Tsg101 (tumor susceptibility 101)

Gene: Tsg101 (tumor susceptibility 101) Rattus norvegicus

Analyze

Symbol:

Tsg101

Name:

tumor susceptibility 101

RGD ID:

3909

Description:

Enables nuclear receptor coactivator activity. Involved in endosome to lysosome transport and protein monoubiquitination. Located in endosome membrane. Human ortholog(s) of this gene implicated in breast cancer; breast carcinoma; cervix carcinoma; endometrial adenocarcinoma; and prostate cancer. Orthologous to human TSG101 (tumor susceptibility 101); PARTICIPATES IN autophagy pathway; endocytosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

ESCRT-I complex subunit TSG101; Rw; tumor supressor; Tumor supressor gene; tumor susceptibility gene 101

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TSG101 (tumor susceptibility 101)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Tsg101 (tumor susceptibility gene 101)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tsg101 (tumor susceptibility 101)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TSG101 (tumor susceptibility 101)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TSG101 (tumor susceptibility 101)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	LOC101970059 (uncharacterized LOC101970059)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TSG101 (tumor susceptibility 101)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TSG101 (tumor susceptibility 101)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tsg101 (tumor susceptibility 101)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SCARF1 (scavenger receptor class F member 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	TSG101 (tumor susceptibility 101)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tsg101 (tumor susceptibility gene 101)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tsg101a (tumor susceptibility 101a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tsg101b (tumor susceptibility 101b)	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	TSG101	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	STP22	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	tsg-101	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	106,549,035 - 106,578,859 (-)	NCBI		GRCr8
mRatBN7.2	1	97,412,689 - 97,442,589 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	97,410,848 - 97,442,554 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	102,805,766 - 102,835,099 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	111,277,750 - 111,307,082 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	104,561,098 - 104,590,847 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	102,941,151 - 102,971,017 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	102,941,231 - 102,970,950 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	104,015,969 - 104,044,641 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	97,445,040 - 97,475,141 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	97,523,152 - 97,553,252 (-)	NCBI
Celera	1	91,659,356 - 91,689,173 (-)	NCBI		Celera
Cytogenetic Map	1	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

breast cancer (ISO)

Breast Cancer, Familial (ISO)

breast carcinoma (ISO)

cervix carcinoma (ISO)

endometrial adenocarcinoma (ISO)

genetic disease (ISO)

hypertrophic cardiomyopathy 12 (ISO)

intellectual disability (ISO)

ovarian cancer (ISO)

progressive myoclonus epilepsy 7 (ISO)

prostate cancer (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

1,2-dimethylhydrazine (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

aflatoxin B1 (ISO)

aldosterone (ISO)

antimycin A (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (EXP)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

Brodifacoum (EXP)

cadmium dichloride (EXP)

camptothecin (ISO)

captan (ISO)

carnosic acid (ISO)

ciguatoxin CTX1B (ISO)

deguelin (ISO)

diallyl disulfide (EXP)

dibenz[a,h]anthracene (EXP)

dicrotophos (ISO)

doxorubicin (ISO)

enzyme inhibitor (ISO)

ethanol (ISO)

fenpyroximate (ISO)

fenthion (ISO)

folic acid (ISO)

fulvestrant (ISO)

gentamycin (EXP)

ivermectin (ISO)

lead diacetate (EXP)

lead nitrate (ISO)

lead(0) (EXP,ISO)

lipopolysaccharide (ISO)

methidathion (ISO)

paracetamol (ISO)

picoxystrobin (ISO)

potassium dichromate (ISO)

pyrene (EXP)

quercetin (ISO)

resveratrol (ISO)

rotenone (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium fluoride (ISO)

tebufenpyrad (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (ISO)

triptonide (ISO)

vincristine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (ISO)

cell division (IEA)

endosome to lysosome transport (IBA,IEA,IMP)

exosomal secretion (IEA,ISO)

extracellular transport (IEA,ISO)

keratinocyte differentiation (IEA,ISO)

negative regulation of cell population proliferation (IEA,ISO)

negative regulation of epidermal growth factor receptor signaling pathway (IEA,ISO)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

positive regulation of DNA-templated transcription (IEA)

positive regulation of exosomal secretion (IEA,ISO)

positive regulation of ubiquitin-dependent endocytosis (IEA,ISO)

positive regulation of viral budding via host ESCRT complex (IEA,ISO)

protein modification process (IEA)

protein monoubiquitination (IDA)

protein transport (IEA)

regulation of cell cycle (IEA,ISO)

regulation of cell growth (IEA,ISO)

regulation of extracellular exosome assembly (IEA,ISO)

