Itgb4 (integrin subunit beta 4) - Rat Genome Database

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Gene: Itgb4 (integrin subunit beta 4) Rattus norvegicus
Analyze
Symbol: Itgb4
Name: integrin subunit beta 4
RGD ID: 2928
Description: Predicted to enable G protein-coupled receptor binding activity and integrin binding activity. Predicted to contribute to insulin-like growth factor I binding activity and neuregulin binding activity. Predicted to be involved in several processes, including hemidesmosome assembly; integrin-mediated signaling pathway; and skin morphogenesis. Predicted to act upstream of or within several processes, including filopodium assembly; peripheral nervous system myelin formation; and trophoblast cell migration. Located in cell cortex. Is active in glutamatergic synapse and postsynaptic membrane. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and junctional epidermolysis bullosa with pyloric atresia. Orthologous to human ITGB4 (integrin subunit beta 4); PARTICIPATES IN integrin mediated signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; cell-extracellular matrix signaling pathway; INTERACTS WITH (+)-pilocarpine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GP150; integrin beta 4; integrin beta-4; integrin, beta 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810101,705,592 - 101,741,933 (+)NCBIGRCr8
mRatBN7.210101,206,657 - 101,243,012 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10101,206,665 - 101,243,012 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10106,268,387 - 106,304,610 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010105,731,475 - 105,767,696 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010101,127,619 - 101,163,963 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010104,524,000 - 104,560,180 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10104,523,996 - 104,561,078 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010103,725,179 - 103,761,358 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410106,080,452 - 106,116,632 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110106,094,955 - 106,131,136 (+)NCBI
Celera1099,781,746 - 99,817,137 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(E)-roxithromycin  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
2-acetamidofluorene  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8'-apo-beta,psi-caroten-8'-al  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
aristolochic acids  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
berberine  (ISO)
beta-carotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
butane-2,3-dione  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cadmium nitrate  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clarithromycin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyanocob(III)alamin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dichromium trioxide  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethylparaben  (ISO)
fipronil  (EXP)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP)
glycidol  (EXP)
glycidyl methacrylate  (ISO)
glycine betaine  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methylseleninic acid  (ISO)
ML-7  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
ochratoxin A  (EXP)
ofloxacin  (ISO)
omega-6 fatty acid  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propanal  (ISO)
rac-lactic acid  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sotorasib  (ISO)
sulindac  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (EXP)
Y-27632  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Beta 4 integrin expression in myelinating Schwann cells is polarized, developmentally regulated and axonally dependent. Feltri ML, etal., Development 1994 May;120(5):1287-301.
2. Cloning and sequence of the cDNA encoding the beta 4 integrin subunit in rat peripheral nerve. Feltri ML, etal., Gene 1997 Feb 28;186(2):299-304.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Regional Regulation of Purkinje Cell Dendritic Spines by Integrins and Eph/Ephrins. Heintz TG, etal., PLoS One. 2016 Aug 12;11(8):e0158558. doi: 10.1371/journal.pone.0158558. eCollection 2016.
6. Berberine regulates the microRNA-21-ITGΒ4-PDCD4 axis and inhibits colon cancer viability. Lü Y, etal., Oncol Lett. 2018 Apr;15(4):5971-5976. doi: 10.3892/ol.2018.7997. Epub 2018 Feb 8.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
15. Differential localization of laminin gamma and integrin beta in primary cultures of the rat gingival epithelium. Tanno M, etal., J Periodontal Res. 2006 Feb;41(1):15-22.
