL
  A6HNC7_RAT UniProtKB/TrEMBL
  LRP4_RAT UniProtKB/Swiss-Prot
  Q76LU2 ENTREZGENE, UniProtKB/TrEMBL
  Q9QYP1 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-11 Lrp4  LDL receptor related protein 4  Lrp4  low density lipoprotein receptor-related protein 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Lrp4  low density lipoprotein receptor-related protein 4      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Lrp4  low density lipoprotein receptor-related protein 4      Symbol and Name status set to provisional 70820 PROVISIONAL