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (IEA,ISO,ISS)

viral budding (IEA,ISO,ISS)

viral release from host cell (IEA)

Cellular Component

centrosome (IEA)

cytoplasm (ISO,ISS)

cytosol (IEA,ISO)

early endosome (IEA,ISO)

early endosome membrane (IEA)

endosome (IEA,ISO)

endosome membrane (IDA)

ESCRT I complex (IBA,IEA,ISO,ISS)

extracellular exosome (IEA,ISO)

Flemming body (IEA)

late endosome (IEA,ISO)

late endosome membrane (IEA)

nucleolus (IEA,ISO)

nucleus (IEA)

plasma membrane (IEA,ISO)

Molecular Function

calcium-dependent protein binding (IEA,ISO)

nuclear receptor coactivator activity (IDA)

protein binding (ISO)

protein homodimerization activity (IEA,ISO)

protein-containing complex binding (IEA,ISO)

transcription corepressor activity (IEA,ISO)

ubiquitin binding (IBA,IEA,ISO)

ubiquitin protein ligase binding (IEA,ISO)

virion binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

autophagy pathway (ISO)

endocytosis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes.	Bishop N and Woodman P, J Biol Chem. 2001 Apr 13;276(15):11735-42. Epub 2000 Dec 27.
2.	TSG101 interacts with apoptosis-antagonizing transcription factor and enhances androgen receptor-mediated transcription by promoting its monoubiquitination.	Burgdorf S, etal., J Biol Chem 2004 Apr 23;279(17):17524-34. Epub 2004 Feb 2.
3.	Analysis of TSG101 tumour susceptibility gene transcripts in cervical and endometrial cancers.	Chang JG, etal., Br J Cancer. 1999 Feb;79(3-4):445-50.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Significant increase of a specific variant TSG101 transcript during the progression of cervical neoplasia.	Klaes R, etal., Eur J Cancer. 1999 May;35(5):733-7.
6.	Ubiquitylation of the gap junction protein connexin-43 signals its trafficking from early endosomes to lysosomes in a process mediated by Hrs and Tsg101.	Leithe E, etal., J Cell Sci. 2009 Nov 1;122(Pt 21):3883-93. Epub 2009 Oct 6.
7.	The TSG101 tumor susceptibility gene is located in chromosome 11 band p15 and is mutated in human breast cancer.	Li L, etal., Cell. 1997 Jan 10;88(1):143-54.
8.	Aberrant expression of TSG101 in Taiwan Chinese breast cancer.	Lo YF, etal., Breast Cancer Res Treat. 2000 Apr;60(3):259-66.
9.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
10.	Role of TSG101 in uterine cervix cancer.	O'Boyle JD, etal., Gynecol Oncol. 1999 Dec;75(3):401-5.
11.	Tsg101 is upregulated in a subset of invasive human breast cancers and its targeted overexpression in transgenic mice reveals weak oncogenic properties for mammary cancer initiation.	Oh KB, etal., Oncogene. 2007 Aug 30;26(40):5950-9. Epub 2007 Mar 19.
12.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
13.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
14.	GOA pipeline	RGD automated data pipeline
15.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
17.	How do ESCRT proteins control autophagy?	Rusten TE and Stenmark H, J Cell Sci. 2009 Jul 1;122(Pt 13):2179-83.
18.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
19.	Frequent abnormalities of TSG101 transcripts in human prostate cancer.	Sun Z, etal., Oncogene. 1997 Dec 18;15(25):3121-5.
20.	Stress-induced aberrant splicing of TSG101: association to high tumor grade and p53 status in breast cancers.	Turpin E, etal., Oncogene. 1999 Dec 16;18(54):7834-7.
21.	Up-regulation of tumor susceptibility gene 101 conveys poor prognosis through suppression of p21 expression in ovarian cancer.	Young TW, etal., Clin Cancer Res. 2007 Jul 1;13(13):3848-54.