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:8707838   PMID:11891657   PMID:12482924   PMID:12867433   PMID:16365040   PMID:16436605   PMID:17011173   PMID:19199708   PMID:19403692   PMID:19765400   PMID:19933311   PMID:20510671  
PMID:20682778   PMID:21310825   PMID:21464233   PMID:21606200   PMID:22274697   PMID:22351760   PMID:23154389   PMID:23382219   PMID:23496044   PMID:24007983   PMID:24851274   PMID:29315582  
PMID:32220495  


Genomics

Comparative Map Data
Itgb4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810101,705,592 - 101,741,933 (+)NCBIGRCr8
mRatBN7.210101,206,657 - 101,243,012 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10101,206,665 - 101,243,012 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10106,268,387 - 106,304,610 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010105,731,475 - 105,767,696 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010101,127,619 - 101,163,963 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010104,524,000 - 104,560,180 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10104,523,996 - 104,561,078 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010103,725,179 - 103,761,358 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410106,080,452 - 106,116,632 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110106,094,955 - 106,131,136 (+)NCBI
Celera1099,781,746 - 99,817,137 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
ITGB4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381775,721,459 - 75,757,818 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1775,721,328 - 75,757,818 (+)EnsemblGRCh38hg38GRCh38
GRCh371773,717,539 - 73,753,899 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361771,229,111 - 71,265,494 (+)NCBINCBI36Build 36hg18NCBI36
Build 341771,229,110 - 71,265,493NCBI
Celera1770,307,618 - 70,343,945 (+)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1769,141,364 - 69,178,763 (+)NCBIHuRef
CHM1_11773,782,244 - 73,818,973 (+)NCBICHM1_1
T2T-CHM13v2.01776,614,671 - 76,651,043 (+)NCBIT2T-CHM13v2.0
Itgb4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911115,865,556 - 115,899,238 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11115,865,535 - 115,899,238 (+)EnsemblGRCm39 Ensembl
GRCm3811115,974,725 - 116,008,412 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11115,974,709 - 116,008,412 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711115,836,039 - 115,869,725 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611115,791,069 - 115,824,502 (+)NCBIMGSCv36mm8
Celera11127,737,663 - 127,770,611 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1180.91NCBI
Itgb4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555066,493,466 - 6,526,778 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555066,493,466 - 6,526,778 (-)NCBIChiLan1.0ChiLan1.0
ITGB4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21991,764,488 - 91,801,919 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11796,589,205 - 96,626,633 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01769,671,252 - 69,708,520 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11775,222,441 - 75,259,401 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1775,222,376 - 75,259,401 (+)Ensemblpanpan1.1panPan2
ITGB4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.194,825,148 - 4,855,266 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl94,825,292 - 4,855,820 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha95,504,986 - 5,534,992 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.095,495,318 - 5,525,359 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl95,495,318 - 5,525,460 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.195,534,766 - 5,564,815 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.095,644,907 - 5,674,940 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.095,705,723 - 5,735,767 (-)NCBIUU_Cfam_GSD_1.0
Itgb4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056025,467,140 - 5,499,662 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936594912,291 - 946,012 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936594912,302 - 944,819 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGB4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl125,651,292 - 5,685,611 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1125,651,292 - 5,685,601 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2125,597,667 - 5,631,833 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITGB4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11645,926,543 - 45,962,967 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607716,683,754 - 16,721,078 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itgb4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248015,613,861 - 5,650,214 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248015,613,752 - 5,646,046 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itgb4
135 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:177
Count of miRNA genes:134
Interacting mature miRNAs:142
Transcripts:ENSRNOT00000065339
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091228102104060283Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1096703043107057807Rat
631539Oia6Oil induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1097010147104670812Rat

Markers in Region
RH130868  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210101,242,714 - 101,242,912 (+)MAPPERmRatBN7.2
Rnor_6.010104,559,891 - 104,560,088NCBIRnor6.0
Rnor_5.010103,725,271 - 103,725,468UniSTSRnor5.0
RGSC_v3.410106,116,343 - 106,116,540UniSTSRGSC3.4
Celera1099,816,848 - 99,817,045UniSTS
Cytogenetic Map10q32.3UniSTS
RH94625  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210101,242,819 - 101,242,981 (+)MAPPERmRatBN7.2
