Syn2 (synapsin II) - Rat Genome Database

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Gene: Syn2 (synapsin II) Rattus norvegicus
Analyze
Symbol: Syn2
Name: synapsin II
RGD ID: 3798
Description: Enables calcium-dependent protein binding activity. Predicted to be involved in calcium-ion regulated exocytosis; neurotransmitter secretion; and synaptic vesicle clustering. Located in synaptic vesicle. Is extrinsic component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human SYN2 (synapsin II); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: synapsin 2; synapsin-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84149,858,919 - 150,016,845 (+)NCBIGRCr8
mRatBN7.24148,178,846 - 148,347,010 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4148,186,270 - 148,344,192 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4154,411,352 - 154,569,498 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04150,194,433 - 150,352,589 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04148,818,234 - 148,976,405 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04147,037,179 - 147,195,096 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4147,037,179 - 147,195,096 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04210,326,340 - 210,483,842 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44151,255,241 - 151,413,220 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14151,500,081 - 151,650,682 (+)NCBI
Celera4137,080,501 - 137,237,898 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
ammonium chloride  (EXP)
ATP  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
capsaicin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
clozapine  (EXP,ISO)
cocaine  (ISO)
copper(II) chloride  (ISO)
curcumin  (ISO)
decabromodiphenyl ether  (EXP)
dopamine  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
gamma-aminobutyric acid  (ISO)
gamma-tocopherol  (ISO)
genistein  (ISO)
haloperidol  (EXP)
isoprenaline  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (ISO)
nitroglycerin  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
permethrin  (ISO)
phencyclidine  (ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
propanal  (ISO)
prostaglandin F2alpha  (EXP)
Ptaquiloside  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tacrine  (EXP)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
tocopherol  (ISO)
trichloroethene  (EXP)
trichostatin A  (EXP)
trimellitic anhydride  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses. Boyken J, etal., Neuron. 2013 Apr 24;78(2):285-97. doi: 10.1016/j.neuron.2013.02.027.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Synapsin IIb interacts with the C-terminal SH2 and SH3 domains of PLCgamma1 and inhibits its enzymatic activity. Han SJ, etal., Cell Biol Int. 2004;28(12):943-8.
5. Synapsins as major neuronal Ca2+/S100A1-interacting proteins. Heierhorst J, etal., Biochem J. 1999 Dec 1;344 Pt 2:577-83.
6. Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON. Jaffrey SR, etal., Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3199-204. Epub 2002 Feb 26.
7. A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini. Lam PP, etal., Mol Biol Cell. 2007 Jul;18(7):2473-80. Epub 2007 Apr 18.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Synapsins: mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteins. Sudhof TC, etal., Science 1989 Sep 29;245(4925):1474-80.
13. Synapsin II. Mapping of a domain in the NH2-terminal region which binds to small synaptic vesicles. Thiel G, etal., J Biol Chem. 1990 Sep 25;265(27):16527-33.
14. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
Additional References at PubMed
PMID:7777057   PMID:9593663   PMID:10358015   PMID:15071120   PMID:16413126   PMID:17114649   PMID:17634366   PMID:18535671   PMID:18945891   PMID:19292454   PMID:19609639   PMID:20338242  
PMID:22871113   PMID:25429150   PMID:28755400   PMID:29476059   PMID:32357304  