Additional References at PubMed

PMID:1300501	PMID:10888872	PMID:11595185	PMID:11916981	PMID:11943869	PMID:14519844	PMID:14556380	PMID:15126635	PMID:15218037	PMID:15256501	PMID:15326289	PMID:15489334
PMID:15611048	PMID:16501490	PMID:16554368	PMID:16973552	PMID:17229889	PMID:17552904	PMID:17714434	PMID:17940959	PMID:18005716	PMID:18077552	PMID:18643869	PMID:19056867
PMID:19520058	PMID:20654576	PMID:21757351	PMID:22232651	PMID:22315426	PMID:22660413	PMID:23092844	PMID:23376485	PMID:23533145	PMID:24105262	PMID:24205035	PMID:25392495
PMID:30782301

Genomics

Comparative Map Data

Tsg101
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	106,549,035 - 106,578,859 (-)	NCBI		GRCr8
mRatBN7.2	1	97,412,689 - 97,442,589 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	97,410,848 - 97,442,554 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	102,805,766 - 102,835,099 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	111,277,750 - 111,307,082 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	104,561,098 - 104,590,847 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	102,941,151 - 102,971,017 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	102,941,231 - 102,970,950 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	104,015,969 - 104,044,641 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	97,445,040 - 97,475,141 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	97,523,152 - 97,553,252 (-)	NCBI
Celera	1	91,659,356 - 91,689,173 (-)	NCBI		Celera
Cytogenetic Map	1	q22	NCBI

TSG101
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	18,480,311 - 18,526,942 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	18,468,336 - 18,526,951 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	18,501,858 - 18,548,489 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	18,458,434 - 18,505,065 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	18,458,435 - 18,505,065	NCBI
Celera	11	18,637,463 - 18,684,120 (-)	NCBI		Celera
Cytogenetic Map	11	p15.1	NCBI
HuRef	11	18,187,557 - 18,234,372 (-)	NCBI		HuRef
CHM1_1	11	18,501,223 - 18,547,842 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	18,578,331 - 18,624,993 (-)	NCBI		T2T-CHM13v2.0

Tsg101
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	46,538,693 - 46,569,716 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	46,538,697 - 46,569,717 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	46,888,949 - 46,926,320 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	46,888,949 - 46,919,969 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	54,144,397 - 54,175,300 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	46,757,396 - 46,787,915 (-)	NCBI		MGSCv36	mm8
Celera	7	42,369,255 - 42,400,171 (-)	NCBI		Celera
Cytogenetic Map	7	B3	NCBI
cM Map	7	30.62	NCBI

Tsg101
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955414	33,154,812 - 33,193,769 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955414	33,154,812 - 33,193,769 (-)	NCBI	ChiLan1.0	ChiLan1.0

TSG101
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	20,797,111 - 20,843,855 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	20,757,432 - 20,804,234 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	18,518,110 - 18,564,814 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	18,201,381 - 18,248,149 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	18,189,868 - 18,248,149 (-)	Ensembl	panpan1.1		panPan2

TSG101
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	40,910,870 - 40,952,922 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	40,910,874 - 40,952,808 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	40,390,143 - 40,432,212 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	42,032,656 - 42,074,737 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	42,032,614 - 42,074,722 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	41,026,209 - 41,068,217 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	41,213,135 - 41,255,211 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	41,590,866 - 41,632,952 (-)	NCBI		UU_Cfam_GSD_1.0