Rnor_6.010104,559,996 - 104,560,157NCBIRnor6.0
Rnor_5.010103,725,202 - 103,725,363UniSTSRnor5.0
RGSC_v3.410106,116,448 - 106,116,609UniSTSRGSC3.4
Celera1099,816,953 - 99,817,114UniSTS
Cytogenetic Map10q32.3UniSTS
AU047884  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210101,240,329 - 101,240,474 (+)MAPPERmRatBN7.2
Rnor_6.010104,557,506 - 104,557,650NCBIRnor6.0
Rnor_5.010103,727,709 - 103,727,853UniSTSRnor5.0
RGSC_v3.410106,113,958 - 106,114,102UniSTSRGSC3.4
Celera1099,814,463 - 99,814,607UniSTS
Cytogenetic Map10q32.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 2 2 9 4
Low 39 53 39 17 39 8 11 50 35 30 7 8
Below cutoff 4 2 2 2 24 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000065339   ⟹   ENSRNOP00000059783
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10101,206,665 - 101,243,012 (+)Ensembl
Rnor_6.0 Ensembl10104,523,996 - 104,560,182 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086747   ⟹   ENSRNOP00000073188
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10101,206,665 - 101,243,012 (+)Ensembl
Rnor_6.0 Ensembl10104,524,008 - 104,561,078 (+)Ensembl
RefSeq Acc Id: NM_013180   ⟹   NP_037312
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810101,705,592 - 101,741,933 (+)NCBI
mRatBN7.210101,206,665 - 101,243,012 (+)NCBI
Rnor_6.010104,524,000 - 104,560,180 (+)NCBI
Rnor_5.010103,725,179 - 103,761,358 (-)NCBI
RGSC_v3.410106,080,452 - 106,116,632 (+)RGD
Celera1099,781,746 - 99,817,137 (+)RGD
Sequence:
RefSeq Acc Id: XM_039085295   ⟹   XP_038941223
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810101,705,783 - 101,741,933 (+)NCBI
mRatBN7.210101,206,657 - 101,243,012 (+)NCBI
RefSeq Acc Id: XM_039085296   ⟹   XP_038941224
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810101,705,783 - 101,741,933 (+)NCBI
mRatBN7.210101,206,657 - 101,243,012 (+)NCBI
RefSeq Acc Id: XM_039085297   ⟹   XP_038941225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810101,705,783 - 101,741,933 (+)NCBI
mRatBN7.210101,206,658 - 101,243,012 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_037312   ⟸   NM_013180
- Peptide Label: precursor
- UniProtKB: Q64632 (UniProtKB/Swiss-Prot),   F1LSD3 (UniProtKB/TrEMBL),   A6HKS7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000059783   ⟸   ENSRNOT00000065339
RefSeq Acc Id: ENSRNOP00000073188   ⟸   ENSRNOT00000086747
RefSeq Acc Id: XP_038941223   ⟸   XM_039085295
- Peptide Label: isoform X1
- UniProtKB: Q64632 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038941224   ⟸   XM_039085296
- Peptide Label: isoform X2
- UniProtKB: Q64632 (UniProtKB/Swiss-Prot),   A0A0G2K4V5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941225   ⟸   XM_039085297
- Peptide Label: isoform X3
- UniProtKB: Q64632 (UniProtKB/Swiss-Prot)
Protein Domains
Calx-beta   EGF-like   Fibronectin type-III   PSI   VWFA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64632-F1-model_v2 AlphaFold Q64632 1-1807 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697899
Promoter ID:EPDNEW_R8424
Type:initiation region
Name:Itgb4_1
Description:integrin subunit beta 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010104,524,095 - 104,524,155EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2928 AgrOrtholog
BioCyc Gene G2FUF-22639 BioCyc
Ensembl Genes ENSRNOG00000005580 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065339 ENTREZGENE
  ENSRNOT00000065339.3 UniProtKB/TrEMBL
  ENSRNOT00000086747.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.2030 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  4.10.1240.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ligand-binding face of the semaphorins, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CalX-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calx_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  I-EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_beta_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_bsu-4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_bsu_tail UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_bsu_tail_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_bsu_VWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25724 UniProtKB/Swiss-Prot
NCBI Gene 25724 ENTREZGENE
PANTHER PTHR10082 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10082:SF42 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Calx-beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  I-EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_B_tail UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PSI_integrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Itgb4 PhenoGen
PIRSF Integrin_B4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS INTEGRINB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot
  FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTEGRIN_BETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005580 RatGTEx
SMART Calx_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_B_tail UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Plexin repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF141072 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF69687 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC202060
UniProt A0A0G2K4V5 ENTREZGENE, UniProtKB/TrEMBL
  A6HKS7 ENTREZGENE, UniProtKB/TrEMBL
  A6HKS8_RAT UniProtKB/TrEMBL
  F1LSD3 ENTREZGENE, UniProtKB/TrEMBL
  ITB4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Itgb4  integrin subunit beta 4  Itgb4  integrin, beta 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-02-09 Itgb4  integrin, beta 4  Itgb4  integrin beta 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Itgb4  Integrin, beta 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the abaxonal surface of myelinating Schwann cells 729025
gene_expression expressed in myelinating Schwann cells 729025