Genomics

Comparative Map Data
Syn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84149,858,919 - 150,016,845 (+)NCBIGRCr8
mRatBN7.24148,178,846 - 148,347,010 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4148,186,270 - 148,344,192 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4154,411,352 - 154,569,498 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04150,194,433 - 150,352,589 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04148,818,234 - 148,976,405 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04147,037,179 - 147,195,096 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4147,037,179 - 147,195,096 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04210,326,340 - 210,483,842 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44151,255,241 - 151,413,220 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14151,500,081 - 151,650,682 (+)NCBI
Celera4137,080,501 - 137,237,898 (+)NCBICelera
Cytogenetic Map4q42NCBI
SYN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38312,004,388 - 12,192,032 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl312,004,388 - 12,192,032 (+)EnsemblGRCh38hg38GRCh38
GRCh37312,045,862 - 12,233,532 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36312,020,862 - 12,208,532 (+)NCBINCBI36Build 36hg18NCBI36
Build 34312,020,864 - 12,207,885NCBI
Celera311,982,988 - 12,170,949 (+)NCBICelera
Cytogenetic Map3p25.2NCBI
HuRef311,979,136 - 12,167,274 (+)NCBIHuRef
CHM1_1311,995,629 - 12,183,794 (+)NCBICHM1_1
T2T-CHM13v2.0312,002,345 - 12,190,266 (+)NCBIT2T-CHM13v2.0
Syn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396115,111,863 - 115,259,587 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6115,111,863 - 115,258,967 (+)EnsemblGRCm39 Ensembl
GRCm386115,134,902 - 115,282,626 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6115,134,902 - 115,282,006 (+)EnsemblGRCm38mm10GRCm38
MGSCv376115,084,920 - 115,232,644 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366115,916,516 - 116,057,028 (+)NCBIMGSCv36mm8
MGSCv366115,100,521 - 115,240,707 (+)NCBIMGSCv36mm8
Celera6116,972,908 - 117,121,654 (+)NCBICelera
Cytogenetic Map6E3NCBI
cM Map653.2NCBI
Syn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542914,676,286 - 14,724,625 (+)NCBIChiLan1.0ChiLan1.0
SYN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2211,996,087 - 12,180,017 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1312,000,852 - 12,184,778 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0311,935,680 - 12,118,981 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1312,275,084 - 12,465,806 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl312,282,573 - 12,464,413 (+)Ensemblpanpan1.1panPan2
SYN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1206,368,348 - 6,569,355 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl206,369,122 - 6,568,508 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha206,404,468 - 6,604,803 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0206,397,481 - 6,598,475 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl206,397,505 - 6,598,637 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1206,115,658 - 6,316,632 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0206,466,601 - 6,671,741 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0206,442,191 - 6,642,971 (-)NCBIUU_Cfam_GSD_1.0
Syn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494217,360,718 - 17,449,110 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366021,461,338 - 1,507,272 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366021,460,602 - 1,506,509 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SYN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1368,050,535 - 68,221,496 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11368,050,015 - 68,221,504 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21375,262,707 - 75,435,410 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SYN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12247,994,593 - 48,171,291 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2248,092,452 - 48,171,492 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041118,328,888 - 118,521,429 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Syn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624956303,011 - 349,857 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624956302,239 - 467,319 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Syn2
481 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:145
Count of miRNA genes:101
Interacting mature miRNAs:122
Transcripts:ENSRNOT00000011292
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4124303370169303370Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4126395976167139601Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131730738167139601Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132642577167139601Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4147278504167139601Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4148090542168069246Rat