LOC101970059
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	44,718,596 - 44,726,328 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936528	752,694 - 808,888 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936528	752,572 - 809,127 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TSG101
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	2	40,673,187 - 40,720,681 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	43,759,512 - 43,783,691 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TSG101
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	46,401,889 - 46,451,122 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	46,402,024 - 46,450,916 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	143,746,335 - 143,804,463 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tsg101
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624766	9,934,228 - 9,977,697 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624766	9,932,190 - 9,977,725 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tsg101
145 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	53
Count of miRNA genes:	49
Interacting mature miRNAs:	52
Transcripts:	ENSRNOT00000018194
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631688	Hcas2	Hepatocarcinoma susceptibility QTL 2	3	0.0001	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	5925874	115540829	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	22340647	102268831	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	30882023	123479925	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32356093	162846471	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32737458	199368955	Rat
2313051	Bss57	Bone structure and strength QTL 57	3.7	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	43284731	118944897	Rat
2313059	Bss55	Bone structure and strength QTL 55	3.2	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	1	43284731	118944897	Rat
2313072	Bss53	Bone structure and strength QTL 53	4.3	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	43284731	118944897	Rat
2313078	Bss54	Bone structure and strength QTL 54	3.5	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	1	43284731	118944897	Rat
2313094	Bss58	Bone structure and strength QTL 58	3.7	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	43284731	118944897	Rat
2313098	Bmd70	Bone mineral density QTL 70	3.6	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	43284731	118944897	Rat
2313099	Bss56	Bone structure and strength QTL 56	2.4	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	1	43284731	118944897	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	48963584	144267916	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	49393172	159356837	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49393289	199050459	Rat
61342	Bp27	Blood pressure QTL 27	3.4	0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	56732668	98773277	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	1	56949932	101949932	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	57336763	151090257	Rat
1300121	Hrtrt1	Heart rate QTL 1	3.7		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	65789093	115540829	Rat
7421628	Bp361	Blood pressure QTL 361		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	66023617	118608521	Rat
1358192	Ept13	Estrogen-induced pituitary tumorigenesis QTL 13	3.4		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	1	77494165	122494165	Rat
10054135	Gmadr2	Adrenal mass QTL 2	1.97	0.0129	adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	77857876	122857876	Rat
1549903	Bp267	Blood pressure QTL 267			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	77876254	106047988	Rat
61344	Bp29	Blood pressure QTL 29	7.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	78350581	123350581	Rat
7411712	Strs4	Sensitivity to stroke QTL 4	8.7		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	1	78430536	123430536	Rat
1582234	Gluco18	Glucose level QTL 18	3.4	0.0003	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	78479925	123479925	Rat
4889494	Scort2	Serum corticosterone level QTL 2	4.2		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	1	80592172	125592172	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	81591954	219808434	Rat
2313083	Bmd74	Bone mineral density QTL 74	4	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	82174743	118944897	Rat
738022	Anxrr13	Anxiety related response QTL 13	4.6	0.00039	locomotor behavior trait (VT:0001392)	number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)	1	83547917	128547917	Rat
2300324	Fetw1	Fetal weight QTL 1	12.1	0.005	fetal growth trait (VT:0004201)	fetal body weight (CMO:0002080)	1	85424647	100358001	Rat
724529	Cm16	Cardiac mass QTL 16	2.7		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	1	87580395	150700247	Rat
724521	Uae1	Urinary albumin excretion QTL 1	3.8	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	90508614	173018436	Rat
1358902	Bw47	Body weight QTL 47	1.67		body mass (VT:0001259)	body weight (CMO:0000012)	1	90508614	180359386	Rat
1302788	Scl19	Serum cholesterol QTL 19	4.6	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	90532338	123479925	Rat
1300153	Bp171	Blood pressure QTL 171	3.37		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	90664883	143200202	Rat
2293142	Bp314	Blood pressure QTL 314			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	92184926	137184926	Rat
724567	Tcas6	Tongue tumor susceptibility QTL 6	6.85		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	1	92948896	144267916	Rat
1331800	Scl25	Serum cholesterol level QTL 25	3.013		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	94494440	117601394	Rat
1331793	Bp200	Blood pressure QTL 200	3.71601		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94494440	172949803	Rat
1331751	Bp199	Blood pressure QTL 199	3.60022		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	94494440	181830018	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	94494440	198211706	Rat
70209	Niddm23	Non-insulin dependent diabetes mellitus QTL 23	2.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	94494440	198324465	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94642644	214537671	Rat

