Stk10 (serine/threonine kinase 10) - Rat Genome Database

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Gene: Stk10 (serine/threonine kinase 10) Rattus norvegicus
Analyze
Symbol: Stk10
Name: serine/threonine kinase 10
RGD ID: 3779
Description: Predicted to enable protein homodimerization activity and protein serine/threonine kinase activity. Predicted to be involved in lymphocyte aggregation and regulation of lymphocyte migration. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm. Orthologous to human STK10 (serine/threonine kinase 10); INTERACTS WITH 1-benzylpiperazine; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: serine/threonine-protein kinase 10
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81017,622,149 - 17,716,337 (+)NCBIGRCr8
mRatBN7.21017,117,860 - 17,212,065 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1017,117,878 - 17,212,061 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1021,863,541 - 21,960,798 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01021,352,145 - 21,449,405 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01016,842,732 - 16,937,737 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01017,420,964 - 17,521,810 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1017,421,075 - 17,519,706 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01017,316,575 - 17,409,682 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41017,379,245 - 17,481,768 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11017,438,282 - 17,482,813 (+)NCBI
Celera1016,764,695 - 16,858,924 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-benzylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cobalt dichloride  (EXP)
coumarin  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (ISO)
disodium selenite  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (EXP)
methoxychlor  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
picoxystrobin  (ISO)
potassium chromate  (ISO)
rac-lactic acid  (ISO)
rotenone  (ISO)
sodium dodecyl sulfate  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
testosterone enanthate  (ISO)
thioacetamide  (EXP)
thiophenes  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
plasma membrane  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. The identification of a novel cDNA preferentially expressed in the olfactory-limbic system of the adult rat. Schaar DG, etal., Brain Res 1996 May 20;721(1-2):217-28.
8. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:10692593   PMID:12639966   PMID:18239682   PMID:19255442   PMID:20458337   PMID:37721438  


Genomics

Comparative Map Data
Stk10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81017,622,149 - 17,716,337 (+)NCBIGRCr8
mRatBN7.21017,117,860 - 17,212,065 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1017,117,878 - 17,212,061 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1021,863,541 - 21,960,798 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01021,352,145 - 21,449,405 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01016,842,732 - 16,937,737 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01017,420,964 - 17,521,810 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1017,421,075 - 17,519,706 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01017,316,575 - 17,409,682 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41017,379,245 - 17,481,768 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11017,438,282 - 17,482,813 (+)NCBI
Celera1016,764,695 - 16,858,924 (+)NCBICelera
Cytogenetic Map10q12NCBI
STK10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385172,042,079 - 172,188,224 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5172,042,079 - 172,188,224 (-)EnsemblGRCh38hg38GRCh38
GRCh375171,469,083 - 171,615,228 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365171,401,679 - 171,547,951 (-)NCBINCBI36Build 36hg18NCBI36
Build 345171,403,229 - 171,547,865NCBI
Celera5167,501,519 - 167,647,757 (-)NCBICelera
Cytogenetic Map5q35.1NCBI
HuRef5166,566,183 - 166,679,569 (-)NCBIHuRef
CHM1_15170,901,480 - 171,048,064 (-)NCBICHM1_1
T2T-CHM13v2.05172,582,378 - 172,728,531 (-)NCBIT2T-CHM13v2.0
Stk10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391132,483,266 - 32,574,595 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1132,483,305 - 32,574,587 (+)EnsemblGRCm39 Ensembl
GRCm381132,533,266 - 32,624,595 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1132,533,305 - 32,624,587 (+)EnsemblGRCm38mm10GRCm38
MGSCv371132,433,266 - 32,524,595 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361132,433,305 - 32,524,587 (+)NCBIMGSCv36mm8
Celera1134,952,605 - 35,043,796 (+)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1118.97NCBI
Stk10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540824,862,365 - 24,977,713 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540824,864,033 - 24,977,713 (-)NCBIChiLan1.0ChiLan1.0
STK10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24167,184,526 - 167,327,758 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15165,324,071 - 165,467,219 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05167,396,133 - 167,539,286 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15174,311,171 - 174,455,082 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5174,311,171 - 174,455,082 (-)Ensemblpanpan1.1panPan2
STK10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1440,087,558 - 40,199,934 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl440,086,698 - 40,198,029 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha440,036,481 - 40,148,888 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0440,463,149 - 40,575,387 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl440,463,067 - 40,575,385 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1440,278,578 - 40,390,727 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0440,468,463 - 40,580,898 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0440,978,687 - 41,091,100 (+)NCBIUU_Cfam_GSD_1.0
Stk10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721394,370,867 - 94,481,111 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366093,093,554 - 3,203,792 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366093,093,597 - 3,203,786 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STK10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1652,003,887 - 52,140,367 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11652,003,768 - 52,140,378 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21656,726,108 - 56,743,092 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STK10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12374,196,033 - 74,343,450 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660344,279,131 - 4,430,618 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stk10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473317,829,773 - 17,949,532 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473317,829,802 - 17,955,643 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Stk10
592 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:276
Count of miRNA genes:187
Interacting mature miRNAs:224
Transcripts:ENSRNOT00000047011
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat

Markers in Region
D10Got34  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21017,210,462 - 17,210,616 (+)MAPPERmRatBN7.2
Rnor_6.01017,520,208 - 17,520,361NCBIRnor6.0
Rnor_5.01017,408,080 - 17,408,233UniSTSRnor5.0
RGSC_v3.41017,480,165 - 17,480,319RGDRGSC3.4
RGSC_v3.41017,480,166 - 17,480,319UniSTSRGSC3.4
RGSC_v3.11017,481,214 - 17,481,368RGD
Celera1016,857,322 - 16,857,475UniSTS
RH 2.0 Map10180.1RGD
Cytogenetic Map10q12.3UniSTS
D10Wox27  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21017,210,509 - 17,210,637 (+)MAPPERmRatBN7.2
Rnor_6.01017,520,255 - 17,520,382NCBIRnor6.0
Rnor_5.01017,408,127 - 17,408,254UniSTSRnor5.0
RGSC_v3.41017,480,212 - 17,480,340RGDRGSC3.4
RGSC_v3.41017,480,213 - 17,480,340UniSTSRGSC3.4
RGSC_v3.11017,481,261 - 17,481,389RGD
Celera1016,857,369 - 16,857,496UniSTS
Cytogenetic Map10q12.3UniSTS
AA997828  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21017,211,842 - 17,212,023 (+)MAPPERmRatBN7.2
Rnor_6.01017,521,588 - 17,521,768NCBIRnor6.0
Rnor_5.01017,409,460 - 17,409,640UniSTSRnor5.0
RGSC_v3.41017,481,546 - 17,481,726UniSTSRGSC3.4
Celera1016,858,702 - 16,858,882UniSTS
Cytogenetic Map10q12.3UniSTS
RH129287  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21017,211,795 - 17,211,980 (+)MAPPERmRatBN7.2
Rnor_6.01017,521,541 - 17,521,725NCBIRnor6.0
Rnor_5.01017,409,413 - 17,409,597UniSTSRnor5.0
RGSC_v3.41017,481,499 - 17,481,683UniSTSRGSC3.4
Celera1016,858,655 - 16,858,839UniSTS
Cytogenetic Map10q12.3UniSTS
AU049011  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21017,210,424 - 17,210,609 (+)MAPPERmRatBN7.2
Rnor_6.01017,520,170 - 17,520,354NCBIRnor6.0
Rnor_5.01017,408,042 - 17,408,226UniSTSRnor5.0
RGSC_v3.41017,480,128 - 17,480,312UniSTSRGSC3.4
Celera1016,857,284 - 16,857,468UniSTS
Cytogenetic Map10q12.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 14 6 19 6 7 25 10
Low 43 43 35 35 8 11 74 28 16 1 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000047011   ⟹   ENSRNOP00000044325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1017,117,878 - 17,212,061 (+)Ensembl
Rnor_6.0 Ensembl1017,421,075 - 17,519,706 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080404   ⟹   ENSRNOP00000074413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1017,117,878 - 17,212,061 (+)Ensembl
Rnor_6.0 Ensembl1017,486,579 - 17,519,706 (+)Ensembl
RefSeq Acc Id: NM_019206   ⟹   NP_062079
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81017,622,164 - 17,716,337 (+)NCBI
mRatBN7.21017,117,880 - 17,212,065 (+)NCBI
Rnor_6.01017,420,969 - 17,521,810 (+)NCBI
Rnor_5.01017,316,575 - 17,409,682 (+)NCBI
RGSC_v3.41017,379,245 - 17,481,768 (+)RGD
Celera1016,764,695 - 16,858,924 (+)RGD
Sequence:
RefSeq Acc Id: XM_039085736   ⟹   XP_038941664
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81017,622,149 - 17,716,335 (+)NCBI
mRatBN7.21017,117,860 - 17,212,063 (+)NCBI
RefSeq Acc Id: XM_039085737   ⟹   XP_038941665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81017,665,809 - 17,716,335 (+)NCBI
mRatBN7.21017,161,529 - 17,212,063 (+)NCBI
RefSeq Acc Id: XM_063268809   ⟹   XP_063124879
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81017,622,149 - 17,716,335 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_062079   ⟸   NM_019206
- UniProtKB: H9KVF6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074413   ⟸   ENSRNOT00000080404
RefSeq Acc Id: ENSRNOP00000044325   ⟸   ENSRNOT00000047011
RefSeq Acc Id: XP_038941664   ⟸   XM_039085736
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K7Z9 (UniProtKB/TrEMBL),   H9KVF6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941665   ⟸   XM_039085737
- Peptide Label: isoform X3
- UniProtKB: H9KVF6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063124879   ⟸   XM_063268809
- Peptide Label: isoform X2
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PTG8-F1-model_v2 AlphaFold E9PTG8 1-967 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697092
Promoter ID:EPDNEW_R7617
Type:multiple initiation site
Name:Stk10_1
Description:serine/threonine kinase 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01017,420,998 - 17,421,058EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3779 AgrOrtholog
BioCyc Gene G2FUF-25624 BioCyc
Ensembl Genes ENSRNOG00000004217 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000047011 ENTREZGENE
  ENSRNOT00000047011.5 UniProtKB/TrEMBL
  ENSRNOT00000080404.2 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STK10_STKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 29398 ENTREZGENE
PANTHER PROTEIN KINASE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE 10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PKK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Stk10 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004217 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC217910
UniProt A0A0G2K7Z9 ENTREZGENE, UniProtKB/TrEMBL
  A6HDF4_RAT UniProtKB/TrEMBL
  A6HDF5_RAT UniProtKB/TrEMBL
  A6HDF7_RAT UniProtKB/TrEMBL
  E9PTG8 ENTREZGENE
  H9KVF6 ENTREZGENE, UniProtKB/TrEMBL
  STK10_RAT UniProtKB/Swiss-Prot
UniProt Secondary D3ZUC0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Stk10  Serine/threonine kinase 10      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains has potential coiled coil formation domains which encode a highly alpha-helical molecule 634157
gene_expression expressed in the olfactory-limbic system of the adult rat brain 634157
gene_process helps in the survival of substantia nigra (SN) dopaminergic neurons 634157