Markers in Region
D4Got124  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24148,190,092 - 148,190,377 (+)MAPPERmRatBN7.2
Rnor_6.04147,041,002 - 147,041,286NCBIRnor6.0
Rnor_5.04210,330,163 - 210,330,447UniSTSRnor5.0
RGSC_v3.44151,259,063 - 151,259,348RGDRGSC3.4
RGSC_v3.44151,259,064 - 151,259,348UniSTSRGSC3.4
RGSC_v3.14151,503,905 - 151,504,189RGD
Celera4137,084,324 - 137,084,624UniSTS
RH 3.4 Map4950.41UniSTS
RH 3.4 Map4950.41RGD
RH 2.0 Map4937.5RGD
Cytogenetic Map4q42UniSTS
AI841723  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24148,343,960 - 148,344,105 (+)MAPPERmRatBN7.2
Rnor_6.04147,194,865 - 147,195,009NCBIRnor6.0
Rnor_5.04210,483,611 - 210,483,755UniSTSRnor5.0
RGSC_v3.44151,412,989 - 151,413,133UniSTSRGSC3.4
Celera4137,237,667 - 137,237,811UniSTS
Cytogenetic Map4q42UniSTS
RH143121  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24148,324,575 - 148,324,813 (+)MAPPERmRatBN7.2
Rnor_6.04147,175,480 - 147,175,717NCBIRnor6.0
Rnor_5.04210,464,226 - 210,464,463UniSTSRnor5.0
RGSC_v3.44151,393,604 - 151,393,841UniSTSRGSC3.4
Celera4137,218,282 - 137,218,519UniSTS
RH 3.4 Map4952.1UniSTS
Cytogenetic Map4q42UniSTS
BI295795  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24148,337,050 - 148,337,251 (+)MAPPERmRatBN7.2
Rnor_6.04147,187,955 - 147,188,155NCBIRnor6.0
Rnor_5.04210,476,701 - 210,476,901UniSTSRnor5.0
RGSC_v3.44151,406,079 - 151,406,279UniSTSRGSC3.4
Celera4137,230,757 - 137,230,957UniSTS
RH 3.4 Map4950.71UniSTS
Cytogenetic Map4q42UniSTS
AF096867  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24148,336,768 - 148,336,876 (+)MAPPERmRatBN7.2
Rnor_6.04147,187,673 - 147,187,780NCBIRnor6.0
Rnor_5.04210,476,419 - 210,476,526UniSTSRnor5.0
RGSC_v3.44151,405,797 - 151,405,904UniSTSRGSC3.4
Celera4137,230,475 - 137,230,582UniSTS
Cytogenetic Map4q42UniSTS
RH132165  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24148,302,616 - 148,302,801 (+)MAPPERmRatBN7.2
Rnor_6.04147,153,526 - 147,153,710NCBIRnor6.0
Rnor_5.04210,442,272 - 210,442,456UniSTSRnor5.0
RGSC_v3.44151,371,650 - 151,371,834UniSTSRGSC3.4
Celera4137,196,429 - 137,196,613UniSTS
RH 3.4 Map4951.9UniSTS
Cytogenetic Map4q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 56 1
Low 3 39 7 2 4 6 12 22 35 6 4
Below cutoff 4 24 18 15 18 4 5 6 13 5 4 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000011292   ⟹   ENSRNOP00000011292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4148,186,270 - 148,344,192 (+)Ensembl
Rnor_6.0 Ensembl4147,037,179 - 147,195,096 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106627   ⟹   ENSRNOP00000084691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4148,186,394 - 148,344,192 (+)Ensembl
RefSeq Acc Id: NM_001034020   ⟹   NP_001029192
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84149,858,919 - 150,016,845 (+)NCBI
mRatBN7.24148,186,270 - 148,344,204 (+)NCBI
Rnor_6.04147,037,179 - 147,195,096 (+)NCBI
Rnor_5.04210,326,340 - 210,483,842 (+)NCBI
RGSC_v3.44151,255,241 - 151,413,220 (+)RGD
Celera4137,080,501 - 137,237,898 (+)RGD
Sequence:
RefSeq Acc Id: NM_019159   ⟹   NP_062032
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84149,858,919 - 150,009,454 (+)NCBI
mRatBN7.24148,186,270 - 148,336,813 (+)NCBI
Rnor_6.04147,037,179 - 147,187,717 (+)NCBI
Rnor_5.04210,326,340 - 210,483,842 (+)NCBI
RGSC_v3.44151,255,241 - 151,413,220 (+)RGD
Celera4137,080,501 - 137,230,519 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001029192   ⟸   NM_001034020
- Peptide Label: isoform 1
- UniProtKB: Q9Z1H0 (UniProtKB/Swiss-Prot),   Q63537 (UniProtKB/Swiss-Prot),   G3V733 (UniProtKB/TrEMBL),   A6IKX9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_062032   ⟸   NM_019159
- Peptide Label: isoform 2
- UniProtKB: A6IKY0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000011292   ⟸   ENSRNOT00000011292
RefSeq Acc Id: ENSRNOP00000084691   ⟸   ENSRNOT00000106627
Protein Domains
Synapsin ATP-binding   Synapsin pre-ATP-grasp

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63537-F1-model_v2 AlphaFold Q63537 1-586 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693319
Promoter ID:EPDNEW_R3843
Type:initiation region
Name:Syn2_1
Description:synapsin II
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04147,037,185 - 147,037,245EPDNEW
RGD ID:13693327
Promoter ID:EPDNEW_R3844
Type:single initiation site
Name:AC128901_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04147,122,082 - 147,122,142EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3798 AgrOrtholog
BioCyc Gene G2FUF-43328 BioCyc
Ensembl Genes ENSRNOG00000008157 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011292 ENTREZGENE
  ENSRNOT00000011292.3 UniProtKB/TrEMBL
  ENSRNOT00000106627.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1490.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-grasp fold, B domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ATP_grasp_subdomain_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PreATP-grasp_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Synapsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Synapsin_ATP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Synapsin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Synapsin_P_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Synapsin_pre-ATP-grasp_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29179 UniProtKB/Swiss-Prot
NCBI Gene 29179 ENTREZGENE
PANTHER PTHR10841:SF20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SYNAPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Synapsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Synapsin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Synapsin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Syn2 PhenoGen
PRINTS SYNAPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SYNAPSIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SYNAPSIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008157 RatGTEx
Superfamily-SCOP Glutathione synthetase ATP-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52440 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZYM8_RAT UniProtKB/TrEMBL
  A6IKX9 ENTREZGENE, UniProtKB/TrEMBL
  A6IKY0 ENTREZGENE, UniProtKB/TrEMBL
  A6IKY1_RAT UniProtKB/TrEMBL
  G3V733 ENTREZGENE, UniProtKB/TrEMBL
  Q63537 ENTREZGENE
  Q9Z1H0 ENTREZGENE
  SYN2_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q9Z1H0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Syn2  synapsin II    synapsin 2  Name updated 1299863 APPROVED
2002-06-10 Syn2  synapsin 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression protein expressed in nerve terminals 70028