Markers in Region

D1Rat267

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	97,437,006 - 97,437,180 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	102,965,445 - 102,965,617	NCBI	Rnor6.0
Rnor_5.0	1	104,039,136 - 104,039,308	UniSTS	Rnor5.0
RGSC_v3.4	1	97,469,635 - 97,469,808	RGD	RGSC3.4
RGSC_v3.4	1	97,469,636 - 97,469,808	UniSTS	RGSC3.4
RGSC_v3.1	1	97,547,746 - 97,547,919	RGD
Celera	1	91,683,670 - 91,683,840	UniSTS
SHRSP x BN Map	1	49.61	RGD
SHRSP x BN Map	1	49.61	UniSTS
Cytogenetic Map	1	q22	UniSTS

RH130601

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	97,415,035 - 97,415,219 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	102,943,496 - 102,943,679	NCBI	Rnor6.0
Rnor_5.0	1	104,018,236 - 104,018,419	UniSTS	Rnor5.0
RGSC_v3.4	1	97,447,307 - 97,447,490	UniSTS	RGSC3.4
Celera	1	91,661,623 - 91,661,806	UniSTS
RH 3.4 Map	1	909.1	UniSTS
Cytogenetic Map	1	q22	UniSTS

AU047244

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	97,415,866 - 97,416,052 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	102,944,326 - 102,944,511	NCBI	Rnor6.0
Rnor_5.0	1	104,019,066 - 104,019,251	UniSTS	Rnor5.0
RGSC_v3.4	1	97,448,137 - 97,448,322	UniSTS	RGSC3.4
Celera	1	91,662,453 - 91,662,638	UniSTS
Cytogenetic Map	1	q22	UniSTS

AW140530

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	97,421,881 - 97,422,037 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	102,950,340 - 102,950,495	NCBI	Rnor6.0
Rnor_5.0	1	104,025,080 - 104,025,235	UniSTS	Rnor5.0
RGSC_v3.4	1	97,454,151 - 97,454,306	UniSTS	RGSC3.4
Celera	1	91,668,467 - 91,668,622	UniSTS
RH 3.4 Map	1	909.1	UniSTS
Cytogenetic Map	1	q22	UniSTS

BI276330

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	97,412,802 - 97,412,956 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	102,941,263 - 102,941,416	NCBI	Rnor6.0
Rnor_5.0	1	104,016,003 - 104,016,156	UniSTS	Rnor5.0
RGSC_v3.4	1	97,445,074 - 97,445,227	UniSTS	RGSC3.4
Celera	1	91,659,390 - 91,659,543	UniSTS
RH 3.4 Map	1	908.29	UniSTS
Cytogenetic Map	1	q22	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_181628	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008759341	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105117	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105126	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284274	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284275	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC099150	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY293306	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC070951	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ231102	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000018194 ⟹ ENSRNOP00000018194

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	97,412,765 - 97,442,508 (-)	Ensembl
Rnor_6.0 Ensembl	1	102,941,231 - 102,970,950 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000097244 ⟹ ENSRNOP00000080249

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	97,412,794 - 97,442,554 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000112656 ⟹ ENSRNOP00000080071

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	97,410,848 - 97,442,502 (-)	Ensembl

RefSeq Acc Id:

NM_181628 ⟹ NP_853659

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	106,549,035 - 106,578,775 (-)	NCBI
mRatBN7.2	1	97,412,769 - 97,442,513 (-)	NCBI
Rnor_6.0	1	102,941,229 - 102,970,950 (-)	NCBI
Rnor_5.0	1	104,015,969 - 104,044,641 (-)	NCBI
RGSC_v3.4	1	97,445,040 - 97,475,141 (-)	RGD
Celera	1	91,659,356 - 91,689,173 (-)	RGD

Sequence:

show sequence

GTGGCGCCTACCCTCTGCCTGTGGGGACGGAGGAGTGCGCCATGGCGGTGTCCGAGAGTCAGCT
GAAGAAGATGATGTCCAAGTACAAATACAGAGATCTAACCGTCCGTCAAACTGTCAATGTCATC
GCTATGTACAAAGATCTCAAACCTGTATTGGATTCGTATGTTTTTAATGATGGCAGTTCCAGGG
AGCTGGTGAACCTCACTGGGACAATCCCTGTGCGCTATCGAGGTAATATATATAACATTCCAAT
ATGCCTGTGGCTCCTGGACACATACCCATATAACCCCCCTATCTGTTTTGTTAAGCCTACTAGT
TCAATGACTATTAAAACAGGAAAGCATGTGGATGCAAATGGGAAAATCTACCTGCCTTACCTAC
ATGACTGGAAACACCCACGGTCAGAGTTGCTGGAACTTATTCAGATCATGATTGTGATATTTGG
CGAGGAGCCTCCAGTGTTCTCCCGACCTACCGTTTCTGCATCCTACCCACCGTACACAGCAGCA
GGGCCACCAAACACCTCCTACTTGCCAAGCATGCCAAGTGGAATCTCTGCATATCCATCTGGAT
ACCCTCCCAACCCCAGTGGTTATCCTGGCTGTCCTTACCCACCTGCTGGCCCATACCCTGCCAC
AACAAGCTCACAGTACCCTTCCCAGCCTCCTGTGACCACTGCTGGTCCCAGCAGAGATGGCACA
ATCAGCGAGGACACTATTCGAGCATCTCTCATCTCAGCAGTCAGTGACAAACTGAGATGGCGGA
TGAAGGAGGAAATGGATGGTGCCCAGGCAGAGCTTAATGCCTTGAAACGGACAGAGGAAGATCT
AAAAAAAGGCCACCAGAAACTGGAAGAGATGGTCACCCGCTTAGATCAGGAAGTAGCTGAAGTT
GATAAAAACATAGAACTATTGAAAAAGAAGGATGAAGAACTAAGTTCTGCTCTGGAGAAAATGG
AAAATCAATCTGAAAATAATGATATTGATGAAGTTATCATTCCCACAGCCCCATTGTATAAACA
GATTCTAAATCTGTATGCAGAGGAAAATGCTATTGAAGACACTATCTTTTACCTTGGAGAAGCC
TTGAGGCGGGGAGTAATAGACCTGGATGTGTTCCTGAAGCACGTCCGCCTCCTGTCCCGTAAAC
AGTTCCAGCTAAGGGCACTAATGCAAAAAGCAAGAAAGACTGCGGGCCTTAGTGACCTCTACTG
ACGTGTGCTATCAGCTGGAGACCGGCCTCTTCGTAAAGCATTCTTTTCTTCTCTTTCTTTTTCT
CATCAGTAGGAAGAACCCAGAATAAGTTATTGCAGTTTATCATTTGAGTGTTAAATATTTTGAA
TTGATAATATATTTTCTGTTTCCTTTGGGTAAAGACTGGCTTTTATTAATGCACTTTCTACCCT
CTGTAAGCTTCTGTGCTGTGCTGGGACTGACTGGGCTAAATAAAATTTGTTGCATAAAAAAAAA
AAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_008759341 ⟹ XP_008757563

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	106,549,035 - 106,578,851 (-)	NCBI
mRatBN7.2	1	97,412,691 - 97,442,589 (-)	NCBI
Rnor_6.0	1	102,941,151 - 102,971,017 (-)	NCBI

Sequence:

show sequence

GCGCCGGCTTCCTGCTTGGCAGGGGCGGGGCGGCGGCGGCGATTGTCTGGCGGCCTGGGGCGGC
CCCGTGGCGCCTACCCTCTGCCTGTGGGGACGGAGGAGTGCGCCATGGCGGTGTCCGAGAGTCA
GCTGAAGAAGATGATGTCCAAGTACAAATACAGAGATCTAACCGTCCGTCAAACTGTCAATGTC
ATCGCTATGTACAAAGATCTCAAACCTGTATTGGATTCGTATGTTTTTAATGATGGCAGTTCCA
GGGAGCTGGTGAACCTCACTGGGACAATCCCTGTGCGCTATCGAGGTAATATATATAACATTCC
AATATGCCTGTGGCTCCTGGACACATACCCATATAACCCCCCTATCTGTTTTGTTAAGCCTACT
AGTTCAATGACTATTAAAACAGGAAAGCATGTGGATGCAAATGGGAAAATCTACCTGCCTTACC
TACATGACTGGAAACACCCACGGTCAGAGTTGCTGGAACTTATTCAGATCATGATTGTGATATT
TGGCGAGGAGCCTCCAGTGTTCTCCCGACCTACCGTTTCTGCATCCTACCCACCGTACACAGCA
GCAGGGCCACCAAACAGTCCCAGCAGAGATGGCACAATCAGCGAGGACACTATTCGAGCATCTC
TCATCTCAGCAGTCAGTGACAAACTGAGATGGCGGATGAAGGAGGAAATGGATGGTGCCCAGGC
AGAGCTTAATGCCTTGAAACGGACAGAGGAAGATCTAAAAAAAGGCCACCAGAAACTGGAAGAG
ATGGTCACCCGCTTAGATCAGGAAGTAGCTGAAGTTGATAAAAACATAGAACTATTGAAAAAGA
AGGATGAAGAACTAAGTTCTGCTCTGGAGAAAATGGAAAATCAATCTGAAAATAATGATATTGA
TGAAGTTATCATTCCCACAGCCCCATTGTATAAACAGATTCTAAATCTGTATGCAGAGGAAAAT
GCTATTGAAGACACTATCTTTTACCTTGGAGAAGCCTTGAGGCGGGGAGTAATAGACCTGGATG
TGTTCCTGAAGCACGTCCGCCTCCTGTCCCGTAAACAGTTCCAGCTAAGGGCACTAATGCAAAA
AGCAAGAAAGACTGCGGGCCTTAGTGACCTCTACTGACGTGTGCTATCAGCTGGAGACCGGCCT
CTTCGTAAAGCATTCTTTTCTTCTCTTTCTTTTTCTCATCAGTAGGAAGAACCCAGAATAAGTT
ATTGCAGTTTATCATTTGAGTGTTAAATATTTTGAATTGATAATATATTTTCTGTTTCCTTTGG
GTAAAGACTGGCTTTTATTAATGCACTTTCTACCCTCTGTAAGCTTCTGTGCTGTGCTGGGACT
GACTGGGCTAAATAAAATTTGTTGCATAATTTTTCTCTTTCTTGGACTTGAGGAAAGATGCACA
AAAGAGCCCTGGATTCTCATTAATAAACAAGGCACAATGTTCA

hide sequence

RefSeq Acc Id:

XM_039105117 ⟹ XP_038961045

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	106,549,035 - 106,571,633 (-)	NCBI
mRatBN7.2	1	97,412,689 - 97,442,568 (-)	NCBI

RefSeq Acc Id:

XM_039105126 ⟹ XP_038961054

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	106,549,035 - 106,569,252 (-)	NCBI
mRatBN7.2	1	97,412,691 - 97,442,568 (-)	NCBI

RefSeq Acc Id:

XM_063284274 ⟹ XP_063140344

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	106,549,035 - 106,578,859 (-)	NCBI

RefSeq Acc Id:

XM_063284275 ⟹ XP_063140345

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	106,549,035 - 106,567,536 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_853659	(Get FASTA)	NCBI Sequence Viewer
	XP_008757563	(Get FASTA)	NCBI Sequence Viewer
	XP_038961045	(Get FASTA)	NCBI Sequence Viewer
	XP_038961054	(Get FASTA)	NCBI Sequence Viewer
	XP_063140344	(Get FASTA)	NCBI Sequence Viewer
	XP_063140345	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH70951	(Get FASTA)	NCBI Sequence Viewer
	AAP45008	(Get FASTA)	NCBI Sequence Viewer
	EDM07247	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000018194.7
	ENSRNOP00000080071
	ENSRNOP00000080071.1
	ENSRNOP00000080249.1
GenBank Protein	Q6IRE4	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_853659 ⟸ NM_181628

- UniProtKB:

Q7TSE5 (UniProtKB/Swiss-Prot), Q6IRE4 (UniProtKB/Swiss-Prot), A0A8I5ZSM6 (UniProtKB/TrEMBL), A6JBD7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAVSESQLKKMMSKYKYRDLTVRQTVNVIAMYKDLKPVLDSYVFNDGSSRELVNLTGTIPVRYR
GNIYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHDWKHPRSELLELI
QIMIVIFGEEPPVFSRPTVSASYPPYTAAGPPNTSYLPSMPSGISAYPSGYPPNPSGYPGCPYP
PAGPYPATTSSQYPSQPPVTTAGPSRDGTISEDTIRASLISAVSDKLRWRMKEEMDGAQAELNA
LKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSSALEKMENQSENNDIDEVII
PTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARKT
AGLSDLY

hide sequence

RefSeq Acc Id:	XP_008757563 ⟸ XM_008759341
- Peptide Label:	isoform X2
- UniProtKB:	A0A8L2Q9C5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAVSESQLKKMMSKYKYRDLTVRQTVNVIAMYKDLKPVLDSYVFNDGSSRELVNLTGTIPVRYR GNIYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHDWKHPRSELLELI QIMIVIFGEEPPVFSRPTVSASYPPYTAAGPPNSPSRDGTISEDTIRASLISAVSDKLRWRMKE EMDGAQAELNALKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSSALEKMENQ SENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQ LRALMQKARKTAGLSDLY hide sequence

RefSeq Acc Id:

ENSRNOP00000018194 ⟸ ENSRNOT00000018194

RefSeq Acc Id:	XP_038961045 ⟸ XM_039105117
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I5ZSM6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038961054 ⟸ XM_039105126
- Peptide Label:	isoform X4

RefSeq Acc Id:

ENSRNOP00000080249 ⟸ ENSRNOT00000097244

RefSeq Acc Id:

ENSRNOP00000080071 ⟸ ENSRNOT00000112656

RefSeq Acc Id:	XP_063140344 ⟸ XM_063284274
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063140345 ⟸ XM_063284275
- Peptide Label:	isoform X3

Protein Domains

SB UEV

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6IRE4-F1-model_v2	AlphaFold	Q6IRE4	1-391	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690070

Promoter ID:

EPDNEW_R595

Type:

initiation region

Name:

Tsg101_1

Description:

tumor susceptibility 101

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	102,970,983 - 102,971,043	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3909	AgrOrtholog
BioCyc Gene	G2FUF-59602	BioCyc
Ensembl Genes	ENSRNOG00000013381	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000018194.7	UniProtKB/TrEMBL
	ENSRNOT00000097244.1	UniProtKB/TrEMBL
	ENSRNOT00000112656	ENTREZGENE
	ENSRNOT00000112656.1	UniProtKB/Swiss-Prot
Gene3D-CATH	3.10.110.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	6.10.140.820	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	6.10.250.370	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7100763	IMAGE-MGC_LOAD
InterPro	ESCRT_assembly_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SB_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UBQ-conjugating_enzyme/RWD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UEV_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:292925	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:91392	IMAGE-MGC_LOAD
NCBI Gene	Tsg101	ENTREZGENE
PANTHER	TUMOR SUSCEPTIBILITY GENE 101 PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	UEV	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Vps23_core	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Tsg101	PhenoGen
PROSITE	PS51312	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UEV	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000013381	RatGTEx
SMART	UBCc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF140111	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF54495	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5ZSM6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2Q9C5	ENTREZGENE, UniProtKB/TrEMBL
	A6JBD7	ENTREZGENE, UniProtKB/TrEMBL
	Q6IRE4	ENTREZGENE
	Q7TSE5	ENTREZGENE
	TS101_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	Q7TSE5	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-09-17	Tsg101	tumor susceptibility 101	Tsg101	tumor susceptibility gene 101	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Tsg101	Tumor supressor gene			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_physical_interaction	binds apoptosis-antagonizing transcription factor (AATF)	1300501

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)